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121. 发明申请

WO2016065349A2 SHORT NON-CODING PROTEIN REGULATORY RNAS (SPRRNAS) AND METHODS OF USE 审中-公开
标题翻译：短期非编码蛋白调节RNAs（SPRRNAS）及其使用方法
公开(公告)号：WO2016065349A2
公开(公告)日：2016-04-28
申请号：PCT/US2015/057259
申请日：2015-10-24
申请人： UNIVERSITY OF MARYLAND, BALTIMORE
发明人： MAO, Li , MEI, Yupin
IPC分类号： C12N15/113 , C12Q1/68
CPC分类号： C12N15/113 , C12N2310/113 , C12Q1/6886 , C12Q2600/136 , C12Q2600/178
摘要： The present invention provides isolated nucleic acid molecules comprising short non-coding protein regulatory RNAs (sprRNA), variants, fragments and inhibitors thereof and compositions and methods of using the same.
摘要翻译：本发明提供了分离的核酸分子，其包含短的非编码蛋白质调节RNA（sprRNA），变体，片段和抑制剂以及其使用组合物和方法。

122. 发明申请

WO2016019393A1 METHODS AND SYSTEMS FOR PROCESSING PARTICLES 审中-公开
标题翻译：处理颗粒的方法和系统
公开(公告)号：WO2016019393A1
公开(公告)日：2016-02-04
申请号：PCT/US2015/043500
申请日：2015-08-03
申请人： GPB SCIENTIFIC, LLC , THE TRUSTEES OF PRINCETON UNIVERSITY , UNIVERSITY OF MARYLAND, BALTIMORE
发明人： GRISHAM, Michael , CIVIN, Curt, I. , STURM, James, C. , AUSTIN, Robert, H. , D'SILVA, Joseph , CHEN, Yu
IPC分类号： C12N9/00 , G01N30/00 , G01N30/50
CPC分类号： C12N9/00 , G01N27/447 , G01N30/60
摘要： Described herein are improved microfluidic devices and methods for processing cells that can improve cell quality, streamline workflows, and lower costs. Applications include research and clinical diagnostics in cancer, infectious disease, and inflammatory disease, among other disease areas.
摘要翻译：本文描述了用于处理可改善细胞质量，简化工作流程和降低成本的细胞的改进的微流体装置和方法。应用包括癌症，传染病和炎性疾病等疾病领域的研究和临床诊断。

123. 发明申请

WO2015157223A1 METHODS OF TREATING CORONAVIRUS INFECTION 审中-公开
标题翻译：治疗宫颈感染的方法
公开(公告)号：WO2015157223A1
公开(公告)日：2015-10-15
申请号：PCT/US2015/024631
申请日：2015-04-07
申请人： UNIVERSITY OF MARYLAND, BALTIMORE , FRIEMAN, Matthew , JARHLING, Peter , HENSLEY, Lisa
发明人： FRIEMAN, Matthew , JARHLING, Peter , HENSLEY, Lisa
IPC分类号： A61K31/5415 , A61K31/506 , A61K31/135 , A61K31/435 , A61K31/513 , A61P31/14
CPC分类号： A61K31/7068 , A61K31/13 , A61K31/138 , A61K31/435 , A61K31/46 , A61K31/4706 , A61K31/4709 , A61K31/496 , A61K31/506 , A61K31/522 , A61K31/5415 , A61K31/55 , A61K31/662 , A61K31/675 , A61K31/7012 , A61K31/7056 , A61K31/7072 , A61K31/7125 , A61K38/21 , A61K38/212 , A61K38/215 , A61K38/217 , A61K45/06 , A61K2300/00
摘要： The present invention provides methods for treating a coronavirus infection. For example, treatment may be effected by administering a neurotransmitter inhibitor, a signaling kinase inhibitor, an estrogen receptor inhibitor, a DNA metabolism inhibitor or an anti-parasitic agent. Also provided are methods for treating a coronaviruse infection in which an anti-viral drug also is administered during any of the described methods.
摘要翻译：本发明提供治疗冠状病毒感染的方法。例如，可以通过施用神经递质抑制剂，信号转导酶抑制剂，雌激素受体抑制剂，DNA代谢抑制剂或抗寄生虫剂来治疗。还提供了治疗冠状病毒感染的方法，其中在任何所述方法中也施用抗病毒药物。

124. 发明申请

WO2015153948A2 MICROTENTACLE IMAGING IN PATIENT TUMOR SAMPLES 审中-公开
标题翻译：患者肿瘤样本中的微小病灶成像
公开(公告)号：WO2015153948A2
公开(公告)日：2015-10-08
申请号：PCT/US2015/024207
申请日：2015-04-03
申请人： UNIVERSITY OF MARYLAND, BALTIMORE , MARTIN, Stuart, S.
发明人： MARTIN, Stuart, S.
IPC分类号： C12Q1/68
CPC分类号： G01N33/5026 , G01N21/95 , G01N33/50 , G01N33/574 , G01N2800/7028 , G02B21/0028
摘要： The present invention provides a method for imaging microtentacles on isolated, living, non-adherent primary tumor cells from a cancer subject comprising: i) obtaining one or more living, non-adherent primary tumor cells that has been isolated from a solid tumor from the subject; and ii) imaging the one or more living, non-adherent primary tumor cells and detecting the microtentacles.
摘要翻译：本发明提供了对来自癌症受试者的分离的，活的，非粘附的原发性肿瘤细胞成像微囊泡的方法，其包括：i）获得一种或多种活的，非贴壁的原发性肿瘤细胞，其具有从受试者的实体瘤中分离出来; 和ii）对一个或多个活的非粘附原发性肿瘤细胞进行成像并检测微小触角。

125. 发明申请

WO2015123452A1 QPCR-BASED METHOD TO ASSESS T CELL FUNCTION 审中-公开
标题翻译：基于QPCR的方法来评估细胞功能
公开(公告)号：WO2015123452A1
公开(公告)日：2015-08-20
申请号：PCT/US2015/015685
申请日：2015-02-12
申请人： UNIVERSITY OF MARYLAND, BALTIMORE , WEBB, Tonya
发明人： WEBB, Tonya
IPC分类号： C12Q1/68 , C12N5/0783
CPC分类号： C12Q1/6886 , C12N5/0636 , C12N5/0638 , C12Q2600/106 , C12Q2600/158
摘要： The invention provides a method of determining T cell function in a subject in need of immunotherapy comprising: i) providing a blood sample comprising a population of T cells from the subject; ii) activating the T cells in the sample; and iii) assaying an expression level of one or more T cell activation markers using quantitative real time PCR (qPCR) after activating the T cells in the sample.
摘要翻译：本发明提供了确定需要免疫治疗的受试者中的T细胞功能的方法，包括：i）提供包含来自受试者的T细胞群体的血液样品; ii）激活样品中的T细胞; 和iii）在激活样品中的T细胞后，使用定量实时PCR（qPCR）测定一种或多种T细胞活化标记物的表达水平。

126. 发明申请

WO2015054468A1 METHODS FOR IDENTIFYING FUNGI 审中-公开
标题翻译：识别真菌的方法
公开(公告)号：WO2015054468A1
公开(公告)日：2015-04-16
申请号：PCT/US2014/059853
申请日：2014-10-09
申请人： UNIVERSITY OF MARYLAND, BALTIMORE
发明人： GOODLETT, David , ERNST, Robert
IPC分类号： C12Q1/04 , G01N33/92
CPC分类号： C12Q1/04 , C40B30/02 , G01N33/56961 , G01N33/92 , G01N2333/37 , G01N2560/00
摘要： Methods for identifying fungal species by analysis of fungal membrane lipids, such as glycerophospholipids, sphingolipids and sterols, using mass spectrometry ionization patterns are disclosed.
摘要翻译：公开了通过使用质谱电离模式分析真菌膜脂质，例如甘油磷脂，鞘脂和甾醇来鉴定真菌的方法。

127. 发明申请

WO2014107690A1 BIOCOMPATIBLE COATING COMPOSITIONS 审中-公开
标题翻译：生物涂料组合物
公开(公告)号：WO2014107690A1
公开(公告)日：2014-07-10
申请号：PCT/US2014/010391
申请日：2014-01-06
申请人： UNIVERSITY OF MARYLAND, BALTIMORE , GARIMELLA, Narayana , WU, Zhongjun , GRIFFITH, Bartley
发明人： GARIMELLA, Narayana , WU, Zhongjun , GRIFFITH, Bartley
IPC分类号： A61K31/14 , A61L33/10
CPC分类号： A61L33/0023 , A61L33/0011 , A61L33/0029 , A61L33/0076 , A61L33/04 , A61L33/064 , A61L2300/208 , A61L2300/236 , A61L2300/42 , A61L2300/608 , A61L2420/02 , A61L2420/06 , A61L2420/08 , C08L39/06
摘要： Hemo-compatible, anti- and non-thrombogenic, heparin-based bioactive coat a surface to be contacted with blood, such as a surface of an oxygenator device (e.g., a Hollow Fiber Membrane (HFM) surface) or an artificial lung, which coatings include a quaternary ammonium salt and heparin complex (QUAT). The surface is treated with polyvinylpyrrolidone (PVP), followed by a coating layer of said quaternary ammonium salts and heparin complex (QUAT) to form a PVP-QUAT coating. According to other example embodiments, anionic functional groups are created on the one or more surfaces of the HFM by modifying the surf ace of the HFM using ionic complexes dissolved in a solvent mixture that includes major quantity of alcohol along with a minor quantity of organic dissolving agents. Also provided are methods of making the provided coatings, methods of coating a surface, devices that have been coated, and kits that include such coatings.
摘要翻译：血液相容性，抗和非血栓形成的基于肝素的生物活性涂层与血液接触的表面，例如氧合器装置的表面（例如中空纤维膜（HFM）表面））或人造肺，其中涂层包括季铵盐和肝素复合物（QUAT）。用聚乙烯吡咯烷酮（PVP）处理表面，然后用所述季铵盐和肝素复合物（QUAT）的涂层进行处理以形成PVP-QUAT涂层。根据其他示例性实施方案，通过使用溶解在包括主要量的醇的溶剂混合物中的离子络合物以及少量有机溶解来改变HFM的一个或多个表面上的阴离子官能团代理商。还提供了制备所提供的涂层，涂覆表面的方法，已经被涂覆的装置以及包括这种涂层的试剂盒的方法。

128. 发明申请

WO2014062580A1 BACTERIAL LIVE VECTOR VACCINES EXPRESSING CHROMOSOMALLY-INTEGRATED FOREIGN ANTIGENS 审中-公开
标题翻译：表现出色素整合外源抗原的细菌活载体疫苗
公开(公告)号：WO2014062580A1
公开(公告)日：2014-04-24
申请号：PCT/US2013/064872
申请日：2013-10-14
申请人： UNIVERSITY OF MARYLAND, BALTIMORE
发明人： GALEN, James E. , WANG, Jin-Yuang
IPC分类号： C12N1/21 , C12N15/74 , A61K39/112
CPC分类号： A61K39/0275 , A61K39/0291 , A61K39/08 , A61K2039/522 , A61K2039/523 , C12N15/74 , Y02A50/407 , Y02A50/484
摘要： Bacterial live vector vaccines represent a vaccine development strategy that offers exceptional flexibility. In the present invention, genes encoding protective antigens of unrelated bacterial, viral, parasitic, or fungal pathogens are expressed in an attenuated bacterial vaccine strain that delivers these foreign antigens to the immune system, thereby eliciting relevant immune responses. Rather than expressing these antigens using only low copy expression plasmids, expression of foreign proteins is accomplished using both low copy expression plasmids in conjunction with chromosomal integrations within the same live vector. This strategy compensates for the inherent disadvantage of loss of gene dosage (versus exclusive plasmid-based expression) by integrating antigen expression cassettes into multiple chromosomal sites already inactivated in an attenuated vector.
摘要翻译：细菌活载体疫苗代表疫苗开发策略，提供卓越的灵活性。在本发明中，编码不相关细菌，病毒，寄生或真菌病原体的保护性抗原的基因在减少的细菌疫苗株中表达，所述菌株将这些外来抗原递送至免疫系统，从而引发相关的免疫应答。不仅使用低拷贝表达质粒表达这些抗原，而是使用低拷贝表达质粒与同一活载体中的染色体整合结合来实现外源蛋白的表达。该策略通过将抗原表达盒整合到已经在减毒载体中已经失活的多个染色体位点来补偿基因剂量损失（相对于基于质粒的表达）的固有缺点。

129. 发明申请

WO2014018565A1 TECHNIQUES FOR EMERGENCY APNEIC OXYGENATION 审中-公开
标题翻译：紧急APNEIC OXYGENATION的技术
公开(公告)号：WO2014018565A1
公开(公告)日：2014-01-30
申请号：PCT/US2013/051739
申请日：2013-07-23
申请人： UNIVERSITY OF MARYLAND, BALTIMORE
发明人： WOLF, Jeffrey S. , IACONO, Aldo T.
IPC分类号： A61M16/04 , A61M25/01 , A61M25/088
CPC分类号： A61M25/0041 , A61M16/0472 , A61M16/0486 , A61M25/0606
摘要： Techniques for emergency apneic oxygenation include a cannula having a longitudinal inner passage with an inner diameter. A distal portion has a first outer diameter greater than the inner diameter, and is made of shape memory material shaped to bend in a first direction along the inner passage. A cannula base has a second outer diameter greater than the first outer diameter. A distance from a distal end of the cannula to a proximal end of the distal portion of the cannula is less than a distance from a surface of a throat of a subject to a distal surface of an airway of the subject. The inner passage is configured to pass a catheter connected at a proximal end to an oxygen source. In various embodiments, the cannula is used with a trocar and, optionally, a system base, or supplied in a kit with a catheter.
摘要翻译：用于紧急呼吸暂停充氧的技术包括具有内径的纵向内部通道的套管。远侧部分具有大于内径的第一外径，并且由形状记忆材料制成，以形成为沿着内部通道在第一方向上弯曲。套管基座具有大于第一外径的第二外径。从插管的远端到套管的远端部分的近端的距离小于从受试者的喉部的表面到受试者的气道的远端表面的距离。内部通道构造成将在近端连接的导管通过氧源。在各种实施例中，插管与套管针和任选的系统基座一起使用，或者在具有导管的套件中提供。

130. 发明申请

WO2013120066A1 CHEMOENZYMATIC GLYCOENGINEERING OF ANTIBODIES AND FC FRAGMENTS THEREOF 审中-公开
标题翻译：抗体及其FC片段的化学成分分析
公开(公告)号：WO2013120066A1
公开(公告)日：2013-08-15
申请号：PCT/US2013/025553
申请日：2013-02-11
申请人： UNIVERSITY OF MARYLAND, BALTIMORE
发明人： WANG, Lai-Xi , HUANG, Wei
IPC分类号： C12P21/08 , C07K16/18 , A61K39/395
CPC分类号： C07K14/473 , A61K47/6849 , A61K47/6867 , A61P31/18 , A61P35/00 , C07K14/4725 , C07K16/00 , C07K16/18 , C07K16/2809 , C07K16/2887 , C07K2317/10 , C07K2317/14 , C07K2317/41 , C07K2317/52 , C07K2317/72 , C07K2317/92 , C07K2317/94 , C12N1/20 , C12N9/2402 , C12P21/005 , C12R1/46 , C12Y302/01096
摘要： The present invention provides for recombinant Endo-S mutants that exhibit reduced hydrolysis activity and increased transglycosylation activity for the synthesis of glycoproteins wherein a desired sialylated oxazoline or synthetic oligosaccharide oxazoline is added to a core fucosylated or nonfucosylated GlcNAc-protein acceptor. Such recombinant Endo-S mutants are useful for efficient glycosylation remodeling of IgGl-Fc domain to provide different antibody glycoforms carrying structurally well-defined Fc N-glycans.
摘要翻译：本发明提供了表达降低的水解活性和增加糖蛋白合成的转糖基活性的重组Endo-S突变体，其中将所需的唾液酸化恶唑啉或合成寡糖恶唑啉加入核心岩藻糖基化或非岩藻糖基化GlcNAc-蛋白受体。这样的重组Endo-S突变体可用于IgG1-Fc结构域的有效糖基重建，以提供携带结构良好定义的FcN-聚糖的不同抗体糖结构。

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