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111. 发明授权

US09012414B2 Cosmetic composition 有权
标题翻译：化妆品组成
公开(公告)号：US09012414B2
公开(公告)日：2015-04-21
申请号：US13639997
申请日：2011-04-14
申请人： Charlotte Simmler , Virginie Leplanquais , Emmanuelle Noblesse , Patrice Andre , Annelise Lobstein
发明人： Charlotte Simmler , Virginie Leplanquais , Emmanuelle Noblesse , Patrice Andre , Annelise Lobstein
IPC分类号： A61K31/7034 , A61K8/60 , A61K8/49 , A61Q19/08 , C07H15/203 , C07H1/08 , C07H15/207
CPC分类号： A61K8/602 , A61K8/498 , A61K31/7034 , A61Q19/08 , C07H1/08 , C07H15/203 , C07H15/207
摘要： The invention relates to novel eucomic acid (2-(4-hydroxybenzyl)malic acid) derivatives or plant extracts comprising such derivatives, and also to cosmetic or dermatological compositions containing these compounds or these extracts, and to cosmetic care methods using said compositions. Exemplary compounds are represented by formula (I) below: in which, with the proviso that R1, R2 and R3 are not simultaneously a hydrogen atom, R1 and R3 each independently represent a hydrogen atom or a saturated or unsaturated, preferably C1-C12, hydrocarbon-based chain comprising an aromatic group, preferably a phenyl, said aromatic group being preferably substituted with a group comprising a sugar, preferably a monosaccharide or disaccharide, said chain optionally also comprising one or more heteroatoms preferably chosen from O, S and N, and R2 represents a hydrogen atom or a sugar, preferably a monosaccharide or disaccharide, said sugar being optionally substituted, in particular with a residue comprising a saturated or unsaturated, preferably C1-C12, hydrocarbon-based chain itself comprising an aromatic group, preferably a phenyl, said hydrocarbon-based chain optionally also comprising one or more heteroatoms preferably chosen from O, S and N.
摘要翻译：本发明涉及包含这些衍生物的新型的泛酸（2-（4-羟基苄基）苹果酸）衍生物或植物提取物，以及含有这些化合物或这些提取物的化妆品或皮肤病学组合物以及使用所述组合物的化妆品护理方法。示例性化合物由下式（I）表示：其中，条件是R1，R2和R3不同时为氢原子，R1和R3各自独立地表示氢原子或饱和或不饱和的，优选C1-C12，优选苯基的所述芳族基团优选被包含糖，优选单糖或二糖的基团取代，所述链任选还包含一个或多个优选选自O，S和N的杂原子，并且R 2表示氢原子或糖，优选单糖或二糖，所述糖任选被取代，特别是与包含饱和或不饱和的，优选C 1 -C 12的基于烃的链本身包含芳族基团的残基，优选为苯基，所述烃基链任选还包含一个或多个优选选自O，S和N的杂原子。

112. 发明申请

US20150065440A1 SULFATED OLIGOSACCHARIDE DERIVATIVES 审中-公开
标题翻译：硫化寡糖衍生物
公开(公告)号：US20150065440A1
公开(公告)日：2015-03-05
申请号：US14479101
申请日：2014-09-05
申请人： Progen Pharmaceuticals Limited
发明人： Vito Ferro , Tomislav Karoli , Ligong Liu , Paul Newton Handley , Kenneth David Johnstone , Norbert Wimmer , Edward Timothy Hammond
IPC分类号： C07J43/00 , C07H15/04 , C07J31/00
CPC分类号： C07J43/003 , C07H3/04 , C07H3/06 , C07H5/02 , C07H5/04 , C07H5/06 , C07H11/00 , C07H15/04 , C07H15/207 , C07H15/24 , C07H15/26 , C07H17/02 , C07J17/005 , C07J31/006 , C07J41/0088 , C07J41/0094
摘要： The invention relates to novel compounds that have utility as inhibitors of heparan sulfate-binding proteins; compositions comprising the compounds, and use of the compounds and compositions thereof for the antiangiogenic, antimetastatic, anti-inflammatory, antimicrobial, anticoagulant and/or antithrombotic treatment of a mammalian subject.
摘要翻译：本发明涉及可用作硫酸乙酰肝素结合蛋白的抑制剂的新型化合物; 包含该化合物的组合物，以及该化合物及其组合物用于哺乳动物受试者的抗血管生成，抗转移，抗炎，抗微血管和/或抗血栓形成治疗的用途。

113. 发明申请

US20140274930A1 MANNOSE DERIVATIVES FOR TREATING BACTERIAL INFECTIONS 有权
标题翻译：用于治疗细菌感染的MANNOSE衍生物
公开(公告)号：US20140274930A1
公开(公告)日：2014-09-18
申请号：US14206303
申请日：2014-03-12
申请人： Vertex Pharmaceuticals Incorporated
发明人： Evelyne Dietrich , Carl Poisson , Michel Gallant , Stephanie Lessard , Bingcan Liu , Sanjoy Kumar Das , Yeeman Ramtohul , Thumkunta Jagadeeswar Reddy , Julien Martel , Frederic Vallee , Jean-Francois Lévesque
IPC分类号： C07H15/26 , C07H15/22 , C07D493/10 , C07H15/207
CPC分类号： C07D493/10 , C07H15/18 , C07H15/20 , C07H15/203 , C07H15/207 , C07H15/22
摘要： The present invention relates to compounds useful for the treatment or prevention of bacteria infections. These compounds have formula I: The invention also provides processes for making the compounds described herein. Furthermore, the present invention provides a composition comprising the compounds described herein, and a pharmaceutically acceptable carrier, adjuvant, or vehicle. The present invention also provides methods of treating or preventing bacteria infection in a subject, comprising administering to the subject an effective amount of the compound or the composition described herein.
摘要翻译：本发明涉及可用于治疗或预防细菌感染的化合物。这些化合物具有式I：本发明还提供了制备本文所述化合物的方法。此外，本发明提供包含本文所述化合物和药学上可接受的载体，佐剂或载体的组合物。本发明还提供了治疗或预防受试者细菌感染的方法，包括给予受试者有效量的本文所述的化合物或组合物。

114. 发明申请

US20130288992A1 GLYCOSIDE COMPOUND 有权
标题翻译：甘氨酸化合物
公开(公告)号：US20130288992A1
公开(公告)日：2013-10-31
申请号：US13923881
申请日：2013-06-21
申请人： AJINOMOTO CO., INC.
发明人： Wataru KUROSAWA , Takuya Toyoda , Risa Ubagai , Yoshihito Nogusa , Kana Oyama , Yusuke Amino
IPC分类号： C07H15/207 , C12P19/46
CPC分类号： C07H15/207 , A23L33/10 , C07H15/203 , C12P19/46
摘要： Compounds of formula (I″) wherein: R11, R12, R13, R14 and R15 are hydrogen, hydroxyl, C1-6 alkyl, C1-6 alkoxy, C1-6 alkyl-carbonyloxy, or a G-O— group, and at least one of R11, R12, R13, R14 and R15 is a G-O— group, wherein G is a saccharide residue, X1 is a single bond, or a methylene group, an ethylene group, a trimethylene group, a vinylene group or —CH═CH—CH2—, X2 is —CO—O— or —O—CO—, p and q are integer ofs 0 to 7, and p+q=0 to 8, Y1 is methylene, ethylene or an alkenylene group having a carbon number of 2 to 15 and 1 to 3 double bonds, and R16 and R17 are hydrogen, methyl or ethyl, or R16 and R17 form a C3-6 cycloalkyl group, are useful as GLP-1 secretion promoting agents.
摘要翻译：式（I“）的化合物其中：R 11，R 12，R 13，R 14和R 15是氢，羟基，C 1-6烷基，C 1-6烷氧基，C 1-6烷基 - 羰基氧基或GO-基团，至少 R11，R12，R13，R14和R15之一是GO-基团，其中G是糖残基，X1是单键，或亚甲基，亚乙基，三亚甲基，亚乙烯基或-CH = CH-CH 2 - ，X 2是-CO-O-或-O-CO-，p和q是0〜7的整数，p + q = 0〜8，Y 1是亚甲基，亚乙基或具有碳的亚烯基 2至15个和1至3个双键，R16和R17是氢，甲基或乙基，或R16和R17形成C3-6环烷基，可用作GLP-1分泌促进剂。

115. 发明授权

US08501698B2 Crystal structures of SGLT2 inhibitors and processes for preparing same 有权
标题翻译： SGLT2抑制剂的晶体结构及其制备方法
公开(公告)号：US08501698B2
公开(公告)日：2013-08-06
申请号：US13049712
申请日：2011-03-16
申请人： Jack Z. Gougoutas , Hildegard Lobinger , Srividya Ramakrishnan , Prashant P. Deshpande , Jeffrey T. Bien , Chiajen Lai , Chenchi Wang , Peter Riebel , John Anthony Grosso , Alexandra A. Nirschl , Janak Singh , John D. DiMarco
发明人： Jack Z. Gougoutas , Hildegard Lobinger , Srividya Ramakrishnan , Prashant P. Deshpande , Jeffrey T. Bien , Chiajen Lai , Chenchi Wang , Peter Riebel , John Anthony Grosso , Alexandra A. Nirschl , Janak Singh , John D. DiMarco
IPC分类号： A61K31/351 , C07D309/10 , C07H7/04
CPC分类号： C07H15/207 , A61K31/7034 , A61K45/06 , A61P3/10 , C07H7/04
摘要： The present invention relates to physical crystal structures of a compound of the formula I: wherein R1, R2, R2a, R3 and R4 are as defined herein, especially pharmaceutical compositions containing structures of compound I or II, processes for preparing same, intermediates used in preparing same, and methods of treating diseases such as diabetes using such structures.
摘要翻译：本发明涉及式I化合物的物理结晶结构：其中R1，R2，R2a，R3和R4如本文所定义，特别是含有化合物I或II结构的药物组合物，其制备方法，制备方法以及使用这种结构治疗糖尿病等疾病的方法。

116. 发明申请

US20120165277A1 NOVEL GALACTOSIDE INHIBITORS OF GALECTINS 有权
标题翻译： GALECTINS的新型糖皮质激素抑制剂
公开(公告)号：US20120165277A1
公开(公告)日：2012-06-28
申请号：US13266960
申请日：2010-04-26
申请人： Hakon Leffler , Ulf J. Nilsson , Henrik Von Wachenfeldt
发明人： Hakon Leffler , Ulf J. Nilsson , Henrik Von Wachenfeldt
IPC分类号： A61K31/7036 , C07H15/22 , A61P25/00 , A61P29/00 , A61P35/00 , A61P37/06 , C07H15/26 , A61K31/7056
CPC分类号： C07H15/207 , C07H15/22 , C07H19/056
摘要： Compounds having an effect as i.a. galectin inhibitors, to the use of said compounds as a medicament, as well as for the manufacture of a medicament for treatment of disorders relating to the binding of galectin to receptors in a mammal, where in the galectin is preferably a galectin-3. The novel compounds are defined by the general formula:
摘要翻译：化合物具有如i.a. 半乳凝素抑制剂，使用所述化合物作为药物，以及用于制备用于治疗与半乳凝素与哺乳动物中的受体结合有关的病症的药物，其中半乳凝素优选半乳凝素-3。新化合物由以下通式定义：

117. 发明授权

US07943594B2 Solid-phase and solution-phase synthesis of glycosylphosphatidylinositol glycans 有权
标题翻译：糖基磷脂酰肌醇聚糖的固相和溶液相合成
公开(公告)号：US07943594B2
公开(公告)日：2011-05-17
申请号：US10520963
申请日：2003-07-10
申请人： Peter H. Seeberger , Michael C. Hewitt , Daniel A. Snyder
发明人： Peter H. Seeberger , Michael C. Hewitt , Daniel A. Snyder
IPC分类号： A61K31/715 , A61K31/70 , A61K31/7028 , A61K31/7034 , C07H5/04 , C08B37/00
CPC分类号： C08B37/006 , C07H15/203 , C07H15/207
摘要： One aspect of the present invention relates to solution-phase approaches to GPI synthesis. Another aspect of the present invention relates to key building blocks, and syntheses thereof, useful for GPI assembly. Yet another aspect of the invention relates to an automated method for the synthesis of GPIs and fragments thereof.
摘要翻译：本发明的一个方面涉及GPI合成的溶液相方法。本发明的另一方面涉及可用于GPI组装的关键构造块及其合成。本发明的另一方面涉及用于合成GPI及其片段的自动化方法。

118. 发明申请

US20110097753A1 Chemiluminescent methods and reagents for analyte detection 审中-公开
标题翻译：用于分析物检测的化学发光方法和试剂
公开(公告)号：US20110097753A1
公开(公告)日：2011-04-28
申请号：US12287916
申请日：2008-10-15
申请人： Tianxin Wang , Xing Xiang Li
发明人： Tianxin Wang , Xing Xiang Li
IPC分类号： C12Q1/66 , C07H17/00 , C07H15/26
CPC分类号： C07D321/00 , A61K31/7056 , C07D405/12 , C07H15/207 , C07H15/26 , C07H17/00 , C12Q1/66 , G01N33/535
摘要： The present invention relates to chemiluminescent method and regent to detect analyte. One aspect of the current invention relates to using enzyme substrate that can be cleaved by target enzyme to release chemiluminescent compound giving light signal for the detection of varieties of target enzymes. Another aspect of the current invention relates to use chemiluminescent enzyme coupled with analyte binding molecules to detect specific analyte molecules in a homogenous phase.
摘要翻译：本发明涉及化学发光方法和检测分析物的方法。本发明的一个方面涉及使用酶底物，其可被靶酶切割以释放化学发光化合物，给出用于检测各种目标酶的光信号。本发明的另一方面涉及使用化学发光酶与分析物结合分子偶联以检测均匀相中的特异性分析物分子。

119. 发明申请

US20100279965A1 HETEROBIFUNCTIONAL INHIBITORS OF E-SELECTINS AND CXCR4 CHEMOKINE RECEPTORS 有权
标题翻译：电子选择和CXCR4 CHEMOKINE受体的异种功能性抑制剂
公开(公告)号：US20100279965A1
公开(公告)日：2010-11-04
申请号：US12768173
申请日：2010-04-27
申请人： John L. Magnani , Arun K. Sarkar
发明人： John L. Magnani , Arun K. Sarkar
IPC分类号： A61K31/7064 , C07H15/226 , A61K31/7052 , A61P35/00
CPC分类号： C07H15/26 , A61K31/7034 , A61K31/7052 , A61K31/7064 , C07H15/207 , C07H15/22
摘要： Compounds, compositions and methods are provided for treating cancer and inflammatory diseases, and for releasing cells such as stem cells (e.g., bone marrow progenitor cells) into circulating blood and enhancing retention of the cells in the blood. More specifically, heterobifunctional compounds that inhibit both E-selectins and CXCR4 chemokine receptors are described.
摘要翻译：提供化合物，组合物和方法用于治疗癌症和炎性疾病，以及用于将细胞例如干细胞（例如骨髓祖细胞）释放到循环血液中并增强细胞在血液中的保留。更具体地，描述了抑制E-选择蛋白和CXCR4趋化因子受体的异双功能化合物。

120. 发明授权

US07618954B2 Inositol pyrophosphates, and methods of use thereof 有权
标题翻译：肌醇焦磷酸盐及其使用方法
公开(公告)号：US07618954B2
公开(公告)日：2009-11-17
申请号：US11328313
申请日：2006-01-09
申请人： Yves Claude Nicolau , Jean-Marie Lehn , Konstantina Fylaktakidou , Ruth Greferath
发明人： Yves Claude Nicolau , Jean-Marie Lehn , Konstantina Fylaktakidou , Ruth Greferath
IPC分类号： A61K31/663 , C07F9/02
CPC分类号： A61K31/6615 , A61K31/66 , A61K31/70 , A61K31/715 , A61K35/18 , C07F9/117 , C07F9/65746 , C07H15/207 , C12N5/0641
摘要： The present invention comprises compounds, compositions thereof, and methods capable of delivering modified inositol hexaphospahte (IHP) comprising an internal pyrophosphate ring to the cytoplasm of mammalian cells. In certain embodiments, the present invention relates to compounds, compositions thereof, and methods that enhance the ability of mammalian red blood cells to deliver oxygen, by delivering IHP to the cytoplasm of the red blood cells.
摘要翻译：本发明包括化合物，其组合物和能够将包含内部焦磷酸盐环的改性肌醇六磷酸（IHP）递送至哺乳动物细胞的细胞质的方法。在某些实施方案中，本发明涉及通过将IHP递送至红细胞的细胞质来增强哺乳动物红细胞传递氧的能力的化合物，其组合物和方法。

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