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111. 发明申请

WO02062482A2 FLUID SEPARATION DEVICES, SYSTEMS AND/OR METHODS USING A FLUID PRESSURE DRIVEN AND/OR BALANCED CONFIGURATION 审中-公开
标题翻译：使用流体压力驱动和/或平衡配置的流体分离装置，系统和/或方法
公开(公告)号：WO02062482A2
公开(公告)日：2002-08-15
申请号：PCT/US0146940
申请日：2001-11-02
申请人： GAMBRO INC
发明人： HLAVINKA DENNIS J , FELT THOMAS J
IPC分类号： A61M1/02 , A61M1/36 , A61M1/38 , B04B5/04 , B04B7/08 , B04B9/08 , B04B
CPC分类号： B04B5/0442 , A61M1/0231 , A61M1/3693 , A61M1/3696 , A61M1/38 , B04B5/0428 , B04B7/08 , B04B9/08 , B04B2005/045 , B04B2005/0464 , B04B2009/143
摘要： A centrifugal fluid separation system is disclosed for centrifugally separating a composite fluid into components thereof. This centrifugal separation system includes at least a centrifugal rotor which has a composite fluid containment area, several fluid flow channels and at least two separated component collection areas defined therein. A composite fluid to be separated is delivered to the fluid containment area from which it travels through an inlet channel to a substantially circumferential fluid separation channel where under centrifugal forces the composite fluid is separated into components which each then travel to distinct first and second separated fluid outlet channels, and thence on to exit therefrom into the respective collection areas. The first and second fluid outlet channels also have respective first and second heights which are related to each other so as to provide a balanced fluid pressure relationship for the respective separated component fluids flowing therethrough. Such a pressure balance controls the interface of the separated fluid components within the circumferential separation channel. The preferred fluid pressure balance relationship is rho 2g2h2 = rho 3g3h3 wherein the first height of the first outlet channel is h2, and the second height of the second outlet channel is h3, wherein g2 and g3 are gravitational or centrifugal acceleration values and rho 2 and rho 3 represent the respective densities of the separated fluids in the first and second outlet channels. A similar, continuously forward flow drive relationship involves also the height h1 of the inlet channel and the density rho 1 of the fluid therein such that rho 1g1h1 > rho 2g2h2 or rho 1g1h1 > rho 3g3h3. The preferred centrifugal drive motor used here produces a rotating magnetic field, which co-acts with a magnetically reactive material disposed in the rotor to rotate the rotor with the rotating magnetic field. A loopless, sealless continuous flow centrifuge is thus available herefrom. Adisposable bag and tubing system is also disclosed for use with preferably reusable rotor devices.
摘要翻译：公开了用于将复合流体离心分离成其组分的离心流体分离系统。该离心分离系统至少包括具有复合流体容纳区域，若干流体流动通道和限定在其中的至少两个分离的部件收集区域的离心转子。要分离的复合流体被输送到流体容纳区域，从该入口通道行进通过入口通道到基本上圆周的流体分离通道，在离心力作用下，复合流体被分离成各自分成不同的第一和第二分离流体出口通道，然后从那里退出到相应的收集区域。第一和第二流体出口通道还具有彼此相关的相应的第一和第二高度，以便为流过其中的各个分离的组分流体提供平衡的流体压力关系。这种压力平衡控制在圆周分离通道内的分离的流体组分的界面。优选的流体压力平衡关系为rho 2g2h2 = rho 3g3h3，其中第一出口通道的第一高度为h2，第二出口通道的第二高度为h3，其中g2和g3为重力或离心加速度值，rho 2和 rho 3表示第一和第二出口通道中分离的流体的相应密度。类似的，连续向前的流动驱动关系还涉及入口通道的高度h1和其中流体的密度rho 1，使得r 1g1h1> rho 2g2h2或rho1g1h1> rho3g3h3。这里使用的优选的离心驱动马达产生旋转磁场，其与设置在转子中的磁反应性材料共同作用，以使转子与旋转磁场一起旋转。因此，可以使用无孔，无密封的连续流离心机。还公开了可用于优选可重复使用的转子装置的相关袋和管系统。

112. 发明申请

WO0226270A2 INACTIVATION OF CONTAMINANTS USING PHOTOSENSITIZERS AND PULSED LIGHT 审中-公开
标题翻译：使用光敏剂和脉冲光灭活污染物
公开(公告)号：WO0226270A2
公开(公告)日：2002-04-04
申请号：PCT/US0130026
申请日：2001-09-26
申请人： GAMBRO INC
发明人： HLAVINKA DENNIS
IPC分类号： A61L2/00 , A61L2/08 , A61L2/10
CPC分类号： A61L2/08 , A61L2/0011 , A61L2/10
摘要： Methods and apparatuses are provided for inactivation of pathogens in fluids. Preferably the fluids contain blood or blood products and may include biologically active proteins. Preferred methods include the steps of adding an effective, non-toxic amount of a photosensitizer to a fluid and exposing the fluid to pulsed light, wherein the pulsed radiation emitting source emits radiation sufficient to activate the photosensitizer whereby pathogens are inactivated.
摘要翻译：提供了用于灭活流体中的病原体的方法和装置。优选地，流体含有血液或血液制品，并且可以包括生物活性蛋白质。优选的方法包括以下步骤：将有效的无毒量的光敏剂添加到流体中并将流体暴露于脉冲光，其中脉冲辐射发射源发射足以激活光敏剂的辐射，由此使病原体灭活。

113. 发明专利

CA2655644C SOLUTION AND METHOD TO REDUCE, TREAT AND/OR PREVENT OXIDATIVE STRESS AND CELL ACTIVATION 未知
公开(公告)号：CA2655644C
公开(公告)日：2013-01-08
申请号：CA2655644
申请日：2007-06-21
申请人： GAMBRO INC
发明人： DEPPISCH REINHOLD , BECK WERNER , SCHNELL ANDREA , DRIESCHMANNS HANS-RAINER
IPC分类号： A61K31/191 , A61K31/198 , A61K31/375 , A61K38/38 , A61P39/06 , A61P43/00
摘要： The present invention concerns a solution and methods to reduce, treat and/or prevent oxidative stress and cell activation. According to the invention the solution gives rise to the following concentrations of constituents within a blood flow of 0.1-18 mM N-acetyl-cysteine, optionally of 0.01-0.21 mM vitamin C, optionally of 2-26 mM gluconic acid and optionally of 0.01-5 mM glutathione. According to the invention the methods comprises adding a solution according to the invention in an extracorporeal setting through the membrane by adding the solution to the dialysis fluid, or by infusion of a solution according to the invention, either by bolus injection, continuous injection or a combination thereof.

114. 发明专利

CA2585179C METHOD AND APPARATUS FOR INACTIVATION OF BIOLOGICAL CONTAMINANTS USING PHOTOSENSITIZERS 未知
公开(公告)号：CA2585179C
公开(公告)日：2012-07-03
申请号：CA2585179
申请日：1999-07-21
申请人： GAMBRO INC
发明人： GOODRICH RAYMOND PAUL JR , CORBIN FRANK III , WOOD EDWARD C JR , HLAVINKA DENNIS
IPC分类号： A01N1/02 , A23L2/50 , A23L3/26 , A23L3/34 , A61L2/08 , A61L2/18 , A61M1/28 , A61M1/36 , C07H19/22
摘要： Methods and apparatuses are provided for inactivation of microorganisms in fluids or on surfaces. Preferably the fluids contain blood or blood products and comprise biologically active proteins. Preferred methods include the steps of adding an effective, non-toxic amount of an endogenous photosensitizer to a fluid and exposing the fluid to photoradiation sufficient to activate the endogenous photosensitizer whereby microorganisms are inactivated. Other fluids, including juices, water and the like, may also be decontaminated by these methods as may surfaces of foods, animal carcasses, wounds, food preparation surfaces and bathing and washing vessel surfaces. Alloxazines and K- and L- vitamins are among the preferred photosensitizers. Systems and apparatuses for flow-through and batch processes are also provided for decontamination of such fluids using photosensitizers.

115. 发明专利

CA2387779C ISOALLOXAZINE DERIVATIVES TO NEUTRALIZE BIOLOGICAL CONTAMINANTS 未知
公开(公告)号：CA2387779C
公开(公告)日：2010-10-12
申请号：CA2387779
申请日：2000-09-15
申请人： GAMBRO INC
发明人： PLATZ MATTHEW STEWART , GOODRICH RAYMOND PAUL JR
IPC分类号： C07D475/14 , A01N43/90 , A61K31/525 , A61K35/14 , A61L2/00 , A61L2/08 , A61L2/10 , A61L2/16 , A61M1/02 , A61M1/28 , A61P17/02
摘要： Methods are provided for neutralization of microorganisms in fluids or on surfaces. Preferably the fluids contain blood or blood products and comprise biologically active proteins. Preferred methods include the steps of adding an activation-effective amount of a microorganism neutralizer with an isoalloxazine backbone to a fluid and exposing the fluid to a triggering event. Preferred triggering events include light of a suitable wavelength and intensity to activate the microorganism neutralizer or a pH sufficient to activate the microorganism neutralizer. Other fluids, including juices, water and the like, may also be decontaminated by these methods as may surfaces of foods, animal carcasses, wounds, food preparation surfaces and bathing and washing vessel surfaces. Compounds with an isoalloxazine backbone are also provided.

116. 发明专利

CA2474448C INACTIVATION OF WEST NILE VIRUS AND MALARIA USING PHOTOSENSITIZERS 未知
公开(公告)号：CA2474448C
公开(公告)日：2010-09-07
申请号：CA2474448
申请日：2003-02-03
申请人： GAMBRO INC
发明人： REDDY HEATHER , GOODRICH RAYMOND P
IPC分类号： A61J3/00 , A61K41/00 , A61K31/7056 , A61K35/14
摘要： Methods and apparatuses are provided for inactivation of parasites (Pl. falciparum) or virus (West Nile Virus) in fluids. Preferably the fluids contain blood or blood products and comprise biologically active proteins. Preferred methods include the steps of adding an effective, non-toxic amount of a photosensitizer (riboflavin) to a fluid and exposing the fluid to photoradiation sufficient to activate the photosensitizer whereby microorganisms are inactivated.

117. 发明专利

DE60035474T2 未知
公开(公告)号：DE60035474T2
公开(公告)日：2008-03-13
申请号：DE60035474
申请日：2000-12-22
申请人： GAMBRO INC
发明人： BAINBRIDGE MARLENE , FELT THOMAS
IPC分类号： A61M1/38 , A61M1/30 , A61M1/34 , A61M1/36
摘要： A method and apparatus for controlling a fluid separation system in response to fluid pressure changes in a fluid flow, said method comprising the steps of sensing a fluid pressure; comparing the fluid pressure to a threshold value, and if the fluid pressure is below the threshold value, then pausing fluid flow for a selected period. During the selected period, either the fluid pressure sensed automatically resolves or the method further comprises a step of setting a full alarm condition. The method and apparatus may further include interpreting a particular quantity of fluid pressure comparisons where the fluid pressure is below the threshold value occurring within a particular time period, and then, signaling an alarm. Threshold values may be calculated by the method or apparatus according to a formula such as the following: Threshold Value = Config + 75 - 0.3309 * Qin/(1-Hin) - 0.3026 * Qn/(1-Hn) ; where, Config = a configuration pre-selected pressure value Qin = fluid flow rate in the inlet tubing line; Hin = Hematocrit in the inlet tubing line; Qn = fluid flow rate in the needle; and Hn = Hematocrit in the needle.

118. 发明专利

CA2482021C REMOVAL OF ADENINE DURING A PROCESS OF PATHOGEN REDUCING BLOOD AND BLOOD COMPONENTS 未知
公开(公告)号：CA2482021C
公开(公告)日：2007-06-19
申请号：CA2482021
申请日：2003-04-24
申请人： GAMBRO INC
发明人： DOANE SUZANN K , GOODRICH RAYMOND P
IPC分类号： A61J1/00 , A61K35/14 , A01N1/02 , A01N43/90 , A61K31/525 , A61K35/18 , A61K41/00 , A61L2/00 , A61L2/08 , A61L2/10 , A61L2/16 , A61M1/02 , A61M1/34 , A61M1/36 , A61N5/06 , A61P7/08 , C12N7/04
摘要： The methods of this invention involve preventing the formation of a complex between adenine and riboflavin by reducing the amount of adenine in a soluti on containing blood or blood components to be pathogen reduced.

119. 发明专利

DE69636518T2 未知
公开(公告)号：DE69636518T2
公开(公告)日：2007-05-03
申请号：DE69636518
申请日：1996-06-05
申请人： GAMBRO INC
发明人： BAINBRIDGE MARLENE ADELE , BILODEAU LEON E , BLAKESLEE JEFFREY J , BRIERTON MARK J , CORBIN FRANK , CRUZ EDWARD V , DOLECEK VICTOR D , GARRISON DENISE C , HEMPSTEAD RUSSELL , HOARD DAVID W , HOLMES BRIAN M , KAPPUS JOHN J , LANGLEY ROBERT W , MENHENNETT THOMAS L , MUDLOFF FREDERICK S , MURRAY RICHARD E , SHOULDICE DAVID R , STEELE CHAD C , WAHL TERRY R
IPC分类号： A61M1/02 , A61M1/36 , A61M1/30 , B04B5/04 , B04B9/08
摘要： An extracorporeal blood processing system is disclosed which includes a variety of novel components and which may be operated in accordance with a variety of novel methodologies. For instance, the system includes a graphical operator interface which directs the operator through various aspects of the apheresis procedure. Moreover, the system also includes a variety of features relating to loading a blood processing vessel into a blood processing channel and removing the same after completion of the procedure. Furthermore, the system also includes a variety of features relating to utilizing a blood priming of at least portions of the apheresis system in preparation for the procedure. In addition, the system includes a variety of features enhancing the performance of the apheresis system, including the interrelationship between the blood processing vessel and the utilization of high packing factors for the procedure.

120. 发明专利

DE60311981D1 未知
公开(公告)号：DE60311981D1
公开(公告)日：2007-04-05
申请号：DE60311981
申请日：2003-04-28
申请人： GAMBRO INC
发明人： HLAVINKA J , MARTINEZ J
IPC分类号： A61L2/08 , A61L2/00 , A61L2/10 , A61M1/02 , A61M1/36 , B01F5/06 , B01F9/00 , B01F11/00 , B01F13/00
摘要： A mixing system, apparatus and/or method. Pathogen reduction of and/or mixing storage solutions into blood or blood components are useful purposes for these. Squeezing or clapping devices may be used to activate the mixing process, as may rotational devices or laterally movable, rotational and/or orbital devices. Constriction elements may also be used to create useful vortex mixing actions. Photoradiation may be provided while the components continue to be mixed together for pathogen reduction of blood or blood components.

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