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121. 发明申请

US20090082824A1 METHOD FOR EXCLUSION OF ECTOPIC EVENTS FROM HEART RATE VARIABILITY METRICS 有权
标题翻译：从心率变异性度量中排除经验性事件的方法
公开(公告)号：US20090082824A1
公开(公告)日：2009-03-26
申请号：US12235868
申请日：2008-09-23
申请人： John A. Dyjach , Gerrard M. Carlson
发明人： John A. Dyjach , Gerrard M. Carlson
IPC分类号： A61N1/365
CPC分类号： A61B5/0468 , A61B5/4035 , A61N1/3622
摘要： Heart rate variability metrics are derived from the intervals between successive heart beats, referred to as BB intervals. A method implementable by an implantable cardiac device for excluding BB intervals due to ectopic beats based on a function of preceding BB intervals is presented. It is desirable to remove such BB intervals from a BB interval time series used to calculate a heart rate variability metric.
摘要翻译：心率变异性度量是从连续的心跳之间的间隔导出的，称为BB间隔。提出了一种可植入心脏装置的方法，用于根据先前的BB间隔的功能排除由于异位搏动造成的BB间隔。期望从用于计算心率变异性度量的BB间隔时间序列中去除这样的BB间隔。

122. 发明申请

US20090069720A1 Logging daily average metabolic activity using a motion sensor 有权
标题翻译：使用运动传感器记录日常平均代谢活动
公开(公告)号：US20090069720A1
公开(公告)日：2009-03-12
申请号：US11900596
申请日：2007-09-12
申请人： Kenneth Beck , Ramesh Wariar , Chie Kawahara , Gerrard M. Carlson
发明人： Kenneth Beck , Ramesh Wariar , Chie Kawahara , Gerrard M. Carlson
IPC分类号： A61B5/00
CPC分类号： A61B5/1118 , A61B5/0002 , A61B5/4866
摘要： An implantable activity detector can detect metabolic stress levels, which can be normalized, such as to identify times of activities such as walking and running or to identify trends such as a decrease in metabolic activity. The data can be derived from different sources such as an accelerometer and pedometer. This data can be compared to independently specifiable thresholds, such as to trigger an alert or responsive therapy, or to display one or more trends. The information can also be combined with other congestive heart failure (CHF) indications. The alert can notify the patient or a caregiver, such as via remote monitoring. Metabolic activity data from one or more of the activity detectors can be used to establish a model of metabolic stress, to which further activity data can be compared for identifying periods of increased or decreased metabolic stress.
摘要翻译：可植入活动检测器可以检测代谢应激水平，其可以被归一化，例如识别诸如步行和跑步的活动的时间，或者识别诸如代谢活动降低的趋势。数据可以来自不同的来源，例如加速度计和计步器。该数据可以与独立指定的阈值进行比较，例如触发警报或响应治疗，或显示一个或多个趋势。信息也可以与其他充血性心力衰竭（CHF）指征结合使用。该警报可以通过远程监视来通知病人或看护者。来自一个或多个活性检测器的代谢活动数据可以用于建立代谢应激模型，进一步的活动数据可以被比较以识别增加或减少的代谢应激的时期。

123. 发明申请

US20090018461A1 Method and apparatus for third heart sound detection 有权
标题翻译：第三心音检测方法及装置
公开(公告)号：US20090018461A1
公开(公告)日：2009-01-15
申请号：US12283760
申请日：2008-09-16
申请人： Krzysztof Z. Siejko , Gerrard M. Carlson
发明人： Krzysztof Z. Siejko , Gerrard M. Carlson
IPC分类号： A61B5/02
CPC分类号： A61B7/04
摘要： A cardiac rhythm management system includes a heart sound detector providing for detection of the third heart sounds (S3). An implantable sensor such as an accelerometer or a microphone senses an acoustic signal indicative heart sounds including the second heart sounds (S2) and S3. The heart sound detector detects occurrences of S2 and starts S3 detection windows each after a predetermined delay after a detected occurrence of S2. The occurrences of S3 are then detected from the acoustic signal within the S3 detection windows.
摘要翻译：心律管理系统包括提供检测第三心音的心音检测器（S3）。诸如加速度计或麦克风的可植入传感器感测指示包括第二心音（S2）和S3的心音的声信号。心音检测器检测到S2的发生，并且在检测到S2发生之后经过预定延迟之后开始S3检测窗口。然后从S3检测窗口内的声信号检测S3的出现。

124. 发明授权

US07433853B2 Expert system for patient medical information analysis 有权
标题翻译：患者医疗信息分析专家系统
公开(公告)号：US07433853B2
公开(公告)日：2008-10-07
申请号：US10889353
申请日：2004-07-12
申请人： Marina Brockway , Gerrard M. Carlson , Veerichetty Kadhiresan , Vladimir Kovtun
发明人： Marina Brockway , Gerrard M. Carlson , Veerichetty Kadhiresan , Vladimir Kovtun
IPC分类号： G06N5/04
CPC分类号： G06N5/04 , A61B5/0002 , A61B5/0205 , A61B5/021 , A61B5/0215 , A61B5/053 , A61B5/076 , A61B5/0816 , A61B5/7232 , A61B5/7264 , A61B5/7267 , A61B5/7475 , G06F19/00 , G06N7/005 , G16H50/20 , G16H50/30
摘要： A plurality of chronic sensors are used to facilitate diagnosis and medical decision making for an individual patient. An expert system evaluates the sensor data, combines the sensor data with stored probability data and provides an output signal for notification or medical intervention.
摘要翻译：使用多个慢性传感器来促进个体患者的诊断和医学决策。专家系统评估传感器数据，将传感器数据与存储的概率数据组合，并提供用于通知或医疗干预的输出信号。

125. 发明授权

US07431699B2 Method and apparatus for third heart sound detection 有权
标题翻译：第三心音检测方法及装置
公开(公告)号：US07431699B2
公开(公告)日：2008-10-07
申请号：US10746853
申请日：2003-12-24
申请人： Krzysztof Z. Siejko , Gerrard M. Carlson
发明人： Krzysztof Z. Siejko , Gerrard M. Carlson
IPC分类号： A61B5/02
CPC分类号： A61B7/04
摘要： A cardiac rhythm management system includes a heart sound detector providing for detection of the third heart sounds (S3). An implantable sensor such as an accelerometer or a microphone senses an acoustic signal indicative heart sounds including the second heart sounds (S2) and S3. The heart sound detector detects occurrences of S2 and starts S3 detection windows each after a predetermined delay after a detected occurrence of S2. The occurrences of S3 are then detected from the acoustic signal within the S3 detection windows.
摘要翻译：心律管理系统包括用于检测第三心音的心音检测器（S 3）。诸如加速度计或麦克风的可植入传感器感测到指示包括第二心音（S 2）和S 3的心音的声信号。心音检测器检测到S 2的发生，并且在检测到的S 2发生之后，在预定延迟之后开始S 3检测窗口。然后从S 3检测窗口内的声信号检测出S 3的出现。

126. 发明授权

US07428436B2 Method for exclusion of ectopic events from heart rate variability metrics 有权
标题翻译：排除异位事件与心律变异性指标的方法
公开(公告)号：US07428436B2
公开(公告)日：2008-09-23
申请号：US10728124
申请日：2003-12-04
申请人： John A. Dyjach , Gerrard M. Carlson
发明人： John A. Dyjach , Gerrard M. Carlson
IPC分类号： A61N1/00
CPC分类号： A61B5/0468 , A61B5/4035 , A61N1/3622
摘要： Heart rate variability metrics are derived from the intervals between successive heart beats, referred to as BB intervals. A method implementable by an implantable cardiac device for excluding BB intervals due to ectopic beats based on a function of preceding BB intervals is presented. It is desirable to remove such BB intervals from a BB interval time series used to calculate a heart rate variability metric.
摘要翻译：心率变异性度量是从连续的心跳之间的间隔导出的，称为BB间隔。提出了一种可植入心脏装置的方法，用于根据先前的BB间隔的功能排除由于异位搏动造成的BB间隔。期望从用于计算心率变异性度量的BB间隔时间序列中去除这样的BB间隔。

127. 发明申请

US20080119749A1 RESPIRATION-SYNCHRONIZED HEART SOUND TRENDING 审中-公开
标题翻译：呼吸同步心音变化
公开(公告)号：US20080119749A1
公开(公告)日：2008-05-22
申请号：US11561428
申请日：2006-11-20
申请人： Carlos Haro , Yi Zhang , Abhilash Patangay , Gerrard M. Carlson
发明人： Carlos Haro , Yi Zhang , Abhilash Patangay , Gerrard M. Carlson
IPC分类号： A61B5/02
CPC分类号： A61B5/025 , A61B5/0031 , A61B5/0205 , A61B5/029 , A61B5/0295 , A61B5/0402 , A61B5/053 , A61B5/0816 , A61B5/103 , A61B7/00 , A61B7/04 , A61N1/36521 , A61N1/36542 , A61N1/36578
摘要： Respiration-synchronized heart sound trends can be detected using an implantable medical device, including a respiration sensor, a respiration phase detector, a heart sound sensor, a heart sound detector, and a processor. The implantable medical device can also include a cardiac sensor. The respiration-synchronized heart sound trends can include heart sounds occurring during specific phases of a respiration signal, such as inspiration or expiration. The heart sound signal can be gated or the heart sound sensor can be enabled or disabled using the cardiac sensor or the respiration sensor. Further, the heart sound trends can be displayed using an external display, and can provide information about a cardiovascular status using an analysis module, or the analysis module and a blood volume sensor.
摘要翻译：可以使用可植入医疗装置（包括呼吸传感器，呼吸相位检测器，心脏声音传感器，心脏声音检测器和处理器）来检测呼吸同步的心音趋势。可植入医疗装置还可以包括心脏传感器。呼吸同步的心音趋势可以包括在呼吸信号的特定阶段期间发生的心音，例如吸气或呼气。可以使用心脏传感器或呼吸传感器对心音信号进行门控或心音传感器启用或禁用。此外，可以使用外部显示器显示心脏音频趋势，并且可以使用分析模块或分析模块和血液量传感器提供关于心血管状态的信息。

128. 发明申请

US20080114219A1 MONITORING OF CHRONOBIOLOGICAL RHYTHMS FOR DISEASE AND DRUG MANAGEMENT USING ONE OR MORE IMPLANTABLE DEVICE 有权
标题翻译：使用一个或多个可植入装置监测疾病和药物管理的血液生殖系统
公开(公告)号：US20080114219A1
公开(公告)日：2008-05-15
申请号：US11554986
申请日：2006-10-31
申请人： Yi Zhang , John D. Hatlestad , Gerrard M. Carlson , Yousufali Dalal , Marina V. Brockway , Kent Lee , Richard O. Kuenzler , Carlos Haro , Krzysztof Z. Siejko , Abhilash Patangay
发明人： Yi Zhang , John D. Hatlestad , Gerrard M. Carlson , Yousufali Dalal , Marina V. Brockway , Kent Lee , Richard O. Kuenzler , Carlos Haro , Krzysztof Z. Siejko , Abhilash Patangay
IPC分类号： A61B5/00
CPC分类号： A61M5/1723 , A61B5/02055 , A61B5/0215 , A61B5/024 , A61B5/02405 , A61B5/053 , A61B5/0816 , A61B5/1116 , A61B5/686 , A61B5/7275 , A61N1/36114 , A61N1/36135 , A61N1/3621 , A61N1/365 , A61N1/36585 , G06F19/00
摘要： The health state of a subject is automatically evaluated or predicted using at least one implantable device. In varying examples, the health state is determined by sensing or receiving information about at least one physiological process having a circadian rhythm whose presence, absence, or baseline change is associated with impending disease, and comparing such rhythm to baseline circadian rhythm prediction criteria. Other chronobiological rhythms beside circadian may also be used. The baseline prediction criteria may be derived using one or more past physiological process observation of the subject or population of subjects in a non-disease health state. The prediction processing may be performed by the at least one implantable device or by an external device in communication with the implantable device. Systems and methods for invoking a therapy in response to the health state, such as to prevent or minimize the consequences of predicted impending heart failure, are also discussed.
摘要翻译：使用至少一个可植入装置自动评价或预测受试者的健康状况。在不同的实施例中，通过感测或接收关于至少一个具有昼夜节律的生理过程的信息来确定健康状况，所述生理过程的存在，不存在或基线变化与即将发生的疾病相关联，并将该节律与基线昼夜节律预测标准进行比较。也可以使用昼夜节律以外的其他时间生理节律。可以使用在非疾病健康状态下的受试者或受试者群体的一个或多个过去的生理过程观察来导出基线预测标准。预测处理可以由至少一个可植入装置或与可植入装置通信的外部装置执行。还讨论了响应于健康状态调用疗法的系统和方法，例如预防或最小化预期的即将到来的心力衰竭的后果。

129. 发明授权

US07113825B2 Method and apparatus for detecting acoustic oscillations in cardiac rhythm 有权
公开(公告)号：US07113825B2
公开(公告)日：2006-09-26
申请号：US10138046
申请日：2002-05-03
申请人： Joseph M. Pastore , William C. Lincoln , Gerrard M. Carlson , Qingsheng Zhu , Jiang Ding
发明人： Joseph M. Pastore , William C. Lincoln , Gerrard M. Carlson , Qingsheng Zhu , Jiang Ding
IPC分类号： A61N1/39 , A61B5/02
CPC分类号： A61N1/3925 , A61N1/3622 , A61N1/3627 , A61N1/36514 , A61N1/36521 , A61N1/36542 , A61N1/3684
摘要： A cardiac rhythm management device is configured to detect oscillations in cardiac rhythm by measuring the amplitudes of heart sounds during successive heart beats. Upon detection of acoustic alternans, the device may adjust its operating behavior to compensate for the deleterious effects of the condition.

130. 发明授权

US07069070B2 Statistical method for assessing autonomic balance 失效
公开(公告)号：US07069070B2
公开(公告)日：2006-06-27
申请号：US10436876
申请日：2003-05-12
申请人： Gerrard M. Carlson , Ronald D. Berger
发明人： Gerrard M. Carlson , Ronald D. Berger
IPC分类号： A61B5/0452
CPC分类号： A61B5/02405 , A61B5/4035 , A61N1/3622
摘要： A computationally efficient method for assessing a subject's autonomic balance by measurement of heart rate variability is disclosed which is particularly suitable for implementation by an implantable medical device. Statistical surrogates are used to represent frequency components of an RR time series. A ratio of the low frequency component to the high frequency component may then be estimated to assess the subject's autonomic balance.

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