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121. 发明授权

EP0249811B1 New pharmaceutical compositions for parenteral use containing a calcitonin as the active ingredient 失效
标题翻译：用于以钙离子为主成分的用途的新药用组合物
公开(公告)号：EP0249811B1
公开(公告)日：1991-08-28
申请号：EP87108063.6
申请日：1987-06-04
申请人： SCLAVO S.p.A.
发明人： Lattanzi, Filippo , Vanni, Riccardo
IPC分类号： A61K37/30 , A61K37/02
CPC分类号： A61K9/19 , A61K38/23 , A61K47/42 , Y10S514/808

122. 发明公开

EP0336511A3 Method of protection of the carboxy groups in the chemistry of beta-lactam compounds 失效
标题翻译：在BETA-LACTAM化合物的化学中保护羧基的新方法
公开(公告)号：EP0336511A3
公开(公告)日：1991-07-03
申请号：EP89200832.7
申请日：1989-03-31
申请人： SCLAVO S.p.A.
发明人： Fuganti, Claudio , Baldaro, Eva , Faiardi, Daniela , Lazzarini, Ameriga
IPC分类号： C07D501/04 , C07D501/10 , C07D499/08 , C12P35/00 , C12P35/02 , C12P37/00
CPC分类号： C07D499/00 , C12P35/00 , C12P35/02 , C12P37/00 , Y02P20/55
摘要： The present invention relates to a new method of protection of the carboxy group in the chemistry of the compounds of β-lactam type. According to such a method, the carboxy group is protected by being transformed into its corresponding phenyl-acetoxy-methyl ester, which is then removed by an enzymatic route by means of penicillinacylase. In particular, if the β-lactam compound also bears a phenyl-acetamidic substituent, this latter is simultaneously hydrolysed during the same step of removal of the carboxy function protecting group.

123. 发明授权

EP0231728B1 Synthetic peptide with human interleukin 1 activity 失效
标题翻译：具有人类白细胞介素1活性的合成肽
公开(公告)号：EP0231728B1
公开(公告)日：1991-05-22
申请号：EP86830299.3
申请日：1986-10-17
申请人： SCLAVO S.p.A.
发明人： Tagliabue, Aldo , Boraschi, Diana , Antoni, Guido , Presentini, Rivo
IPC分类号： C07K7/06 , A61K37/02
CPC分类号： C07K14/545 , Y10S514/885 , Y10S930/141

124. 发明公开

EP0406931A2 New analogues of all-bond retroinverted thymopentin, the method for the synthesis of the same and their employment for the preparation of pharmaceutical compositions 失效
标题翻译：胸腺五肽与所有反转化合物的类似物，它们的制备方法和它们的药物组合物的制备中的用途。
公开(公告)号：EP0406931A2
公开(公告)日：1991-01-09
申请号：EP90201609.6
申请日：1990-06-20
申请人： SCLAVO S.p.A.
发明人： Mariotti, Sabina , Sisto, Alessandro , Nencioni, Luciano , Villa, Luigi , Pessi, Antonello
IPC分类号： C07K5/02 , C07K7/02
CPC分类号： C07K5/0212 , A61K38/00 , C07K7/02
摘要： New thymopentin (TP5) analogues whose bonds in the peptide chain are all retro-inverted are disclosed.
Such new compounds have the following general formula (I)
wherein R is hydrogen or an acyl radical, and R¹ is a group of the formula -OR², wherein R² is a hydrogen atom or a hydrocarbon radical, and the corresponding basic or acid addition salts which are pharmaceutically acceptable.
The new compounds have immunostimulating activity.
摘要翻译：新胸腺五肽（TP5）类似物谁的键在肽链都逆转化的是游离缺失盘。搜索新的化合物具有下述通式（I） worin R是氢或基团的酰基，且R <1>是下式基团的-OR <2>，worinř<2>是氢原子或烃基，和相应的碱性或酸加成盐是药学可接受的。新化合物具有免疫刺激活性。

125. 发明公开

EP0351458A1 Process for preparing human alpha-foetoprotein 失效
标题翻译： Verfahren zur Herstellung von menschlichem Alpha-Foetoprotein。
公开(公告)号：EP0351458A1
公开(公告)日：1990-01-24
申请号：EP88201580.3
申请日：1988-07-21
申请人： SCLAVO S.p.A.
发明人： Tecce, Mario Felice , Terrana, Benedetto
IPC分类号： C12P21/00 , C12N5/00 , A61K39/395 , G01N33/574
CPC分类号： C07K16/30 , A61K38/00 , C07K14/4715
摘要： Process and means for preparing human alpha-foetoprotein (AFP) which comprises cultivating in a serum-free medium cells of human hepatoma capable of secreting alpha-foetoprotein as the major proteinic component, and of secreting albumin in negligible amounts relatively to alpha-foetoprotein, and separating and purifying AFP under non-denaturant conditions.
The so obtained human alpha-foetoprotein is used for preparing specific monoclonal and polyclonal antibodies useful for the diagnosis of primary hepatic tumor, teratocarcinomas and foetal physiopathologies and for the management of primary hepatic carcinoma.
摘要翻译：用于制备人α-甲胎蛋白（AFP）的方法和方法，其包括在无血清培养基中培养能够分泌α-甲胎蛋白作为主要蛋白质组分的人类肝细胞的细胞，以及相对于α-甲胎蛋白以可忽略的量分泌白蛋白，并在非变性条件下分离和纯化AFP。如此获得的人α-甲胎蛋白用于制备用于诊断原发性肝肿瘤，畸胎癌和胎儿生理病理学以及原发性肝癌的治疗的特异性单克隆和多克隆抗体。

126. 发明公开

EP0336413A1 A novel system of inducible positive regulation of use for production of heterologous proteins 失效
标题翻译：用于生产异源蛋白的诱导使用积极的监管体制。
公开(公告)号：EP0336413A1
公开(公告)日：1989-10-11
申请号：EP89106060.0
申请日：1989-04-06
申请人： SCLAVO S.p.A.
发明人： Gross, Roy , Rappuoli, Rino
IPC分类号： C12N15/74 , C12N1/21
CPC分类号： C12N15/74
摘要： The description relates to a novel system of inducible positive regulation of use in the construction of vectors reproducible by expression in host microorganisms for controlled production of heterologous proteins in high yields. More particularly the system comprises the vir EcoRI-XhoI region of about 4.5 kb contained in the chromosomal DNA of Bordetella which codes for one or more regulating factors, and a terminal 5′ region situated in front of the promotor of the chromosomal Bordetella genes capable of being activated or repressed in trans by the aforementioned factors.
The description also relates to vectors which can be replicated by expression and contain the regulating system and microorganisms transformed by the vectors.
摘要翻译：的描述涉及在由表达可再现的在宿主微生物用于控制生产高产率的异源蛋白的载体的构建使用的诱导型正调控的一种新颖的系统。更具体地，系统包括包含在一个或多个调控因子博德特氏菌，其编码的染色体DNA大约4.5kb的AS对vir的EcoRI-XhoI位区域，和位于染色体博德特氏菌的基因能够启动子的前一个终端5分钟区域被激活或由上述因素中的反式阻抑。这样的描述涉及可通过表达被复制并且含有所述调节系统和微生物由载体转化的载体。

127. 发明公开

EP0253190A3 Partially retro-inverted tuftsin analogues, method for the preparation thereof and pharmaceutical compositions containing them 失效
标题翻译：部分逆转TUFTSIN类似物，其制备方法和含有它们的药物组合物
公开(公告)号：EP0253190A3
公开(公告)日：1989-10-04
申请号：EP87109318.3
申请日：1987-06-29
申请人： ENIRICERCHE S.p.A. , SCLAVO S.p.A.
发明人： Verdini, Antonio Silvio , Bonelli, Fabio , Pessi, Antonello , Cardinali, Franco , Boraschi, Diana , Censini, Stefano , Di Trapani, Romano
IPC分类号： C07K5/02 , C07K1/00 , A61K37/02
CPC分类号： C07K5/0212 , C07C271/22 , C07C323/00
摘要： New partially retro-inverted tuftsin analogues of general formula I
wherein
R represents the side-chain of the amino acids threonine, methionine or leucine
R¹ represents the side-chain of the amino acids lysine or arginine
R² is hydrogen or a metabolically labile acyl group,
all the asymmetric carbon atoms are either of the S- or R-configuration, or, alternatively, the first, third, and fourth asymmetric carbons, starting from the N-terminal residue, are of the S-configuration while the second one is of the R- or (R,S)-configuration, and the corresponding pharmacologically acceptable salts, esters and amides. The new compounds which share the same pharmacological properties of tuftsin, are much more stable toward the enzymatic degradation than the parent molecule.

128. 发明公开

EP0306082A2 Method for the immunolocalization of antigens 失效
标题翻译： Verfahren zur Immunlokalisierung von Antigenen。
公开(公告)号：EP0306082A2
公开(公告)日：1989-03-08
申请号：EP88201812.0
申请日：1988-08-25
申请人： SCLAVO S.p.A.
发明人： Ruggiero, Paolo , Petracca, Roberto
IPC分类号： G01N33/543 , G01N33/58
CPC分类号： G01N33/581 , G01N2001/2846 , Y10S435/81 , Y10S435/96 , Y10S436/825 , Y10S436/827
摘要： A method is given for the immunolocalization of epitopes of non-glucidic nature, in cellular cultures, in tissue slices, or immobilized on such supports as nitrocellulose, by means of the incubation of the sample with specific antibodies for the antigen to be immunolocalized, belonging to the class of the IgM's, and sequential treatment of concanavalin A and with an enzymatic marker capable of binding with concanavalin A, such as, e.g., peroxidase. The method comprises, before the incubation, a suitable treatment of the sample under test, e.g., with periodic acid, in order to prevent concanavalin A from binding with the carbohydrates present in the sample.
摘要翻译：给出了在细胞培养物，组织切片中的免疫定位的方法，或者固定在硝酸纤维素等载体上的方法，通过将样品与要免疫定位的抗原的特异性抗体一起孵育，归属于以及伴随着伴刀豆球蛋白A（例如过氧化物酶）结合的酶标记物的伴刀豆球蛋白A的顺序处理。该方法包括在孵育之前，对例如用高碘酸进行试验的样品进行适当的处理，以防止伴刀豆球蛋白A与样品中存在的碳水化合物结合。

129. 发明授权

EP0152977B1 Process for the preparation of L-alpha-aminoacids 失效
标题翻译：制备L-阿尔法 - 氨基酸的方法
公开(公告)号：EP0152977B1
公开(公告)日：1988-07-20
申请号：EP85200098.3
申请日：1985-01-31
申请人： SCLAVO S.p.A.
发明人： Olivieri, Roberto , Eletti Bianchi, Giancarlo , Fascetti, Eugenio , Centini, Felice
IPC分类号： C12P13/04 , C12P13/06 , C12P13/22 , C12P13/08 , C07C101/02 , C07C101/08
CPC分类号： C12P41/009 , C12P17/10

130. 发明公开

EP0253190A2 Partially retro-inverted tuftsin analogues, method for the preparation thereof and pharmaceutical compositions containing them 失效
标题翻译：部分地逆转化的它们的制备方法和含有它们的药物组合物的促吞噬肽类似物，方法。
公开(公告)号：EP0253190A2
公开(公告)日：1988-01-20
申请号：EP87109318.3
申请日：1987-06-29
申请人： ENIRICERCHE S.p.A. , SCLAVO S.p.A.
发明人： Verdini, Antonio Silvio , Bonelli, Fabio , Pessi, Antonello , Cardinali, Franco , Boraschi, Diana , Censini, Stefano , Di Trapani, Romano
IPC分类号： C07K5/02 , C07K1/00 , A61K37/02
CPC分类号： C07K5/0212 , C07C271/22 , C07C323/00
摘要： New partially retro-inverted tuftsin analogues of general formula I
wherein
R represents the side-chain of the amino acids threonine, methionine or leucine
R¹ represents the side-chain of the amino acids lysine or arginine
R² is hydrogen or a metabolically labile acyl group,
all the asymmetric carbon atoms are either of the S- or R-configuration, or, alternatively, the first, third, and fourth asymmetric carbons, starting from the N-terminal residue, are of the S-configuration while the second one is of the R- or (R,S)-configuration, and the corresponding pharmacologically acceptable salts, esters and amides.
The new compounds which share the same pharmacological properties of tuftsin, are much more stable toward the enzymatic degradation than the parent molecule.
摘要翻译：新的通式部分逆转化的促吞噬肽类似物I worinřdarstellt氨基酸苏氨酸，甲硫氨酸或亮氨酸的R侧链<1> darstellt氨基酸赖氨酸或精氨酸 - [R <2>的侧链是氢或代谢不稳定的酰基，所有的不对称碳原子的是无论是S-或R-构型，或，可选地，所述第一，第三和第四不对称碳原子，从N末端残基开始，是的 S-构型，而第二个是R或（R，S） - 构型，以及相应的药理学上可接受的盐，酯和酰胺的。共享促吞噬肽的相同的药理学性质的新的化合物，要稳定得多朝向比母体分子的酶促降解。

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