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111. 发明申请

US20140044769A1 COMPOSITE ABSORBABLE/BIODEGRADABLE RINGS FOR CONTROLLED DRUG DELIVERY 审中-公开
标题翻译：用于控制药物输送的复合吸收/可生物降解环
公开(公告)号：US20140044769A1
公开(公告)日：2014-02-13
申请号：US13771201
申请日：2013-02-20
申请人： Shalaby W. Shalaby
发明人： Shalaby W. Shalaby
IPC分类号： A61L31/12 , A61L31/16
CPC分类号： A61K47/34 , A61K47/10 , A61K47/32 , A61L31/129 , A61L31/16 , A61L2300/602
摘要： A fiber-reinforced composite ring for the controlled release of at least one bioactive agent includes a biocompatible matrix reinforced with absorbable/biodegradable fibers capable of providing the mechanical properties needed for inserting and maintaining the ring in a body cavity for a desired period of time. Such ring system as can be used for the intravaginal, intraperitoneal, and subcutaneous delivery of at least one bioactive agent, including those used as contraceptives, antimicrobial agents, and/or antiviral agents, as well as those for the treatment of cancer.
摘要翻译：用于控制释放至少一种生物活性剂的纤维增强复合环包括用可吸收/可生物降解的纤维增强的生物相容性基质，其能够提供将环在体腔中插入和保持所需时间所需的机械性能。可用于阴道内，腹膜内和皮下递送至少一种生物活性剂（包括用作避孕药，抗微生物剂和/或抗病毒剂）以及用于治疗癌症的生物活性剂的环状体系。

112. 发明申请

US20130197099A1 PARTIALLY ABSORBABLE FIBER-REINFORCED COMPOSITES FOR CONTROLLED DRUG DELIVERY 审中-公开
公开(公告)号：US20130197099A1
公开(公告)日：2013-08-01
申请号：US13766907
申请日：2013-02-14
申请人： Shalaby W. Shalaby
发明人： Shalaby W. Shalaby
IPC分类号： A61K9/00
CPC分类号： A61L31/129 , A61F2250/0031 , A61K9/0002 , A61K9/0024 , A61K9/0034 , A61K9/0036 , A61K9/0046 , A61K9/146 , A61K31/375 , A61K31/4164 , A61K31/7135 , A61L15/44 , A61L15/64 , A61L31/148 , A61L31/16 , A61L2300/222 , A61L2300/256 , A61L2300/404 , A61L2300/408 , A61L2300/43 , A61L2300/602
摘要： This invention describes a partially absorbable, fiber-reinforced composite in the form of a ring, or a suture-like thread, with modified terminals for use as a controlled delivery system of at least one bioactive agent, wherein said composite comprising an absorbable fiber construct capable of providing time-dependent mechanical properties of a biostable elastomeric matrix containing an absorbable microparticulate ion-exchanger to modulate the release of the bioactive agent(s) for a desired period(s) of time at a specific biological site; this can be a vaginal canal, peritoneal cavity, scrotum, prostate gland, an ear loop or subcutaneous tissue. Such drug delivery systems can be used for the local administration of at least one bioactive agent, including those used as contraceptive, antimicrobial, anti-inflammatory and/or antiviral agents as well as for cancer treatment.

113. 发明申请

US20130144264A1 ABSORBABLE CRYSTALLINE COPOLYESTER-BASED BIOACTIVE HYDROFORMING LUMINAL LINER COMPOSITIONS 审中-公开
公开(公告)号：US20130144264A1
公开(公告)日：2013-06-06
申请号：US13754110
申请日：2013-01-30
申请人： Shalaby W. Shalaby , Kenneth David Gray , Georgios T. Hilas
发明人： Shalaby W. Shalaby , Kenneth David Gray , Georgios T. Hilas
IPC分类号： A61K47/34 , A61M31/00
CPC分类号： A61K31/7036 , A01N25/34 , A61K9/0034 , A61K9/0053 , A61K31/12 , A61K31/192 , A61K31/337 , A61K31/4025 , A61K31/4164 , A61K31/4174 , A61K31/4196 , A61K31/427 , A61K31/436 , A61K31/496 , A61K31/497 , A61K31/505 , A61K31/506 , A61K31/65 , A61K47/34 , A61M25/002 , A61M25/04 , A61M25/10 , A61M31/00 , A61M31/007 , A61M2025/0024 , A61M2025/105 , B65B3/04 , B65B51/10 , B65B55/04 , B65B55/14 , B65D65/38
摘要： Bioactive, hydroforming luminal liner compositions are formed of high molecular weight crystalline, absorbable copolyesters dissolved in a liquid derivative of a polyether glycol that undergoes transformation into a tissue-adhering, resilient interior cover or liner for the controlled release of its bioactive payload at clinically compromised conduits in humans as in the case of bacteria- and yeast-infected vaginal canals, esophagi, and arteries following angioplasty.

114. 发明授权

US08404272B2 Fiber-reinforced composite rings for intravaginal controlled drug delivery 有权
标题翻译：用于阴道内控制药物递送的纤维增强复合环
公开(公告)号：US08404272B2
公开(公告)日：2013-03-26
申请号：US10860677
申请日：2004-06-03
申请人： Shalaby W. Shalaby
发明人： Shalaby W. Shalaby
IPC分类号： A61F6/14 , A61F13/00
CPC分类号： A61K47/34 , A61K47/10 , A61K47/32 , A61L31/129 , A61L31/16 , A61L2300/602
摘要： A fiber-reinforced composite ring for the controlled release of at least one bioactive agent includes a biocompatible matrix reinforced with absorbable/biodegradable fibers capable of providing the mechanical properties needed for inserting and maintaining the ring in a body cavity for a desired period of time. Such ring system as can be used for the intravaginal, intraperitoneal, and subcutaneous delivery of at least one bioactive agent, including those used as contraceptives, antimicrobial agents, and/or antiviral agents, as well as those for the treatment of cancer.
摘要翻译：用于控制释放至少一种生物活性剂的纤维增强复合环包括用可吸收/可生物降解的纤维增强的生物相容性基质，其能够提供将环在体腔中插入和保持所需时间所需的机械性能。可用于阴道内，腹膜内和皮下递送至少一种生物活性剂（包括用作避孕药，抗微生物剂和/或抗病毒剂）以及用于治疗癌症的生物活性剂的环状体系。

115. 发明授权

US08399013B2 Partially absorbable fiber-reinforced composites for controlled drug delivery 有权
公开(公告)号：US08399013B2
公开(公告)日：2013-03-19
申请号：US10935808
申请日：2004-09-08
申请人： Shalaby W. Shalaby
发明人： Shalaby W. Shalaby
IPC分类号： A61F6/14 , A61F13/00
CPC分类号： A61L31/129 , A61F2250/0031 , A61K9/0002 , A61K9/0024 , A61K9/0034 , A61K9/0036 , A61K9/0046 , A61K9/146 , A61K31/375 , A61K31/4164 , A61K31/7135 , A61L15/44 , A61L15/64 , A61L31/148 , A61L31/16 , A61L2300/222 , A61L2300/256 , A61L2300/404 , A61L2300/408 , A61L2300/43 , A61L2300/602
摘要： This invention describes a partially absorbable, fiber-reinforced composite in the form of a ring, or a suture-like thread, with modified terminals for use as a controlled delivery system of at least one bioactive agent, wherein said composite comprising an absorbable fiber construct capable of providing time-dependent mechanical properties of a biostable elastomeric matrix containing an absorbable microparticulate ion-exchanger to modulate the release of the bioactive agent(s) for a desired period(s) of time at a specific biological site; this can be a vaginal canal, peritoneal cavity, scrotum, prostate gland, an ear loop or subcutaneous tissue. Such drug delivery systems can be used for the local administration of at least one bioactive agent, including those used as contraceptive, antimicrobial, anti-inflammatory and/or antiviral agents as well as for cancer treatment.

116. 发明申请

US20110117352A1 Self-primed fabric in self-reinforced polyethylene composites 审中-公开
标题翻译：自增强聚乙烯复合材料自发织物
公开(公告)号：US20110117352A1
公开(公告)日：2011-05-19
申请号：US12925741
申请日：2010-10-28
申请人： Shalaby W. Shalaby , Shawn Peniston
发明人： Shalaby W. Shalaby , Shawn Peniston
IPC分类号： B32B5/02
CPC分类号： B29C70/224 , A61L27/40 , A61L27/48 , A61L27/54 , A61L31/12 , A61L2300/404 , A61L2300/41 , A61L2300/412 , A61L2300/442 , B29B15/08 , B29C67/24 , B29C70/04 , B29K2023/0683 , B29K2223/065 , B29K2223/0683 , B32B5/26 , B32B2255/02 , B32B2255/26 , B32B2260/023 , B32B2260/046 , B32B2262/0253 , B32B2307/558 , B32B2437/04 , B32B2571/00 , B32B2571/02 , Y10T428/249921 , C08L71/02
摘要： A self-reinforced polyethylene composite includes a self-primed fabric reinforcement, such as a warp-knitted mesh, and has a fabric/matrix weight ratio of 10/90 to 45/55. Prior to inclusion in the composite the fabric reinforcement is self-primed by dipping in a polyethylene priming solution. The composite is derived from pre-formed sheets stacked in different patterns which yield upon compression molding into composite devices with variable thickness and degrees of mechanical properties. The primer may contain one or more additives to impart certain properties to the final composite.
摘要翻译：自增强聚乙烯复合材料包括自织织物加强件，例如经编网眼织物/织物/基质重量比为10/90至45/55。在包含在复合材料中之前，通过浸入聚乙烯起泡溶液中将织物增强层自行涂覆。该复合材料来自以不同图案堆叠的预成型片材，其压缩成型可以具有可变厚度和机械性能程度的复合材料。底漆可以含有一种或多种添加剂以赋予最终复合材料一定的性能。

117. 发明申请

US20100062039A1 Intravaginal Ringed Mesh Device And Applicator Therefor 有权
标题翻译：阴道环网装置及其施药器
公开(公告)号：US20100062039A1
公开(公告)日：2010-03-11
申请号：US11667933
申请日：2005-12-14
申请人： Shalaby W. Shalaby
发明人： Shalaby W. Shalaby
IPC分类号： A61F6/14 , A61P15/18 , A61K31/295
CPC分类号： A61K9/0036 , A61F6/142
摘要： This invention generally covers a ringed-mesh intravaginal device and applicator therefore wherein the ringed-mesh comprises a composite ring comprising a flexible matrix containing one or more bioactive agent or agents and needed excipients or modulators, and the said matrix is reinforced with a fibrous construct to provided needed initial and in-use biomechanical stability. Of special application of the medicated, ringed-mesh is its use for securing contraception relying on biomechanical, pharmacological, and biochemical means.
摘要翻译：本发明通常涵盖环形网状阴道内装置和施用器，其中环形网包括复合环，复合环包含含有一种或多种生物活性剂或试剂和所需赋形剂或调节剂的柔性基质，所述基质用纤维结构以提供所需的初始和使用中的生物力学稳定性。特殊应用的戒药网是用于依靠生物力学，药理学和生化手段确保避孕方法。

118. 发明申请

US20090024162A1 Absorbable / biodegradable composite yarn constructs and applicatons thereof 有权
标题翻译：可吸收/可生物降解的复合纱线构造及其应用
公开(公告)号：US20090024162A1
公开(公告)日：2009-01-22
申请号：US11879357
申请日：2007-07-17
申请人： Shalaby W. Shalaby , Shawn Peniston , M. Scott Taylor , Douglas D. Greene
发明人： Shalaby W. Shalaby , Shawn Peniston , M. Scott Taylor , Douglas D. Greene
IPC分类号： A61L17/00
CPC分类号： A61F2/0063 , A61F2002/0068 , A61F2210/0004 , A61F2250/003 , A61L17/005 , A61L17/105 , A61L17/12 , A61L17/145 , A61L31/10 , A61L31/129 , A61L2430/00 , D04B21/12 , D04C1/12 , D10B2509/04 , D10B2509/08 , C08L67/04
摘要： Absorbable composite medical devices such as surgical meshes and braided sutures, which display two or more absorption/biodegradation and breaking strength retention profiles and exhibit unique properties in different clinical settings, are made using combinations of at least two types of yarns having distinctly different physicochemical and biological properties and incorporate in the subject construct special designs to provide a range of unique properties as clinically useful implants.
摘要翻译：使用至少两种具有明显不同的物理化学和不同物理化学性质的纱线的组合来制备可吸收的复合医疗装置，例如外科手术网和编织缝合线，其显示两种或更多种吸收/生物降解和断裂强度保持分布并且在不同的临床环境中显示独特的性质生物学特性并纳入主题构建特殊设计，以提供一系列独特的性质作为临床上有用的植入物。

119. 发明申请

US20090017083A1 Bioswellable sutures 有权
标题翻译：生物可维护的缝线
公开(公告)号：US20090017083A1
公开(公告)日：2009-01-15
申请号：US12229142
申请日：2008-08-20
申请人： Shalaby W. Shalaby
发明人： Shalaby W. Shalaby
IPC分类号： A01N25/34 , A61K9/14 , A61K9/00
CPC分类号： A61B17/06166 , A61B2017/00889 , A61L17/145 , A61L27/34 , A61L29/085
摘要： Swellable, coated sutures have a swellable polymeric coating and a fibrous component, wherein the coating is formed of an absorbable or non-absorbable polymer, while the fibrous component is formed of a synthetic absorbable or non-absorbable monofilament yarn, synthetic absorbable or non-absorbable braided multifilament yarn, braided silk multifilament yarn or combinations thereof. In certain instances, the coating is used as a carrier for the controlled delivery of different types of bioactive agents, including those having antimicrobial, anti-inflammatory, anesthetic, tissue growth-promoting, and antineoplastic activities.
摘要翻译：可膨胀的涂层缝合线具有可溶胀的聚合物涂层和纤维组分，其中涂层由可吸收或不可吸收的聚合物形成，而纤维组分由合成的可吸收或不可吸收的单丝纱线，合成的可吸收或不可吸收的聚合物形成，可吸收编织复丝纱，编织丝复丝纱或其组合。在某些情况下，涂层用作用于受控递送不同类型的生物活性剂的载体，包括具有抗微生物，抗炎，麻醉，组织生长促进和抗肿瘤活性的生物活性剂。

120. 发明申请

US20090004470A1 Inorganic-organic melt-extruded hybrid filaments and medical applications thereof 审中-公开
标题翻译：无机 - 有机熔融挤出混合长丝及其医疗应用
公开(公告)号：US20090004470A1
公开(公告)日：2009-01-01
申请号：US12217314
申请日：2008-07-03
申请人： Shalaby W. Shalaby
发明人： Shalaby W. Shalaby
IPC分类号： D01F8/00 , A61B6/00
CPC分类号： D01F1/10 , A61L17/10 , A61L31/128 , A61L31/18 , Y10T428/249938 , Y10T428/2913 , Y10T428/2927 , Y10T428/298
摘要： Inorganic-organic hybrid, melt-extruded filaments having variable cross-sectional geometry with a cross-sectional area ranging between 100μ2 and 4 mm2 include an inorganic component that comprises at least 10 weight percent of the total system and is present as dispersed micro-/nanoparticles in an organic absorbable or non-absorbable matrix representing no more than 90 weight percent. Hybrid filaments are particularly useful for the production of absorbable/disintegratable coil components of an absorbable/disintegratable endoureteral stent and radiopaque surgical markers or sutures.
摘要翻译：无机 - 有机杂化物，具有横截面积在100m 2和4mm 2之间的截面几何形状的熔体挤出长丝包括无机组分，其包含总体系的至少10重量％，并以分散的微孔/ 表示不超过90重量％的有机可吸收或不可吸收的基质中的纳米颗粒。混合细丝特别可用于生产可吸收/可分解的输尿管支架和不透射线外科标记物或缝合线的可吸收/可分解的线圈组件。

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