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    • 111. 发明申请
    • Display device, display panel driver and method of driving display panel
    • 显示设备,显示面板驱动程序和驱动显示面板的方法
    • US20070268524A1
    • 2007-11-22
    • US11798578
    • 2007-05-15
    • Takashi NoseHirobumi Furihata
    • Takashi NoseHirobumi Furihata
    • G06F15/00
    • G09G3/2092G09G3/2007G09G3/3406G09G3/3611G09G2320/0271G09G2320/0646G09G2320/0673G09G2360/16
    • An LCD device according to the present invention has: an LCD panel; an operation and correction circuit configured to perform a correction operation with respect to an input gray-scale data of a target frame image by using an arithmetic expression to generate an output gray-scale data; a data line driver configured to drive the LCD panel in accordance with the output gray-scale data; and a correction data calculation circuit configured to generate a correction data that specifies a relationship between the input gray-scale data and the output gray-scale data of the target frame image, depending on the input gray-scale data of the target frame image or an input gray-scale data of a precedent frame image followed by the target frame image. The operation and correction circuit determines coefficients of the arithmetic expression from the correction data.
    • 根据本发明的LCD装置具有:LCD面板; 操作和校正电路,被配置为通过使用算术表达式对目标帧图像的输入灰度数据执行校正操作,以生成输出灰度数据; 数据线驱动器,被配置为根据输出的灰度数据驱动LCD面板; 以及校正数据计算电路,被配置为根据目标帧图像的输入灰度数据生成指定目标帧图像的输入灰度数据和输出灰度数据之间的关系的校正数据,或者 前一帧图像的输入灰度数据跟随目标帧图像。 操作和校正电路从校正数据确定算术表达式的系数。
    • 114. 发明授权
    • PDE IV inhibitors
    • PDE IV抑制剂
    • US07115623B2
    • 2006-10-03
    • US10480378
    • 2002-06-11
    • Tomoji AotsukaKentarou KumazawaNagatoshi WagatsumaKouki IshitaniTakashi Nose
    • Tomoji AotsukaKentarou KumazawaNagatoshi WagatsumaKouki IshitaniTakashi Nose
    • C07D471/02A61K31/44
    • C07D471/04
    • The purpose is to provide selective PDE IV inhibitors which have a potent anti-asthmatic profile with excellent safety. A compound of the formula (1): wherein A is methylene, lower alkylmethylene, carbonyl, etc., Y is a 5- or 6-membered heteroaryl group containing one or two heteroatoms selected from nitrogen, sulfur and oxygen, Z is i) a fused ring in which any of 5- or 6-membered heteroaryl groups is fused to a benzene ring, or ii) a phenyl group which may be unsubstituted or optionally substituted with one or more members selected from the group consisting of nitro, amino, an amino nitrogen-containing group, etc., provided that when A is methylene, Y is a 5- or 6-membered heteroaryl group selected from the group consisting of pyrrolyl, pyridyl, etc., and Z is a phenyl group which may be unsubstituted or substituted, the substituent on said phenyl group is amino, or an amino nitrogen-containing group; or a pharmaceutically acceptable salt thereof, possesses excellent PDE IV inhibition and is useful as a pharmaceutical drug, preferably an anti-asthmatic, etc.
    • 目的是提供选择性PDE IV抑制剂,其具有优异的抗哮喘特征,具有优异的安全性。 式(1)的化合物:其中A是亚甲基,低级烷基亚甲基,羰基等,Y是含有一个或两个选自氮,硫和氧的杂原子的5或6元杂芳基,Z是i) 其中5-或6-元杂芳基中的任一个与苯环稠合的稠合环,或ii)可以是未取代的或任选被一个或多个选自以下的成员取代的苯基:硝基,氨基, 氨基含氮基团等,条件是当A是亚甲基时,Y是选自吡咯基,吡啶基等的5或6元杂芳基,Z是可以是 未取代或取代的,所述苯基上的取代基是氨基或氨基含氮基团; 或其药学上可接受的盐具有优异的PDE IV抑制作用,并且可用作药物,优选抗哮喘等。
    • 115. 发明申请
    • Pyrazolonaphthyridine derivative
    • 吡唑并萘啶衍生物
    • US20060040972A1
    • 2006-02-23
    • US10533806
    • 2003-11-05
    • Hashime KanazawaTomoji AotsukaKentarou KumazawaKouki IshitaniTakashi Nose
    • Hashime KanazawaTomoji AotsukaKentarou KumazawaKouki IshitaniTakashi Nose
    • A61K31/4745C07D471/14
    • A61K31/4375A61K31/444C07D471/14
    • The target is to provide PDE IV inhibitors which have a highly potent anti-asthmatic and/or COPD-prophylactic/therapeutic profile with unexpectedly excellent safety. A compound of the formula (1): wherein A is phenyl, pyridyl, 1-oxypyridyl, or thienyl, which may be unsubstituted or optionally substituted with one or more members selected from the group consisting of hydroxyl, halogen, cyano, nitro, lower alkyl, lower alkoxy, lower alkylcarbonyloxy, amino, carboxyl, lower alkoxycarbonyl, carboxy-lower alkylene, lower alkoxycarbonyl-lower alkylene, lower alkylsulfonyl, lower alkylsulfonylamino, and ureido; R1 is a group selected from the group consisting of hydrogen, hydroxyl, halogen, cyano, nitro, lower alkoxy, amino, carboxyl, and lower alkoxycarbonyl; R2 is hydrogen or lower alkyl; and m is an integer of 1 to 3; or a pharmaceutically acceptable salt thereof, possesses highly excellent PDE IV-specific inhibitory actions and is useful as an anti-asthmatic drug and/or a prophylactic/therapeutic drug for COPD with high safety.
    • 目标是提供具有非常有效的抗哮喘和/或COPD预防/治疗特征的PDE IV抑制剂,具有出人意料的极好的安全性。 式(1)的化合物:其中A是苯基,吡啶基,1-氧代吡啶基或噻吩基,其可以是未取代的或任选地被一个或多个选自羟基,卤素,氰基,硝基,低级 烷基,低级烷氧基,低级烷基羰基氧基,氨基,羧基,低级烷氧基羰基,羧基 - 低级亚烷基,低级烷氧基羰基 - 低级亚烷基,低级烷基磺酰基,低级烷基磺酰基氨基和脲基。 R 1是选自氢,羟基,卤素,氰基,硝基,低级烷氧基,氨基,羧基和低级烷氧基羰基的基团。 R 2是氢或低级烷基; m为1〜3的整数。 或其药学上可接受的盐具有非常优异的PDE IV特异性抑制作用,并且可用作具有高度安全性的抗哮喘药和/或用于COPD的预防/治疗药物。