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111. 发明授权

KR101315346B1 홍해삼 추출물을 이용한 피부 상태 개선제 조성물 有权
标题翻译：使用j us提取物改善皮肤状况的组合物
公开(公告)号：KR101315346B1
公开(公告)日：2013-10-08
申请号：KR1020110012510
申请日：2011-02-11
申请人： 재단법인 제주테크노파크 , 제주특별자치도
发明人： 박수영 , 고형범 , 이욱재 , 서인수 , 정용환 , 김동현 , 박성민 , 이경아 , 백순엽 , 박아름 , 윤미영
IPC分类号： A61K8/98 , A61Q19/00 , A61Q19/08 , A61Q19/10 , A61K35/616 , A23L1/30
摘要： 본 발명은 섬유아세포의 증식을 촉진하고 피부 보습을 개선시키며, 손상된 피부 조직을 회복시키는 등의 활성을 가진 홍해삼 추출물을 이용한 피부 상태 개선제 조성물을 개시한다.

112. 发明授权

KR101300845B1 백수오와 이엽우피소의 감별 방법 및 그 키트 有权
标题翻译： Cynanchum wilfordii和Cynanchum auriculatum之间的歧视方法及其工具
公开(公告)号：KR101300845B1
公开(公告)日：2013-08-29
申请号：KR1020110109104
申请日：2011-10-25
申请人： 재단법인 제주테크노파크
发明人： 정용환 , 오대주 , 이창훈 , 박재권 , 부희정 , 김대신 , 박수영 , 이욱재 , 김봉찬 , 이상순 , 오한준
IPC分类号： C12Q1/68 , C12N15/29
摘要： 본 발명은 백수오 및 이엽우피소의 감별 방법 및 그 키트에 관한 것이다. 본 발명의 백수오 및 이엽우피소의 감별 방법 및 그 키트는 백수오의 ITS에 존재하는
Xcm I 제한효소 인식 부위와 이에 대한 이엽우피소의 대립 서열을 이용하거나 백수오와 이엽우피소의 ITS 서열을 이용함을 특징으로 한다.

113. 发明公开

KR1020130073179A 참다래 과실 발효물을 이용한 항염증제 조성물 및 피부 미백제 조성물 有权
标题翻译：使用发酵产品的脱脂组合物和皮肤白化组合物
公开(公告)号：KR1020130073179A
公开(公告)日：2013-07-03
申请号：KR1020110140888
申请日：2011-12-23
申请人： 재단법인 제주테크노파크
发明人： 박수영 , 함영민 , 윤원종 , 김길남 , 오대주 , 정용환
IPC分类号： A61K36/18 , A61K36/185 , A61P29/00 , A61P17/00
摘要： PURPOSE: An anti-inflammatory composition and a skin whitening composition using a kiwi fruit fermentation are provided to suppress NO, PGE2, and inflammatory cytokine generation, and melanogenesis. CONSTITUTION: An anti-inflammatory composition contains a kiwi fruit fermentation which is prepared by inoculating lactic acid bacteria and yeast to a crushed kiwi fruit and fermenting. Sugar is added to the crushed kiwi fruit as an energy source. The lactic acid bacteria and the yeast are Lactobacillus plantarum and Saccharomyces cerevisiae. The composition is a pharmaceutical composition, a food composition, or a cosmetic composition.
摘要翻译：目的：提供使用猕猴桃发酵的抗炎组合物和皮肤美白组合物，以抑制NO，PGE2和炎性细胞因子的产生以及黑素生成。构成：抗炎组合物含有猕猴桃发酵，其通过将乳酸菌和酵母接种到破碎的猕猴桃中并发酵而制备。糖被添加到被碾碎的猕猴桃作为能源。乳酸菌和酵母是植物乳杆菌（Lactobacillus plantarum）和酿酒酵母（Saccharomyces cerevisiae）。组合物是药物组合物，食品组合物或化妆品组合物。

114. 发明公开

KR1020130071666A 블라디놀 Ｆ를 이용한 항염증성 조성물 无效
标题翻译：使用VLADINOL F的抗炎组合物
公开(公告)号：KR1020130071666A
公开(公告)日：2013-07-01
申请号：KR1020110139005
申请日：2011-12-21
申请人： 재단법인 제주테크노파크
发明人： 윤원종 , 함영민 , 정용환 , 박수영 , 오대주
IPC分类号： A61K31/343 , A61K31/045 , A61P29/00
CPC分类号： A61K36/60 , A61K31/12
摘要： PURPOSE: An anti-inflammatory composition using vladinol F isolated from F. erecta var. sieboldii is provided to suppress generation of NO, PGE2 (prostaglandin), and inflammatory cytokines (TNF-alpha, IL-1beta, and IL-6). CONSTITUTION: An anti-inflammatory composition contains vladinol F as an active ingredient. A method for isolating vladinol F from F. erecta var. sieboldii comprises the steps of: dipping F. erecta var. sieboldii leaves, stems, or a mixture thereof in a mixture solvent of ethanol and water and preparing a power extract; suspending the extract in distilled water, and sequentially fractioning to obtain a dichloromethane fraction; coating a celite surface with the fraction and performing column chromatography using hexane, dichloromethane, ethyl acetate, and methanol to obtain 4 purified materials; performing normal phase column chromatography of a second purified material using hexane:ethyl acetate:methanol (1:2:0.2, v/v) to obtain total 20 purified materials; performing normal phase silicagel column chromatography of 16th purified material among 20 purified materials using chloroform:methanol (10:1, v/v) and preparing total 18 purified materials; and collecting 9th purified material among 18 purified materials. [Reference numerals] (AA) MC fraction of a F. erecta var. sieboldii extract (11.2g); (BB) Column chromatography; (CC) Normal phase silica gel (5cm×60cm); (DD) Normal phase silica gel (2.0cm×50cm)
摘要翻译：目的：使用从F. erecta var。分离的vladinol F的抗炎组合物。提供sieboldii以抑制NO，PGE2（前列腺素）和炎性细胞因子（TNF-α，IL-1β和IL-6）的产生。构成：抗炎组合物含有vladinol F作为活性成分。一种从F. erecta var。中分离vladinol F的方法。 sieboldii包括以下步骤：浸渍F.frecta var。 sieboldii叶，茎或其在乙醇和水的混合溶剂中的混合物，并制备动力提取物; 将提取物悬浮在蒸馏水中，并依次分级得到二氯甲烷馏分; 用级分涂覆硅藻土表面，并使用己烷，二氯甲烷，乙酸乙酯和甲醇进行柱层析，得到4种纯化物; 使用己烷：乙酸乙酯：甲醇（1:2:0.2，v / v）进行第二纯化物质的正相柱色谱，得到总共20种纯化物质; 使用氯仿：甲醇（10:1，v / v）在20个纯化物中进行第16次纯化物质的正相硅胶柱色谱，并制备总共18种纯化物质; 并在18种纯化材料中收集第9种纯化材料。（参考数字）（AA）MC分数F.frecta var。 sieboldii提取物（11.2g）; （BB）柱色谱; （CC）正相硅胶（5cm×60cm）; （DD）正相硅胶（2.0cm×50cm）

115. 发明授权

KR101217769B1 항염증제 조성물 및 항암제 조성물 有权
标题翻译：作为抗炎药物的组合物和抗癌药物的组合物
公开(公告)号：KR101217769B1
公开(公告)日：2013-01-02
申请号：KR1020110128480
申请日：2011-12-02
申请人： 재단법인 제주테크노파크 , 제주특별자치도
发明人： 박수영 , 고형범 , 함영민 , 윤원종 , 김길남 , 정용환 , 이욱재
IPC分类号： A61K35/60 , A61P35/00 , A61P29/00
摘要： 본발명은항염증제조성물및 항암제조성물을개시한다. 구체적으로본 발명은홍해삼추출물을이용한항염증제조성물및 항암제조성물을개시한다.

116. 发明公开

KR1020120100859A 좁은잎천선과 잎 추출물을 이용한 항염증제 조성물 有权
标题翻译：使用FICUS ERECTA LEAF提取物的抗炎组合物
公开(公告)号：KR1020120100859A
公开(公告)日：2012-09-12
申请号：KR1020120082039
申请日：2012-07-26
申请人： 재단법인 제주테크노파크
发明人： 정용환 , 윤원종 , 함영민 , 오대주 , 송관필 , 김길남 , 박수영 , 이경후 , 김지현
IPC分类号： A61K36/60 , A61P29/00
CPC分类号： A61K36/60 , A23L33/105 , A23V2002/00 , A23V2200/324
摘要： PURPOSE: An anti-inflammatory composition using Ficus erecta leaf extract is provided to suppress IL-1beta generation and iNOS and COX-2 expression. CONSTITUTION: An anti-inflammatory composition contains Ficus erecta leaf extract as an active ingredient. The extract is selected from: extract prepared with alcohol of 1-5 carbon atoms, acetone, hexane, ethyl acetate, dichloromethane, water or a mixture thereof; extract of a fraction solvent layer prepared by fractioning solid extract with water and hexane, water and dichloromethane, or water and ethyl acetate; and extract prepared by suspending the solid extract in the water and fractioning with hexane, dichloromethane, and ethyl acetate in order. The composition is a pharmaceutical composition and food composition.
摘要翻译：目的：提供使用Ficus erecta叶提取物的抗炎组合物，以抑制IL-1beta的产生和iNOS和COX-2的表达。构成：抗炎组合物含有榕叶提取物作为活性成分。提取物选自：用1-5个碳原子的醇制备的提取物，丙酮，己烷，乙酸乙酯，二氯甲烷，水或其混合物; 通过用水和己烷，水和二氯甲烷或水和乙酸乙酯分离固体提取物制备的级分溶剂层的提取物; 和通过将固体提取物悬浮在水中制备的提取物，并依次用己烷，二氯甲烷和乙酸乙酯分馏。组合物是药物组合物和食物组合物。

117. 发明公开

KR1020120062615A 부챗말 추출물 또는 분획물을 이용한 피부 외용제 조성물 有权
标题翻译：外用组合物，使用提取物或皮脂腺脂蛋白的分类
公开(公告)号：KR1020120062615A
公开(公告)日：2012-06-14
申请号：KR1020110109289
申请日：2011-10-25
申请人： 재단법인 제주테크노파크
发明人： 김지영 , 정용환 , 김동삼 , 김영주 , 서인수 , 박소현 , 윤원종
IPC分类号： A61K36/03 , A61K36/02 , A61P31/04 , A61P17/00
CPC分类号： A61K36/03 , A61K8/9706 , A61K9/0014 , A61K9/06 , A61K2236/333 , Y10S514/859
摘要： PURPOSE: An external use skin composition containing Padina arborescens extract and/or fraction thereof is provided to ensure antibacterial function and to treat acne. CONSTITUTION: An antibacterial external use skin composition contains ethanol solution extract of Padina arborescens or hexane fraction, dichloromethane fraction thereof, or ethyl acetate fraction thereof as an active ingredient. The external use skin composition has antibacterial function against Staphylococcus aureus, Staphylococcus epidermidis, or Propionibacterium acne. The external use skin composition is a cosmetic, cleansing, or pharmaceutical composition.
摘要翻译：目的：提供含有Padina arborescens提取物和/或其部分的外用皮肤组合物，以确保抗菌功能并治疗痤疮。构成：抗菌外用皮肤组合物含有Padina arborescens或己烷级分的乙醇溶液提取物，其二氯甲烷级分或其乙酸乙酯级分作为活性成分。外用皮肤组合物对金黄色葡萄球菌，表皮葡萄球菌或痤疮丙酸杆菌具有抗菌作用。外用皮肤组合物是化妆品，清洁剂或药物组合物。

118. 发明公开

KR1020110084132A 홍해삼 추출물을 이용한 피부 상태 개선제 조성물 有权
标题翻译：使用刺激性红细胞提取物改善皮肤病症的组合物
公开(公告)号：KR1020110084132A
公开(公告)日：2011-07-21
申请号：KR1020110012510
申请日：2011-02-11
申请人： 재단법인 제주테크노파크 , 제주특별자치도
发明人： 박수영 , 고형범 , 이욱재 , 서인수 , 정용환 , 김동현 , 박성민 , 이경아 , 백순엽 , 박아름 , 윤미영
IPC分类号： A61K8/98 , A61Q19/00 , A61Q19/08 , A61Q19/10 , A61K35/616 , A23L1/30
CPC分类号： A61K8/987 , A23L33/10 , A61K35/616 , A61Q19/005 , A61Q19/007 , A61Q19/08 , A61Q19/10
摘要： PURPOSE: A composition containing Stichopus japonicus extract is provided to improve skin condition and to manufacture a cosmetic products, soap, drugs, and foods. CONSTITUTION: A composition for improving skin condition contains Stichopus japonicus extract as an active ingredient. The skin condition includes enhancement of skin elasticity, anti-aging, and skin moisturizing and skin irritation relief. The composition is a cosmetic, pharmaceutical, or food composition. The cosmetic composition is soap.
摘要翻译：目的：提供含有日本St us提取物的组合物，以改善皮肤状况并制造化妆品，肥皂，药物和食品。构成：用于改善皮肤状况的组合物含有日本St us提取物作为活性成分。皮肤状况包括增强皮肤弹性，抗衰老，皮肤保湿和皮肤刺激缓解。组合物是化妆品，药物或食品组合物。化妆品组合物是肥皂。

119. 发明公开

KR1020090118154A 붉가시나무 추출물을 유효성분으로 함유하는 항산화 및항암용 조성물 有权
标题翻译：用于抗氧化的组合物和包含作为活性成分的QUERCUS ACUTA的提取物的抗癌剂
公开(公告)号：KR1020090118154A
公开(公告)日：2009-11-18
申请号：KR1020080043774
申请日：2008-05-13
申请人： 재단법인 제주테크노파크
发明人： 박수영 , 김길남 , 윤원종 , 함영민 , 정용환 , 송관필
IPC分类号： A61K36/185 , A61P17/18 , A61P35/00
摘要： PURPOSE: A composition containing Quercus acuta Thunb extract is provided to ensure the effect of DNA damage suppression and cancer cell proliferation suppression. CONSTITUTION: A method for producing fraction of Quercus acuta Thunb extract comprises: a step of preparing stems with leaves of Quercus acuta Thunb then pulverizing; a step of extracting the pulverized Quercus acuta Thunb powder with ethanol; a step of decompress-concentrating then suspending with distilled water; and a step of extracting with hexane, dichloromethane, ethylacetate, butanol, and water. A composition for antioxidation contains fraction of Quercus acuta Thunb extract.
摘要翻译：目的：提供含有栎属藜提取物的组合物，以确保DNA损伤抑制和癌细胞增殖抑制的作用。构成：生产栎属栎提取物的方法，包括：用槲皮栎树叶制备茎的步骤，然后粉碎; 用乙醇提取粉碎的栎树栎粉末的步骤; 减压浓缩步骤，然后用蒸馏水悬浮; 和用己烷，二氯甲烷，乙酸乙酯，丁醇和水萃取的步骤。用于抗氧化的组合物含有栎属栎提取物的分数。

120. 发明公开

KR1020080020738A 항염활성 및 골대사 관련인자 억제활성을 나타내는까마귀쪽나무 추출물 有权
标题翻译：具有抗炎活性和骨代谢因子抑制活性的LITSEA JAPONICA提取物
公开(公告)号：KR1020080020738A
公开(公告)日：2008-03-06
申请号：KR1020060083944
申请日：2006-09-01
申请人： 재단법인 제주테크노파크
发明人： 박수영 , 정용환 , 윤원종 , 이정아 , 김지영 , 오대주 , 유은숙 , 이혜자
IPC分类号： A61K36/54 , A61P39/06
CPC分类号： A61K36/54 , A23V2200/304 , A61K2236/33 , Y10S514/825
摘要： A composition comprising the extract of Litsea japonica is provided to prevent and treat inflammatory disease and metabolic bone disease including osteoporosis and osteopetrosis by inhibiting inflammation and bone metabolic factors including IL-6(interleukin-6), COX-2(cyclooxygenase-2) and PGE2(prostaglandin E2) without side effects. A composition for preventing and treating inflammatory disease and metabolic bone disease comprises the extract of Litsea japonica which is prepared by drying leaf, stem or fruit of Litsea japonica juss in the shade, pulverizing the dried Litsea japonica juss, dipping the pulverized Litsea japonica juss in 80% ethanol, sonicating the Litsea japonica juss solution for 1 hour, repeating the sonication in three times to prepare the ethanol extract of Litsea japonica juss, collecting the supernatant and concentrating the supernatant under reduced pressure, suspending the concentrate in distilled water, and extracting the suspension with hexane, dichloromethane, ethyl acetate and butanol sequentially, and is formulated as food additives or drink.
摘要翻译：提供包含日本蓟马提取物的组合物，通过抑制炎症和包括IL-6（白细胞介素-6），COX-2（环氧合酶-2）和骨质疏松素-2）在内的骨代谢因子来预防和治疗包括骨质疏松和骨质疏松的炎性疾病和代谢性骨病， PGE2（前列腺素E2）无副作用。用于预防和治疗炎性疾病和代谢性骨疾病的组合物包括通过在树荫下干燥荔枝枣的叶，茎或果实制备的荔枝提取物，粉碎干燥的枸杞，将粉碎的荔枝粳稻 80％乙醇，将Litsea japonica juss溶液超声处理1小时，三次重复超声处理，制备日本it杷的乙醇提取物，收集上清液，减压浓缩上清液，将浓缩物悬浮于蒸馏水中，萃取依次用己烷，二氯甲烷，乙酸乙酯和丁醇悬浮，配制成食品添加剂或饮料。

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