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111. 发明授权

US5039670A Antithrombotic substituted cycloalkano(B)dihydroindole- and -indole-sulphonamides and use 失效
标题翻译：抗血栓取代环烷（B）二氢吲哚 - 和吲哚磺酰胺和用途
公开(公告)号：US5039670A
公开(公告)日：1991-08-13
申请号：US599321
申请日：1990-10-17
申请人： Horst Boshagen , Ulrich Muller , Ulrich Rosentreter , Erwin Bischoff , Volker-Bernd Fiedler , Elisabeth Perzborn , Joachim Hutter , Peter Norman , Nigel J. Cuthbert , Hilary P. Francis , Marie G. McKenniff
发明人： Horst Boshagen , Ulrich Muller , Ulrich Rosentreter , Erwin Bischoff , Volker-Bernd Fiedler , Elisabeth Perzborn , Joachim Hutter , Peter Norman , Nigel J. Cuthbert , Hilary P. Francis , Marie G. McKenniff
IPC分类号： C07D209/86 , A61K31/40 , A61K31/403 , A61P7/02 , A61P9/08 , A61P9/10 , A61P11/00 , A61P37/08 , C07D209/88 , C07D209/94
CPC分类号： C07D209/88
摘要： Substituted antithrombotic substituted cycloalkano[b]-dihydroindole- and -indole-sulphonamides for treatment of thromboses, thromboembolisms, ischemias, asthma and allergies, of the formula ##STR1## in which R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are hydrogen or other radicals,X is aryl, alkyl or CF.sub.3,m and Z each is 1,2,3 or 4,n is 0, 1 or 2,A is a bond or --NH--, andY is OH, alkoxy, aryloxy, amino or sulphonylamine, with the proviso that, in all cases, two of the substituents R.sup.1 -R.sup.4 are other than hydrogen in the event that m represents the number 2 and Y represents the hydroxyl group,or a salt thereof.
摘要翻译：用于治疗式（I）的血栓形成，血栓栓塞，缺血，哮喘和过敏的取代的抗血栓形成取代的环烷基[b] - 二氢吲哚和吲哚磺酰胺，其中R 1，R 2，R 3和R 4是氢或其它基团，X是芳基，烷基或CF 3，m和Z各自为1,2,3或4，n为0,1或2，A为键或-NH-，Y为OH，烷氧基，芳氧基，氨基或磺酰胺，条件是在所有情况下，在m表示数2且Y表示羟基的情况下，两个取代基R 1 -R 4不同于氢，或其盐。

112. 发明授权

US4876255A Substituted 1,4-dihydropyridines for control of circulation and thromboses 失效
标题翻译：用于控制循环和血栓形成的取代的1,4-二氢吡啶
公开(公告)号：US4876255A
公开(公告)日：1989-10-24
申请号：US178710
申请日：1988-04-07
申请人： Gerhard Franckowiak , Ulrich Rosentreter , Elisabeth Perzborn , Friedel Seuter , Michael Kayser , Gunther Thomas
发明人： Gerhard Franckowiak , Ulrich Rosentreter , Elisabeth Perzborn , Friedel Seuter , Michael Kayser , Gunther Thomas
IPC分类号： A61K31/50 , A61K31/505 , A61P7/02 , A61P9/00 , C07D211/90 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14
CPC分类号： C07D401/12 , C07D211/90 , C07D401/14 , C07D409/14 , C07D413/14
摘要： For the control of coronary diseases and thromboses there are provided the novel compounds ##STR1## in which R.sup.1 is an optionally substituted phenyl or heterocyclic radical,R.sup.2 is a cyano, keto, carboxy, ester or amide group, andX is from 0 to 6,and physiologically acceptable salts thereof.
摘要翻译：为了控制冠状动脉疾病和血栓形成，提供了新的化合物（I），其中R 1是任选取代的苯基或杂环基，R 2是氰基，酮基，羧基，酯或酰胺基，X是 0至6，及其生理上可接受的盐。

113. 发明授权

US4698344A 1-Heteroaryl-4-aryl-pyrazolin-5-ones for use as medicaments 失效
标题翻译： 1-杂芳基-4-芳基 - 吡唑啉-5-酮，用作药物
公开(公告)号：US4698344A
公开(公告)日：1987-10-06
申请号：US800485
申请日：1985-11-21
申请人： Klaus Sasse , Michael Hammond , Friedel Seuter , Elisabeth Perzborn , Bernhard Pelster , Graham Sturton , Trevor Abram
发明人： Klaus Sasse , Michael Hammond , Friedel Seuter , Elisabeth Perzborn , Bernhard Pelster , Graham Sturton , Trevor Abram
IPC分类号： C07D213/77 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/4412 , A61K31/4418 , A61K31/4427 , A61K31/443 , A61K31/505 , A61P7/02 , A61P29/00 , A61P37/08 , C07D231/22 , C07D251/46 , C07D317/00 , C07D401/04 , C07D403/04 , C07D405/14 , C12N9/99
CPC分类号： C07D401/04 , C07D403/04 , C07D405/14
摘要： The invention relates to 1-heteroaryl-4-aryl-pyrazolin-5-ones, a preparation process and the use in combating diseases, in particular for use as lipoxygenase inhibitors.
摘要翻译：本发明涉及1-杂芳基-4-芳基 - 吡唑啉-5-酮，其制备方法以及抗疾病特别用作脂氧合酶抑制剂的用途。

114. 发明授权

US4686229A 1,4-dihydropyridines 失效
标题翻译： 1,4-二氢吡啶
公开(公告)号：US4686229A
公开(公告)日：1987-08-11
申请号：US765908
申请日：1985-08-14
申请人： Ulrich Rosentreter , Elisabeth Perzborn , Friedel Seuter
发明人： Ulrich Rosentreter , Elisabeth Perzborn , Friedel Seuter
IPC分类号： A61K31/44 , A61K31/4427 , A61K31/443 , A61K31/50 , A61P7/02 , A61P9/08 , A61P9/10 , C07C45/64 , C07C47/56 , C07D211/90 , C07D237/00 , C07D401/14 , C07D405/14
CPC分类号： C07D401/14 , C07C45/64 , C07C47/56 , C07D211/90 , C07D405/14
摘要： 1,4-Dihydropyridines of the formula ##STR1## in which R.sup.1 is hydrogen, or alkyl optionally substituted by halogen, nitro, cyano, alkoxy, carboxyl, alkoxycarbonyl or carboxamide,R.sup.2 is hydrogen or alkyl,R.sup.3 is hydrogen, alkyl, carboxyl, alkoxycarbonyl or aryl optionally substituted by hydroxyalkyl, carboxyl, sulphoxy, acloxyalkyl, or ##STR2## R.sup.4 is alkyl, aryl, heteroaryl, aralkyl, heteroaralkyl, ##STR3## X is oxygen, sulphur or NH, and n is 1 to 6,or physiologically acceptable salts thereof, which are active in combating thromboembolic and ischaemic disorders.
摘要翻译：式为“IMAGE”的1,4-二氢吡啶，其中R1为氢，或任选被卤素，硝基，氰基，烷氧基，羧基，烷氧基羰基或羧酰胺取代的烷基，R2为氢或烷基，R3为氢，烷基，羧基，任选被羟烷基，羧基，磺氧基，酰氧基烷基取代的烷氧基羰基或芳基，或者R 4是烷基，芳基，杂芳基，芳烷基，杂芳烷基，X是氧，硫或NH，n是1至 6或其生理上可接受的盐，其对抗血栓栓塞和缺血性疾病是有活性的。

115. 发明授权

US4670460A Inhibiting lipoxygenase with pyrazolone derivatives 失效
标题翻译：用吡唑啉酮衍生物抑制脂氧合酶
公开(公告)号：US4670460A
公开(公告)日：1987-06-02
申请号：US808582
申请日：1985-12-13
申请人： Mithat Mardin , Friedel Seuter , Elisabeth Perzborn , Klaus Schlossmann , Dieter Mayer , Volker Fiedler
发明人： Mithat Mardin , Friedel Seuter , Elisabeth Perzborn , Klaus Schlossmann , Dieter Mayer , Volker Fiedler
IPC分类号： A61K31/415
CPC分类号： A61K31/415
摘要： A method of inhibiting lipoxygenase in a patient, for the prophylaxis and/or treatment of ischaemias and disorders in cardiac rhythm, inflammations of the skin and the eye, and of rheumatic, allergic and asthmatic diseases, oedemas, pulmonary embolisms, pulmonary hypertension, shock lung, oxygen intoxications and ulcerations which comprises administering to such patient an effective amount of a compound of the formula ##STR1## wherein R represents an aryl or heteroaryl radical which has 6 to 12 C atoms and optionally contains 1 to 3 identical or different substituents from the group comprising halogen, trifluoromethyl, alkyl, alkenyl, alkoxy, alkylamino, cyano, trifluoromethoxy, nitro, hydroxyl, SO.sub.n -alkyl (n=0 to 2) or SO.sub.n -trifluoromethyl (n=0 to 2), alkyl, alkenyl and alkoxy in each case being understood as meaning radicals with 1 to 4 C atoms,R.sup.1 represents hydrogen or a hydrocarbon radical which has 1 to 18 C atoms and optionally contains a hydroxyl, ether, ester or carboxyl group and optionally 1 to 3 halogen atoms,R.sup.2 has the meaning of R.sup.1 or represents radical ##STR2## R.sup.3 represents hydrogen or an acyl or sulphonyl radical with in each case 1 to 15 C atoms andX represents one of the groups --O--CH.sub.2 --CH.sub.2 --, --S--CH.sub.2 --CH.sub.2 --, --CH.sub.2 --CH.sub.2 --CH.sub.2 --, --CH.sub.2 --CH.sub.2 --, --CH.sub.2 or ##STR3## the oxygen or sulphur atom being bonded to the radical R, and with the provisio that X does not represent --O--CH.sub.2 --CH.sub.2 -- if R=.beta.-naphthyl, R.sup.1 =CH.sub.3 and R.sup.2 =R.sup.3 =H.
摘要翻译：一种在患者体内抑制脂氧合酶的方法，用于预防和/或治疗心脏节律，皮肤和眼睛炎症以及风湿性，过敏性和哮喘性疾病，oedemas，肺栓塞，肺动脉高压，休克肺，氧中毒和溃疡，其包括向此类患者施用有效量的式（I）化合物，其中R表示具有6至12个C原子并且任选地含有1至3个相同或相同或相同的1至3个的芳基或杂芳基，硝基，羟基，SO1-烷基（n = 0至2）或SO 3 - 三氟甲基（n = 0至2）的不同取代基，烷基，环烷基，烯基和烷氧基在每种情况下被理解为含有1至4个C原子的基团，R 1表示氢或具有1至18个C原子并且任选地含有羟基，醚，酯或羧基的烃基 p和任选的1至3个卤素原子，R 2具有R 1的含义或表示基团R 3表示氢或酰基或磺酰基，在每种情况下为1至15个C原子，X表示基团-O-CH 2 -CH 2 - ， - CH 2 -CH 2 - ， - CH 2 -CH 2 - ， - CH 2 -CH 2 - ， - CH 2或者 - 或者与基团R键合的氧原子或硫原子，如果R =β-萘基，R1 = CH3，R2 = R3 = H，则不表示-O-CH2-CH2-。

116. 发明申请

US20100003542A1 Coating of artificial surfaces of medical aids and instruments, and cleaning and/or pretreatment of catheters and other medical aids and instruments 审中-公开
标题翻译：医疗辅助和器械人造表面的涂层，以及导管和其他医疗辅助器具的清洁和/或预处理
公开(公告)号：US20100003542A1
公开(公告)日：2010-01-07
申请号：US12375016
申请日：2007-07-16
申请人： Elisabeth Perzborn , Frank Misselwitz
发明人： Elisabeth Perzborn , Frank Misselwitz
IPC分类号： B32B9/04
CPC分类号： A61L31/16 , A61L27/54 , A61L33/0041 , A61L2300/42
摘要： The present invention relates to the use of factor Xa (FXa) inhibitors with anticoagulant action for the antithrombotic coating and/or treatment of artificial surfaces of medical aids and/or devices for the prevention of fibrin deposits and/or formation of blood clots and of thrombi, and the use of FXa inhibitors in the cleaning and/or pretreatment of catheters and other medical aids and devices.
摘要翻译：本发明涉及使用具有抗凝血作用的因子Xa（FXa）抑制剂用于抗血栓形成涂层和/或治疗用于预防纤维蛋白沉积和/或形成血块的医疗辅助剂和/或装置的人造表面，和血栓，以及在导管和其他医疗辅助设备的清洁和/或预处理中使用FXa抑制剂。

117. 发明申请

US20080306070A1 Combination Therapy Comprising Substituted Oxazolidinones for the Prevention and Treatment of Cerebral Circulatory Disorders 审中-公开
标题翻译：包括取代的恶唑烷酮用于预防和治疗脑循环障碍的组合疗法
公开(公告)号：US20080306070A1
公开(公告)日：2008-12-11
申请号：US12089169
申请日：2006-09-22
申请人： Elisabeth Perzborn , Thomas Krahn
发明人： Elisabeth Perzborn , Thomas Krahn
IPC分类号： A61K31/5377 , A61P9/06
CPC分类号： A61K31/4439 , A61K31/538 , A61K2300/00
摘要： The present invention relates to combinations of A) oxazolidinones of the formula (I), with B) antiarrhythmics, processes for the production of these combinations, their use for the prophylaxis and/or treatment of diseases, and their use for the manufacture of medicaments for the prophylaxis and/or treatment of diseases, especially of thromboembolic disorders and/or complications.
摘要翻译：本发明涉及式（I）的A）恶唑烷酮与B）抗心律失常药物的组合，这些组合的制备方法，其用于预防和/或治疗疾病的用途及其用于制备药物的用途用于预防和/或治疗疾病，特别是血栓栓塞性疾病和/或并发症。

118. 发明申请

US20080058314A1 Novel dicarboxylic acid derivatives with pharmaceutical properties 失效
标题翻译：具有药物性质的新型二羧酸衍生物
公开(公告)号：US20080058314A1
公开(公告)日：2008-03-06
申请号：US11823462
申请日：2007-06-27
申请人： Cristina Alonso-Alija , Markus Heil , Dietmar Flubacher , Paul Naab , Johannes-Peter Stasch , Frank Wunder , Klaus Dembowsky , Elisabeth Perzborn , Elke Stahl
发明人： Cristina Alonso-Alija , Markus Heil , Dietmar Flubacher , Paul Naab , Johannes-Peter Stasch , Frank Wunder , Klaus Dembowsky , Elisabeth Perzborn , Elke Stahl
IPC分类号： A61K31/192 , A61K31/4412 , A61K31/495 , A61K31/5375 , A61K31/54 , A61K31/55
CPC分类号： C07D213/64 , C07C63/33 , C07C63/72 , C07C65/24 , C07C65/28 , C07C69/76 , C07C69/92 , C07C69/94 , C07C217/22 , C07C229/38 , C07C229/52 , C07C233/25 , C07C235/42 , C07C275/42 , C07C323/56 , C07C323/62 , C07D211/60 , C07D213/65 , C07D231/12 , C07D233/90 , C07D261/08 , C07D263/57 , C07D271/06 , C07D277/24 , C07D295/088 , C07D295/185 , C07D295/21 , C07D307/42 , C07D333/54
摘要： The present invention relates to the use of compounds of the formula (I) and to their salts and stereoisomers, for the preparation of medicaments for the treatment of cardiovascular disorders.
摘要翻译：本发明涉及式（I）化合物及其盐和立体异构体用于制备用于治疗心血管疾病的药物的用途。

119. 发明授权

US07087644B1 Derivatives of dicarboxylic acid having pharmaceutical properties 失效
标题翻译：具有药物性质的二羧酸的衍生物
公开(公告)号：US07087644B1
公开(公告)日：2006-08-08
申请号：US10088060
申请日：2000-08-31
申请人： Cristina Alonso-Alija , Markus Heil , Dietmar Flubacher , Paul Naab , Josef Pernerstorfer , Johannes-Peter Stasch , Frank Wunder , Klaus Dembowsky , Elisabeth Perzborn , Elke Stahl
发明人： Cristina Alonso-Alija , Markus Heil , Dietmar Flubacher , Paul Naab , Josef Pernerstorfer , Johannes-Peter Stasch , Frank Wunder , Klaus Dembowsky , Elisabeth Perzborn , Elke Stahl
IPC分类号： C07C229/00 , A61K31/20
CPC分类号： C07D239/30 , C07C229/38 , C07C233/25 , C07C235/56 , C07C237/12 , C07C255/54 , C07C275/24 , C07C317/18 , C07C323/19 , C07C2601/14 , C07C2602/10 , C07D239/38 , C07D271/06 , C07D277/24 , C07D285/06 , C07D295/088 , C07D333/16
摘要： The invention relates to compounds of formula (I) as well as the salts and stereoisomers thereof wherein the several variable groups are as defined in the specification and claims. Processes for making these materials, pharmaceutical compositions containing them, and methods for using them for treatment of cardiovascular disorders are also disclosed and claimed.
摘要翻译：本发明涉及式（I）化合物及其盐和立体异构体，其中若干可变基团如说明书和权利要求中所定义。还公开并要求保护制备这些材料的方法，含有它们的药物组合物及其用于治疗心血管疾病的方法。

120. 发明授权

US5374647A Antithrombotic substituted cycloalkano (B) dihydroindole sulphonamides 失效
标题翻译：抗血栓代用环烷基（B）二氢吲哚磺酰胺
公开(公告)号：US5374647A
公开(公告)日：1994-12-20
申请号：US42857
申请日：1993-04-05
申请人： Horst Bohagen , Ulrich Muller , Ulrich Rosentreter , Erwin Bischoff , Volker-Bernd Fiedler , Elisabeth Perzborn , Joachim Hutter , Peter Norman , Nigel J. Cuthbert , Hilary P. Francis , Marie G. McKenniff
发明人： Horst Bohagen , Ulrich Muller , Ulrich Rosentreter , Erwin Bischoff , Volker-Bernd Fiedler , Elisabeth Perzborn , Joachim Hutter , Peter Norman , Nigel J. Cuthbert , Hilary P. Francis , Marie G. McKenniff
IPC分类号： C07D209/86 , A61K31/40 , A61K31/403 , A61P7/02 , A61P9/08 , A61P9/10 , A61P11/00 , A61P37/08 , C07D209/88 , C07D209/94
CPC分类号： C07D209/88
摘要： Substituted antithrombotic substituted cycloalkano[b]dihydroindole- and -indole-sulphonamides for treatment of thromboses, thromboembolisms, ischaemias, asthma and allergies, of the formula ##STR1## in which R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are hydrogen or other radicals,X is aryl, alkyl or CF.sub.3,m and Z each is 1,2,3 or 4,n is 0,1 or 2,A is a bond or --NH--, andY is OH, alkoxy, aryloxy, amino or sulphonylamine,with the proviso, that in all cases, two of the substituents R.sup.1 -R.sup.4 are other than hydrogen in the event that m represents the number 2 and Y represents the hydroxyl group, or a salt thereof.
摘要翻译：取代的抗血栓形成取代的环烷基[b]二氢吲哚 - 和吲哚磺酰胺，用于治疗其他基团的血栓形成，血栓栓塞，局部缺血，哮喘和过敏，X是芳基，烷基或CF 3，m和Z各自为1 ，2,3或4，n为0,1或2，A为键或-NH-，Y为OH，烷氧基，芳氧基，氨基或磺酰胺，条件是在所有情况下，两个取代基在m表示数2，Y表示羟基的情况下，R 1 -R 4不是氢，或其盐。

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