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111. 发明专利

IN5113DEN2012A "URACIL OR THYMINE DERIVATIVE FOR TREATING HEPATITIS C" 未知
公开(公告)号：IN5113DEN2012A
公开(公告)日：2015-10-23
申请号：IN5113DEN2012
申请日：2012-06-08
申请人： ABBOTT LAB
发明人： WAGNER ROLF , TUFANO MICHAEL D , STEWART KENT D , ROCKWAY TODD W , RANDOLPH JOHN T , PRATT JOHN K , MOTTER CHRISTOPHER E , MARING CLARENCE J , LONGENECKER KENTON L , LIU YAYA , LIU DACHUN , KRUEGER ALLAN C , KATI WARREN M , HUTCHINSON DOUGLAS K , HUANG PEGGY P , FLENTGE CHARLES A , DONNER PAMELA L , DEGOEY DAVID A , BETEBENNER DAVID A , BARNES DAVID M , CHEN SHUANG , FRANCZYK II THADDEUS S , GAO YI , HAIGHT ANTHONY R , HENGEVELD JOHN E , HENRY RODGER F , KOTECKI BRIAN J , LOU XIAOCHUN , SARRIS KATHY , ZHANG GEOFF G Z
IPC分类号： C07D239/22
摘要： Present application relates to the compounds of formula I useful to treat hepatitis C (HCV) infections. In the structure of the disclosed compounds is the uracil or thymine derivative linked via a phenylene into either fused 2- ring cyclic system (R6) or alternatively via additional two-atom linker (L) to a 5-6 membered monocycle (R6). Application further discloses polymorphs I and pseudopolymorphs of two specific compounds: N-(6(3-t-butyl-5-(2>4- dioxo-3,4-dihydropyrimidin-1 (2H)- y!)2-methoxy-pheny1)naphthalen-2- yl)methanesulfonamide and (E)-N-(4(3-t- butyl-5-(2,4-dioxo-3)4-dihydropyrimidin-1 (2H)-yl)2-method-styryl-phemyl)methanesulfonamide.

112. 发明专利

PH12013500365A1 ANTI-INFECTIVE AGENTS AND USES THEREOF 未知
公开(公告)号：PH12013500365A1
公开(公告)日：2014-09-08
申请号：PH12013500365
申请日：2013-02-25
申请人： ABBOTT LAB
发明人： WAGNER ROLF , TUFANO MICHAEL D , STEWART KENT D , ROCKWAY TODD W , RANDOLPH JOHN T , PRATT JOHN K , MOTTER CHRISTOPHER E , MARING CLARENCE J , LONGENECKER KENTON L , LIU YAYA , LIU DACHUN , KRUEGER ALLAN C , KATI WARREN M , HUTCHINSON DOUGLAS K , HUANG PEGGY P , FLENTGE CHARLES A , DONNER PAMELA L , DEGOEY DAVID A , BETEBENNER DAVID A , BARNES DAVID M , CHEN SHUANG , FRANCZYK THADDEUS S II , GAO YI , HAIGHT ANTHONY R , HENGEVELD JOHN E , HENRY RODGER F , KOTECKI BRIAN J , LOU XIAOCHUN , SARRIS KATHY , ZHANG GEOFF G Z
IPC分类号： C07D403/10 , A61K31/513 , A61K31/5377 , A61P1/16 , A61P31/14 , C07D239/22 , C07D239/54 , C07D401/10 , C07D405/10 , C07D409/10 , C07D413/10 , C07D417/10 , C07D417/14
摘要： This invention relates to: (a) compounds and salts thereof that, inter alia, inhibit HCV; (b) intermediates useful for the preparation of such compounds and salts; (c) compositions comprising such compounds and salts; (d) methods for preparing such intermediates, compounds, salts, and compositions; (e) methods of use of such compounds, salts, and compositions; and (f) kits comprising such compounds, salts, and compositions.

113. 发明专利

DOP2013000185A COMPUESTOS ANTIVIRALES 未知
公开(公告)号：DOP2013000185A
公开(公告)日：2013-09-30
申请号：DO2013000185
申请日：2013-08-13
申请人： ABBOTT LAB
发明人： WAGNER ROLF , TUFANO MICHAEL D , RANDOLPH JOHN T , PRATT JOHN K , MARING CLARENCE J , LIU DACHUN , KRUEGER ALLAN C , KATI WARREN M , HUTCHINSON DOUGLAS K , DONNER PAMELA L , DEGOEY DAVID A , BETEBENNER DAVID A , SARRIS KATHY , WOLLER KEVIN R , NELSON LISSA T , PATEI SACHIN V , KEDDY RYAN G , JINKERSON TAMMIE K , SOLTWEDEL TODD N , LAVIN MICHAEL J , CASPI DANIEL D , HUTCHINS CHARLES W , MOTTER CHRISTOPHER E , MATULENKO MARK A , ROCKWAY TODD W , FLENTGE CHARLES A , CALIFANO JEAN C , BELLIZZI MARY E , LI WENKE , WAGAW SEBLE H
IPC分类号： A61K31/4025 , A61K31/4184 , A61K31/4196 , A61K31/4439 , A61P31/14 , C07D401/14 , C07D403/14 , C07D417/14
摘要： compuestos eficaces para inhibir la replicación del virus de la hepatitis C (HCV). Esta invención también se relaciona con procesos de elaboración de tales compuestos, con composiciones que comprenden a dichos compuestos y con métodos de uso de dichos compuestos para tratar una infección por HCV.

114. 发明专利

NZ569817A Anti-viral compounds 未知
公开(公告)号：NZ569817A
公开(公告)日：2011-10-28
申请号：NZ56981706
申请日：2006-12-20
申请人： ABBOTT LAB
发明人： BETEBENNER DAVID A , DEGOEY DAVID A , MARING CLARENCE J , KRUEGER ALLAN C , IWASAKI NOBUHIKO , ROCKWAY TODD W , COOPER CURT S , ANDERSON DAVID D , DONNER PAMELA L , GREEN BRIAN E , KEMPF DALE J , LIU DACHUN , MCDANIEL KEITH F , MADIGAN DAROLD L , MOTTER CHRISTOPHER E , PRATT JOHN K , SHANLEY JASON P , TUFANO MICHAEL D , WAGNER ROLF , ZHANG RONG , MOLLA AKHTERUZZAMAN , MO HONGMEI , PILOT-MATIAS TAMI J , MASSE SHERIE V L , CARRICK ROBERT J , HE WEPING , LU LIANGJUN , GRAMPOVNIK DAVID J
IPC分类号： C07D471/04 , A61K31/4375 , A61K31/519 , A61P31/12
摘要： Disclosed is a pyrido[2,3-d]pyrimidin-4-yl compound, a tautomer of the compound, or a pharmaceutically acceptable salt of the compound or tautomer, wherein the compound has Formula I, wherein: W1, W2 and W3 are each N, and W4 is C(R33); Z is a bond, -CR41R41'- or -NR41-, wherein R41 and R41 ' are each independently selected from the group consisting of hydrogen, alkyl, alkenyl and alkynyl; A is a carbocyclyl or heterocyclyl, R10 is hydrogen or halogen; R17, R33 and R35, X, R22, R50 are defined in the specification, e.g. 4-(4-Amino-3-methyl-phenoxy)-N-(4-bromo-phenyl)-3-(7-isopropy-1-pyrido[2,3-d]pyrimidin-4-ylamino)-benzamide for the treatment of HCV infection.

115. 发明专利

ES2348557T3 COMPUESTOS ANTIVIRALES. 未知
公开(公告)号：ES2348557T3
公开(公告)日：2010-12-09
申请号：ES06848056
申请日：2006-12-20
申请人： ABBOTT LAB
发明人： ZHANG RONG , CARRICK ROBERT J , KEMPF DALE J , MO HONGMEI , KRUEGER ALLAN C , SHANLEY JASON P , TUFANO MICHAEL D , LU LIANGJUN , ANDERSON DAVID D , MOLLA AKHTERUZZAMAN , BETEBENNER DAVID A , MASSE SHERIE VL , MOTTER CHRISTOPHER E , HE WEPING , ROCKWAY TODD W , MADIGAN DAROLD L , IWASAKI NOBUHIKO , PILOT-MATIAS TAMI , COOPER CURT S , WAGNER ROLF
IPC分类号： C07D471/04
摘要： Un compuesto, un tautómero del compuesto, o una sal farmacéuticamente aceptable del compuesto o tautómero, donde el compuesto tiene la Fórmula II(a) o II(b), donde: 10 R 2 y R 3 se seleccionan independientemente del grupo que consiste en hidrógeno, alquilo, alcoxicarbonilo, y alcoxialquilaminocarbonilo; R 4 se selecciona del grupo que consiste en hidrógeno, alcoxicarbonilo, y alcoxicarbonilalquilo; 15 R 7 se selecciona del grupo que consiste en hidrógeno, alquilo, haloalquilo, alcoxi, cicloalquilo, alcoxicarbonilalquilo, alcoxicarbonilalquilamino, cianoalcoxicarbonilalquilo, cianoalquilo, hidroxialquilo, morfolino, hidrazino, alquilaminoalcoxi, alcoxialquilamino, y arilo; R 9 se selecciona del grupo que consiste en arilalquilamino, N-[alquilarilamino(arilsulfanil)arilalquil]-N-[(alcoxicarbonil)alquil] amino, alcoxiarilalcoxi, haloarilalcoxi, nitroarilalcoxi, cianoarilalcoxi, ariloxialquilo, haloariloxialquilo, arilalcoxi, alquilarilalcoxi, haloalquilaril- aminocarbonilo, alquilaminoarilaminocarbonilo, y arilalcoxi; R 11 se selecciona del grupo que consiste en hidrógeno, hidroxi, haloariloxi, y alquilo; R 12 se selecciona del grupo que consiste en arilsulfanilo, arilsulfinilo, ariloxi, arilaminocarbonilo, arilo, alcoxiarilo, arilalcoxi, y alquilcarbonilaminoarilo; donde R 12 está sustituido opcionalmente con uno o más sustituyentes seleccionados independientemente entre R 16 ; R 16 se selecciona del grupo que consiste en hidrógeno, halógeno, alquilo, alcoxi, hidroxi, aminocarbonilo, alquilaminocarbonilo, amino, alquilcarbonilamino, alquilheteroarilcarbonilamino, heteroarilcarbonilamino, hidroxiheteroarilcarbonilamino, hidroxialquilheteroarilcarbonilamino, heteroarilcarbonilaminoalquilcarbonilamino, heteroarilalquilcarbonilamino, ariloxiarilalquilcarbonilamino, alilaminocarbonilo, alcoxicarbonilo, hidroxialquilo, arilaminocarbonilo, hidroxiarilaminocarbonilo, alcoxialquilo, alcoxiarilaminocarbonilo, azidoalquilo, alquilaminoarilsulfoniloxi, alquilsulfoniloxi, arilalquilsulfoniloxi, alcoxicarbonilalcoxi, hidroxicarbonilalcoxi, cicloalquilcarbonilamino,arilalcoxicarbonilheterociclocarbonilamino, ariloxi, iminoalquilo, alquiltiona, arilalquilcarbonilamino, alquilariloxialquilcarbonilamino, arilalcoxialquilcarbonilamino, heteroarilcarbonilaminoalquilcarbonilamino, heteroarilalquilcarbonilamino, alquilcarbonilheterociclocarbonilamino, amino, aminocarbonilo, alquilaminocarbonilo, hidroxialquilo, aminoalquilo, alcoxialquilaminocarbonilo, hidroxiiminoalquilo, heteroarilo sustituido con alquilo, y heteroarilo; R 13 se selecciona del grupo que consiste en hidrógeno, halógeno, alquilo, alquilcarbonilaminoarilsulfonilo, aminoarilsulfanilo, arilalcoxi, haloarilalcoxi, alquilcarbonilaminoariloxi, alquilaminoariloxi, hidroxiariloxi, alquilaminocarbonilarilalcoxi, y alquilcarbonilaminoarilalcoxi.

116. 发明专利

DE602006015861D1 ANTIVIRALE VERBINDUNGEN 未知
公开(公告)号：DE602006015861D1
公开(公告)日：2010-09-09
申请号：DE602006015861
申请日：2006-12-20
申请人： ABBOTT LAB
发明人： ROCKWAY TODD W , BETEBENNER DAVID A , KRUEGER ALLAN C , IWASAKI NOBUHIKO , COOPER CURT S , ANDERSON DAVID D , KEMPF DALE J , MADIGAN DAROLD L , MOTTER CHRISTOPHER E , SHANLEY JASON P , TUFANO MICHAEL D , WAGNER ROLF , ZHANG RONG , MOLLA AKHTERUZZAMAN , MO HONGMEI , PILOT-MATIAS TAMI , MASSE SHERIE VL , CARRICK ROBERT J , HE WEPING , LU LIANGJUN
IPC分类号： C07D471/04

117. 发明专利

MX2010002905A DERIVADOS DE URACILO O TIMINA PARA TRATAR LA HEPATITIS C. 未知
公开(公告)号：MX2010002905A
公开(公告)日：2010-07-05
申请号：MX2010002905
申请日：2008-09-17
申请人： ABBOTT LAB
发明人： BARNES DAVID M , PRATT JOHN K , BETEBENNER DAVID A , DONNER PAMELA L , MARING CLARENCE J , WAGNER ROLF , RANDOLPH JOHN T , DEGOEY DAVID A , FLENTGE CHARLES A , HUANG PEGGY P , HUTCHINSON DOUGLAS K , KRUEGER ALLAN C , HENRY RODGER F , KOTECKI BRIAN J , HAIGHT ANTHONY R , GAO YI , STEWART KENT D , LONGENECKER KENTON L , ROCKWAY TODD W , MOTTER CHRISTOPHER E , TUFANO MICHAEL D , LIU DACHUN , ZHANG GEOFF G Z , LOU XIAOCHUN , SARRIS KATHY , CHEN SHUANG , KATI WARREN M , LIU YAYA , FRANCZYK THADDEUS S II , HENGEVELD JOHN E
IPC分类号： C07D239/22 , A61K31/513 , A61P31/12 , C07D239/54 , C07D401/10 , C07D403/10 , C07D409/10 , C07D413/10 , C07D417/10
摘要： Esta invención se relaciona con: (a) compuestos y sales de los mismos que, entre otros, inhiben el HCV; (b) intermediarios de utilidad para la preparación de dichos compuestos y sales; (c) composiciones que comprenden tales compuestos y sales; (d) métodos para preparar tales intermediarios, compuestos, sales y composiciones; (e) métodos de uso de tales compuestos, sales y composiciones; y (f) conjuntos de elementos que comprenden tales compuestos, sales y composiciones.

119. 发明专利

CA2633757A1 ANTI-VIRAL COMPOUNDS 未知
公开(公告)号：CA2633757A1
公开(公告)日：2007-07-05
申请号：CA2633757
申请日：2006-12-20
申请人： ABBOTT LAB
发明人： KRUEGER ALLAN C , DEGOEY DAVID A , MARING CLARENCE J , ROCKWAY TODD W , WAGNER ROLF , ANDERSON DAVID D , IWASAKI NOBUHIKO , DONNER PAMELA L , ZHANG RONG , HE WEPING , MOTTER CHRISTOPHER E , GRAMPOVNIK DAVID J , MOLLA AKHTERUZZAMAN , LU LIANGJUN , BETEBENNER DAVID A , GREEN BRIAN E , CARRICK ROBERT J , COOPER CURT S , KEMPF DALE J , PILOT-MATIAS TAMI J , LIU DACHUN , MO HONGMEI , SHANLEY JASON P , MASSE SHERIE VL , MADIGAN DAROLD L , MCDANIEL KEITH F , PRATT JOHN K , TUFANO MICHAEL D
IPC分类号： C07D471/04
摘要： Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) or other viruses are disclosed. This invention is also directed to compositions comprising such compounds, co-formulation or co-administration of such compounds with other anti-viral or therapeutic agents, processes and intermediates for the syntheses of such compounds, and methods of using such compounds for the treatment of HCV or other viral infections.

120. 发明专利

AU2006330924A1 Anti-viral compounds 未知
公开(公告)号：AU2006330924A1
公开(公告)日：2007-07-05
申请号：AU2006330924
申请日：2006-12-20
申请人： ABBOTT LAB
发明人： KEMPF DALE J , WAGNER ROLF , KRUEGER ALLAN C , GREEN BRIAN E , PILOT-MATIAS TAMI J , ANDERSON DAVID D , GRAMPOVNIK DAVID J , PRATT JOHN K , MCDANIEL KEITH F , MARING CLARENCE J , MOTTER CHRISTOPHER E , MADIGAN DAROLD L , LU LIANGJUN , TUFANO MICHAEL D , ZHANG RONG , MASSE SHERIE VL , HE WEPING , MOLLA AKHTERUZZAMAN , MO HONGMEI , SHANLEY JASON P , COOPER CURT S , CARRICK ROBERT J , ROCKWAY TODD W , LIU DACHUN , DONNER PAMELA L , IWASAKI NOBUHIKO , DEGOEY DAVID A , BETEBENNER DAVID A
IPC分类号： C07D471/04
摘要： Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) or other viruses are disclosed. This invention is also directed to compositions comprising such compounds, co-formulation or co-administration of such compounds with other anti-viral or therapeutic agents, processes and intermediates for the syntheses of such compounds, and methods of using such compounds for the treatment of HCV or other viral infections.

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