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121. 发明授权

US09784799B2 Multi-node synchronous on-site test method 有权
公开(公告)号：US09784799B2
公开(公告)日：2017-10-10
申请号：US14378954
申请日：2012-05-02
申请人： Maolin Pei , Ping Sun , Chunqiang Zhang , Jian Liu , Haimei Hu , Ming Zhu
发明人： Maolin Pei , Ping Sun , Chunqiang Zhang , Jian Liu , Haimei Hu , Ming Zhu
IPC分类号： G01R31/40 , H02J13/00 , G01R21/133
CPC分类号： G01R31/40 , G01R21/133 , H02J13/0079
摘要： A multi-node synchronous on-site test method, the method comprising: using GPS time as time reference, and conducting synchronous on-site tests on the devices to be tested and systems distributed at different places at an appointed time; controlling the synchronous phase control simulation devices distributed at multiple nodes via a synchronous test control center; within a uniform time section, synchronously outputting secondary side AC simulation signals, and simulating various actual operating conditions, thus achieving the detection of the monitoring and control performances of various dynamic monitoring and control systems, and ensuring the normal functions of the systems. The method of the present invention is able to conduct multi-node dynamic simulation test with synchronized GPS time, and achieves the detection of large-area multi-node monitoring and control systems. The present invention is suitable for the test of a wide area measurement system (WAMS) function, the simulation test of a damping control function, the simulation test of transiently stable state analysis and control functions, the simulation test of voltage stabilization and control functions, the simulation test of an islanding control function, the simulation test of wide area protection system functions and the like.

122. 外观设计

USD773488S1 Display screen with graphical user interface for viewing and installing applications in an electronic mall 有权
标题翻译：具有图形用户界面的显示屏幕，用于在电子商城中查看和安装应用程序
公开(公告)号：USD773488S1
公开(公告)日：2016-12-06
申请号：US29431152
申请日：2012-09-04
申请人： Jian Gao , Jianbo Liang , Jian Liu
设计人： Jian Gao , Jianbo Liang , Jian Liu

123. 发明授权

US09260474B2 Method for solid phase synthesis of liraglutide 有权
标题翻译：利拉鲁肽固相合成方法
公开(公告)号：US09260474B2
公开(公告)日：2016-02-16
申请号：US14344660
申请日：2012-08-30
申请人： Junfeng Pan , Jian Liu , Yaping Ma , Jiancheng Yuan
发明人： Junfeng Pan , Jian Liu , Yaping Ma , Jiancheng Yuan
IPC分类号： C07K1/20 , C07K14/575 , C07K1/04 , C07K1/107 , C07K1/06 , C07K14/605 , C07K1/14
CPC分类号： C07K1/042 , C07K1/064 , C07K1/1077 , C07K1/14 , C07K14/605 , Y02P20/55
摘要： Provided is a method for solid phase synthesis of liraglutide, comprising the following steps: A), Fmoc-Gly-resin being obtained by coupling resin solid phase carrier with glycine with N-end protected by Fmoc(Fmoc-Gly-OH) in the presence of activator system; B) according to the peptide sequence of the main chain of liraglutide, successively coupling with amino acids with N-ends protected by Fmoc and protected side chains by the method for solid phase synthesis, wherein lysine employs Fmoc-Lys(Alloc)-OH; C) removing the protective group, Alloc, from the side chain of lysine; D) coupling the side chain of lysine with Palmitoyl-Glu-OtBu by the method for solid phase synthesis; E) cleavage, removing protection groups and resin to obtain crude liraglutide; F) purifying and lyophilizing to obtain liraglutide.
摘要翻译：本发明提供了利拉鲁肽的固相合成方法，其包括以下步骤：A），通过将树脂固相载体与由Fmoc（Fmoc-Gly-OH）保护的N-末端的甘氨酸偶联得到的Fmoc-Gly-树脂活化剂体系的存在; B）根据利拉鲁肽主链的肽序列，通过固相合成方法依次与由Fmoc和被保护的侧链保护的N-末端的氨基酸偶联，其中赖氨酸使用Fmoc-Lys（Alloc）-OH; C）从赖氨酸侧链中除去保护基团，分配; D）通过固相合成方法将赖氨酸侧链与棕榈酰-Glu-OtBu偶联; E）裂解，去除保护基和树脂以获得粗利拉鲁肽; F）纯化和冻干以获得利拉鲁肽。

124. 发明授权

US09221269B2 Method and apparatus for high speed surface blackening and coloring with ultrafast fiber lasers 有权
标题翻译：用于高速表面黑化和超快速光纤激光着色的方法和装置
公开(公告)号：US09221269B2
公开(公告)日：2015-12-29
申请号：US13973856
申请日：2013-08-22
申请人： Jian Liu
发明人： Jian Liu
IPC分类号： B82Y30/00 , B82Y40/00 , B23K26/00 , B41J2/435 , B41J2/32 , B41J2/44
CPC分类号： B41J2/32 , B23K26/352 , B23K26/355 , B41J2/442 , B82Y30/00 , B82Y40/00
摘要： Methods and systems for high speed surface blackening and/or coloring are disclosed, including generating electromagnetic radiation from an ultrashort pulse laser (UPL); coupling the electromagnetic radiation from the UPL to a scanner comprising a scanning and focus range, wherein the scanner is configured to receive the electromagnetic radiation from the UPL and to scan and focus the electromagnetic radiation onto a sample; using a computer to adjust the pulse repetition rate and the energy of the UPL; using a five degree of freedom motorized stage to position the sample; using a dichroic filter positioned between the scanner and the sample; focusing an imager through the dichroic filter and onto the surface of the sample; using a processor to acquire and process images to monitor the surface blackening and/or coloring of the sample within the scanning and focus range of the electromagnetic radiation. Other embodiments are described and claimed.
摘要翻译：公开了用于高速表面黑化和/或着色的方法和系统，包括从超短脉冲激光（UPL）产生电磁辐射; 将来自UPL的电磁辐射耦合到包括扫描和聚焦范围的扫描器，其中扫描器被配置为从UPL接收电磁辐射并扫描并聚焦到样品上; 使用电脑调节UPL的脉冲重复率和能量; 使用五自由度机动化阶段来定位样品; 使用位于扫描仪和样品之间的二向色滤光片; 将成像器通过二向色滤光片聚焦到样品的表面上; 使用处理器来获取和处理图像以在电磁辐射的扫描和聚焦范围内监测样品的表面变黑和/或着色。描述和要求保护其他实施例。

125. 发明申请

US20150063380A1 Method and Apparatus for Generating Ultrafast, High Energy, High Power Laser Pulses 审中-公开
标题翻译：用于产生超快，高能量，大功率激光脉冲的方法和装置
公开(公告)号：US20150063380A1
公开(公告)日：2015-03-05
申请号：US14016064
申请日：2013-08-31
申请人： Jian Liu
发明人： Jian Liu
IPC分类号： H01S3/11 , H01S3/067
CPC分类号： H01S3/2391 , H01S3/0057 , H01S3/0085 , H01S3/06754 , H01S3/1618 , H01S3/2383
摘要： Methods and systems for generating ultrafast, high energy, high power fiber laser pulses are disclosed, including generating a sequence of signal laser pulses from a broadband, mode locked, seed fiber laser oscillator; using a pulse stretcher to stretch the signal laser pulses; using a pulse picker to down select the stretched laser pulses; using a wavelength separator to separate the down selected laser pulses into two or more wavelength channels; using two or more delays lines to independently adjust for time differences between the laser pulses of the two or more wavelength channels; using two or more amplifier chains to amplify the delay line adjusted laser pulses; using a wavelength combiner to combine the amplified laser pulses; and using a compressor to compress the combined laser pulses to emit an ultrafast, high energy, high power laser pulse. Other embodiments are described and claimed.
摘要翻译：公开了用于产生超快，高能量，高功率光纤激光脉冲的方法和系统，包括从宽带锁模晶粒激光振荡器产生一系列信号激光脉冲; 使用脉冲担架拉伸信号激光脉冲; 使用脉冲选择器来选择拉伸的激光脉冲; 使用波长分离器将下降的选定的激光脉冲分离成两个或更多个波长信道; 使用两个或更多个延迟线来独立地调整两个或更多个波长通道的激光脉冲之间的时间差; 使用两个或多个放大器链放大延迟线调整的激光脉冲; 使用波长组合器来组合放大的激光脉冲; 并且使用压缩机压缩组合的激光脉冲以发射超快，高能量，高功率的激光脉冲。描述和要求保护其他实施例。

126. 发明申请

US20140350219A1 METHOD FOR SOLID PHASE SYNTHESIS OF LIRAGLUTIDE 有权
标题翻译：方法用于链霉素的固相合成
公开(公告)号：US20140350219A1
公开(公告)日：2014-11-27
申请号：US14344660
申请日：2012-08-30
申请人： Junfeng Pan , Jian Liu , Yaping Ma , Jiancheng Yuan
发明人： Junfeng Pan , Jian Liu , Yaping Ma , Jiancheng Yuan
IPC分类号： C07K1/04 , C07K1/14
CPC分类号： C07K1/042 , C07K1/064 , C07K1/1077 , C07K1/14 , C07K14/605 , Y02P20/55
摘要： Provided is a method for solid phase synthesis of liraglutide, comprising the following steps: A), Fmoc-Gly-resin being obtained by coupling resin solid phase carrier with glycine with N-end protected by Fmoc(Fmoc-Gly-OH) in the presence of activator system; B) according to the peptide sequence of the main chain of liraglutide, successively coupling with amino acids with N-ends protected by Fmoc and protected side chains by the method for solid phase synthesis, wherein lysine employs Fmoc-Lys(Alloc)-OH; C) removing the protective group, Alloc, from the side chain of lysine; D) couplilng the side chain of lysine with Palmitoyl-Glu-Offiu by the method for solid phase synthesis; E) cleavage, removing protection groups and resin to obtain crude liraglutide; F) purifying and lyophilizing to obtain liraglutide.
摘要翻译：本发明提供了利拉鲁肽的固相合成方法，其包括以下步骤：A），通过将树脂固相载体与由Fmoc（Fmoc-Gly-OH）保护的N-末端的甘氨酸偶联得到的Fmoc-Gly-树脂活化剂体系的存在; B）根据利拉鲁肽主链的肽序列，通过固相合成方法依次与由Fmoc和被保护的侧链保护的N-末端的氨基酸偶联，其中赖氨酸使用Fmoc-Lys（Alloc）-OH; C）从赖氨酸侧链中除去保护基团，分配; D）通过固相合成方法使赖氨酸侧链与棕榈酰-Glu-Offiu偶联; E）裂解，去除保护基和树脂以获得粗利拉鲁肽; F）纯化和冻干以获得利拉鲁肽。

127. 发明申请

US20140312089A1 Holster 审中-公开
标题翻译：皮套
公开(公告)号：US20140312089A1
公开(公告)日：2014-10-23
申请号：US13867798
申请日：2013-04-22
申请人： Jian Liu
发明人： Jian Liu
IPC分类号： F41C33/02 , F41C33/06
CPC分类号： F41C33/0209
摘要： A holster purse system that secures and conceals a weapon in a holster compartment within a side pocket of the purse. The holster compartment contains an extender tab at the opening of the purse holster to create a larger opening to the holster compartment that accommodates larger weapons and prevents weapons from becoming stuck at the holster compartment opening. The holster compartment allows easy insertion of the weapon while also securing the weapon. The holster compartment contains is shaped to accommodate the contours of the weapon. Once the weapon has been inserted in the compartment, the extender automatically reverts to a closed position such that the opening of the compartment decreases in size, preventing the unintentional release of the weapon. The present invention provides greater accessibility to the weapon in the holster compartment while also decreasing the visibility of the weapon since the holster compartment is not visible to passersby.
摘要翻译：一个皮套钱包系统，用于保护和隐藏在钱包的侧袋内的皮套箱中的武器。皮套隔间在钱包皮套的开口处包含一个延伸片，以形成一个更大的开口，可以容纳较大的武器，并防止武器卡在皮套隔间开口。枪套隔间允许轻松插入武器，同时也可以固定武器。皮套隔间包含成形以适应武器的轮廓。一旦将武器插入隔间，扩展器将自动恢复到关闭位置，使得隔间的开口尺寸减小，从而防止武器的无意释放。本发明提供了对枪套隔间中的武器的更大的可访问性，同时也降低了武器的可见性，因为枪套隔间对于路人是不可见的。

128. 发明申请

US20140088124A1 IMIDAZOLE DERIVATIVES 审中-公开
标题翻译：咪唑衍生物
公开(公告)号：US20140088124A1
公开(公告)日：2014-03-27
申请号：US14123246
申请日：2012-06-01
申请人： Robert J. DeVita , QingMei Hong , Zhong Lai , Kevin D. Dykstra , Yang Yu , Jian Liu , Donald M. Sperbeck , Tianying Jian , Deodial Guiadeen , Ginger Xu-qiang Yang , Zhicai Wu , Shuwen He , Pauline C. Ting , Robert Aslanian , Jeffrey T. Kuethe , James Balkovec , Rongze Kuang , Gang Zhou , Heping Wu
发明人： Robert J. DeVita , QingMei Hong , Zhong Lai , Kevin D. Dykstra , Yang Yu , Jian Liu , Donald M. Sperbeck , Tianying Jian , Deodial Guiadeen , Ginger Xu-qiang Yang , Zhicai Wu , Shuwen He , Pauline C. Ting , Robert Aslanian , Jeffrey T. Kuethe , James Balkovec , Rongze Kuang , Gang Zhou , Heping Wu
IPC分类号： C07D401/14 , C07D417/14 , C07D493/04 , C07D471/04
CPC分类号： C07D401/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D493/04
摘要： Described herein are compounds of formula (I), The compounds of formula I act as DGAT1 inhibitors and can be useful in preventing, treating or acting as a remedial agent for hyperlipidemia, diabetes mellitus and obesity.
摘要翻译：本文描述的是式（I）的化合物。式I化合物作为DGAT1抑制剂，可用于预防，治疗或作为高脂血症，糖尿病和肥胖症的补救剂。

129. 发明申请

US20130337471A1 CELL IDENTIFICATION WITH NANOPARTICLES, COMPOSITIONS AND METHODS RELATED THERETO 审中-公开
标题翻译：细胞识别与纳米颗粒，组合物和方法相关
公开(公告)号：US20130337471A1
公开(公告)日：2013-12-19
申请号：US13517895
申请日：2012-06-14
申请人： Shuming Nie , Jian Liu , Brad A. Kairdolf
发明人： Shuming Nie , Jian Liu , Brad A. Kairdolf
IPC分类号： G01N21/76
CPC分类号： G01N33/587 , G01N33/57426
摘要： The present disclosure provides a method for identifying rare or low-abundant biological entities such as Hodgkin's and Reed-Sternberg cells, circulating tumor cells in peripheral blood, circulating fetal cells, stem cells, somatic cells, HIV-infected T cells, bacteria or viruses in water, adenoviruses, enteroviruses, hepatitis A and E, dengue, Swine Flu, bovine diarrhea, and protozpa/helminthes. The method uses a suite of nanoparticle-conjugated agents to mark biological targets of interest for subsequent fluorescence imaging. In certain embodiments, the nanoparticle-conjugated agents are fluorescent semiconductor nanocrystals conjugated with antibodies with affinity for CD15, CD30, CD45, and Pax5. In certain embodiments, a method is developed to differentiate Hodgkin's and Reed-Sternberg (HRS) cells from amongst surrounding immune cells such as T and B lymphocytes with greater specificity and precision than traditional immunohistochemistry (IHC) for the diagnosis of Hodgkin's lymphoma.
摘要翻译：本公开提供了一种用于鉴定罕见或低丰度生物实体的方法，例如霍奇金和里德 - 斯特伯格细胞，外周血循环肿瘤细胞，循环胎儿细胞，干细胞，体细胞，HIV感染的T细胞，细菌或病毒在水，腺病毒，肠道病毒，甲型和E型，登革热，猪流感，牛腹泻和原虫/癣。该方法使用一套纳米颗粒偶联剂来标记感兴趣的生物靶标用于随后的荧光成像。在某些实施方案中，纳米颗粒偶联剂是与抗CD15，CD30，CD45和Pax5具有亲和力的荧光半导体纳米晶体。在某些实施方案中，开发了一种方法，以将Hodgkin's和Reed-Sternberg（HRS）细胞与周围免疫细胞如T和B淋巴细胞区分开来，具有比传统的免疫组化（IHC）更高的特异性和精确度，用于诊断霍奇金淋巴瘤。

130. 发明申请

US20130278930A1 Near-Field Material Processing System 有权
标题翻译：近场材料加工系统
公开(公告)号：US20130278930A1
公开(公告)日：2013-10-24
申请号：US13454042
申请日：2012-04-23
申请人： Jian Liu , Huan Huang
发明人： Jian Liu , Huan Huang
IPC分类号： G01J3/443
CPC分类号： G01N21/718 , G01N33/0057
摘要： Methods and systems for real time feedback and control of near-field material processing are disclosed, including generating electromagnetic radiation from a USP laser coupled to a central processing unit; coupling the electromagnetic radiation to an acousto-optic modulator; coupling the electromagnetic radiation to a beam delivery system; coupling the electromagnetic radiation to a beam delivery fiber; using the electromagnetic radiation to generate a plasma on a target mounted to an adjustable stage coupled to the central processing unit; coupling the electromagnetic radiation from the plasma to a plasma spectrum collection system; coupling the electromagnetic radiation to a spectrum analysis unit; coupling the electromagnetic radiation to a detector; and coupling the detector to the central processing unit; wherein the central processing unit uses the output from the detector as feedback in making adjustments to the USP laser and the adjustable stage. Other embodiments are described and claimed.
摘要翻译：公开了用于近场材料处理的实时反馈和控制的方法和系统，包括从耦合到中央处理单元的USP激光产生电磁辐射; 将电磁辐射耦合到声光调制器; 将电磁辐射耦合到光束传送系统; 将电磁辐射耦合到束输送光纤; 使用所述电磁辐射在安装到可耦合到所述中央处理单元的可调节台上的目标上产生等离子体; 将来自等离子体的电磁辐射耦合到等离子体谱采集系统; 将电磁辐射耦合到频谱分析单元; 将电磁辐射耦合到检测器; 并将检测器耦合到中央处理单元; 其中中央处理单元使用来自检测器的输出作为对USP激光器和可调节级进行调整的反馈。描述和要求保护其他实施例。

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