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111. 发明公开

EP3038604A2 DETERRING ABUSE OF PHARMACEUTICAL PRODUCTS AND ALCOHOL 审中-公开
标题翻译： VERHINDERUNG DES MISSBRAUCHS VON PHARMAZEUTISCHEN PRODUKTEN UND ALKOHOL
公开(公告)号：EP3038604A2
公开(公告)日：2016-07-06
申请号：EP14842598.6
申请日：2014-09-09
申请人： Nova Southeastern University
发明人： OMIDIAN, Hossein , MASTROPIETRO, David, J. , MUPPALANENI, Srinath
IPC分类号： A61K9/20 , A61K9/24
CPC分类号： A61K31/135 , A61K9/10 , A61K9/143 , A61K9/1676 , A61K9/2009 , A61K9/2027 , A61K9/2054 , A61K9/2059 , A61K9/2086 , A61K47/02 , A61K47/10 , A61K47/32 , A61K47/48015 , A61K47/4823 , A61K47/52 , A61K47/61
摘要： A therapeutic dosage form includes a pharmaceutically active ingredient, a crosslinked polyacid, and a linear polyacids. The crosslinked polyacid is insoluble in water, and the linear polyacid is soluble in water. An example of a crosslinked polyacids is sodium carboxymethylcellulose. The linear polyacid possesses sufficient binding sites to form a stable complex with the pharmaceutically active ingredient. An example of a linear polyacid is polymethacrylic acid. The ingredients are formed into a tablet or capsule, either admixed, in layers, or separated by a coating. Abuse is deterred in that crushing causes the active ingredient to be bound and not abusable, and placing the dosage in solution causes a strong complex to be formed between the polyacid and the active ingredient, including a solution with ethanol. Other therapeutic dosage forms for reducing the incidence of tampering and abuse of pharmaceutical products and alcohol, and specifically preventing the isolation and concentration of drug constituents for misuse, and preventing excessive intake are also disclosed.
摘要翻译：治疗剂型包括药物活性成分，交联多酸和线性多元酸。交联的多酸不溶于水，线性多元酸可溶于水。线性多元酸具有足够的结合位点以与药物活性成分形成稳定的复合物。成分形成片剂或胶囊，混合，分层，或由涂层分开。阻止滥用是因为破碎导致活性成分结合而不可滥用，并将剂量置于溶液中导致在多酸和活性成分之间形成强烈的复合物，包括用乙醇溶液。还公开了用于降低药物和酒精的篡改和滥用的发生率的其它治疗剂型，并且具体地防止滥用药物成分的分离和浓缩以及防止过度摄入。

112. 发明公开

EP2268254A1 METHOD AND KIT FOR DELIVERING REGENERATIVE ENDODONTIC TREATMENT 审中-公开
标题翻译：方法和试剂盒用于管理的可再生牙髓治疗
公开(公告)号：EP2268254A1
公开(公告)日：2011-01-05
申请号：EP08861918.4
申请日：2008-12-12
申请人： Nova Southeastern University
发明人： MURRAY, Peter E. , GARCIA-GODOY, Franklin
IPC分类号： A61K6/00
CPC分类号： A61K6/0032
摘要： The present invention provides novel methods and kits for removing unhealthy or necrotic pulp tissue from inside the root canals of a tooth, and to replace it with new vascularized tissue created by regenerative endodontic treatment. The present invention provides alternatives to current root canal therapies, as well as obturation of the root canal with dental materials.

113. 发明公开

EP4313140A1 CLADE C HIV-1 ENVELOPE (ENV) TRIMER IMMUNOGENS, COMPOSITIONS INCLUDING THE CLADE C HIV-1 ENVELOPE (ENV) TRIMER IMMUNOGENS, AND USES THEREOF 审中-实审
公开(公告)号：EP4313140A1
公开(公告)日：2024-02-07
申请号：EP22782096.6
申请日：2022-03-30
申请人： Nova Southeastern University , The Forsyth Institute
发明人： CAYABYAB, Mark J. , BONTEMPO, Alexander
IPC分类号： A61K39/12 , A61K39/21 , C07K14/16 , A61P31/18

114. 发明公开

EP3866774A1 SUBLINGUAL EPINEPHRINE COMPOSITIONS INCLUDING PH-MODIFYING EXCIPIENTS AND PENETRATION ENHANCERS AND METHODS FOR USE THEREOF 审中-公开
公开(公告)号：EP3866774A1
公开(公告)日：2021-08-25
申请号：EP19872893.3
申请日：2019-10-18
申请人： Nova Southeastern University
发明人： RAWAS-QALAJI, Mutasem
IPC分类号： A61K31/137 , A61K47/12 , A61K47/26

115. 发明公开

EP2861224A2 EPINEPHRINE NANOPARTICLES, METHODS OF FABRICATION THEREOF, AND METHODS FOR USE THEREOF FOR TREATMENT OF CONDITIONS RESPONSIVE TO EPINPHRINE 审中-公开
标题翻译： EPINEPHRINNANOPARTIKEL，方法其制造及其使用方法处理对肾上腺素吸引莱顿
公开(公告)号：EP2861224A2
公开(公告)日：2015-04-22
申请号：EP13812628.9
申请日：2013-06-14
申请人： Nova Southeastern University , Rachid, Ousama , Simons, Keith , Simons, Estelle
发明人： RACHID, Ousama , SIMONS, Keith , SIMONS, Estelle , RAWAS-QALAJI, Mutasem
IPC分类号： A61K31/137
CPC分类号： A61K31/137 , A61K9/0056 , A61K9/006 , A61K9/14 , A61K9/2013 , A61K9/2054
摘要： The invention provides compositions including epinephrine nanoparticles and methods for therapeutic use of the compositions for the treatment of conditions responsive to epinephrine such as a cardiac event or an allergic reaction, particularly anaphylaxis. The epinephrine nanoparticles can be incorporated into orally-disintegrating and fast-disintegrating tablet pharmaceutical formulations and can significantly increase the sublingual bioavailability of epinephrine, and thereby reduce the epinephrine dose required. Additionally, the invention provides methods for fabrication of stabilized epinephrine nanoparticles for use in the described compositions.
摘要翻译：本发明提供了组合物，包括肾上腺素纳米颗粒和制备用于响应于肾上腺素病症的治疗治疗用途的组合物的方法：如心脏事件或过敏反应，特别是过敏性反应的。肾上腺素纳米颗粒可掺入到口腔崩解和快速崩解片剂的药物配方的反馈，可显着提高舌下肾上腺素的生物利用度，并由此减少所需的肾上腺素剂量。此外，本发明提供了纳米粒子的制造方法稳定化的肾上腺素对在所描述的组合物的用途。

116. 发明公开

EP2271341A1 SPECIFIC INHIBITORS FOR VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTORS 有权
标题翻译：特异性抑制剂血管内皮生长因子受体
公开(公告)号：EP2271341A1
公开(公告)日：2011-01-12
申请号：EP08767636.7
申请日：2008-05-08
申请人： Nova Southeastern University
发明人： RATHINAVELU, Appu , DAKSHANAMURHTY, Sivanesan , PATTABIRAMAN, Nagarajan
IPC分类号： A61K31/445 , A61K31/522
CPC分类号： A61K31/445 , A61K31/522
摘要： The present application describes isoindoles and derivatives thereof or pharmaceutically acceptable salt forms thereof, which are useful inhibitors of VEGFR.

117. 发明公开

EP3888642A1 EPINEPHRINE FINE PARTICLES AND METHODS FOR USE THEREOF FOR TREATMENT OF CONDITIONS RESPONSIVE TO EPINEPHRINE 审中-实审转让
公开(公告)号：EP3888642A1
公开(公告)日：2021-10-06
申请号：EP21170027.3
申请日：2014-03-24
申请人： Nova Southeastern University
发明人： RACHID, Ousama , SIMONS, Keith , SIMONS, Estelle , RAWAS-QALAJI, Mutasem
IPC分类号： A61K31/137 , A61K9/00
摘要： The invention provides pharmaceutical compositions formulated for buccal or sublingual administration including epinephrine microparticles. Further, the invention provides a pharmaceutical composition comprising epinephrine microparticles, wherein the composition is for use in a method for enhancing buccal or sublingual bioavailability of epinephrine in a subject in need thereof or is for use in a method for treatment of a breathing difficulty in a subject in need thereof or is for use in a method for treating a condition responsive to epinephrine in a subject in need thereof or is for use in a method for treatment of an allergic emergency in a subject diagnosed with or suspected of having an allergic emergency

119. 发明公开

EP3344974A1 DETECTING EARLY TISSUE DAMAGE DUE TO MECHANICAL DEFORMATION, SHEAR, FRICTION, AND/OR PROLONGED APPLICATION OF PRESSURE 审中-公开
公开(公告)号：EP3344974A1
公开(公告)日：2018-07-11
申请号：EP16842794.6
申请日：2016-08-30
申请人： Nova Southeastern University
发明人： HETTRICK, Heather
IPC分类号： G01N21/62 , G01N21/63 , A61B5/00
CPC分类号： A61B5/00 , A61B5/0077 , A61B5/447 , G01N21/62 , G01N21/63
摘要： A system and method for using a forensic alternative light source (ALS) to detect tissue damage related to pressure ulcer/injury pathophysiology before visible manifestations of the tissue damage are evident with the naked (unaided) eye.

120. 发明公开

EP3965895A1 REGULATION OF NUCLEOTIDE EXCISION REPAIR (NER) BY MICRORNA FOR TREATMENT OF BREAST CANCER 审中-实审
公开(公告)号：EP3965895A1
公开(公告)日：2022-03-16
申请号：EP20801895.2
申请日：2020-05-08
申请人： Nova Southeastern University
发明人： LATIMER, Jean, J.
IPC分类号： A61P35/00 , A61K33/24 , A61P43/00 , C12Q1/68 , A61K45/06 , A61K31/713

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