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    • 116. 发明授权
    • Stent coating for eluting medication
    • 用于洗脱药物的支架涂层
    • US08367151B2
    • 2013-02-05
    • US12755777
    • 2010-04-07
    • Robert C. O'BrienChristine A. Frysz
    • Robert C. O'BrienChristine A. Frysz
    • A61L33/00
    • A61L31/084A61F2/91A61F2250/0067A61F2250/0068A61L31/146A61L31/16A61L2300/108Y10T29/49885
    • A vascular stent comprising a drug-eluting outer layer of a porous sputtered columnar metal having each column capped with a biocompatible carbon-containing material is described. This is done by placing the stent over a close-fitting mandrel and rotating the assembly in a sputter flux. The result is a coating that is evenly distributed over the outward-facing side of the stent's wire mesh while preventing the sputtered columnar coating from reaching the inward facing side where a smooth hemocompatible surface is required. The stent is then removed from the mandrel, exposing all surfaces, and finally coated with a layer of carbon such as amorphous carbon or diamond-like carbon. The carbonaceous coating enhances biocompatibility without preventing elutriation of a therapeutic drug provided in the porosity formed between the columnar structures. The result is a stent that is adapted to both the hemodynamic and the immune response requirements of its vascular environment.
    • 描述了一种包含多孔溅射柱状金属的药物洗脱外层的血管支架,每个柱用生物相容性含碳材料封盖。 这通过将支架放置在紧密的心轴上并将组件旋转在溅射通量中来完成。 其结果是均匀地分布在支架的金属丝网的向外侧上的涂层,同时防止溅射的柱状涂层到达需要光滑的血液相容表面的内侧。 然后将支架从心轴移除,暴露所有表面,并最终涂覆有碳层如无定形碳或类金刚石碳。 碳质涂层增强生物相容性,而不阻止在柱状结构之间形成的孔隙中提供的治疗药物的淘析。 其结果是适应于其血管环境的血液动力学和免疫应答要求的支架。
    • 118. 发明授权
    • Functionally graded coatings for lead wires in medical implantable hermetic feedthrough assemblies
    • 用于医疗植入式密封馈通组件中的导线功能分级涂层
    • US07812691B1
    • 2010-10-12
    • US12267932
    • 2008-11-10
    • Andrew E. FiskRichard X. FuChristine A. Frysz
    • Andrew E. FiskRichard X. FuChristine A. Frysz
    • H03H7/00
    • H03H1/0007
    • A feedthrough filter capacitor assembly is described. The feedthrough filter capacitor assembly comprises an outer ferrule hermetically sealed to an insulator of a dielectric material seated within the ferrule. The insulative material is also hermetically sealed to at least one lead wire. Instead of being made of platinum or platinum/iridium, the lead wire comprises a core of a non-noble metal supporting a functionally graded coating. The metal core has an inner layer of the same the non-noble metal of the core and an outer layer of a noble metal. A gradient transition zone exists between the non-noble metal and the outer noble metal. Consequently, lead wires having all the beneficial attributes of platinum and platinum/iridium wire can be built into hermetic feedthroughs, but at a significantly reduced cost. In a preferred form, a filter capacitor is mounted on the insulator and electrically connected to the lead wires and to the ferrule to prevent unwanted EMI signals from traveling along the wires and entering the interior of the medical device.
    • 描述了馈通滤波电容器组件。 馈通滤波电容器组件包括密封到位于套圈内的介电材料的绝缘体的外套圈。 绝缘材料也与至少一根导线密封。 引线包括不支持铂或铂/铱的非贵金属的芯,而不支撑功能梯度的涂层。 金属芯具有与芯的非贵金属相同的内层和贵金属的外层。 在非贵金属和外部贵金属之间存在梯度过渡区。 因此,具有铂和铂/铱丝的所有有益属性的导线可以被构建在气密馈通中,但是显着降低成本。 在优选形式中,滤波电容器安装在绝缘体上并电连接到引线和套圈,以防止不必要的EMI信号沿着导线行进并进入医疗装置的内部。
    • 119. 发明申请
    • Stent Coating For Eluting Medication
    • 用于洗脱药物的支架涂层
    • US20100100172A1
    • 2010-04-22
    • US12646096
    • 2009-12-23
    • Robert C. O'BrienChristine A. Frysz
    • Robert C. O'BrienChristine A. Frysz
    • A61F2/82B05D3/02
    • A61L31/084A61F2/91A61F2250/0067A61F2250/0068A61L31/146A61L31/16A61L2300/108Y10T29/49885
    • A vascular stent comprising a drug-eluting outer layer of a porous sputtered columnar metal having each column capped with a biocompatible carbon-containing material is described. This is done by placing the stent over a close-fitting mandrel and rotating the assembly in a sputter flux. The result is a coating that is evenly distributed over the outward-facing side of the stent's wire mesh while preventing the sputtered columnar coating from reaching the inward facing side where a smooth hemocompatible surface is required. The stent is then removed from the mandrel, exposing all surfaces, and finally coated with a layer of carbon such as amorphous carbon or diamond-like carbon. The carbonaceous coating enhances biocompatibility without preventing elutriation of a therapeutic drug provided in the porosity formed between the columnar structures. The result is a stent that is adapted to both the hemodynamic and the immune response requirements of its vascular environment.
    • 描述了一种包含多孔溅射柱状金属的药物洗脱外层的血管支架,每个柱用生物相容性含碳材料封盖。 这通过将支架放置在紧密的心轴上并将组件旋转在溅射通量中来完成。 其结果是均匀地分布在支架的金属丝网的向外侧上的涂层,同时防止溅射的柱状涂层到达需要光滑的血液相容表面的内侧。 然后将支架从心轴移除,暴露所有表面,并最终涂覆有碳层如无定形碳或类金刚石碳。 碳质涂层增强生物相容性,而不阻止在柱状结构之间形成的孔隙中提供的治疗药物的淘析。 其结果是适应于其血管环境的血液动力学和免疫应答要求的支架。