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111. 发明申请

US20120090039A1 Immunocompromised Ungulates 审中-公开
标题翻译：免疫受损的有蹄类动物
公开(公告)号：US20120090039A1
公开(公告)日：2012-04-12
申请号：US13092242
申请日：2011-04-22
申请人： David L. Ayares , Michael Mendicino , Kevin Wells , Amy Dandro
发明人： David L. Ayares , Michael Mendicino , Kevin Wells , Amy Dandro
IPC分类号： G01N33/483 , C12Q1/68 , C12Q1/02 , G01N33/566 , A01K67/027 , C12P21/00
CPC分类号： A01K67/0276 , A01K67/0273 , A01K67/0275 , A01K2217/052 , A01K2217/075 , A01K2227/108 , A01K2267/01 , A01K2267/0387 , C07K14/70521 , C07K2319/30 , C12N15/8509 , C12N2015/8518 , C12N2015/8527 , G01N33/5088
摘要： Porcine animals, tissue and organs as well as cells and cell lines derived from such animals are provided that lack functional endogenous immunoglobulin loci and are deficient in immunoglobulin expression and B-cells. These animals are useful as model systems for research and for development of new pharmaceutical and biological agents. In addition, methods are provided to prepare such animals.
摘要翻译：提供猪动物，组织和器官以及源自这些动物的细胞和细胞系，其缺乏功能性内源性免疫球蛋白基因座并且缺乏免疫球蛋白表达和B细胞。这些动物可用作研究和开发新的药物和生物制剂的模型系统。此外，提供了制备这种动物的方法。

112. 发明授权

US08071369B2 Compositions for reprogramming somatic cells 有权
标题翻译：用于重编程体细胞的组合物
公开(公告)号：US08071369B2
公开(公告)日：2011-12-06
申请号：US12703015
申请日：2010-02-09
申请人： Rudolf Jaenisch , Konrad Hochedlinger
发明人： Rudolf Jaenisch , Konrad Hochedlinger
IPC分类号： C12N5/00 , C12N5/07
CPC分类号： C12N5/0696 , A01K67/0273 , A01K67/0275 , A01K2217/05 , A01K2227/105 , C07K14/4702 , C12N15/85 , C12N15/8509 , C12N15/8775 , C12N2501/602 , C12N2501/603 , C12N2501/605 , C12N2506/1307 , C12N2510/00 , C12N2830/003 , C12N2830/006
摘要： The invention provides methods for reprogramming somatic cells to generate multipotent or pluripotent cells. Such methods are useful for a variety of purposes, including treating or preventing a medical condition in an individual. The invention further provides methods for identifying an agent that reprograms somatic cells to a less differentiated state.
摘要翻译：本发明提供了重编程体细胞产生多潜能或多潜能细胞的方法。这些方法可用于各种目的，包括治疗或预防个体的医疗状况。本发明进一步提供了用于鉴定将体细胞重新编程为较差分化状态的药剂的方法。

113. 发明申请

US20110231943A1 TRANSGENIC ANIMALS AND USES THEREOF 审中-公开
标题翻译：转基因动物及其用途
公开(公告)号：US20110231943A1
公开(公告)日：2011-09-22
申请号：US13080923
申请日：2011-04-06
申请人： JAMES M. ROBL , YOSHIMI KUROIWA , POOTHAPPILLAI KASINATHAN , ISAO ISHIDA , KAZUMA TOMIZUKA
发明人： JAMES M. ROBL , YOSHIMI KUROIWA , POOTHAPPILLAI KASINATHAN , ISAO ISHIDA , KAZUMA TOMIZUKA
IPC分类号： A01K67/027
CPC分类号： A01K67/0271 , A01K67/0273 , A01K67/0276 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/072 , A01K2217/075 , A01K2227/101 , A01K2267/01 , A01K2267/02 , A01K2267/0343 , C07K2317/00 , C07K2317/21 , C12N15/8509 , C12N15/8771
摘要： In general, the invention features genetically modified non-human mammals (e.g., bovines and other ungulates), and methods of making these mammals. In particular, the invention features transgenic ungulates having reduced levels of endogenous IgM heavy chain and/or prion protein.
摘要翻译：通常，本发明的特征在于遗传修饰的非人哺乳动物（例如牛和其他有蹄类动物）以及制造这些哺乳动物的方法。特别地，本发明具有具有降低的内源性IgM重链和/或朊病毒蛋白水平的转基因有蹄类动物。

114. 发明授权

US07928285B2 Method of producing xenogenous antibodies using a bovine 有权
标题翻译：使用牛制备异种抗体的方法
公开(公告)号：US07928285B2
公开(公告)日：2011-04-19
申请号：US12215085
申请日：2008-06-25
申请人： James M. Robl , Yoshimi Kuroiwa , Poothappillai Kasinathan , Isao Ishida , Kazuma Tomizuka
发明人： James M. Robl , Yoshimi Kuroiwa , Poothappillai Kasinathan , Isao Ishida , Kazuma Tomizuka
IPC分类号： A01K67/00 , A01K67/027 , A01K67/033 , C12P21/00 , C12N15/00
CPC分类号： A01K67/0271 , A01K67/0273 , A01K67/0276 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/072 , A01K2217/075 , A01K2227/101 , A01K2267/01 , A01K2267/02 , A01K2267/0343 , C07K2317/00 , C07K2317/21 , C12N15/8509 , C12N15/8771
摘要： In general, the invention features genetically modified non-human mammals (e.g., bovines and other ungulates), and methods of making these mammals. In particular, the invention features transgenic ungulates having reduced levels of endogenous IgM heavy chain and/or prion protein.
摘要翻译：通常，本发明的特征在于遗传修饰的非人哺乳动物（例如牛和其他有蹄类动物）以及制造这些哺乳动物的方法。特别地，本发明具有具有降低的内源性IgM重链和/或朊病毒蛋白水平的转基因有蹄类动物。

115. 发明申请

US20100293626A1 METHODS FOR IMPROVEMENT OF BIRTH RATES IN CANIDAE ON SOMATIC CELL NUCLEAR TRANSFER 审中-公开
标题翻译：改善角膜细胞核转移中生殖系统发生率的方法
公开(公告)号：US20100293626A1
公开(公告)日：2010-11-18
申请号：US12517567
申请日：2008-11-19
申请人： Byeong Chun Lee , Min Kyu Kim , Goo Jang , Hyun Ju Oh , So Gun Hong , Jung Eun Park , Jung Taek Kang
发明人： Byeong Chun Lee , Min Kyu Kim , Goo Jang , Hyun Ju Oh , So Gun Hong , Jung Eun Park , Jung Taek Kang
IPC分类号： C12N15/06
CPC分类号： C12N5/16 , A01K67/0273 , A01K2227/10 , C12N15/877 , C12N2501/405 , C12N2517/10
摘要： The present invention relates to a method for increasing the efficiency of offspring production in producing animals belonging to the family Canidae (canines) by somatic cell nuclear transfer. More specifically, relates to a method for increasing the efficiency of production of cloned canines by a method for cloning canines comprising enucleating the oocyte of a canine to prepare an enucleated oocyte, fusing a nuclear donor cell with the enucleated oocyte to prepare a nuclear transfer embryo and transferring the nuclear transfer embryo into the oviduct of a surrogate mother, wherein the nuclear donor cell is cultured in a medium containing a specific cell cycle synchronization-inducing substance such as roscovitine in the preparation thereof. The method enables to clone canines with high efficiency, and thus can contribute to the development of studies in the fields of veterinary medicine, anthropology and medical science such as the propagation of superior canines, the conservation of rare or nearly extinct canines, xenotransplantation and disease animal models.
摘要翻译：本发明涉及通过体细胞核转移提高属于犬科（犬科）的动物的后代生产效率的方法。更具体地，涉及通过克隆犬的方法来提高克隆犬的生产效率的方法，包括将犬的卵母细胞去核以制备去核卵母细胞，将核供体细胞与去核卵母细胞融合以制备核转移胚并将核转移胚胎转移到替代母体的输卵管中，其中在其制备中，在含有特定细胞周期同步诱导物质如roscovitine的培养基中培养核供体细胞。该方法能够高效地克隆犬科动物，从而有助于兽医，人类学和医学领域的研究发展，如高等犬传播，保护罕见或几乎灭绝的犬，异种移植和疾病动物模型。

116. 发明申请

US20100146655A1 METHODS AND MATERIALS FOR PRODUCING TRANSGENIC ANIMALS 有权
标题翻译：生产转基因动物的方法和材料
公开(公告)号：US20100146655A1
公开(公告)日：2010-06-10
申请号：US12504364
申请日：2009-07-16
申请人： SCOTT C. FAHRENKRUG , DANIEL F. CARLSON , ARON M. GEURTS
发明人： SCOTT C. FAHRENKRUG , DANIEL F. CARLSON , ARON M. GEURTS
IPC分类号： A01K67/027 , C12N15/12 , C07H21/00 , C12N15/63
CPC分类号： C12N15/8509 , A01K67/0273 , A01K67/0275 , A01K2217/058 , A01K2217/203 , A01K2227/101 , A01K2227/103 , A01K2227/105 , A01K2227/108 , A01K2267/03 , A01K2267/035 , A61D19/00 , C07K14/4712 , C12N15/1138 , C12N2015/8527 , C12N2310/14 , C12N2800/30 , C12N2800/90
摘要： Transgenic artiodactyls are described as well as methods of making and using such artiodactyls.
摘要翻译：本发明描述了转基因偶蹄菌，以及制备和使用这些偶氮酰基的方法。

117. 发明申请

US20100144031A1 METHODS FOR REPROGRAMMING SOMATIC CELLS 有权
公开(公告)号：US20100144031A1
公开(公告)日：2010-06-10
申请号：US12703061
申请日：2010-02-09
申请人： Rudolf Jaenisch , Konrad Hochedlinger
发明人： Rudolf Jaenisch , Konrad Hochedlinger
IPC分类号： C12N5/074 , C12N5/07 , C12N5/02
CPC分类号： C12N5/0696 , A01K67/0273 , A01K67/0275 , A01K2217/05 , A01K2227/105 , C07K14/4702 , C12N15/85 , C12N15/8509 , C12N15/8775 , C12N2501/602 , C12N2501/603 , C12N2501/605 , C12N2506/1307 , C12N2510/00 , C12N2830/003 , C12N2830/006
摘要： The invention provides methods for reprogramming somatic cells to generate multipotent or pluripotent cells. Such methods are useful for a variety of purposes, including treating or preventing a medical condition in an individual. The invention further provides methods for identifying an agent that reprograms somatic cells to a less differentiated state.

118. 发明申请

US20100122356A1 PIG MODEL FOR PSORIASIS 审中-公开
标题翻译： PSORIASIS的PIG模型
公开(公告)号：US20100122356A1
公开(公告)日：2010-05-13
申请号：US12529812
申请日：2008-03-07
申请人： Peter Michael Kragh , Lars Axel Bolund , Karsten Kristiansen , Charlotte Brandt Sørensen , Jacob Giehm Mikkelsen , Nicklas Heine Staunstrup , Thomas Kongstad Petersen , Lars Svensson
发明人： Peter Michael Kragh , Lars Axel Bolund , Karsten Kristiansen , Charlotte Brandt Sørensen , Jacob Giehm Mikkelsen , Nicklas Heine Staunstrup , Thomas Kongstad Petersen , Lars Svensson
IPC分类号： A61K49/00 , A01K67/027 , C12N5/10 , C12N15/63 , A61P17/06
CPC分类号： A01K67/0273 , A01K2207/15 , A01K2217/00 , A01K2227/108 , A01K2267/0325 , C12N15/8778 , C12N2517/04 , C12N2800/30 , C12N2800/90 , G01N2500/00
摘要： The present invention relates to a genetically modified pig as a model for studying psoriasis. The modified pig model displays one or more phenotypes associated with psoriasis. Disclosed is also a modified pig comprising a mutation in the endogenous ILK-I Ra, JunB/cJun, CD18, IKK2, and/or LIG1 gene, and/or a human, porcine and/or murine PPARs, PPAR-δ, lκB-α, STAT3c, Integrin beta 1, Integrin alpha 2, MEK1, Amphiregulin, BMP-6, VEGF, JunBΔec-JunΔep, IL-I a, TGF.beta 1, CD18 hypo, Cre/lkk2FL/FL, Dsg1, SCCE, TGF-a, TNF-a, IL-20, IFN-g, LIG1 KO, KGF, IL-6, PAFR1 Cre/lkk2FL/FL, IL1 R, Dsg3, IFN-gamma, p40, ILI Ra, IKK2, JunB/c-Jun, and/or LIG1 gene, transcriptional and/or translational product or part thereof. The invention further relates to methods for producing the modified pig; and methods for evaluating the effect of a therapeutical treatment of psoriasis, for screening the efficacy of a pharmaceutical composition, and a method for treatment of human being suffering from psoriasis are disclosed.
摘要翻译：本发明涉及一种转基因猪作为研究牛皮癣的模型。修改后的猪模型显示与牛皮癣相关的一种或多种表型。还公开了包含内源性ILK-IRa，JunB / cJun，CD18，IKK2和/或LIG1基因和/或人，猪和/或鼠PPARs，PPAR-δ， B-α，STAT3c，整合素β1，整合素α2，MEK1，Amphiregulin，BMP-6，VEGF，JunB＆Dgr; ec-Jun＆Dgr; ep，IL-1α，TGFβ1，CD18 hypo，Cre / lkk2FL / FL ，Dsg1，SCCE，TGF-α，TNF-α，IL-20，IFN-g，LIG1KO，KGF，IL-6，PAFR1 Cre / Ikk2FL / FL，IL1R，Dsg3，IFN-γ，p40，，IKK2，JunB / c-Jun和/或LIG1基因，转录和/或翻译产物或其一部分。本发明还涉及生产改性猪的方法; 公开了用于评价银屑病治疗效果，用于筛选药物组合物的功效以及治疗患有牛皮癣的方法的方法。

119. 发明申请

US20090255005A1 Method for Preparing Fish Embryo 失效
标题翻译：鱼胚制备方法
公开(公告)号：US20090255005A1
公开(公告)日：2009-10-08
申请号：US12224284
申请日：2006-02-24
申请人： Yuko Wakamatsu , Kenjiro Ozato , Norihiko Ozato
发明人： Yuko Wakamatsu , Kenjiro Ozato , Norihiko Ozato
IPC分类号： A01K67/027 , C12N15/87 , C12N5/00
CPC分类号： A01K67/0273 , A01K2227/40 , C12N2517/04
摘要： An object of the invention is to effectively prepare a fish embryo with a correct chromosomal ploidy by nuclear transplantation in which an exogenous fish nucleus is transplanted in a cytoplasmic recipient. For this object, the invention comprises a step of preparing a fish embryo by transplanting a fish cell nucleus to an unfertilized egg. The step of preparing a fish embryo comprises a step of imposing physical and/or chemical stress to the unfertilized egg after activation. By imposing such stress, the stage of haplosis in a female nucleus which happens at the early stage of a series of developmental steps occurring in an unfertilized egg is suppressed and the correct ploidy of an obtained embryo is at least secured.
摘要翻译：本发明的目的是通过核移植有效地制备具有正确染色体倍性的鱼胚，其中将外源鱼核移植到细胞质受体中。为此，本发明包括通过将鱼细胞核移植到未受精卵而制备鱼胚的步骤。制备鱼胚的步骤包括在活化后对未受精卵施加物理和/或化学应力的步骤。通过施加这种压力，抑制发生在未受精卵中的一系列发育步骤的早期发生在雌性核中的单倍体的阶段，并且至少确保获得的胚胎的正确倍性。

120. 发明授权

US07420099B2 Transgenic animals and uses thereof 失效
标题翻译：转基因动物及其用途
公开(公告)号：US07420099B2
公开(公告)日：2008-09-02
申请号：US11111310
申请日：2005-04-21
申请人： James M. Robl , Yoshimi Kuroiwa , Poothappillai Kasinathan , Isao Ishida , Kazuma Tomizuka
发明人： James M. Robl , Yoshimi Kuroiwa , Poothappillai Kasinathan , Isao Ishida , Kazuma Tomizuka
IPC分类号： A01K67/027 , C12P21/00 , C12N15/00
CPC分类号： A01K67/0271 , A01K67/0273 , A01K67/0276 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/072 , A01K2217/075 , A01K2227/101 , A01K2267/01 , A01K2267/02 , A01K2267/0343 , C07K2317/00 , C07K2317/21 , C12N15/8509 , C12N15/8771
摘要： In general, the invention features genetically modified non-human mammals (e.g., bovines and other ungulates), and methods of making these mammals. In particular, the invention features transgenic ungulates having reduced levels of endogenous IgM heavy chain and/or prion protein.
摘要翻译：通常，本发明的特征在于遗传修饰的非人哺乳动物（例如牛和其他有蹄类动物）以及制造这些哺乳动物的方法。特别地，本发明具有具有降低的内源性IgM重链和/或朊病毒蛋白水平的转基因有蹄类动物。

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