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121. 发明专利

JP2864491B2 失效
公开(公告)号：JP2864491B2
公开(公告)日：1999-03-03
申请号：JP23577593
申请日：1993-08-26
申请人： KURARE KK
发明人： TORIHARA MASAHIRO , TAMAI HIRONOBU
IPC分类号： C07B53/00 , C07C45/29 , C07C45/59 , C07C49/433 , C07C51/09 , C07C62/02 , C07C62/32 , C07D317/72

122. 发明专利

JPH07316155A CYCLOPROPANE DERIVATIVE AND PRODUCTION THEREOF 失效
公开(公告)号：JPH07316155A
公开(公告)日：1995-12-05
申请号：JP17549594
申请日：1994-07-27
申请人： AJINOMOTO KK
发明人： ONISHI TOMOYUKI , TSUJI HISASHI , MATSUZAWA TOSHIHIRO
IPC分类号： C07C62/02 , C07C235/40 , C07D307/93 , C07D473/00 , C07D473/04 , C07D473/16 , C07D473/18 , C07D473/32 , C07D473/34 , C07D473/40
摘要： PURPOSE:To obtain a new compound useful as an antiviral agent. CONSTITUTION:This is a compound of formula I (B is a purine derivative residue such as guanine-9-yl, 2-amino-6-chloropurine-9-yl and 2-acetamino-6- chloropurine-9-yl), e.g. 2-amino-6-chloro-9-(3'-oxa-2'-oxobicyclo[3,1,0]hexane-1'-yl) methylpurine. A compound of formula I is obtained by substituting the hydroxyl group of (3-oxa-2-oxobicyclo[3,1,0]hexane-1-yl)methanol of formula II with a leaving group followed by the reaction with a purine derivative. Further, the reduction of a compound of formula I can lead to a compound of formula III.

123. 发明专利

JPH05238978A 失效
公开(公告)号：JPH05238978A
公开(公告)日：1993-09-17
申请号：JP7894392
申请日：1992-02-28
申请人： SANTEN PHARMA CO LTD
发明人： MITA SHIRO , KAWASHIMA YOICHI , MORISHITA MASATAKA
IPC分类号： A61K31/075 , A61K31/095 , A61K31/12 , A61K31/122 , A61K31/19 , A61K31/215 , A61K31/357 , A61P37/00 , A61P37/04 , A61P43/00 , C07C31/135 , C07C43/30 , C07C49/493 , C07C62/02 , C07C62/08 , C07C69/757 , C07C323/22 , C07C323/53
摘要： PURPOSE:To obtain a new compound capable of exhibiting a thymulin-like activity and useful as a therapeutic agent, etc., for immunodeficiency and autoimmune diseases, etc. CONSTITUTION:A compound of formula I [R and R are (protected)hydroxy or (protected)sulfhydryl; X is carboxyl, lower-alkoxycarbonyl, =O, etc.; A and B are each lower alkylene], e.g. c-2,c-4-bis(benzylthiomethyl)-gamma-1- cyclopentanecarboxylic acid. Furthermore, the compound of formula I is obtained by treating e.g. a compound of formula II in a liquid ammonia in the presence of metallic sodium.

124. 发明专利

JPS63501720A 失效
公开(公告)号：JPS63501720A
公开(公告)日：1988-07-14
申请号：JP50000487
申请日：1986-11-25
IPC分类号： C07C69/44 , C07C45/00 , C07C45/30 , C07C49/403 , C07C51/00 , C07C51/16 , C07C51/347 , C07C51/353 , C07C61/06 , C07C62/02 , C07C67/00 , C07C69/74 , C07C231/00 , C07C231/10 , C07C231/14 , C07C233/12 , C07C233/58 , C07C233/63 , C07C241/00 , C07C243/36 , C07C245/12 , C07C251/84

126. 发明专利

JPS6125012B2 JPS6125012B2 - 失效
公开(公告)号：JPS6125012B2
公开(公告)日：1986-06-13
申请号：JP10567476
申请日：1976-09-03
申请人： Wellcome Found
发明人： GURAHAMU ROI RII
IPC分类号： C07C69/743 , C07C51/00 , C07C51/363 , C07C51/367 , C07C51/377 , C07C61/16 , C07C61/37 , C07C61/40 , C07C62/02 , C07C62/18 , C07C67/00 , C07C69/757 , C07C231/00 , C07C231/12 , C07C233/58 , C07C253/00 , C07C255/39 , C07C255/45 , C07C255/48 , C07C301/00 , C07C303/28 , C07C309/63 , C07C309/67 , C07C309/73 , C07C381/00 , C07D209/49 , C07D307/34
CPC分类号： C07C255/00 , C07C309/67 , C07C381/00

127. 发明专利

JPS61118345A Cyclohexene derivative 失效
标题翻译：环己酮衍生物
公开(公告)号：JPS61118345A
公开(公告)日：1986-06-05
申请号：JP23989584
申请日：1984-11-14
申请人： Yasumitsu Tamura
发明人： TAMURA YASUMITSU , SASHO MANABU , OE HIROKO , AKAI SHUJI , KITA YASUYUKI
IPC分类号： C07D311/76 , C07C45/00 , C07C50/36 , C07C51/00 , C07C59/46 , C07C62/02 , C07C67/00 , C07C69/732 , C07C69/757 , C07F7/08 , C07F7/12
摘要： NEW MATERIAL:The compound of formula I [R
1 and R
2 are H or lower alkyl; R
3 is tri (lower alkyl) silyl or H; the group of formula II may be cyclized to form the group of formula III].
EXAMPLE: Ethyl 2-carboethoxy-5-hydroxy-5-trimethylsilylethynyl-1-cyclohexy- lideneacetate.
USE: Synthetic intermediate of daunomycin, etc.
PREPARATION: A compound of formula I whrerein R
1 WR
3 are H can be pre pared by reacting the compound of formula IV (R
1 ' and R
2 ' are lower alkyl) with the compound of formula CH≡C-R
3 , and hydrolyzing and/or desilylating the resultant compound of formula V. The product can be converted to another compound of formula I wherein the group of formula II is the group of formula III and R
3 is H by cyclization.
COPYRIGHT: (C)1986,JPO&Japio
摘要翻译：新材料：式I化合物[R 1和R 2]为H或低级烷基; R 3是三（低级烷基）甲硅烷基或H; 式II的基团可以被环化以形成式III的基团]。实施例：2-乙酰乙氧基-5-羟基-5-三甲基甲硅烷基乙炔基-1-环己基 - 己烯乙酸乙酯。用途：道诺霉素的合成中间体等制备：式Ⅰ化合物R 1 -R 3可以是H，可以通过使式Ⅳ化合物（R 1'和R 2）与式C化合物C-R 3的化合物'是低级烷基），并将所得到的式V化合物水解和/或去甲硅烷基化。该产物可以转化成另一种式I化合物，其中式II基团是基团的式III化合物，R 3为环状的H。

128. 发明专利

JPS60252476A LACTONE DERIVATIVE 失效
公开(公告)号：JPS60252476A
公开(公告)日：1985-12-13
申请号：JP10651784
申请日：1984-05-28
申请人： SHOWA DENKO KK
发明人： TAKANO SEIICHI , OGASAWARA KUNIROU , AKIYAMA MASAJI
IPC分类号： C07D307/33 , C07C51/00 , C07C61/37 , C07C62/02 , C07C67/00 , C07D307/32 , C07D307/93
摘要： NEW MATERIAL:A compound expressed by the formula (X is H or Cl). EXAMPLE:2,2-Dichloro-3-(2-chloro-2-methylethyl)-4-hydroxybutyrolactone. USE:An intermediate for preparing cis-chrysanthemumic acid. PREPARATION:Prenyl alcohol expressed by formula II is reacted with trichloroacetyl chloride (CCl3COCl) in a solvent, e.g. benzene, in the presence of a weakly basic catalyst, e.g. pyridine, at -5-+10 deg.C to give almost quantitatively a compound expressed by formula III, which is then reacted with cuprous chloride in a solvent, e.g. acetonitrile, at 120-160 deg.C to cause free radical cyclization and give the compound expressed by formula I (X is Cl). The resultant compound expressed by formula I (X is Cl) can be treated with a tri-alkyltin hydride, etc. in the presence of a catalytic amount of azobisisobutyronitrile, etc. at 70- 100 deg.C to remove selectively Cl in the alpha-position.

130. 发明专利

JPS5795979A NOVEL CYCLOPROPANE DERIVATIVES, MANUFACTURE AND THEIR USE FOR PRODUCING DIHALOVINYLCYCLOPROPANE CARBOXYLIC ACIDS 失效
公开(公告)号：JPS5795979A
公开(公告)日：1982-06-15
申请号：JP16648781
申请日：1981-10-20
申请人： SHELL INT RESEARCH
发明人： PETORIYUSU ANTONIYUSU KURAMERU
IPC分类号： C07C51/00 , C07C51/09 , C07C61/40 , C07C62/02 , C07C62/18 , C07C67/00 , C07D307/93

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