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111. 发明申请

WO2013014066A1 KOMPLEXVERBINDUNGEN MIT EINEM LIGANDEN MIT EINEM N- UND EINEM P-DONOR UND IHRE VERWENDUNG IM OPTO-ELEKTRONISCHEN BEREICH 审中-公开
标题翻译：具有带有N IN光电子领域的配体和P供体和它们的用途复杂的化合物
公开(公告)号：WO2013014066A1
公开(公告)日：2013-01-31
申请号：PCT/EP2012/064235
申请日：2012-07-19
申请人： EBERHARD KARLS UNIVERSITÄT TÜBINGEN , UNIVERSITÄT REGENSBURG , WESEMANN, Lars , KÜCHLE, Fritz-Robert , MAYER, Hermann August , WERNITZ, Sophie , YERSIN, Hartmut , LEITL, Markus
发明人： WESEMANN, Lars , KÜCHLE, Fritz-Robert , MAYER, Hermann August , WERNITZ, Sophie , YERSIN, Hartmut , LEITL, Markus
IPC分类号： H01L51/46 , C07F1/08 , C07F9/54
CPC分类号： H01L51/009 , C07F1/08 , C09K11/06 , C09K2211/1096 , H01L51/0004 , H01L51/0091 , H01L51/5012 , H05B33/14 , Y02E10/549
摘要： Beschrieben werden elektronische Vorrichtungen, enthaltend eine Metallkomplexverbindung mit mindestens einem Liganden mit einem N- und einem P-Donor mit der Formel (I), in der die Kohlenstoffe C 1 und C 2 Teil eines aromatischen oder nicht aromatischen Ringsystems F 1 sind, P und N Phosphor und Stickstoff sind, wobei der Stickstoff sp 2 -hybridisiert vorliegt, die Reste R 3 und R 4 unabhängig voneinander Wasserstoff oder ein Alkyl-, Cycloalkyl-, Alkenyl-, Cycloalkenyl-, Alkinyl-, Cycloalkinyl-, Alkylcycloalkyl-, Heteroalkyl-, Heterocycloalkyl-, Heteroalkylcycloalkyl-, Aryl-, Heteroaryl-, Aralkyl- oder Heteroaralkyl-Rest mit bis zu 40 C-Atomen sind, und R 1 und R 2 unabhängig voneinander ein Atom oder ein Rest aus der Gruppe umfassend Wasserstoff, Halogen, R-, RO-, RS-, RCO-, RCOO-, RNH-, R 2 N-, RCONR- und -Si(R) X (OR) 3-X mit R = ein Alkyl-, Cycloalkyl-, Alkenyl-, Cycloalkenyl-, Alkinyl-, Cycloalkinyl-, Alkylcycloalkyl-, Heteroalkyl-, Heterocycloalkyl-, Heteroalkylcycloalkyl-, Aryl-, Heteroaryl-, Aralkyl- oder Heteroaralkyl- Rest mit bis zu 40 C-Atomen und X = 1, 2 oder 3 sind. Weiterhin werden ein Verfahren zur Herstellung einer solchen elektronischen Vorrichtung sowie Verfahren zur Erzeugung von Licht bzw. blauer Emission unter Verwendung einer solchen Metallkomplexverbindung beschrieben.
摘要翻译：描述了包含与具有N和具有下式（I），其中碳C1和C2是芳族或非芳族环系统F1，P和N磷的一部分的P-供体和至少一种配体的金属配位化合物的电子设备氮，氮的sp 2杂化，基团R3和R4独立地是氢或烷基，环烷基，烯基，环烯基，炔基，环炔基，烷基环烷基，杂烷基，杂环烷基，Heteroalkylcycloalkyl- 基，芳基，杂芳基，芳烷基或杂芳基团具有至多40个碳原子，并且R1和R2独立地为原子或选自包括氢基团的基团，卤素，R-，RO-，RS-， RCO-，RCOO-，RNH-，R 2 N-，RCONR-和-Si（R）X（OR）3 X，其中R =烷基，环烷基，烯基，环烯基，炔基，环炔基，烷基环烷基 - ，杂烷基，杂环烷基，Heteroalkylcycloalkyl-，芳基，杂芳基，芳烷基或杂芳基团具有至多40个碳原子和X = 1，2或第三此外，可以使用这样的金属配位化合物进行说明一种用于制造这样的电子装置和方法用于产生光或蓝色发光的方法。

112. 发明申请

WO2011114238A3 SHUTTLE VECTOR BASED TRANSFORMATION SYSTEM FOR PYROCOCCUS FURIOSUS 审中-公开
公开(公告)号：WO2011114238A3
公开(公告)日：2011-09-22
申请号：PCT/IB2011/000993
申请日：2011-03-15
申请人： UNIVERSITÄT REGENSBURG , TOMM, Michael , HAUSNER, Winfried , WAEGE, Ingrid
发明人： TOMM, Michael , HAUSNER, Winfried , WAEGE, Ingrid
IPC分类号： C12N15/74
摘要： The present invention relates to vectors for transforming archaea and to transformed archaea, and in particular to shuttle vector systems for transformation of members of the genus Pyrococcus.

113. 发明申请

WO2010072684A1 NORRIN IN THE TREATMENT OF DISEASES ASSOCIATED WITH AN INCREASED TGF-BETA ACTIVITY 审中-公开
标题翻译：治疗与增加的TGF-β活性相关的疾病的标准
公开(公告)号：WO2010072684A1
公开(公告)日：2010-07-01
申请号：PCT/EP2009/067553
申请日：2009-12-18
申请人： UNIVERSITÄT REGENSBURG , TAMM, Ernst , OHLMANN, Andreas
发明人： TAMM, Ernst , OHLMANN, Andreas
IPC分类号： A61K38/17 , A61P1/18 , A61P27/02 , A61P11/00 , A61P9/00 , A61P41/00 , A61P43/00 , A61P31/12 , A61P19/02 , A61P17/02 , A61P27/06 , A61P11/06 , A61P35/00
CPC分类号： A61K38/1709 , C07K14/475
摘要： The present invention relates to Norrin or a functional fragment thereof in the treatment or prevention of diseases associated with an increased TGF-beta activity. In particular, the use of said Norrin or functional fragment thereof to treat fibrotic diseases/disorders or proliferative disorders, like cancers, is part of this invention.
摘要翻译：本发明涉及Norrin或其功能片段，用于治疗或预防与增加的TGF-β活性相关的疾病。特别地，所述Norrin或其功能片段用于治疗纤维化疾病/病症或增殖性疾病如癌症是本发明的一部分。

114. 发明申请

WO2010066384A1 COMPOSITIONS AND METHODS FOR MICRO-RNA EXPRESSION PROFILING OF CANCER STEM CELLS 审中-公开
标题翻译：用于癌细胞的微RNA表达分布的组合物和方法
公开(公告)号：WO2010066384A1
公开(公告)日：2010-06-17
申请号：PCT/EP2009/008679
申请日：2009-12-04
申请人： MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V. , UNIVERSITÄT REGENSBURG , MEISTER, Gunter , WEINMANN, Lasse , BEIER, Dagmar , BEIER, Christoph
发明人： MEISTER, Gunter , WEINMANN, Lasse , BEIER, Dagmar , BEIER, Christoph
IPC分类号： C12Q1/68 , C12N15/113 , A61K31/7105
CPC分类号： A61K31/7105 , C12N15/113 , C12N2310/113 , C12N2310/141 , C12Q1/6886 , C12Q2600/178
摘要： The present invention relates compositions and methods for microRNA expression profiling of cancer stem cells. In particular, the invention relates to a method for identifying and/or diagnosing one or more cancer stem cells, the method comprising identifying from a plurality of nucleic acid molecules, each encoding a microRNA sequence, one or more nucleic acid molecules are differentially expressed in the cancer stem cells and in one or more control cells, wherein the one or more differentially expressed nucleic acid molecules together represent a nucleic acid expression signature that is indicative for the presence of cancer stem cells. The invention further relates to a corresponding diagnostic kit of molecular markers, namely the nucleic acid expression signature. Finally, the invention is directed to a method using such nucleic acid expression signatures for preventing the proliferation and/or self-renewal of such cancer stem cells as well as to a corresponding pharmaceutical composition.
摘要翻译：本发明涉及癌干细胞的微小RNA表达谱的组合物和方法。特别地，本发明涉及用于鉴定和/或诊断一种或多种癌症干细胞的方法，所述方法包括从编码微小RNA序列的多个核酸分子中鉴定出一个或多个核酸分子，其在癌干细胞和一种或多种对照细胞，其中所述一个或多个差异表达的核酸分子一起表示指示癌干细胞存在的核酸表达特征。本发明还涉及分子标记的相应诊断试剂盒，即核酸表达特征。最后，本发明涉及使用这种核酸表达特征来预防这种癌症干细胞以及相应药物组合物的增殖和/或自我更新的方法。

115. 发明申请

WO2007054310A2 PYROGLUE 审中-公开
公开(公告)号：WO2007054310A2
公开(公告)日：2007-05-18
申请号：PCT/EP2006/010756
申请日：2006-11-09
申请人： UNIVERSITÄT REGENSBURG , WIRTH, Reinhard , THOMA, Christine
发明人： WIRTH, Reinhard , THOMA, Christine
IPC分类号： C07K14/195 , C09J189/00
CPC分类号： C07K14/195 , B82Y5/00 , C09J189/00
摘要： The present invention relates to an adhesive material being composed and/or consisting of at least one protein obtained or obtainable from fimbriae from archaea. Furthermore, the present invention relates to the use of at least one protein obtained from fimbriae from archaea for the preparation of an adhesive material and a method for the preparation of an adhesive material comprising the step of isolating and/or purifying at least one protein obtained from fimbriae from archaea.
摘要翻译：本发明涉及由至少一种从古细菌的菌毛获得的或可得自古菌的菌毛的蛋白质组成的和/或由其组成的粘合剂材料。此外，本发明涉及从古细菌菌毛获得的至少一种蛋白质用于制备粘合剂材料和制备粘合剂材料的方法的用途，所述方法包括以下步骤：分离和/或纯化至少一种获得的蛋白质来自古细菌的菌毛。

116. 发明申请

WO2005119285A1 PROCESS FOR THE DETERMINATION OF LIPOPROTEINS IN BODY FLUIDS 审中-公开
标题翻译：用于测定体液中脂蛋白的方法
公开(公告)号：WO2005119285A1
公开(公告)日：2005-12-15
申请号：PCT/EP2005/005886
申请日：2005-06-01
申请人： UNIVERSITÄT REGENSBURG , HUBER, Fritz , KREMER, Werner , KALBITZER, Hans Robert
发明人： HUBER, Fritz , KREMER, Werner , KALBITZER, Hans Robert
IPC分类号： G01R33/465
CPC分类号： G01N24/08 , G01R33/4625 , G01R33/465 , Y10T436/24
摘要： The invention describes a process for the determination of the concentration distribution and size distribution of lipoprotein classes in body fluids, e.g. blood. For this purpose, NMR spectra of a sample to be analysed are measured by magnetic field gradient intensities and temperatures under different diffusion-weighted measuring conditions selected according to different pulse programs (e.g. PFG-STE, PFG-LED etc) and consequently in a differentiated manner according to the relaxation times. The different effects of these measuring conditions on the intensity/line form of the NMR signals of the individual lipoprotein classes are determined and permit the determination of a concentration distribution/size distribution of the individual lipoprotein classes.
摘要翻译：本发明描述了用于测定体液中脂蛋白类别的浓度分布和大小分布的方法，例如，血液。为此，通过根据不同脉冲程序选择的不同扩散加权测量条件下的磁场梯度强度和温度来测量要分析的样品的NMR谱（例如PFG-STE，PFG-LED等），并因此分化方式根据放松时间。确定这些测量条件对各个脂蛋白类别的NMR信号的强度/线形式的不同影响，并且允许测定各个脂蛋白类别的浓度分布/尺寸分布。

117. 发明申请

WO2023046675A1 CARBON NANOFIBER ELECTRODES FOR FLOW-THROUGH ELECTROCHEMICAL SENSORS AND SENSOR 审中-公开
公开(公告)号：WO2023046675A1
公开(公告)日：2023-03-30
申请号：PCT/EP2022/076087
申请日：2022-09-20
申请人： UNIVERSITÄT REGENSBURG
发明人： BÄUMNER, Antje , WONGKAEW, Nongnoot , PERJU, Antonia-Teodora
IPC分类号： G01N27/327 , G01N27/30
摘要： A method of forming a carbon nanofiber electrode, a method of manufacturing a sensor for performing an electrochemical measurement on a liquid sample, and a sensor for performing an electrochemical measurement on a liquid sample. The method of forming a carbon nanofiber electrode comprises providing an electrically insulating porous substrate and forming a mat of electrically insulating nanofibers on the substrate by electrospinning. The electrically insulating nanofibers comprise an organic polymer and an electrode comprising electrically conductive carbon nanofibers is formed in the mat of electrically insulating nanofibers by laser-induced carbonization of the electrically insulating nanofibers.

118. 发明申请

WO2022268969A1 ß-LACTAM ANTIBIOTIC WITH SIGNIFICANT ACTIVITY AGAINST CANCER E.G. COLON MALIGNANCIES 审中-公开
公开(公告)号：WO2022268969A1
公开(公告)日：2022-12-29
申请号：PCT/EP2022/067203
申请日：2022-06-23
申请人： UNIVERSITÄT REGENSBURG
发明人： EL-NAJJAR, Nahed , GESSNER, André
IPC分类号： A61K31/513 , A61K31/546 , A61P35/00 , A61K45/06
摘要： The present invention relates to a cephalosporin for use in a method of preventing and/or treating colon cancer, wherein the cephalosporin comprises a nitrogen, preferably positively charged nitrogen, and a first carboxyl group, preferably a negatively charged carboxyl group; wherein the nitrogen and the carboxyl group of said cephalosporin are spaced apart by three carbon atoms. Furthermore, the present invention relates to a pharmaceutical composition for use in a method of preventing and/or treating colon cancer, wherein said composition comprises a cephalosporin and a pharmaceutically acceptable excipient.

119. 发明申请

WO2021214066A1 COMPOSITIONS FOR USE IN TREATING AUTOSOMAL DOMINANT BEST1-RELATED RETINOPATHIES 审中-公开
公开(公告)号：WO2021214066A1
公开(公告)日：2021-10-28
申请号：PCT/EP2021/060253
申请日：2021-04-20
申请人： UNIVERSITÄT REGENSBURG
发明人： WEBER, Bernhard , MILENKOVIC, Andrea
IPC分类号： C12N15/113 , A61K48/00 , A61P27/00 , C12N9/22
摘要： The present invention refers to a sgRNA molecule comprising a targeting domain for specifically targeting a SNP in the BEST1 coding region of a pathologic allele, wherein said targeting domain consists of a sequence selected from the group consisting of SEQ ID NO: 3- 8, 41-44, 14-20, 50-52 and 54-55, or a sgRNA molecule combination of specifically defined first and second sgRNA molecules, wherein the first and the second sgRNA molecule each comprise a targeting domain for specifically targeting a SNP in the BEST1 gene coding or non- coding region of a pathologic allele. The present invention also refers to a nucleic acid comprising a sequence that encodes the sgRNA molecule or sgRNA molecule combination and to nucleic acid combinations. The present invention further relates to a recombinant adenovirus- associated virus (AAV) comprising the nucleic acids according to the present invention or recombinant AAV combinations. The sgRNA molecule, the nucleic acid, the recombinant AAV and combinations are useful tools for editing of the target domain in the bestrophin-1 (BEST1) gene to restore BEST1 channel function by e.g. CRISPR/Cas9-based gene editing. The present invention further relates to the sgRNA molecule, the sgRNA molecule combination, the nucleic acid, the nucleic acid combination, the recombinant AAV and the recombinant AAV combination for use in a method for treatment of the human or animal body by surgery or therapy and for use in method of treating or preventing BEST1-related retinopathies, in particular autosomal dominant BEST1-related retinopathies.

120. 发明申请

WO2021130022A1 VIRUS-MIMETIC NANOPARTICLES 审中-公开
公开(公告)号：WO2021130022A1
公开(公告)日：2021-07-01
申请号：PCT/EP2020/085363
申请日：2020-12-09
申请人： UNIVERSITÄT REGENSBURG
发明人： MALSANKA-FIGUEROA, Sara , FLEISCHMANN, Daniel , GÖPFERICH, Achim
IPC分类号： A61K47/69 , A61K47/54 , A61K47/62 , A61K47/59 , A61K47/60 , A61K31/197 , A61K31/4418 , A61P13/12 , A61P27/02 , A61P35/00 , B82Y5/00 , A61K47/545 , A61K47/593 , A61K47/6937
摘要： The present invention relates to a nanoparticle comprising a nanomaterial and at least a first ligand and a second ligand tethered to the nanoparticle. The present invention further relates to a nanoparticle for use as a medicament or diagnostic agent. The present invention also relates to a nanoparticle for use in a method of preventing or treating a disease selected from diabetic nephropathy, glomerulonephritis, glomerular VEGF A dysregulation, endothelial VEGF A dysregulation, diabetic retinopathy, rheumatoid arthritis, age-related macular degeneration, and cancer such as breast cancer. Furthermore, the present invention relates to a method of preparing a nanoparticle.

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