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111. 发明授权

US07672716B1 QT-based system and method for detecting and distinguishing dilated cardiomyopathy and heart failure using an implantable medical device 有权
标题翻译：基于QT的系统和方法，用于使用可植入医疗装置检测和区分扩张型心肌病和心力衰竭
公开(公告)号：US07672716B1
公开(公告)日：2010-03-02
申请号：US11397066
申请日：2006-04-03
申请人： Steve Koh
发明人： Steve Koh
IPC分类号： A61B5/0452
CPC分类号： A61B5/0452 , A61B5/02405 , A61B5/7275 , A61N1/3627
摘要： Techniques are provided for detecting dilated cardiomyopathy within a patient using a pacemaker or other implantable medical device. Briefly, values representative of QT duration and QT dispersion are detected within the patient and then the risk of dilated cardiomyopathy is evaluated based on the values of QT duration and QT dispersion. In one particular example, the implanted device calculates an index representative of the extent to which individual QT duration and QT dispersion values deviate from a daily mean. The device then compares the index against a threshold indicative of a substantial likelihood of the presence of dilated cardiomyopathy within the patient. Additional techniques described herein relate to distinguishing dilated cardiomyopathy from heart failure within patients that may have one or both conditions.
摘要翻译：提供了使用起搏器或其他可植入医疗装置来检测患者内的扩张型心肌病的技术。简而言之，在患者体内检测到代表QT持续时间和QT分散的值，然后根据QT持续时间和QT色散的值评估扩张型心肌病的风险。在一个特定示例中，植入装置计算表示各个QT持续时间和QT色散值偏离每日平均值的程度的指标。然后，该装置将该指数与指示患者内存在扩张型心肌病的实质可能性的阈值进行比较。本文所述的附加技术涉及在可能具有一种或两种病症的患者内区分扩张型心肌病与心力衰竭。

112. 发明授权

US07636599B1 Determining patient posture from sensed cardiac data 有权
标题翻译：从感测的心脏数据确定患者姿势
公开(公告)号：US07636599B1
公开(公告)日：2009-12-22
申请号：US11626301
申请日：2007-01-23
申请人： Steve Koh , Euljoon Park
发明人： Steve Koh , Euljoon Park
IPC分类号： A61N1/00
CPC分类号： A61N1/36507 , A61N1/36514 , A61N1/36535 , A61N1/3937 , A61N1/3962
摘要： Exemplary techniques for determining patient posture from cardiac data sensed by an implantable medical device (IMD) are described. One technique involves sensing intracardiac electrogram (IEGM) data from a patient and determining a posture of the patient from the sensed IEGM data. The technique then considers the posture in formulating patient therapy.
摘要翻译：描述了由可植入医疗装置（IMD）感测的心脏数据确定患者姿势的示例性技术。一种技术涉及从患者感知心内电描记图（IEGM）数据，并从感测的IEGM数据确定患者的姿势。然后，该技术考虑了制定患者治疗的姿势。

113. 发明申请

US20090082652A1 IMPLANTABLE BODY FLUID ANALYZER 有权
标题翻译：可植入体液分析仪
公开(公告)号：US20090082652A1
公开(公告)日：2009-03-26
申请号：US11861028
申请日：2007-09-25
申请人： Steve Koh , Jonathan T. Losk
发明人： Steve Koh , Jonathan T. Losk
IPC分类号： A61B5/145
CPC分类号： G01N21/6454 , A61B5/0031 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/411 , A61B2562/028 , G01N21/05 , G01N21/6428 , G01N2021/0328 , G01N2021/0346 , G01N2021/058 , G01N2021/6482
摘要： An exemplary implantable microarray device includes an inlet for a body fluid, a plurality of individual reaction cell arrays where each reaction cell array includes a series of reaction cells configured to receive the body fluid, a sensor array to sense a reaction result for an individual reaction cell array where the reaction result corresponds to a reaction between the body fluid and at least one reagent in each of the reaction cells of the individual reaction cell array and a positioning mechanism to position an individual reaction cell array with respect to the sensor array. Various other exemplary technologies are also disclosed.
摘要翻译：示例性可植入微阵列装置包括用于体液的入口，多个单独的反应池阵列，其中每个反应池阵列包括一系列被配置为接纳体液的反应池，感测器阵列以感测各个反应的反应结果其中反应结果对应于体液和单个反应池阵列的每个反应池中的至少一个试剂之间的反应以及相对于传感器阵列定位单个反应池阵列的定位机构。还公开了各种其它示例性技术。

114. 发明授权

US07413549B1 Detecting and quantifying apnea using ventilatory cycle histograms 有权
标题翻译：使用通气循环直方图检测和量化呼吸暂停
公开(公告)号：US07413549B1
公开(公告)日：2008-08-19
申请号：US10803449
申请日：2004-03-17
申请人： Steve Koh
发明人： Steve Koh
IPC分类号： A61B5/08
CPC分类号： A61B5/0809 , A61B5/4818 , A61N1/3601 , A61N1/3627 , A61N1/36521 , A61N1/3962
摘要： Subject matter includes methods and devices for detecting and quantifying apnea. One exemplary implementation includes deriving a ventilation related parameter in real-time from a patient, deriving apneic intervals based on the parameter, distributing the apneic intervals as counts on a histogram, and calculating a single data point, such as a centroid, for clustered counts on the histogram. Centroids can be calculated at regular intervals and stored for lengthy periods, such as months, because they occupy very little storage space. A position of a centroid on the histogram can indicate an aspect of the patient's health and changes in the centroid positions over time can be used to detect trend changes in the patient's condition.
摘要翻译：主题包括检测和量化呼吸暂停的方法和装置。一个示例性实现包括从患者实时导出通气相关参数，基于参数导出呼吸暂停间隔，将呼吸暂停间隔分配为直方图上的计数，以及计算单个数据点，例如质心，用于聚集计数在直方图上。可以定期计算质心，并存储长时间，如月份，因为它们占用的存储空间非常小。直方图上的质心的位置可以指示患者健康的一个方面，并且随着时间的推移，质心位置的变化可用于检测患者状况中的趋势变化。

115. 发明授权

US07404799B1 System and method for detection of respiration patterns via integration of intracardiac electrogram signals 有权
标题翻译：通过心脏电图信号的集成检测呼吸模式的系统和方法
公开(公告)号：US07404799B1
公开(公告)日：2008-07-29
申请号：US11100189
申请日：2005-04-05
申请人： Steve Koh
发明人： Steve Koh
IPC分类号： A61B5/02 , A61B5/04 , A61B5/08 , A61N1/00
CPC分类号： A61N1/37258 , A61B5/0402 , A61B5/0816 , A61B5/411 , A61B5/4818 , A61B5/7242 , A61N1/3601 , A61N1/365
摘要： Techniques are provided for tracking patient respiration based upon intracardiac electrogram signals or other electrical cardiac signals. Briefly, respiration patterns are detected by integrating cardiac electrical signals corresponding to individual paced cardiac cycles. The integrals may be obtained between consecutive pairs of ventricular pacing pulses or between consecutive pairs of atrial pacing pulses. In either case, cyclical changes in the integrals of the individual cardiac cycles are tracked. The cyclical changes are representative of respiration. Once respiration patterns have been identified, episodes of abnormal respiration, such as apnea, hyperpnea, nocturnal asthma, or the like, may be detected and therapy automatically delivered.
摘要翻译：提供了基于心脏电图信号或其他电心脏信号跟踪患者呼吸的技术。简而言之，通过将对应于各个节奏的心脏周期的心脏电信号整合来检测呼吸模式。可以在连续的心室起搏脉冲对之间或连续的心房起搏脉冲对之间获得积分。在任一种情况下，跟踪各个心脏周期积分的周期性变化。循环变化代表呼吸。一旦确定了呼吸模式，可以检测出异常呼吸发作，例如呼吸暂停，呼吸过度，夜间哮喘等，并且治疗自动递送。

116. 发明授权

US07225021B1 Differentiation of central sleep apnea and obstructive sleep apnea using an implantable cardiac device 有权
标题翻译：使用植入式心脏装置分化中枢性睡眠呼吸暂停和阻塞性睡眠呼吸暂停
公开(公告)号：US07225021B1
公开(公告)日：2007-05-29
申请号：US10769165
申请日：2004-01-30
申请人： Euljoon Park , Steve Koh
发明人： Euljoon Park , Steve Koh
IPC分类号： A61N1/05
CPC分类号： A61N1/3601 , A61N1/368 , A61N2001/0585
摘要： An implantable cardiac device is programmed to differentiate between central sleep apnea and obstructive sleep apnea. The implantable cardiac device utilizes a respiration-related parameter (e.g., respiration rate, tidal volume, and minute ventilation) to determine whether the patient is experiencing an episode of sleep apnea. When sleep apnea is detected, the implantable cardiac device examines the intracardiac electrogram (IEGM) to classify the apnea as either central sleep apnea or obstructive sleep apnea. The cardiac device may be further configured to administer different therapies depending upon the classification of sleep apnea.
摘要翻译：可植入心脏装置被编程以区分中枢性睡眠呼吸暂停和阻塞性睡眠呼吸暂停。可植入心脏装置利用呼吸相关参数（例如呼吸频率，潮气量和分钟通气）来确定患者是否正在经历睡眠呼吸暂停发作。当检测到睡眠呼吸暂停时，可植入的心脏装置检查心内电描记图（IEGM）以将呼吸暂停分为中枢性睡眠呼吸暂停或阻塞性睡眠呼吸暂停。心脏装置还可以被配置为根据睡眠呼吸暂停的分类来施用不同的疗法。

117. 发明授权

US07223244B1 System and method for monitoring hypercapnic ventilatory response 有权
标题翻译：监测高碳酸血通气反应的系统和方法
公开(公告)号：US07223244B1
公开(公告)日：2007-05-29
申请号：US10849066
申请日：2004-05-18
申请人： Steve Koh
发明人： Steve Koh
IPC分类号： A61B5/205
CPC分类号： A61B5/14539 , A61B5/0535 , A61B5/091 , A61B5/145 , G06F19/00
摘要： An exemplary method includes determining a parameter related to CO2 concentration in a patient's blood, as well as determining a parameter related to respiration of the patient. The parameters are then processed to diagnose a cardiac condition based at least in part on the parameters.
摘要翻译：示例性方法包括确定与患者血液中的CO 2浓度相关的参数，以及确定与患者的呼吸相关的参数。然后处理参数以至少部分地基于参数来诊断心脏病。

118. 发明授权

US07207947B2 System and method for detecting circadian states using an implantable medical device 有权
标题翻译：使用可植入医疗装置检测昼夜节律状态的系统和方法
公开(公告)号：US07207947B2
公开(公告)日：2007-04-24
申请号：US10339989
申请日：2003-01-10
申请人： Steve Koh , Euljoon Park
发明人： Steve Koh , Euljoon Park
IPC分类号： A61B5/08
CPC分类号： A61N1/36557 , A61N1/36521 , A61N1/36542
摘要： Techniques are provided for detecting the circadian state of a patient using an implantable medical device based on selected blood carbon dioxide (CO2) parameters. In one example, the implantable device tracks changes in end tidal CO2 (etCO2) levels and changes in maximum variations of pCO2 levels per breathing cycle (ΔcycleCO2) over the course of the day and determines the circadian state based thereon. It has been found that average etCO2 levels are generally highest and average ΔcycleCO2 levels are generally lowest while a patient is asleep and opposite while a patient is awake. Hence, by tracking changes in average etCO2 and ΔcycleCO2 levels over the course of the day, circadian states can be detected. Minute ventilation and activity levels are used to assist in the determination of the circadian state. Additional techniques are directed to detecting the stage of sleep.
摘要翻译：提供了用于基于所选择的血液二氧化碳（CO 2 2）参数来检测使用可植入医疗装置的患者的昼夜节律状态的技术。在一个示例中，可植入装置跟踪最终潮汐CO 2 2（etCO 2 2）水平的变化和每个pCO 2 2水平的最大变化的变化在一天的过程中呼吸循环（增量循环），并且基于此确定昼夜节律状态。已经发现平均水平通常是最高的，并且平均水平通常最低，而患者睡着并且相反而病人清醒。因此，通过在一天中跟踪平均etCO 2和ΔT2水平的变化，可以检测昼夜节律。分钟通气和活动水平用于帮助确定昼夜节律状态。另外的技术涉及检测睡眠阶段。

119. 发明申请

US20050256545A1 System and method for evaluating heart failure using an implantable medical device based on heart rate during patient activity 有权
标题翻译：使用基于患者活动期间的心率的可植入医疗装置评估心力衰竭的系统和方法
公开(公告)号：US20050256545A1
公开(公告)日：2005-11-17
申请号：US10844078
申请日：2004-05-11
申请人： Steve Koh , Euljoon Park
发明人： Steve Koh , Euljoon Park
IPC分类号： A61B5/00 , A61B5/02 , A61B5/0245 , A61B5/042 , A61B5/08 , A61B5/11 , A61B5/22 , A61N1/362 , A61N1/365
CPC分类号： A61N1/36542 , A61B5/0006 , A61B5/0031 , A61B5/0245 , A61B5/0422 , A61B5/0816 , A61B5/1118 , A61B5/145 , A61B5/222 , A61B5/7275 , A61B2562/0219 , A61N1/3627
摘要： Techniques are provided for detecting and tracking heart failure based on heart rate, rest rate and activity levels. Briefly, histograms are generated based on rest-rate adjusted heart rate values and corresponding activity level values. Heart failure is then detected and tracked based on an analysis of the histogram. In one example, so long as the activity level of the patient exceeds some minimum threshold, the ratio of adjusted heart rate to activity level is periodically calculated and resulting values are stored in a histogram. Each day, the histogram is compared against a previous histogram to detect any overall trend. For example, the centroid of the histogram can be calculated each day with any changes in the centroid values used to track progression of heart failure.
摘要翻译：提供了基于心率，静息率和活动水平检测和跟踪心力衰竭的技术。简而言之，基于休息率调整心率值和相应的活动水平值产生直方图。然后基于直方图的分析检测和跟踪心力衰竭。在一个示例中，只要患者的活动水平超过某个最小阈值，则定期计算调整心率与活动水平的比例，并将结果值存储在直方图中。每天，将直方图与先前的直方图进行比较，以检测任何总体趋势。例如，直方图的质心可以每天计算用于跟踪心力衰竭进展的质心值的任何变化。

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