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121. 发明申请

US20070005698A1 Method and apparatuses for locating an expert during a collaboration session 审中-公开
标题翻译：用于在协作会话期间定位专家的方法和装置
公开(公告)号：US20070005698A1
公开(公告)日：2007-01-04
申请号：US11323431
申请日：2005-12-29
申请人： Manish Kumar , Weidong Chen , Lei Zhu , Min Zhu
发明人： Manish Kumar , Weidong Chen , Lei Zhu , Min Zhu
IPC分类号： G06F15/16
CPC分类号： G06Q10/10 , H04L67/14 , H04L67/148 , H04L67/306
摘要： In one embodiment, the methods and apparatuses include requesting an expert during a collaboration session; determining a subject matter of the collaboration session; detecting a potential participant to serve as the expert; and inviting the potential participant to join the collaboration session.
摘要翻译：在一个实施例中，所述方法和装置包括在协作会话期间请求专家; 确定协作会话的主题; 发现潜在参与者担任专家; 并邀请潜在参与者加入协作会议。

122. 发明申请

US20070005695A1 Methods and apparatuses for selectively providing privacy through a dynamic social network system 有权
标题翻译：用于通过动态社交网络系统选择性地提供隐私的方法和装置
公开(公告)号：US20070005695A1
公开(公告)日：2007-01-04
申请号：US11171870
申请日：2005-06-29
申请人： Weidong Chen , Lei Zhu , Min Zhu
发明人： Weidong Chen , Lei Zhu , Min Zhu
IPC分类号： G06F15/16
CPC分类号： H04L67/306 , H04L12/1818
摘要： In one embodiment, the methods and apparatuses initiate a collaboration session from a presenter participant; select an available profile from a plurality of overall profiles based on a hierarchy structure of the plurality of overall profiles and a presenter profile corresponding to the presenter participant; and invite an attendee to the collaboration session by the presenter participant wherein the attendee corresponds to the available profile.
摘要翻译：在一个实施例中，方法和装置从演示者参与者发起协作会话; 基于多个总体简档的层次结构和对应于演示者参与者的演示者简档，从多个总体简档中选择可用的简档; 并且由演示者参与者邀请与会者到协作会话，其中与会者对应于可用的配置文件。

123. 发明申请

US20060283716A1 Method of direct plating of copper on a ruthenium alloy 审中-公开
标题翻译：在钌合金上直接电镀铜的方法
公开(公告)号：US20060283716A1
公开(公告)日：2006-12-21
申请号：US11373635
申请日：2006-03-09
申请人： Hooman Hafezi , Aron Rosenfeld , Zhi-Wen Sun , Hua Chung , Lei Zhu
发明人： Hooman Hafezi , Aron Rosenfeld , Zhi-Wen Sun , Hua Chung , Lei Zhu
IPC分类号： C25D3/38
CPC分类号： C25D5/34 , C25D3/38 , C25D5/10 , C25D5/18 , C25D5/54 , H01L21/2885 , H01L21/76843 , H01L21/76846 , H01L21/76861 , H01L21/76862 , H01L21/76868 , H01L21/76873 , H01L21/76877 , H01L23/53238 , H01L2924/0002 , H01L2924/00
摘要： A method is disclosed for depositing a copper seed layer onto a substrate surface, generally onto a barrier layer that is an alloy of a group VIII metal and a refractory metal. In one aspect, the alloy consists of at least 50% ruthenium and the balance a copper diffusion barrier material. A copper layer is electroplated on the alloy directly. In one aspect, the surface of the barrier layer is conditioned prior to plating to improve adhesion and reduce the critical current density for plating on the barrier layer. The conditioning may include cathodic pre-treatment or a plasma pre-treatment in a hydrogen or hydrogen/helium mixture. In one aspect, the substrate surface is immersed in an acidic plating bath and a nucleation waveform is applied to form a seed layer. In another aspect, the substrate is immersed in a neutral or alkaline copper solution that includes complexed copper ions.
摘要翻译：公开了一种用于将铜籽晶层沉积到基底表面上的方法，通常在作为VIII族金属和难熔金属的合金的阻挡层上。一方面，合金由至少50％的钌组成，余量为铜扩散阻挡材料。铜层直接电镀在合金上。在一个方面，阻隔层的表面在镀覆之前被调节以提高粘附性并降低在阻挡层上电镀的临界电流密度。调理可以包括阴极预处理或氢或氢/氦混合物中的等离子体预处理。在一个方面，将基材表面浸入酸性电镀浴中并施加成核波形以形成种子层。另一方面，将衬底浸入包括络合的铜离子的中性或碱性铜溶液中。

124. 发明申请

US20060003459A1 Determining enantiomeric excess using indicator-displacement assays 失效
标题翻译：使用指示剂置换测定法测定对映体过量
公开(公告)号：US20060003459A1
公开(公告)日：2006-01-05
申请号：US11036642
申请日：2005-01-14
申请人： Eric Anslyn , J. Frantz-Folmer-Andersen , Lei Zhu
发明人： Eric Anslyn , J. Frantz-Folmer-Andersen , Lei Zhu
IPC分类号： C12Q1/68 , G01N33/00
CPC分类号： G01N33/542
摘要： The invention includes an enantioselective indicator-displacement assay useful to determine enantiomeric excess (ee) enantiomeric samples calorimetrically. Determination may be by inspection of color with the naked eye, spectrographic measurement, or mathematical calculation. Concentration may also be determined. The assay may involve two independent absorption measurements. On suitable group of enantiomeric molecules to be assayed include α-hydroxyacids. The inherent relationship between the absorbance of the indicator-displacement ensemble and the overall concentration and ee of the analyte is established through solution equilibria. The invention also includes use of the assay in drug screening and manufacturing, high throughput screening of catalysts and kits for use in conducting assays of the invention.
摘要翻译：本发明包括用于量热测定对映体过量（ee）对映异构体样品的对映选择性指示剂置换测定法。确定可以通过肉眼检查颜色，光谱测量或数学计算。也可以确定浓度。该测定可以涉及两次独立的吸收测量。待分析的对映异构体分子的合适组包括α-羟基酸。通过溶液平衡建立指示剂置换组合的吸光度与分析物的总浓度和ee之间的固有关系。本发明还包括在药物筛选和制造中使用该测定法，用于进行本发明测定的催化剂和试剂盒的高通量筛选。

125. 发明申请

US20050246782A1 Transgenic aves producing human polyclonal antibodies 审中-公开
标题翻译：产生人多克隆抗体的转基因禽类
公开(公告)号：US20050246782A1
公开(公告)日：2005-11-03
申请号：US10508808
申请日：2003-03-24
申请人： Robert Etches , Robert Kay , Philip Leighton , Lei Zhu
发明人： Robert Etches , Robert Kay , Philip Leighton , Lei Zhu
IPC分类号： A01K67/027 , C07K14/705 , C07K16/02 , C12N5/06 , C12N15/85
CPC分类号： C07K16/461 , A01K67/0275 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/075 , A01K2227/30 , A01K2267/01 , C07K14/70503 , C07K16/02 , C07K2317/21 , C12N15/8509 , C12N2800/204 , C12N2800/30
摘要： Human antibodies are produced in transgenic chickens having functional genetic components of the human immune system stably integrated in the genome. Techniques are described to integrate unrearranged human heavy and light chain immunoglobulin loci into the genome of the transgenic chicken. The functional description of the endogenous immunoglobulin loci yields an animal whose antibody repertoire in response to antigen is fully human. In the preferred embodiment, the human immunoglobulin locus is at least as large as the native human locus and exhibits functional class switching to yield IgG isotype antibodies. In addition to monoclonal antibodies secreted from immortalized B cell populations, polyclonal antibodies may be obtained from eggs laid by the transgenic chickens of the invention.
摘要翻译：在具有稳定整合在基因组中的人免疫系统的功能性遗传成分的转基因鸡中产生人抗体。描述了将未经排列的人重链和轻链免疫球蛋白基因座整合到转基因鸡的基因组中的技术。内源性免疫球蛋白基因座的功能描述产生一种抗体对抗原作出全部反应的动物。在优选的实施方案中，人免疫球蛋白基因座至少与天然人基因座一样大，并显示功能类转换以产生IgG同种型抗体。除了从永生化的B细胞群体分泌的单克隆抗体之外，多克隆抗体可以从本发明的转基因鸡放置的卵中获得。

126. 发明授权

US06894173B2 Intermediates useful for synthesis of heteroaryl-substituted urea compounds, and processes of making same 有权
标题翻译：可用于合成杂芳基取代的脲化合物的中间体及其制备方法
公开(公告)号：US06894173B2
公开(公告)日：2005-05-17
申请号：US10361440
申请日：2003-02-10
申请人： Lin-Hua Zhang , Lei Zhu
发明人： Lin-Hua Zhang , Lei Zhu
IPC分类号： C07D295/08 , C07B61/00 , C07D213/40 , C07D231/40 , C07D277/44 , C07D307/52 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/12 , A61P29/00 , A61P37/00
CPC分类号： C07D401/12 , C07D231/40 , C07D401/14 , C07D405/12
摘要： Disclosed are novel processes and novel intermediate compounds for preparing aryl-and heteroaryl-substituted urea compounds of the formula(I) wherein Ar1, Ar2, L, Q and X are described herein. The product compounds are useful in pharmaceutic compositions for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases.
摘要翻译：公开了用于制备式（I）的芳基和杂芳基取代的脲化合物的新方法和新型中间体化合物，其中Ar 1，Ar 2，L，Q和X 在此描述。产品化合物可用于治疗涉及炎症的疾病或病理状况的药物组合物，例如慢性炎性疾病。

127. 发明授权

US06835832B2 Process for synthesis of heteroaryl-substituted urea compounds useful as antiinflammatory agents 有权
标题翻译：用作抗炎剂的杂芳基取代的脲化合物的合成方法
公开(公告)号：US06835832B2
公开(公告)日：2004-12-28
申请号：US10361731
申请日：2003-02-10
申请人： Lin-Hua Zhang , Lei Zhu
发明人： Lin-Hua Zhang , Lei Zhu
IPC分类号： C07D295135
CPC分类号： C07D401/12 , C07D231/40 , C07D401/14 , C07D405/12
摘要： Disclosed are novel processes and novel intermediate compounds for preparing aryl-and heteroaryl-substituted urea compounds of the formula(I) wherein Ar1, Ar2, L, Q and X are described herein. The product compounds are useful in pharmaceutic compositions for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases.
摘要翻译：公开了用于制备式（I）的芳基和杂芳基取代的脲化合物的新方法和新型中间体化合物，其中本文描述了Ar1，Ar2，L，Q和X。产品化合物可用于治疗涉及炎症的疾病或病理状况的药物组合物，例如慢性炎性疾病。

128. 发明授权

US10787453B2 Octahydropyrrolopyrroles their preparation and use 有权
公开(公告)号：US10787453B2
公开(公告)日：2020-09-29
申请号：US15950528
申请日：2018-04-11
申请人： Konstantin Petrukhin , Christopher Cioffi , Graham Johnson , Nicoleta Dobri , Emily Freeman , Ping Chen , Michael Conlon , Lei Zhu
发明人： Konstantin Petrukhin , Christopher Cioffi , Graham Johnson , Nicoleta Dobri , Emily Freeman , Ping Chen , Michael Conlon , Lei Zhu
IPC分类号： A61K31/407 , A61K31/4162 , A61K31/4192 , A61K31/4196 , A61K31/4353 , A61K31/44 , A61K31/498 , A61K31/501 , A61K31/506 , A61K31/5355 , A61K31/5365 , A61K31/55 , C07D487/04 , C07D403/04 , C07D403/12 , C07D401/12 , C07D403/06 , C07D471/04 , C07D498/04 , C07D209/52 , C07D519/00
摘要： The present invention provides compounds comprising variously substituted octahydropyrrolopyrroles, their synthesis, methods of making, methods of using, compositions and formulations thereof.

129. 发明申请

US20170354658A1 FORMULATION INHIBITING EFFECTS OF LOW ACID ENVIRONMENT 审中-公开
公开(公告)号：US20170354658A1
公开(公告)日：2017-12-14
申请号：US15532721
申请日：2015-12-01
申请人： Lei ZHU , Yvonne CEGIELNIK , Qun LU , Merck Sharp & Dohme Corp.
发明人： Lei Zhu , Yvonne Cegielnik , Qun Lu
IPC分类号： A61K31/52 , A61K9/00 , A61K47/02 , A61K47/38 , A61K47/26 , A61K47/32 , A61K47/12 , A61K47/20 , A61K9/10
CPC分类号： A61K31/52 , A61K9/0053 , A61K9/10 , A61K9/1617 , A61K45/06 , A61K47/02 , A61K47/12 , A61K47/20 , A61K47/26 , A61K47/32 , A61K47/38 , C07D487/14 , A61K2300/00
摘要： The present invention is directed to formulations comprising PVP polymer, a dispersion of a compound of Formula I (API), and citric acid, which formulations mitigate the effects of coadministering the compound of Formula I with a proton pump inhibitor compound.

130. 发明授权

US09040839B2 Wiring body connection structure 有权
标题翻译：接线体连接结构
公开(公告)号：US09040839B2
公开(公告)日：2015-05-26
申请号：US13097798
申请日：2011-04-29
申请人： Lei Zhu , Motoyuki Furuta
发明人： Norihiko Furuta , Lei Zhu
IPC分类号： H05K1/00 , H05K3/36 , H05K3/32
CPC分类号： H05K3/361 , H05K3/323 , H05K2201/0133 , H05K2201/0162
摘要： A wiring body connection structure includes a first wiring body and a second wiring body, the first wiring body having a first base material made of an elastomer and a first wiring containing an elastomer and a conductive material, the second wiring body having a second base material and a second wiring. In the wiring body connection structure, a laminated section is partitioned where a first end of the first wiring body and a second end of the second wiring body overlap in a front-rear direction. The wiring body connection structure further includes a cover member arranged on a front surface of the first wiring body, and a conductive adhesive layer bonding the first end and the second end in the laminated section while ensuring a conductive property. The cover member is interposed between a frontmost end of the second end and the first wiring in the laminated section.
摘要翻译：布线体连接结构包括第一布线体和第二布线体，所述第一布线体具有由弹性体构成的第一基材和含有弹性体和导电材料的第一布线，所述第二布线体具有第二基材和第二布线。在布线体连接结构中，在第一布线体的第一端和第二布线体的第二端在前后方向上重叠的层叠部分分隔开。布线体连接结构还包括布置在第一布线体的前表面上的覆盖件，以及在确保导电性的同时将层压部分中的第一端和第二端接合的导电粘合剂层。盖构件插入在第二端的最前端和层压部中的第一布线之间。

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