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111. 发明申请

US20050009137A1 Intracellular estradiol binding protein, a polynucleotide encoding the same and cell lines overexpressing the same 有权
标题翻译：细胞内雌二醇结合蛋白，编码其的多核苷酸和过表达细胞系的细胞系
公开(公告)号：US20050009137A1
公开(公告)日：2005-01-13
申请号：US10840038
申请日：2004-05-06
申请人： John Adams , Hong Chen
发明人： John Adams , Hong Chen
IPC分类号： A61K20060101 , A61K38/17 , C07H21/04 , C07K14/00 , C07K14/72 , C12N5/10 , C12N15/63
CPC分类号： C07K14/721
摘要： Described herein is a novel intracellular estradiol binding protein (“IEBP”), as well as a polynucleotide encoding this protein and various cells and cell lines producing and/or overexpressing it. IEBP is believed to play a role in the modulation of estrogen signaling and in the physiological resistance to the same. Abnormally elevated or decreased levels of IEBP may thus be a component of the etiology of diseases generally correlated with estrogen signaling, such as, by way of example, breast cancer and osteoporosis. Various embodiments of the present invention are believed to provide important tools for developing treatments for these conditions, such as, for example, by providing means for screening therapeutic compounds and identifying a genetic target for therapy.
摘要翻译：本文描述的是新型的细胞内雌二醇结合蛋白（“IEBP”），以及编码该蛋白质的多核苷酸以及产生和/或过表达其的各种细胞和细胞系。 IEBP被认为在调节雌激素信号和对其的生理抵抗力方面发挥作用。因此IEBP异常升高或降低的水平可能是通常与雌激素信号传导相关的疾病的病因学成分，例如乳腺癌和骨质疏松症。认为本发明的各种实施方案提供了用于开发这些病症治疗的重要工具，例如通过提供筛选治疗化合物和鉴定治疗遗传靶点的方法。

112. 发明授权

US06399762B1 Methods and compositions for diagnosing and treating chromosome -18p related disorders 失效
标题翻译：用于诊断和治疗染色体-18p相关疾病的方法和组合物
公开(公告)号：US06399762B1
公开(公告)日：2002-06-04
申请号：US09657474
申请日：2000-09-07
申请人： Hong Chen , Nelson B. Freimer
发明人： Hong Chen , Nelson B. Freimer
IPC分类号： C07H2104
CPC分类号： C07H21/00 , C07K14/47
摘要： The present invention relates of the mammalian HKNG1 gene, a gene associated with bipolar affective disorder (BAD) in humans. The invention relates, in particular, to methods for the diagnostic evaluation, genetic testing and prognosis of HKNG1 neuropsychiatric disorders including schizophrenia, attention deficit disorder, a schizoaffective disorder, a bipolar affective disorder or a unipolar affective disorder.
摘要翻译：本发明涉及哺乳动物HKNG1基因，一种与双相情感障碍（BAD）相关的基因在人类中。本发明特别涉及包括精神分裂症，注意力缺陷障碍，分裂情感障碍，双相情感障碍或单极情感障碍的HKNG1神经精神障碍的诊断评估，遗传测试和预后的方法。

113. 发明授权

US5605797A Bovine .beta.-mannosidase gene and methods of use 失效
标题翻译：牛β-甘露糖苷酶基因及其使用方法
公开(公告)号：US5605797A
公开(公告)日：1997-02-25
申请号：US306546
申请日：1994-09-15
申请人： Karen Friderici , Margaret Z. Jones , Hong Chen , Kevin T. Cavanagh
发明人： Karen Friderici , Margaret Z. Jones , Hong Chen , Kevin T. Cavanagh
IPC分类号： C12N9/24 , C12Q1/68 , C07H21/02 , C07H21/04 , C12P19/34
CPC分类号： C12Q1/6883 , C12N9/2491 , C12Y302/01025 , C12Q2600/156 , C12Q2600/158
摘要： The gene encoding bovine .beta.-mannosidase has been identified, cloned, sequenced and characterized. The full-length cDNA contains 3852 nucleotides encoding 879 amino acids. The mutation involved in bovine .beta.-mannosidosis has also been identified. Oligonucleotides and antibodies raised to the gene product are provided and are used in a variety of methods including assays to screen for an abnormal .beta.-mannosidase gene and diagnosis of .beta.-mannosidosis.
摘要翻译：已经鉴定，克隆，测序和表征了编码牛β-甘露糖苷酶的基因。全长cDNA包含编码879个氨基酸的3852个核苷酸。涉及牛β型糖尿病的突变也已被确定。提供了提供给基因产物的寡核苷酸和抗体，并且以各种方法使用，包括筛选异常β-甘露糖苷酶基因的测定法和β-甘露糖样病的诊断。

114. 外观设计

USD1007032S1 LED submarine light 有权
公开(公告)号：USD1007032S1
公开(公告)日：2023-12-05
申请号：US29805465
申请日：2021-08-27
申请人： Hong Chen
设计人： Hong Chen
摘要： FIG. 1 is a perspective view of the LED submarine light showing my new design;
FIG. 2 is a perspective view thereof from another angle;
FIG. 3 is a front elevational view thereof;
FIG. 4 is a rear elevational view thereof;
FIG. 5 is a left side elevational view thereof;
FIG. 6 is a right side elevational view thereof;
FIG. 7 is a top plan view thereof; and,
FIG. 8 is a bottom plan view thereof.

115. 外观设计

USD974155S1 Waste bag holder 有权
公开(公告)号：USD974155S1
公开(公告)日：2023-01-03
申请号：US29844337
申请日：2022-06-28
申请人： Hong Chen
设计人： Hong Chen

116. 发明授权

US09514120B1 Classification of a string as a typographical error based on feedback 有权
标题翻译：基于反馈将字符串分类为排印错误
公开(公告)号：US09514120B1
公开(公告)日：2016-12-06
申请号：US13532183
申请日：2012-06-25
申请人： Hong Chen , Michael Patrick Bacus , Ming Zhao
发明人： Hong Chen , Michael Patrick Bacus , Ming Zhao
IPC分类号： G06F17/00 , G06F17/27
CPC分类号： G06F17/273 , G06F17/2735 , G06F17/274
摘要： A computing device hosting a server identifies one or more potential typographical errors in a work using an initial reference. The computing device sends data indicative of the presence of the potential typographical errors to users. The computing device collects feedback for the work from the users. The feedback for the work indicates whether the potential typographical errors are author-intended strings. The computing device combines the user feedback for the work with user feedback for other works and sorts the combined user feedback based on one or more selected parameters. The computing device determines, based on the sorted user feedback, that one or more of the potential typographical errors includes an acceptable string and updates the initial reference to include the acceptable string.
摘要翻译：托管服务器的计算设备使用初始参考来识别作品中的一个或多个潜在的排印错误。计算设备向用户发送指示潜在印刷错误存在的数据。计算设备从用户收集工作的反馈。工作的反馈意味着潜在的印刷错误是否是作者意图的字符串。计算设备将用于工作的用户反馈与其他作品的用户反馈相结合，并且基于一个或多个所选参数对组合的用户反馈进行排序。计算设备基于排序的用户反馈确定一个或多个潜在的排印错误包括可接受的字符串，并更新初始参考以包括可接受的字符串。

117. 发明授权

US09230514B1 Simulating variances in human writing with digital typography 有权
标题翻译：用数字印刷模拟人类写作的差异
公开(公告)号：US09230514B1
公开(公告)日：2016-01-05
申请号：US13528732
申请日：2012-06-20
申请人： Michael Patrick Bacus , Shawn C. Deyell , Hong Chen
发明人： Michael Patrick Bacus , Shawn C. Deyell , Hong Chen
IPC分类号： G09G5/24
CPC分类号： G06T11/60 , G06F3/00 , G06F17/214 , G09G5/24 , G09G5/28
摘要： Methods and systems for rendering text to simulate human penmanship are described. A text rendering engine converts a text string into an image that can be displayed on a string using one or more seed numbers to influence the rendering and appearance of the text. The text rendering engine may render each character of the text string using a size, weight, slope, or Bezier curve control point selected based on the seed numbers.
摘要翻译：描述了用于渲染文本以模拟人类手法的方法和系统。文本呈现引擎将文本字符串转换为可以使用一个或多个种子编号显示在字符串上的图像，以影响文本的呈现和显示。文本呈现引擎可以使用基于种子编号选择的大小，权重，斜率或贝塞尔曲线控制点来呈现文本串的每个字符。

118. 发明授权

US09141936B2 Systems and methods for simulating a resource constrained process 有权
标题翻译：用于模拟资源约束过程的系统和方法
公开(公告)号：US09141936B2
公开(公告)日：2015-09-22
申请号：US13046156
申请日：2011-03-11
申请人： Hong Chen , Emily Lada
发明人： Hong Chen , Emily Lada
IPC分类号： G06Q10/10 , G06Q10/06
CPC分类号： G06Q10/10 , G06Q10/0631
摘要： Computer-implemented systems and methods are provided for simulation of a resource constrained process. Controlling entity definition data is received, wherein a controlling entity is configured to control resources using a control hierarchy. Resource definition data is received and populated into a resource data structure, wherein the resource is configured to control other resources using the control hierarchy. The resource constrained process is simulated, wherein simulating the resource constrained process includes propagating the controlling entity through the simulation of the resource constrained process, wherein the resource constrained process contains a plurality of stages, at a stage, associating a first resource with the controlling entity using the control hierarchy when the first resource is not allocated to another entity and the first resource fulfills the one or more resource rules, and generating simulation metrics as the controlling entity propagates through the simulation of the resource constrained process.
摘要翻译：提供了计算机实现的系统和方法，用于模拟资源约束过程。接收控制实体定义数据，其中控制实体被配置为使用控制层级来控制资源。资源定义数据被接收并填充到资源数据结构中，其中资源被配置为使用控制层级来控制其他资源。模拟资源约束过程，其中模拟资源约束过程包括通过模拟资源约束过程来传播控制实体，其中资源约束过程包含多个阶段，在将第一资源与控制实体相关联的阶段当第一资源未分配给另一实体并且第一资源满足一个或多个资源规则时，使用控制层级，并且随着控制实体通过资源约束过程的模拟传播，生成模拟度量。

119. 发明授权

US08692878B2 Methods and apparatus for simultaneously inspecting multiple array regions having different pitches 有权
标题翻译：用于同时检查具有不同间距的多个阵列区域的方法和装置
公开(公告)号：US08692878B2
公开(公告)日：2014-04-08
申请号：US13062934
申请日：2010-06-18
申请人： Hong Chen , Jason Z. Lin
发明人： Hong Chen , Jason Z. Lin
IPC分类号： H04N7/18
CPC分类号： G01N21/956 , G01N2021/95676 , G03F1/84 , H01L22/12
摘要： One embodiment relates to a method of automatically inspecting multiple array regions (102) simultaneously using an imaging apparatus (302). The method includes selecting (211 or 212) an optimal pixel size such that each array region in the multiple array regions has a grouped cell which is an integer number of pixels in size, and adjusting a pixel size of the imaging apparatus to be the selected optimal pixel size. Optimal pixel sizes within an available range of pixel sizes may be determined by finding (202) a largest common divider of cell sizes of the multiple array regions when the cell sizes are expressed in integers. Pre-set criteria may be applied to determine (208) which, if any, of the optimal pixel sizes are acceptable based on pre-set criteria. If none of the optimal pixel sizes are acceptable, then one of the array regions may be marked for digital interpolation (see 216). Other embodiments, aspects, and features are also disclosed.
摘要翻译：一个实施例涉及一种使用成像设备（302）同时自动检查多个阵列区域（102）的方法。该方法包括：选择（211或212）最佳像素大小，使得多个阵列区域中的每个阵列区域具有分组的小区，其大小为整数像素，并且将成像设备的像素大小调整为所选择的最佳像素大小。可以通过在单元格大小以整数表示时，找到（202）多个阵列区域的单元大小的最大公共分频器来确定像素大小的可用范围内的最佳像素大小。可以应用预设标准以基于预设标准来确定（208）哪些最佳像素大小是可接受的。如果没有最佳像素大小是可以接受的，则可以将阵列区域之一标记为数字插值（参见216）。还公开了其它实施例，方面和特征。

120. 发明申请

US20140012672A1 CONTENT-BASED BIDDING IN ONLINE ADVERTISING 审中-公开
标题翻译：基于内容的在线广告投标
公开(公告)号：US20140012672A1
公开(公告)日：2014-01-09
申请号：US13543708
申请日：2012-07-06
申请人： Jun Ye , Yu Cao , Luoqi Chen , Ya Luo , Wei Zhuang , Hanying Feng , Hong Chen
发明人： Jun Ye , Yu Cao , Luoqi Chen , Ya Luo , Wei Zhuang , Hanying Feng , Hong Chen
IPC分类号： G06Q30/02
CPC分类号： G06Q30/0241
摘要： A method of providing targeted online advertisement includes receiving a request for an ad impression. The request includes a first content and a second content. The method also includes determining information related to (i) a context of the first content, (ii) a context of the second content, and (iii) a correlation between the context of the first content and the context of the second content, and providing the determined information to a bidding service, thereby enabling one or more advertisers to place one or more bids on the ad impression based on the provided information. Each of the one or more bids includes a bid price. The method further includes receiving the one or more bids for the ad impression, selecting one of the one or more received bids based at least in part on the bid prices, and providing an ad impression associated with the selected bid.
摘要翻译：提供有针对性的在线广告的方法包括接收对广告印象的请求。该请求包括第一内容和第二内容。该方法还包括确定与（i）第一内容的上下文相关的信息，（ii）第二内容的上下文，以及（iii）第一内容的上下文与第二内容的上下文之间的相关性，以及将确定的信息提供给投标服务，从而使得一个或多个广告商能够基于所提供的信息对广告印象进行一个或多个出价。每个一个或多个出价都包含一个出价。所述方法还包括接收针对所述广告展示的所述一个或多个出价，至少部分地基于所述出价来选择所述一个或多个所接收的出价中的一个，以及提供与所选择的出价相关联的广告展示。

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