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    • 112. 发明授权
    • Glycerol ester derivative
    • 甘油酯衍生物
    • US07371877B2
    • 2008-05-13
    • US10507486
    • 2003-03-27
    • Kazunobu TakahashiHiroshi KitaguchiKazuhiro Aikawa
    • Kazunobu TakahashiHiroshi KitaguchiKazuhiro Aikawa
    • C07F9/02A61K51/04
    • C07D295/15A61K49/0466A61K51/1234C07C69/712C07C233/05C07C275/14C07F9/10C07F9/117
    • A compound represented by the following general formula (IA) or a salt thereof: wherein Ar1 represents hydrogen atom or an aryl group having at least one iodine atom as a substituent; Ar2 represents an aryl group having at least one iodine atom as a substituent; L1 and L2 independently represent a divalent bridging group of which main chain contains 6 or more carbon atoms; L3 represents a single bond or a divalent bridging group of which main chain contains 1 to 6 carbon atoms and one oxygen atom; X represents a functional group containing at least one heteroatom, provided that, when L3 is a single bond, X represents a functional group other than hydroxyl group. The compound can be used as a membrane component of liposomes, and the liposomes can be used as a contrast medium for X-ray radiography.
    • 由以下通式(IA)表示的化合物或其盐:其中Ar 1表示氢原子或具有至少一个碘原子作为取代基的芳基; Ar 2表示具有至少一个碘原子作为取代基的芳基; L 1和L 2独立地表示主链含有6个或更多个碳原子的二价桥连基团; L 3表示主链含有1〜6个碳原子和1个氧原子的单键或二价桥连基团; X表示含有至少一个杂原子的官能团,条件是当L 3为单键时,X表示除羟基以外的官能团。 该化合物可以用作脂质体的膜组分,并且脂质体可以用作X射线照相术的造影剂。