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    • 117. 发明授权
    • Automated laboratory for high-throughput biological assays and RNA interference
    • 用于高通量生物测定和RNA干扰的自动化实验室
    • US07270784B2
    • 2007-09-18
    • US10837218
    • 2004-04-30
    • Minh VuongTodd BennettJavier FloresBrian GrotDaniel HaleHuy NguyenWalter D. NilesTuong PhanSteve RodemsJeff StackPeter J. Coassin
    • Minh VuongTodd BennettJavier FloresBrian GrotDaniel HaleHuy NguyenWalter D. NilesTuong PhanSteve RodemsJeff StackPeter J. Coassin
    • G01N21/00G05B15/00
    • G01N35/1074G01N35/028
    • The invention is an automated multiple-purpose, integrated laboratory system comprising interchangeable modular elements for the construction and measurement of biological assays. The functions of the modular elements may include multiwell platform handling, chemical reagent or cell management, volumetric transfer of liquids for assay construction or for recovery of reaction products for analysis, incubation under controlled environmental conditions, measurement of spectrometric signals originating from the assays, processing and analysis of the resulting spectrometric data, and other functions. The modular elements are arranged around a number of robotic elements that deliver plates to different modular elements, transfer plates to groups of modules served by a different robotic element, or other actions necessary in plate handling. Liquid transfer to and from multiwell platforms, necessary for assay construction or for the initiation of physiological events in cells, is partitioned among different modules specialized for transferring nanoliter or smaller volume quantities of chemical concentrates, or microliter quantities of assay reagents, cells, media and other assay constituents. Applications of this invention include the quantitation and analysis of the expression of multiple genes in cells, measurement of multi-gene expression kinetics, analysis of activation or suppression of multiple signal transduction pathways, screening chemical compounds for modulatory effects on multi-gene expression or on signal transduction pathways or on other biochemical networks of cells, or other analytical biological or biochemical assays.
    • 本发明是一种自动多功能综合实验室系统,包括用于构建和测量生物测定的可互换模块化元件。 模块化元件的功能可以包括多井平台处理,化学试剂或细胞管理,用于测定构建的液体的体积转移或用于回收用于分析的反应产物,在受控环境条件下孵育,来自测定的光谱信号的测量,处理 并对所得光谱数据进行分析等功能。 模块化元件围绕若干机器人元件布置,其将板递送到不同的模块元件,将板传递到由不同的机器人元件服务的模块组或板处理中所需的其他动作。 液体转移至多孔平台,用于测定结构或细胞中生理事件发生所必需的多孔平台,在专门用于转移纳升或更小体积量的化学浓缩物或微量的测定试剂,细胞,培养基和 其他检测成分。 本发明的应用包括细胞中多个基因的表达的定量和分析,多基因表达动力学的测定,多重信号转导途径的激活或抑制分析,筛选化合物对多基因表达的调节作用或 信号转导途径或细胞的其他生物化学网络或其他分析生物或生物化学测定。
    • 118. 发明申请
    • Clock methods and circuits for optimized on-die termination
    • 用于优化片上终端的时钟方法和电路
    • US20070085562A1
    • 2007-04-19
    • US11639119
    • 2006-12-13
    • Huy NguyenVijay GaddeBenedict Lau
    • Huy NguyenVijay GaddeBenedict Lau
    • H03K19/003
    • H03K19/0005H03K5/24H03K19/01H03K21/08H04L25/0278H04L25/0298
    • Described are on-die termination (ODT) systems and methods that facilitate high-speed communication between a driver die and a receiver die interconnected via one or more signal transmission lines. An ODT control system in accordance with one embodiment calibrates and maintains termination resistances and drive currents to produce optimal output swing voltages. Comparison circuitry employed to calibrate the reference resistance is also used to calibrate the drive current. Termination elements in some embodiments are divided into two adjustable resistive portions, both of which are designed to minimize capacitive loading. One portion is optimized to produce a relatively high range of adjustment, while the other is optimized for fine-tuning and glitch-free switching.
    • 描述了便于通过一个或多个信号传输线路互连的驱动器管芯和接收器管芯之间的高速通信的管芯端接(ODT)系统和方法。 根据一个实施例的ODT控制系统校准并维持终端电阻和驱动电流以产生最佳输出摆幅电压。 用于校准参考电阻的比较电路也用于校准驱动电流。 一些实施例中的终端元件被分成两个可调节的电阻部分,它们都被设计成最小化容性负载。 一部分被优化以产生相对较高的调节范围,而另一部分被优化用于微调和无故障切换。