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121. 发明专利

SK10342003A3 A suspension comprising fibrinogen, thrombin and alcohol and a method of coating a carrier with the same, and a method for drying the coating 未知
公开(公告)号：SK10342003A3
公开(公告)日：2004-02-03
申请号：SK10342003
申请日：2002-01-25
申请人： NYCOMED PHARMA AS
发明人： SCHAUFLER ALFRED
IPC分类号： A61K38/46 , A61K38/48 , A61K9/16 , A61K47/34 , A61K47/36 , A61K47/38 , A61K47/42 , A61L20060101 , A61L15/16 , A61L15/22 , A61L15/32 , A61L15/42 , A61L15/44 , A61L15/64 , A61L24/00 , A61L24/08 , A61L24/10 , A61L27/00 , A61L31/04 , A61P7/04 , A61P41/00 , C08H1/06 , C08J20060101 , C08J9/30 , C08L20060101 , C08L89/06
摘要： The present invention relates to a solid composition useful for tissue gluing, tissue sealing and haemostasis consisting essentially of a) a carrier which has at least one of the following physical properties: elasticity module in the range of 5-100 N/cm, density of 1-10 mg/cm 3 , chamber diameter of more than 0.75 mm and less than 4 mm and/or having a chamber diameter average below 3 mm and evenly distributed and fixed upon said carrier, b) solid fibrinogen, and c) solid thrombin. The carrier is a biodegradable polymer such as a polyhyaluronic acid, polyhydroxy acid, e.g. lactic acid, glucolic acid, hydroxybutanoic acid, a cellulose, gelatine or collagen, such as a collagen sponge, e.g. a collagen sponge consisting essentially of collagen type I fibres. The fibrinogen and thrombin are preferably human, purified from a natural source, or transgenic or recombinant human fibrinogen and/or thrombin. In a preferred embodiment the composition does not comprise any antifibronolytic agent such as aprotinin, µ-aminocaproic acid or ±2-antiplasmin,

122. 发明专利

BG107738A PROCESS FOR THE PREPARATION OF AN EMULSION COMPOSITION 未知
公开(公告)号：BG107738A
公开(公告)日：2004-01-30
申请号：BG10773803
申请日：2003-04-17
申请人： NYCOMED PHARMA AS
发明人： SCHLYTER JIMMY H , PIENE JAN Y
IPC分类号： A23L27/00 , A23L33/15 , A61K9/00 , A61K9/107 , A61K47/14 , A61P3/02 , A23L1/302 , A23L1/22 , A61K31/10 , A61K31/5513 , A61K31/55 , A61K31/58
摘要： The method provides a process for the preparation of a liquid emulsion composition having a continuous aqueous phase containing a gelling agent and a thickener and optionally a physiologically tolerable amount of at least one water-soluble vitamin and/or non-vitamin drug, and a discontinuous oil phase, optionally comprising at least one lipophilic vitamin and/or non-vitamin lipophilic drug and optionally a triglyceride. The composition contains at least one emulsifying agent. By the method the formation of an aqueous composition is made, comprising an aqueous solution of a gelling agent and a thickener, and optionally at least one water soluble vitamin and/or non-vitamin drug, formation of a water-immiscible liquid composition, containing at least one emulsifier, and optionally at least one lipophilic vitamin and/or a non-vitamin drug, mixing the water immiscible composition with at least part of the water composition by means of which oil-in-water emulsion is produced. 25 claims

123. 发明专利

CZ20032199A3 Suspension comprising fibrinogen, thrombin and alcohol, a method for preparing such suspension, a method for coating a carrier with such a suspension, a method of drying the coating of the carrier, and a coated collagen sponge 未知
公开(公告)号：CZ20032199A3
公开(公告)日：2003-12-17
申请号：CZ20032199
申请日：2002-01-25
申请人： NYCOMED PHARMA AS
发明人： SCHAUFLER ALFRED
IPC分类号： A61K9/16 , A61K38/46 , A61K38/48 , A61K47/34 , A61K47/36 , A61K47/38 , A61K47/42 , A61L20060101 , A61L15/16 , A61L15/22 , A61L15/32 , A61L15/42 , A61L15/44 , A61L15/64 , A61L24/00 , A61L24/08 , A61L24/10 , A61L27/00 , A61L31/04 , A61P7/04 , A61P41/00 , C08H1/06 , C08J20060101 , C08J9/30 , C08L20060101 , C08L89/06
摘要： The present invention relates to a solid composition useful for tissue gluing, tissue sealing and haemostasis consisting essentially of a) a carrier which has at least one of the following physical properties: elasticity module in the range of 5-100 N/cm, density of 1-10 mg/cm 3 , chamber diameter of more than 0.75 mm and less than 4 mm and/or having a chamber diameter average below 3 mm and evenly distributed and fixed upon said carrier, b) solid fibrinogen, and c) solid thrombin. The carrier is a biodegradable polymer such as a polyhyaluronic acid, polyhydroxy acid, e.g. lactic acid, glucolic acid, hydroxybutanoic acid, a cellulose, gelatine or collagen, such as a collagen sponge, e.g. a collagen sponge consisting essentially of collagen type I fibres. The fibrinogen and thrombin are preferably human, purified from a natural source, or transgenic or recombinant human fibrinogen and/or thrombin. In a preferred embodiment the composition does not comprise any antifibronolytic agent such as aprotinin, µ-aminocaproic acid or ±2-antiplasmin,

124. 发明专利

CZ20032197A3 Carrier with a solid fibrinogen and solid thrombin 未知
公开(公告)号：CZ20032197A3
公开(公告)日：2003-11-12
申请号：CZ20032197
申请日：2002-01-25
申请人： NYCOMED PHARMA AS
发明人： STIMMEDER DAGMAR
IPC分类号： A61K9/16 , A61K38/46 , A61K38/48 , A61K47/34 , A61K47/36 , A61K47/38 , A61K47/42 , A61L20060101 , A61L15/16 , A61L15/22 , A61L15/32 , A61L15/42 , A61L15/44 , A61L15/64 , A61L24/00 , A61L24/08 , A61L24/10 , A61L27/00 , A61L31/04 , A61P7/04 , A61P41/00 , C08H1/06 , C08J20060101 , C08J9/30 , C08L20060101 , C08L89/06
摘要： The present invention relates to a solid composition useful for tissue gluing, tissue sealing and haemostasis consisting essentially of a) a carrier which has at least one of the following physical properties: elasticity module in the range of 5-100 N/cm, density of 1-10 mg/cm 3 , chamber diameter of more than 0.75 mm and less than 4 mm and/or having a chamber diameter average below 3 mm and evenly distributed and fixed upon said carrier, b) solid fibrinogen, and c) solid thrombin. The carrier is a biodegradable polymer such as a polyhyaluronic acid, polyhydroxy acid, e.g. lactic acid, glucolic acid, hydroxybutanoic acid, a cellulose, gelatine or collagen, such as a collagen sponge, e.g. a collagen sponge consisting essentially of collagen type I fibres. The fibrinogen and thrombin are preferably human, purified from a natural source, or transgenic or recombinant human fibrinogen and/or thrombin. In a preferred embodiment the composition does not comprise any antifibronolytic agent such as aprotinin, µ-aminocaproic acid or ±2-antiplasmin,

125. 发明专利

AR032400A1 UN AGENTE CON UN FIBRINOGENO SOLIDO Y UNA TROMBINA SOLIDA 未知
公开(公告)号：AR032400A1
公开(公告)日：2003-11-05
申请号：ARP020100259
申请日：2002-01-25
申请人： NYCOMED PHARMA AS
发明人： STIMMEDER DAGMAR
IPC分类号： A61K9/16 , A61K38/46 , A61K38/48 , A61K47/34 , A61K47/36 , A61K47/38 , A61K47/42 , A61L20060101 , A61L15/16 , A61L15/22 , A61L15/32 , A61L15/42 , A61L15/44 , A61L15/64 , A61L24/00 , A61L24/08 , A61L24/10 , A61L27/00 , A61L31/04 , A61P7/04 , A61P41/00 , C08H1/06 , C08J20060101 , C08J9/30 , C08L20060101 , C08L89/06
摘要： La presente invencion se refiere a una composicion solida util para el pegado de tejidos, el sellado de tejidos y la hemostasia, que consiste esencialmente en a) un portador que tiene al menos una de las siguientes propiedades físicas:modulo de elasticidad en el rango de 5-100 N/cm, densidad de 1-10 mg/cm3, diámetro de cámara superior a 0,75 mm e inferior a 4 mm y/o que tiene un diámetro de cámara promedio inferior a 3 mm, y distribuido en forma pareja fijado a dicho portador, b) fibrinogeno solido y c) trombina solida. El portador es un polímero biodegradable como un ácido polihialuronico, polihidroxiácido, por ejemplo ácido láctico, ácido glucolico, ácido hidroxibutanoico, una celulosa, gelatina o colágeno, como una esponja de colágeno, por ejemplo una esponja de colágeno que consiste esencialmente en fibras de colágeno tipo I. El fibrinogeno y la trombina son, preferentemente, humanos, purificados de una fuente natural, o fibrinogeno y/o trombina humanos transgénicos o recombinantes. En una forma de realizacion preferida, la composicion no comprende ningun agente antifibrinolítico como aprotinina, ácido epsilon-aminocaproico o alfa2-antiplasmina.

126. 发明专利

EE200300341A 未知
公开(公告)号：EE200300341A
公开(公告)日：2003-10-15
申请号：EEP200300341
申请日：2002-01-25
申请人： NYCOMED PHARMA AS
发明人： SCHAUFLER ALFRED
IPC分类号： A61K38/46 , A61K38/48 , A61K9/16 , A61K47/34 , A61K47/36 , A61K47/38 , A61K47/42 , A61L20060101 , A61L15/16 , A61L15/22 , A61L15/32 , A61L15/42 , A61L15/44 , A61L15/64 , A61L24/00 , A61L24/08 , A61L24/10 , A61L27/00 , A61L31/04 , A61P7/04 , A61P41/00 , C08H1/06 , C08J20060101 , C08J9/30 , C08L20060101 , C08L89/06
摘要： The present invention relates to a solid composition useful for tissue gluing, tissue sealing and haemostasis consisting essentially of a) a carrier which has at least one of the following physical properties: elasticity module in the range of 5-100 N/cm, density of 1-10 mg/cm 3 , chamber diameter of more than 0.75 mm and less than 4 mm and/or having a chamber diameter average below 3 mm and evenly distributed and fixed upon said carrier, b) solid fibrinogen, and c) solid thrombin. The carrier is a biodegradable polymer such as a polyhyaluronic acid, polyhydroxy acid, e.g. lactic acid, glucolic acid, hydroxybutanoic acid, a cellulose, gelatine or collagen, such as a collagen sponge, e.g. a collagen sponge consisting essentially of collagen type I fibres. The fibrinogen and thrombin are preferably human, purified from a natural source, or transgenic or recombinant human fibrinogen and/or thrombin. In a preferred embodiment the composition does not comprise any antifibronolytic agent such as aprotinin, µ-aminocaproic acid or ±2-antiplasmin,

127. 发明专利

NO20033296L 未知
公开(公告)号：NO20033296L
公开(公告)日：2003-09-25
申请号：NO20033296
申请日：2003-07-22
申请人： NYCOMED PHARMA AS
发明人： STIMMEDER DAGMAR
IPC分类号： A61K38/46 , A61K9/16 , A61K38/48 , A61K47/34 , A61K47/36 , A61K47/38 , A61K47/42 , A61L20060101 , A61L15/16 , A61L15/22 , A61L15/32 , A61L15/42 , A61L15/44 , A61L15/64 , A61L24/00 , A61L24/08 , A61L24/10 , A61L27/00 , A61L31/04 , A61P7/04 , A61P41/00 , C08H1/06 , C08J20060101 , C08J9/30 , C08L20060101 , C08L89/06 , A61L
摘要： The present invention relates to a solid composition useful for tissue gluing, tissue sealing and haemostasis consisting essentially of a) a carrier which has at least one of the following physical properties: elasticity module in the range of 5-100 N/cm, density of 1-10 mg/cm 3 , chamber diameter of more than 0.75 mm and less than 4 mm and/or having a chamber diameter average below 3 mm and evenly distributed and fixed upon said carrier, b) solid fibrinogen, and c) solid thrombin. The carrier is a biodegradable polymer such as a polyhyaluronic acid, polyhydroxy acid, e.g. lactic acid, glucolic acid, hydroxybutanoic acid, a cellulose, gelatine or collagen, such as a collagen sponge, e.g. a collagen sponge consisting essentially of collagen type I fibres. The fibrinogen and thrombin are preferably human, purified from a natural source, or transgenic or recombinant human fibrinogen and/or thrombin. In a preferred embodiment the composition does not comprise any antifibronolytic agent such as aprotinin, µ-aminocaproic acid or ±2-antiplasmin,

129. 发明专利

NO20033297D0 未知
公开(公告)号：NO20033297D0
公开(公告)日：2003-07-22
申请号：NO20033297
申请日：2003-07-22
申请人： NYCOMED PHARMA AS
发明人： SCHAUFLER ALFRED
IPC分类号： A61K38/46 , A61K9/16 , A61K38/48 , A61K47/34 , A61K47/36 , A61K47/38 , A61K47/42 , A61L20060101 , A61L15/16 , A61L15/22 , A61L15/32 , A61L15/42 , A61L15/44 , A61L15/64 , A61L24/00 , A61L24/08 , A61L24/10 , A61L27/00 , A61L31/04 , A61P7/04 , A61P41/00 , C08H1/06 , C08J20060101 , C08J9/30 , C08L20060101 , C08L89/06 , A61L
摘要： The present invention relates to a solid composition useful for tissue gluing, tissue sealing and haemostasis consisting essentially of a) a carrier which has at least one of the following physical properties: elasticity module in the range of 5-100 N/cm, density of 1-10 mg/cm 3 , chamber diameter of more than 0.75 mm and less than 4 mm and/or having a chamber diameter average below 3 mm and evenly distributed and fixed upon said carrier, b) solid fibrinogen, and c) solid thrombin. The carrier is a biodegradable polymer such as a polyhyaluronic acid, polyhydroxy acid, e.g. lactic acid, glucolic acid, hydroxybutanoic acid, a cellulose, gelatine or collagen, such as a collagen sponge, e.g. a collagen sponge consisting essentially of collagen type I fibres. The fibrinogen and thrombin are preferably human, purified from a natural source, or transgenic or recombinant human fibrinogen and/or thrombin. In a preferred embodiment the composition does not comprise any antifibronolytic agent such as aprotinin, µ-aminocaproic acid or ±2-antiplasmin,

130. 发明专利

NO20031249L 未知
公开(公告)号：NO20031249L
公开(公告)日：2003-05-20
申请号：NO20031249
申请日：2003-03-18
申请人： NYCOMED PHARMA AS
发明人： SCHLYTER JIMMY HIRSCHSPRUNG , PIENE JAN YNGVAR
IPC分类号： A23L27/00 , A23L33/15 , A61K9/00 , A61K9/107 , A61K47/14 , A61P3/02 , A61K
摘要： The invention provides a process for the preparation of a liquid emulsion composition having a continuous aqueous phase containing a gelling agent and a thickener and optionally a physiologically tolerable amount of at least one water soluble vitamin and/or non-vitamin drug, and a discontinuous oil phase, optionally comprising at least one lipophilic vitamin and/or non-vitamin lipophilic drug and optionally an edible triglyceride, said emulsion composition further containing at least one emulsifying agent, said process comprising: forming an aqueous composition comprising an aqueous solution of a gelling agent and a thickener and optionally at least one water soluble vitamin and/or non-vitamin drug; forming a water-immiscible liquid composition comprising at least one emulsifying agent and optionally at least one lipophilic vitamin and/or non-vitamin drug; mixing said water-immiscible composition with at least part of said aqueous composition whereby to form an oil-in-water emulsion; and if required mixing further components with said emulsion whereby to form said liquid emulsion composition.

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