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121. 发明专利

JPH09189681A MASS SPECTROGRAPH 失效
公开(公告)号：JPH09189681A
公开(公告)日：1997-07-22
申请号：JP361296
申请日：1996-01-12
申请人： HITACHI LTD
发明人： NABESHIMA TAKAYUKI , SAKAIRI MINORU , TAKADA YASUAKI , HIRABAYASHI TSUDOI , HIRABAYASHI YUKIKO , KOIZUMI HIDEAKI
IPC分类号： G01N27/62 , H01J49/04
摘要： PROBLEM TO BE SOLVED: To attain reductions in cost and the scale of a device by supplying gas separately to an ion-trap mass spectrographic part and an ion source from a gas supply source, and providing independent pressure control mechanisms in branch gas passages. SOLUTION: A gas with low reactivity is supplied from a gas supply source 3-13 to an ion source 3-3 and an ion-trap mass spectrographic part through pipelines 3-15, 3-16 that branch from a connector 3-14. The pipelines 3-15, 3-16 are provided with pressure reducing valves 3-17, 3-18 for controlling the gas inside the pipelines and with pressure gauges 3-19, 3-20, so that the pressure of the gas going toward the ion source 3-3 and that of the gas going toward the ion-trap mass spectrometric part can be controlled independently. Thus a gas pressure, such that a flow rate most suited for ionization is available, can be set at the ion source. At the ion-trap mass spectrographic part, a gas pressure can be set such that degrees of vacuum optimum for confining ions therein are attainable.

122. 发明专利

JPH09180665A CHARGED PARTICLE DEVICE 失效
公开(公告)号：JPH09180665A
公开(公告)日：1997-07-11
申请号：JP34035895
申请日：1995-12-27
申请人： HITACHI LTD
发明人： HASEGAWA HIDEKI , SAKAIRI MINORU , SAITO SAKAE
IPC分类号： H01J37/12 , H01J49/06
摘要： PROBLEM TO BE SOLVED: To simplify and miniaturize the structure of an electrostatic lens, make it lightweight, and improve its assembling accuracy by sticking an electric conductor to the outer peripheral face and the inner circumferential face of a cylindrical body made of an electric insulator material, and forming the electrostatic lens constituted of an outside electrode and an inside electrode. SOLUTION: The outer peripheral face and the inner circumferential face of a cylindrical body 6 made of an electric insulator material are coated with a conductor such as a metal, and an outside electrode 7 and an inside electrode 8 are stuck together to form an electrostatic lens 3. The ion beam 2 generated by an ion source 1 is extracted and focused by the electrostatic lens 3, then the ions having specific mass and bent with the orbit by the intensity of the magnetic field of a separating magnet 4 are fed to a detector 5.

123. 发明专利

JPH0980022A DATA PROCESSING METHOD IN MASS SPECTROMETER 失效
公开(公告)号：JPH0980022A
公开(公告)日：1997-03-28
申请号：JP23500195
申请日：1995-09-13
申请人： HITACHI LTD
发明人： TAKADA YASUAKI , SAKAIRI MINORU , NABESHIMA TAKAYUKI , HIRABAYASHI YUKIKO , YOSHIDA MOTOKO , KOIZUMI HIDEAKI
IPC分类号： G01N27/62 , G01N27/447
摘要： PROBLEM TO BE SOLVED: To increase the reliability of an analyzed result using a capillary electrophoretic mass spectrometer by a method wherein a plurality of analytical operations are performed under the same analytical condition, the electrophoretic times of at least one substance are compared and the time base of the obtained analyzed result is corrected. SOLUTION: Ion electropherograms obtained, in a first analytical operation and a second analytical operation, of ions whose value m/z obtained by dividing the valence of ions by the molecular weight of ions is (x) are designated respectively as A and B. A peak caused by the ions to which attention is to be paid is designated as P1 , the peak P1 is observed at a time t1 in the electropherogram A, and it is observed at a time t1 in the electropherogram B. When the time base of the electropherogram B is corrected by making use of the peak P1 in the electropherogram A as a reference, the peak P1 in the electropherogram B is observed at the time t1 ' although it should be observed at the time t1 . As a result, the time base in the electropherogram B is multiplied by t1 /t1 ' so as to obtain a time base after it has been corrected in the electropherogram B. Thereby, an apparent time base in the electropherogram A agrees with that in the eletropherogram B, and the elecropherograms A, B can be compared directly.

124. 发明专利

JPH08178899A ION-TRAPPING TYPE MASS SPECTROMETER 失效
公开(公告)号：JPH08178899A
公开(公告)日：1996-07-12
申请号：JP31795094
申请日：1994-12-21
申请人： HITACHI LTD
发明人： SAKAIRI MINORU , HIRABAYASHI TSUDOI , TAKADA YASUAKI
IPC分类号： G01N27/62 , G01N30/72 , H01J49/04 , H01J49/24
摘要： PURPOSE: To provide a mass spectrometer which can sufficiently reduce the pressure in the periphery of a detector, eliminate problems such as discharging or the like at the detector, and measure generated ions with good sensitivity with the use of an atmospheric pressure ionization method which makes it possible to measure ions stably for a long time while a high voltage is applied to the detector. CONSTITUTION: Insulating materials 11a, 11b are inserted between two end cap electrodes 14a, 14b and one ring electrode 15 of an ion trap mass analysis part to turn the mass analysis part into a sufficiently closed space. Helium gas is directly introduced to the insulating material part via a piping from a helium gas feed source 28 which is outside the vacuum space. The ion trap- type mass spectrometer is characterized as above.

125. 发明专利

JPH0862200A ION SOURCE, AND MASS SPECTROSCOPE USING IT 失效
公开(公告)号：JPH0862200A
公开(公告)日：1996-03-08
申请号：JP20176794
申请日：1994-08-26
申请人： HITACHI LTD
发明人： HIRABAYASHI TSUDOI , SAKAIRI MINORU , TAKADA YASUAKI , KOIZUMI HIDEAKI , UMEMURA KAORU
IPC分类号： G01N27/62 , G01N30/72 , H01J27/26 , H01J37/05 , H01J37/08 , H01J49/04 , H01J49/10
摘要： PURPOSE: To provide an ion source whose ionization efficiency is high without applying voltage to a capillary and to provide a mass spectrometer using the ion source, whose ion intensity is 10 times or higher than that of an ionization method in conventional cases and which can be operated safely. CONSTITUTION: A sample solution is introduced into a capillary inside the ion source 2 from a sample-solution supply part 1. The flow rate of a gas which is supplied from a gas supply part 3 is adjusted by a flowmeter 4, the gas is made to flow along the outer circumferential part of the capillary, and the gas is introduced into a gas guide tube which is constituted so as to be spouted at the tip part of the capillary. The sample solution is ionized by the action effect of the spouted gas at the tip part of the capillary so as to be analyzed by a mass spectrometer 11.

126. 发明专利

JPH07161322A ELECTRO SPRAY TYPE ION SOURCE AND FOCUSING ION BEAM DEVICE USING IT 失效
公开(公告)号：JPH07161322A
公开(公告)日：1995-06-23
申请号：JP30516293
申请日：1993-12-06
申请人： HITACHI LTD
发明人： UMEMURA KAORU , SAKAIRI MINORU
IPC分类号： G01N1/28 , H01J27/26 , H01J37/08 , H01J49/10
摘要： PURPOSE:To establish a method for performing a minute processing, analysis or measurement by focusing ion beam from an electro spray type ion source for emitting ion such as various inactive gas and oxygen and nitrogen in high intensity without polluting a minute area of a surface of a semiconductor, etc. CONSTITUTION:Liquid ion material 1 such as inactive gas, O and N is filled in an ion material tank 4 mounted in a cooling tank 10 in an adiabatic vacuum container 28 and kept at low temperature and high voltage is applied between a tip end of a caterpillar 6 of a storage part 5 and an opposite drawing electrode 19. Thereby, the ion material 1 is drawn as a charging droplet 20 and then it is emitted inside a collecting ion beam system by injecting carrier gas 3 as smaller cluster ion.

127. 发明专利

JPH05223806A GLYCOPROTEIN ANALYZING DEVICE 失效
公开(公告)号：JPH05223806A
公开(公告)日：1993-09-03
申请号：JP2650292
申请日：1992-02-13
申请人： HITACHI LTD
发明人： SAKAIRI MINORU , HIRABAYASHI TSUDOI , TAKADA YASUAKI , OKANO KAZUNOBU
IPC分类号： G01N30/88
摘要： PURPOSE:To conduct a primary structural analysis of a sugar chain in glycoprotein. CONSTITUTION:A glycoprotein analyzing device is constituted of a liquid chromatograph 2, mass spectrometer 5a, gas chromatograph 1, control part 8a, data processing part 8b and sample processing part 7. Among different purpose analyses, analyzing means are used in common; a bond position analysis of a sugar chain of glycoprotein is conducted by constitution of the liquid chromatograph and mass spectrometer, a bond position analysis of carbon among the sugar chains, by constitution of the gas chromatograph and mass spectrometer, an arrangement analysis of the sugar chains and anomer analysis, by constitution of the liquid chromatograph and mass spectrometer or liquid chromatograph. In the arrangement analysis of the sugar chains and anomer analysis wherein sample processing operation is complicated, a series of the sample processing operation and analyzing operation from a digestion reaction to concentration and recovery of a digestion reaction solution are automated. The glycoprotein analyzing device capable of labor saving can be provided at a low cost so as to efficiently conduct the glycoprotein analysis.

128. 发明专利

JPS63304564A MASS ANALYZER WITH ATMOSPHERIC PRESSURE IONIZATION 失效
公开(公告)号：JPS63304564A
公开(公告)日：1988-12-12
申请号：JP13972287
申请日：1987-06-05
申请人： HITACHI LTD
发明人： SAKAIRI MINORU , KANBARA HIDEKI
IPC分类号： G01N27/62 , G01N30/72 , H01J49/10 , H01J49/26
摘要： PURPOSE:To have sure identification of specimen by quickly scanning the mass range to be measured while the specimen is ionized and sensed, changing up and down the electric field applied to the intermediate pressure part one scanning after another, and by increasing the strength of molecular ions or, by contrast, increasing the strength fragment ions. CONSTITUTION:Mixture specimen contained in a liquid carrier is separated with a liquid chromatograph 1, and the flowout liquid containing it is poured into an atomizer 3 via a Teflon tube 2 to turn it into liquid drops, and a gasifier 4 turns it into free specimen molecules without solvation. This undergoes a corona discharge treatment using a needle electrode 5 under a vacuum of 1-760Torr, and molecular ions as a product are put in an intermediate pressure part having No.1 electrodes 6 and 7 with small hole, wherein the inside pressure is 0.1-10Torr. The control voltage from power supply 14 is impressed on the electrodes 6 and 7 and generated different mass sensed by an ion sensor 18. Thus the intensities of molecular ions and fragment ions are enlarged by simulation to ensure the identification with mass spectrum.

129. 发明专利

JPS60241634A ATMOSPHERIC PRESSURE IONIZATION MASS ANALYZER 失效
公开(公告)号：JPS60241634A
公开(公告)日：1985-11-30
申请号：JP9645084
申请日：1984-05-16
申请人： HITACHI LTD
发明人： SAKAIRI MINORU , KANBARA HIDEKI
IPC分类号： H01J49/10 , H01J49/14
摘要： PURPOSE:To prevent that generation of ion becomes unstable because electrodes of ion generator are contaminated by sample by individually providing the ion generator and sample introducing part of the atmospheric pressure ionization mass analyzer. CONSTITUTION:An atmospheric pressure ionization mass analyzer is formed in such a manner that an ion generating part consisting of needle electrode for corona discharge arranged opposing to fine holes to be used for supplying ion to an analyzer, a sample introducing part is orthogonally crossing with the ion generating part, and thereby when the sample introduced from sample introducing part reaches between the ion generating part and fine holes, it is mixed with the ion generated from the ion generating part for ionization. Therefore, since the ion generating part and the sample introducing part are provided separately, it can be prevented that the ion generating efficiency is given adverse effect because the electrodes of ion generating part is contaminated when the sample is introduced, and moreover ion can be extracted stably for a long period of time.

130. 发明专利

JPS59100856A Analysis device connecting liquid chromatograph and mass spectrometer 失效
标题翻译：分析装置连接液相色谱和质谱仪
公开(公告)号：JPS59100856A
公开(公告)日：1984-06-11
申请号：JP20941782
申请日：1982-12-01
申请人： Hitachi Ltd
发明人： SAKAIRI MINORU , KANBARA HIDEKI , KARINO SHIGETAKA , SUZUKI SHINGEN
IPC分类号： H01J49/04 , G01N27/62 , G01N30/60 , G01N30/72 , G01N30/78 , G01N30/84 , G01N30/96
CPC分类号： G01N30/724 , G01N30/84 , G01N2030/965
摘要： PURPOSE:To perform efficiently an analysis without inducing clogging, etc. in an atomizing means, etc. by providing a means for removing the salt in the outflow liquid from a liquid chromatograph, atomizing the outflow liquid after removal of the salt and analyzing the same by an ion mass spectrometer. CONSTITUTION:A UV detector 4 for detecting each component, and a post column 5 packed with a cation or anion exchange resin are provided behind a liquid chromatograph 3 in a method for analyzing the sugar, amino acid, nucleic acid, etc. in a bio-sample by separating and eluting the respective components with the liquid chromatograph and subjecting the same to mass spectroscopy. The sample which is passed through the column 5, is atomized with an atomizer 6 and is ionized in an ion source part 7 is analyzed in an ion mass spectrometric part 8. The analysis with good accuracy is thus made possible with high sensitivity without inducing clogging, etc. of the atomizer 6 and the capillary in an ion source part 7 even if a salt soln. is used for an eluate.
摘要翻译：目的：通过提供从液相色谱仪中除去流出液中的盐的方法，在雾化装置等中有效地进行分析而不引起堵塞等，在除去盐之后雾化出流液体并分析其通过离子质谱仪。构成：在用于分析生物中的糖，氨基酸，核酸等的方法中，在液相色谱仪3之后设置有用于检测每种组分的UV检测器4和填充有阳离子或阴离子交换树脂的柱后5 通过用液相色谱仪分离和洗脱各组分并对其进行质谱分析。通过柱5的样品被雾化器6雾化并在离子源部分7中离子化，在离子质谱部分8中进行分析。因此，高灵敏度的分析具有高灵敏度而不引起堵塞等离子源7中的雾化器6和毛细管，即使是盐溶液。用于洗脱液。

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