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111. 发明授权

US06953425B2 Method of treating vulnerable plaque using a catheter-based radiation system 失效
标题翻译：使用基于导管的辐射系统治疗易损斑块的方法
公开(公告)号：US06953425B2
公开(公告)日：2005-10-11
申请号：US10829561
申请日：2004-04-22
申请人： Mark Brister
发明人： Mark Brister
IPC分类号： A61N5/10 , A61N5/00
CPC分类号： A61N5/1002
摘要： The invention provides a method of treating vulnerable plaque at a site in a vessel. A vulnerable plaque site is identified for treatment. A radiation source is introduced into a vessel containing a vulnerable plaque site identified for treatment. The radiation source is guided to a position adjacent to the treatment site. A therapeutically effective dose of radiation is delivered to the vulnerable plaque site. As the radiation impinges upon the wall of the lumen, it promotes cell growth. Such growth can serve to strengthen the thin fibrous cap found atop a vulnerable plaque lesion. With the lesion thus stabilized, time is provided for the use of statin drugs or other agents to shrink or remove the lipid pool beneath the cap.
摘要翻译：本发明提供了一种在容器中的部位处理易损斑块的方法。确定易受伤害的斑块部位进行治疗。将辐射源引入含有鉴定用于治疗的易损斑块部位的容器中。将辐射源引导到与治疗部位相邻的位置。治疗有效的辐射剂量被递送到易损斑块部位。当辐射照射在管腔的壁上时，它促进细胞生长。这种生长可以用于加强在脆弱斑块病变上面发现的薄纤维帽。随着病变如此稳定，提供了使用他汀类药物或其他药物收缩或去除帽下方的脂质池的时间。

112. 发明授权

US10022078B2 Analyte sensor 有权
公开(公告)号：US10022078B2
公开(公告)日：2018-07-17
申请号：US11439630
申请日：2006-05-23
申请人： James H. Brauker , Peter C. Simpson , Robert Boock , Monica Rixman , Mark Brister
发明人： James H. Brauker , Peter C. Simpson , Robert Boock , Monica Rixman , Mark Brister
IPC分类号： A61B5/1486 , A61B5/1473 , G01N33/66 , A61B5/145 , A61B5/00 , C12Q1/00 , G01N33/543
摘要： The present invention relates generally to biointerface membranes utilized with implantable devices, such as devices for the detection of analyte concentrations in a biological sample. More particularly, the invention relates to novel biointerface membranes, to devices and implantable devices including these membranes, methods for forming the biointerface membranes on or around the implantable devices, and to methods for monitoring glucose levels in a biological fluid sample using an implantable analyte detection device.

113. 发明授权

US09060742B2 Transcutaneous analyte sensor 有权
公开(公告)号：US09060742B2
公开(公告)日：2015-06-23
申请号：US12728082
申请日：2010-03-19
申请人： Mark Brister , Paul V. Neale , James Brauker
发明人： Mark Brister , Paul V. Neale , James Brauker
IPC分类号： A61B5/1486 , A61B5/1473 , A61B5/05 , A61B5/1495 , A61B5/00 , A61B5/145 , A61B5/15
CPC分类号： A61B5/14532 , A61B5/0002 , A61B5/0004 , A61B5/05 , A61B5/14 , A61B5/1411 , A61B5/145 , A61B5/14503 , A61B5/14507 , A61B5/14514 , A61B5/14546 , A61B5/1468 , A61B5/1473 , A61B5/14735 , A61B5/1486 , A61B5/14865 , A61B5/1495 , A61B5/150022 , A61B5/6801 , A61B5/6832 , A61B5/6833 , A61B5/6848 , A61B5/6849 , A61B5/72 , A61B17/3468 , A61B2017/3492 , A61B2560/0223 , A61B2560/045 , A61M5/14 , A61M5/14244 , A61M5/1723 , A61M2005/1585 , G06F19/00 , Y02A90/26
摘要： The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.

114. 发明授权

US08986209B2 Transcutaneous analyte sensor 有权
公开(公告)号：US08986209B2
公开(公告)日：2015-03-24
申请号：US13549313
申请日：2012-07-13
申请人： James H. Brauker , Apurv Ullas Kamath , Paul V. Goode , Mark Brister
发明人： James H. Brauker , Apurv Ullas Kamath , Paul V. Goode , Mark Brister
IPC分类号： A61B5/05 , A61B5/145 , A61B5/00 , A61B5/1486 , A61B5/1495
CPC分类号： A61B5/14532 , A61B5/0002 , A61B5/0031 , A61B5/14546 , A61B5/14865 , A61B5/1495 , A61B5/4839 , A61B5/6833 , A61B5/6848 , A61B5/743 , A61B2560/0223 , A61B2560/0252 , A61B2560/04 , A61B2562/085
摘要： The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.

115. 发明授权

US08911369B2 Dual electrode system for a continuous analyte sensor 有权
标题翻译：用于连续分析物传感器的双电极系统
公开(公告)号：US08911369B2
公开(公告)日：2014-12-16
申请号：US12335403
申请日：2008-12-15
申请人： Mark Brister , James R. Petisce , Peter Simpson
发明人： Mark Brister , James R. Petisce , Peter Simpson
IPC分类号： A61B5/05 , A61B5/145 , A61B5/1495 , A61B5/1486 , A61B5/00
CPC分类号： A61B5/14865 , A61B5/14532 , A61B5/1495 , A61B5/7203 , A61B5/742 , A61B2560/0223 , B33Y70/00 , B33Y80/00
摘要： Disclosed herein are systems and methods for a continuous analyte sensor, such as a continuous glucose sensor. One such system utilizes first and second working electrodes to measure additional analyte or non-analyte related signal. Such measurements may provide a background and/or sensitivity measurement(s) for use in processing sensor data and may be used to trigger events such as digital filtering of data or suspending display of data.
摘要翻译：本文公开了用于连续分析物传感器（例如连续葡萄糖传感器）的系统和方法。一个这样的系统利用第一和第二工作电极来测量附加分析物或非分析物相关信号。这样的测量可以提供用于处理传感器数据的背景和/或灵敏度测量，并且可以用于触发诸如数据的数字滤波或暂停显示数据的事件。

116. 发明授权

US08435286B2 Stent with intermittent coating 有权
标题翻译：支架间歇涂层
公开(公告)号：US08435286B2
公开(公告)日：2013-05-07
申请号：US10531822
申请日：2003-10-14
申请人： Mark Brister
发明人： Mark Brister
IPC分类号： A61F2/82
CPC分类号： A61F2/86 , A61F2/91 , A61F2/915 , A61F2002/91541 , A61F2250/0035 , A61F2250/0067 , A61L31/10 , A61L31/16 , A61L2300/00
摘要： The stent with an intermittent coating of the present invention provides a coating having a plurality of discrete coating sections disposed on a stent, i.e., an intermittent coating. The individual coating sections can contain different drugs or therapeutic agents, can be made of different polymers, can be made with different solvents, or combinations thereof. The coating sections can be applied in patterns such as ring patterns, striped patterns, spotted patterns, or dot matrix patterns. In one embodiment, the regions can be large relative to the stent, such as a ring pattern including one therapeutic agent in the radial regions at the ends of a stent and a different therapeutic agent in the radial region in the middle. In another embodiment, the regions can be small relative to the stent, such as a dot matrix pattern with each grid region being a small point.
摘要翻译：具有本发明的间歇涂层的支架提供了具有设置在支架上的多个离散涂层部分的涂层，即间歇涂层。各个涂层部分可以含有不同的药物或治疗剂，可以由不同的聚合物制成，可以用不同的溶剂或其组合制成。涂层部分可以以诸如环形图案，条纹图案，斑点图案或点阵图案的图案来应用。在一个实施方案中，相对于支架的区域可以较大，例如在支架端部的径向区域中包括一种治疗剂的环形图案，以及在中间的径向区域中的不同的治疗剂。在另一个实施例中，相对于支架的区域可以较小，例如每个格栅区域是小点的点阵图案。

117. 发明授权

US08311749B2 Transcutaneous analyte sensor 有权
公开(公告)号：US08311749B2
公开(公告)日：2012-11-13
申请号：US13116871
申请日：2011-05-26
申请人： James H. Brauker , Apurv Ullas Kamath , Paul Goode , Mark Brister
发明人： James H. Brauker , Apurv Ullas Kamath , Paul Goode , Mark Brister
IPC分类号： G01N33/48
CPC分类号： A61B5/14532 , A61B5/0002 , A61B5/0031 , A61B5/14546 , A61B5/14865 , A61B5/1495 , A61B5/4839 , A61B5/6833 , A61B5/6848 , A61B5/743 , A61B2560/0223 , A61B2560/0252 , A61B2560/04 , A61B2562/085
摘要： The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.

118. 发明授权

US08275437B2 Transcutaneous analyte sensor 有权
公开(公告)号：US08275437B2
公开(公告)日：2012-09-25
申请号：US11690752
申请日：2007-03-23
申请人： James H. Brauker , Apurv U. Kamath , Paul V. Goode , Mark Brister
发明人： James H. Brauker , Apurv U. Kamath , Paul V. Goode , Mark Brister
IPC分类号： A61B5/05
CPC分类号： A61B5/14532 , A61B5/0002 , A61B5/0031 , A61B5/14546 , A61B5/14865 , A61B5/1495 , A61B5/4839 , A61B5/6833 , A61B5/6848 , A61B5/743 , A61B2560/0223 , A61B2560/0252 , A61B2560/04 , A61B2562/085
摘要： The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.

119. 再颁专利

USRE43039E1 Dual electrode system for a continuous analyte sensor 有权
标题翻译：用于连续分析物传感器的双电极系统
公开(公告)号：USRE43039E1
公开(公告)日：2011-12-20
申请号：US12839260
申请日：2010-07-19
申请人： Mark Brister , James R. Petisce , Peter C. Simpson , James H. Brauker
发明人： Mark Brister , James R. Petisce , Peter C. Simpson , James H. Brauker
IPC分类号： A61B5/05
CPC分类号： A61B5/14865 , A61B5/14532 , A61B5/1495 , A61B5/7203 , A61B5/742 , A61B2560/0223 , B33Y70/00 , B33Y80/00
摘要： Disclosed herein are systems and methods for a continuous analyte sensor, such as a continuous glucose sensor. One such system utilizes first and second working electrodes to measure additional analyte or non-analyte related signal. Such measurements may provide a background and/or sensitivity measurement(s) for use in processing sensor data and may be used to trigger events such as digital filtering of data or suspending display of data.
摘要翻译：本文公开了用于连续分析物传感器（例如连续葡萄糖传感器）的系统和方法。一个这样的系统利用第一和第二工作电极来测量附加分析物或非分析物相关信号。这样的测量可以提供用于处理传感器数据的背景和/或灵敏度测量，并且可以用于触发诸如数据的数字滤波或暂停显示数据的事件。

120. 发明授权

US07857760B2 Analyte sensor 有权
标题翻译：分析物传感器
公开(公告)号：US07857760B2
公开(公告)日：2010-12-28
申请号：US11360819
申请日：2006-02-22
申请人： Mark Brister , James Brauker , J. Michael Dobbles
发明人： Mark Brister , James Brauker , J. Michael Dobbles
IPC分类号： A61B5/00
CPC分类号： A61B5/1451 , A61B5/0031 , A61B5/14517 , A61B5/14532 , A61B5/14546 , A61B5/1468 , A61B5/1473 , A61B5/1486 , A61B5/14865 , A61B5/1495 , A61B5/6832 , A61B5/6833 , A61B5/6848 , A61B5/6849 , A61B5/7264 , A61B5/742 , A61B2560/0223 , A61B2560/0276 , A61B2560/028 , A61L2/12 , A61L2/206 , G06F19/00 , Y02A90/22 , Y02A90/26 , Y10T29/49004
摘要： The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.
摘要翻译：本发明一般涉及用于测量宿主中分析物的系统和方法。更具体地说，本发明涉及用于经皮测量宿主中的葡萄糖的系统和方法。

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