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121. 发明申请

WO2013114377A1 STABLE LIPOSOMES FOR DRUG DELIVERY 审中-公开
标题翻译：稳定的药物输送药物
公开(公告)号：WO2013114377A1
公开(公告)日：2013-08-08
申请号：PCT/IL2013/050100
申请日：2013-02-03
申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM, LTD
发明人： BARENHOLZ, Yechezkel , BERMAN, Tal , FRIEDMAN, Doron
IPC分类号： A61K9/127
CPC分类号： A61K47/20 , A61K9/127 , A61K9/1271 , A61K9/1278 , A61K31/4745 , A61K31/704 , A61K45/06
摘要： Liposomes with an entrapped amphipathic weak base and alkyl or aryl sulfonate are described as well as methods of making and using these liposomes.
摘要翻译：描述了具有截留的两亲性弱碱和烷基或芳基磺酸盐的脂质体以及制备和使用这些脂质体的方法。

122. 发明申请

WO2013030840A2 ADHESIVE BIOPOLYMERS AND USES THEREOF 审中-公开
标题翻译：粘合生物聚合物及其用途
公开(公告)号：WO2013030840A2
公开(公告)日：2013-03-07
申请号：PCT/IL2012/050340
申请日：2012-08-30
申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. , COLLPLANT LTD. , SHOSEYOV, Oded , LAPIDOT, Shaul , RIVKIN, Amit
发明人： SHOSEYOV, Oded , LAPIDOT, Shaul , RIVKIN, Amit
CPC分类号： A61L24/108 , A61L2430/06 , C07K14/43563 , C08B37/00 , C08H1/00 , C08J3/24 , C08J2300/16 , C09J189/00
摘要： Provided herein are polymers having the general formula I as defined herein, A-L-B Formula I as well as crosslinked polymers having the general formula III: B'-L'-A'-A"-L"-B" Formula III and methods of preparing the polymers, wherein A is a dihydroxyphenyl moiety; A' -A" is a pair of crosslinked dihydroxyphenyl moieties; B, B' and B" are each a biopolymer; and L, L' and L" are each a linking moiety. Further provided are crosslinked adhesives prepared from the polymers, methods of generating same by oxidizing a polymer, and uses thereof. Further provided are kits comprising an adhesive and an oxidizing agent.
摘要翻译：本文提供具有本文所定义的通式I的聚合物，ALB式I以及具有通式III的交联聚合物：B'-L'-A'-A“-L”-B“式III及其制备方法聚合物，其中A是二羟基苯基部分; A'-A“是一对交联的二羟基苯基部分; B，B'和B“各自为生物聚合物; L，L'和L”各自为连接部分。进一步提供由聚合物制备的交联粘合剂，通过氧化聚合物生成相同的方法及其用途。还提供了包含粘合剂和氧化剂的试剂盒。

123. 发明申请

WO2013005211A2 BORON COMPLEXING PLANT MATERIALS AND USES THEREOF CROSS-REFERENCE TO RELATED APPLICATIONS 审中-公开
标题翻译：硼复合植物材料及其用途相关申请的交叉引用
公开(公告)号：WO2013005211A2
公开(公告)日：2013-01-10
申请号：PCT/IL2012/050233
申请日：2012-07-04
申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. , MOSHELION, Menachem , MORAN, Nava , LAMDAN, Netta Li , ATTIA, Ziv
发明人： MOSHELION, Menachem , MORAN, Nava , LAMDAN, Netta Li , ATTIA, Ziv
IPC分类号： B09C1/00 , C02F1/28 , C02F3/32 , C12N15/82
CPC分类号： C02F1/286 , B09C1/105 , C02F1/66 , C02F3/327 , C02F2101/108 , C12N15/8259 , Y02W10/18
摘要： This invention relates to methods for reducing the boron concentration of a water source, solid supports for effecting the same, methods for increasing boron tolerance in a plant and seeds and transgenic plants produced in accordance with the same. The methods of this invention include providing conditions whereby the plant exhibits increased shoot concentrations of malic acid, fructose, glucose, citric acid or a combination thereof, or providing conditions whereby a shoot in said plant contains intracellular complexes of malic acid, fructose, glucose, citric acid or a combination thereof with boron, in turn reducing toxicity of boron to the plant, thereby being a method of increasing boron tolerance in the plant. Methods of reducing soil boron content are also described.
摘要翻译：本发明涉及用于降低水源硼浓度的方法，用于实现其的固体支持物，用于增加植物和种子中的耐硼性的方法以及根据该植物生产的转基因植物。本发明的方法包括提供条件，其中植物表现出苹果酸，果糖，葡萄糖，柠檬酸或其组合的枝条浓度增加，或提供条件，由此所述植物中的芽含有苹果酸，果糖，葡萄糖，柠檬酸或其与硼的组合，从而降低硼对植物的毒性，从而是增加植物中耐硼性的方法。还描述了减少土壤硼含量的方法。

124. 发明申请

WO2012168941A8 FLEXIBLE TRANSPARENT CONDUCTIVE COATINGS BY DIRECT ROOM TEMPERATURE EVAPORATIVE LITHOGRAPHY 审中-公开
公开(公告)号：WO2012168941A8
公开(公告)日：2012-12-13
申请号：PCT/IL2012/050200
申请日：2012-06-07
申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. , MAGDASSI, Shlomo , LAYANI, Michael
发明人： MAGDASSI, Shlomo , LAYANI, Michael
IPC分类号： H05K3/10 , H05K1/09 , H05K3/12 , H05K3/18
摘要： The invention provides a process for forming highly ordered, conductive and transparent patterns on flexible heat-sensitive surfaces. The invention relates to sintering nanoparticles at room temperature. Patterning is done by a patterning device and the self-assembly of the nanoparticles.

125. 发明申请

WO2012104836A1 SNX9 AS A NOVEL BIOMARKER FOR CHRONIC INFLAMMATION AND ASSOCIATED IMMUNOSUPPRESSION AND A NEW REGULATOR OF T CELL RECEPTOR EXPRESSION AND FUNCTION 审中-公开
标题翻译： SNX9作为慢性淋巴细胞白血病和相关免疫抑制剂的新型生物标记物和T细胞受体表达和功能的新调节剂
公开(公告)号：WO2012104836A1
公开(公告)日：2012-08-09
申请号：PCT/IL2012/000053
申请日：2012-01-31
申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. , BANIYASH, Michal , ISH SHALOM, Eliran
发明人： BANIYASH, Michal , ISH SHALOM, Eliran
IPC分类号： G01N33/564 , G01N33/569 , G01N33/574
CPC分类号： G01N33/6893 , C07K14/435 , G01N33/564 , G01N33/569 , G01N33/574
摘要： The present invention relates to diagnostic and prognostic methods and kits for assessing chronic inflammation and associated immune-suppression. More particularly, the invention relates to the use of SNX9 (sorting nexin 9 protein) as a biomarker for chronic inflammation and associated immune-suppression, specifically, in subjects suffering from chronic inflammatory conditions. The invention further provides a prognostic tool for detecting regression or recurrence of the diseases and a powerful tool for assessing efficacy of a treatment. The present invention further provides SNX9 as an immunomodulator and therefore relates to methods for treating immune-related disorders by modulating SNX9 expression.
摘要翻译：本发明涉及用于评估慢性炎症和相关免疫抑制的诊断和预后方法和试剂盒。更具体地，本发明涉及SNX9（分选nexin9蛋白）作为慢性炎症和相关免疫抑制的生物标志物的用途，特别是涉及患有慢性炎症病症的受试者。本发明还提供了一种用于检测疾病的回归或复发的预后工具，以及用于评估治疗效果的强大工具。本发明进一步提供作为免疫调节剂的SNX9，因此涉及通过调节SNX9表达来治疗免疫相关疾病的方法。

126. 发明申请

WO2012077121A2 SCREENING FOR ENZYMES ON THE PHENYLPROPANOID PATHWAY 审中-公开
标题翻译：在酚醛路线上筛选酶
公开(公告)号：WO2012077121A2
公开(公告)日：2012-06-14
申请号：PCT/IL2011/050055
申请日：2011-12-08
申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. , ABELIOVICH, Hagai , ALBERSTEIN, Moti
发明人： ABELIOVICH, Hagai , ALBERSTEIN, Moti
IPC分类号： C12N15/82
CPC分类号： C12Q1/6897 , C12N9/0073 , C12N9/1037 , C12N9/88 , C12N9/93 , C12N15/8243 , C12N15/825 , C12Q1/25 , C12Q1/26 , C12Q1/527 , C12Y114/13011 , C12Y203/01074 , C12Y403/01005 , C12Y602/01012
摘要： The invention relates to a method to screen for a nucleic acid molecule encoding a polypeptide involved in the synthesis of naringenin chalcone which demonstrates altered expression, activity or substrate specificity. The invention further relates to nucleic acid molecules identified by said screen and to transgenic plants modified to express said nucleic acid molecule.
摘要翻译：本发明涉及一种筛选编码参与柚皮素查耳酮合成的多肽的核酸分子的方法，其表现出改变的表达，活性或底物特异性。本发明还涉及由所述筛选鉴定的核酸分子和修饰以表达所述核酸分子的转基因植物。

127. 发明申请

WO2012073243A1 SYSTEM AND METHOD FOR PHOTONICALLY ASSISTED ANALOG TO DIGITAL SIGNAL CONVERSION 审中-公开
标题翻译：用于光电辅助模拟到数字信号转换的系统和方法
公开(公告)号：WO2012073243A1
公开(公告)日：2012-06-07
申请号：PCT/IL2011/050035
申请日：2011-11-29
申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. , MAROM, Dan
发明人： MAROM, Dan
IPC分类号： H03M1/12
CPC分类号： H03M1/1205 , G02F7/00 , H03M1/124 , H03M1/1245
摘要： A photonically assisted analog to digital conversion (ADC) system is presented. The system comprises: an optical sampling signal generator configured and operable for generating an optical sampling signal comprising a predetermined sampling pulse sequence in the form of a time separated pulse train of spectral components dispersed in a periodic fashion, where each pulse is distinguishable by a central wavelength thereof different from its neighboring pulses. The generation of the pulse sampling sequence is achieved by combining broadband dispersion and compensation with a periodic dispersion compensator having a free spectral range smaller than the broad bandwidth of the ultrashort pulse. The second innovative element is the introduction of coherent detection with oversampling of the interference terms of the phase modulated pulse sampling sequence and a reference pulse. The oversampling provides additional measurements of the beat term and by way of error minimization a more reliable phase estimation is provided, translated into a more accurate conversion to digital representation. The system further comprises an electro-optical modulator for interacting an input electric analog signal and an optical sampling signal and generating a modulated optical signal indicative of said input signal; and a detection system configured and operable for receiving said modulated optical signal and generating an output digital signal corresponding to said input electric analog signal.
摘要翻译：提出了一种光子辅助模数转换（ADC）系统。该系统包括：光采样信号发生器，其被配置和可操作用于产生光采样信号，该采样信号包括以周期性方式分散的频谱分量的时间分离脉冲串形式的预定采样脉冲序列，其中每个脉冲可由中央其波长与其相邻脉冲不同。通过将宽带色散和补偿与具有小于超短脉冲的宽带宽的自由光谱范围的周期色散补偿器组合来实现脉冲采样序列的产生。第二个创新因素是引入相干检测，对相位调制脉冲采样序列和参考脉冲的干涉项进行过采样。过采样提供了节拍项的附加测量，并且通过误差最小化提供了更可靠的相位估计，被转换成更准确的数字表示转换。该系统还包括电光调制器，用于与输入电模拟信号和光采样信号相互作用并产生指示所述输入信号的调制光信号; 以及检测系统，其配置和操作用于接收所述调制光信号并产生对应于所述输入电模拟信号的输出数字信号。

128. 发明申请

WO2012047290A1 OXYGENATED DEMINERALIZED BONE MATRIX FOR USE IN BONE GROWTH 审中-公开
标题翻译：用于骨骼生长的氧化骨质骨基质
公开(公告)号：WO2012047290A1
公开(公告)日：2012-04-12
申请号：PCT/US2011/001717
申请日：2011-10-04
申请人： THERACELL, INC. & YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM, LTD. , PHILLIPS, Frank, M. , HOCHSCHULER, Stephen, H. , GAZIT, Dan , PELLED, Gadi , GAZIT, Zulma
发明人： PHILLIPS, Frank, M. , HOCHSCHULER, Stephen, H. , GAZIT, Dan , PELLED, Gadi , GAZIT, Zulma
IPC分类号： A01N63/00 , A61K9/14 , C12N5/00
CPC分类号： A61K35/32 , A61K9/0026 , A61L27/3608 , A61L2430/02
摘要： An improved composition for inducing bone growth is provided that is a combination of at least DBM and an oxygen carrier. Injection/implantation of a composition of DBM and an oxygen carrier (e.g. a perfluorocarbon) results in enhancement of bone formation compared to DBM alone.
摘要翻译：提供了用于诱导骨生长的改进组合物，其是至少DBM和氧载体的组合。 DBM和氧载体（例如全氟化碳）的组合物的注射/植入导致与单独的DBM相比增强骨形成。

129. 发明申请

WO2011161637A3 OPTICAL NETWORK UNIT, OPTICAL ACCESS NETWORK AND A METHOD FOR EXCHANGING INFORMATION 审中-公开
公开(公告)号：WO2011161637A3
公开(公告)日：2011-12-29
申请号：PCT/IB2011/052743
申请日：2011-06-22
申请人： TECHNION R&D FOUNDATION , YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. , NAZARATHY, Moshe , AGMON, Amos , MAROM, Dan
发明人： NAZARATHY, Moshe , AGMON, Amos , MAROM, Dan
IPC分类号： H04J14/00
摘要： An Optical Access Network and an Optical Network Unit (ONU) are provided. The method includes: receiving a pilot signal wherein the pilot signal is received at a pilot frequency slot and the downstream information signals are received at a downstream information frequency slot; wherein the ONU is allocated with a spectral slice; wherein at least one other spectral slice is allocated for exchanging information with at least one other group of ONUs; splitting the downstream information signals to downstream information signals portions; modulating a portion of the pilot signal by upstream information signals to provide upstream information signals that are within the upstream information frequency slot; and modulating a second portion of the downstream information signals by the upstream information signals to provide upstream secondary signals that are outside the pilot frequency slot, the downstream information frequency slot and the upstream information frequency slot.

130. 发明申请

WO2011151822A1 3-SUBSTITUTED VINYLBORONATES AND USES THEREOF 审中-公开
标题翻译： 3-取代的乙烯基硼酸酯及其用途
公开(公告)号：WO2011151822A1
公开(公告)日：2011-12-08
申请号：PCT/IL2011/000423
申请日：2011-05-31
申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. , SREBNIK, Morris , AL-AZIZ QUNTAR, Abed , BOTVINIK, Alina , DAGAN, Arie
发明人： SREBNIK, Morris , AL-AZIZ QUNTAR, Abed , BOTVINIK, Alina , DAGAN, Arie
IPC分类号： A61K31/69 , C07F5/04 , A61P35/00
CPC分类号： A61K31/69 , C07F5/025
摘要： 3-substituted vinylboronates and their use in the treatment of cancer such as colorectal cancer are disclosed. In some embodiments, the 3-substituted vinylboronates have the general Formula I: (see formula) with the variables in the formula being as defined in the specification.
摘要翻译：公开了3-取代的乙烯基硼酸酯及其在治疗癌症中的用途，例如结肠直肠癌。在一些实施方案中，3-取代的乙烯基硼酸酯具有通式I（参见式），式中的变量如说明书中所定义。

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