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111. 发明专利

AR071745A1 COMPUESTOS SACARIDOS UNIDOS A HETEROCICLOS, INHIBIDORES DE POLIMERASAS VIRALES, COMPOSICIONES FARMACEUTICAS QUE LOS COMPRENDEN Y USOS DE LOS MISMOS COMO AGENTES ANTIVIRALES Y/O ANTICANCER. 未知
公开(公告)号：AR071745A1
公开(公告)日：2010-07-14
申请号：ARP090100788
申请日：2009-03-05
申请人： BIOCRYST PHARM INC
IPC分类号： C07H7/06 , C07D471/14 , C07D471/04 , C07D487/04 , C07D487/14 , C07D498/14 , C07D498/147 , A61K31/7052 , A61K31/7042 , A61K31/53 , A61K31/407 , A61K31/5365 , A61K31/5025 , A61K31/4353 , A61K31/4741 , A61K31/4745 , A61P31/12 , A61P31/14 , A61P31/18 , A61P31/20 , A61P35/00
摘要： Reivindicacion 1: Un compuesto de formula (1) caracterizado porque B representa un anillo carboc¡clico o heteroc¡clico de 5, 6, 7 u 8 miembros que comprende uno o varios enlaces dobles, en donde B est opcionalmente sustituido con uno o varios oxo, tioxo, NRcRd, F, CI, Br, I, ORz, SRz, alquilo, C:::N, C:::C-R, N3 o SO2R'; en donde: R es H, alquilo o arilo; R' es OH, NH2 o alquilo; R1 es H, NRaRb, CI, F, ORa, SRa, NHCORa, NHSO2Ra, NHCONHRa, CN, alquilo, arilo, ONRaRb o NRaC(O)ORb; R2 es un grupo de azucar nucleosido; Ra y Rb se seleccionan independientemente del grupo que consiste en H, alquilo, alquilo sustituido, alquenilo, alquenilo sustituido, alquinilo, alquinilo sustituido, cicloalquilo, heteroc¡clico, arilo, arilo sustituido, acilo, acilo sustituido, SO2-alquilo, amino, amino sustituido y NO; o Ra y Rb, junto con el nitrogeno al cual est n unidos, forman un anillo pirrolidino, piperidino, piperazino, azetidino, morfolino o tiomorfolino; Rc y Rd se seleccionan independientemente del grupo que consiste en H, alquilo, alquilo sustituido, alquenilo, alquenilo sustituido, alquinilo, alquinilo sustituido, cicloalquilo, acilo, acilo sustituido y SO2-alquilo; o Rc y Rd, junto con el nitrogeno al cual est n unidos, forman un anillo pirrolidino, piperidino, piperazino, azetidino, morfolino o tiomorfolino; y cada Rz se selecciona independientemente del grupo que consiste en H, alquilo, alquilo sustituido, alquenilo, alquenilo sustituido, alquinilo, alquinilo sustituido, cicloalquilo, acilo y acilo sustituido; o una sal o prodroga farmaceuticamente aceptable de dicho compuesto.

112. 发明专利

IL199664D0 ANTIVIRAL NUCLEOSIDE ANALOGS 未知
公开(公告)号：IL199664D0
公开(公告)日：2010-04-15
申请号：IL19966409
申请日：2009-07-02
申请人： BIOCRYST PHARM INC
IPC分类号： C07H20100101

113. 发明专利

CA2732628A1 THERAPEUTIC AGENTS 未知
公开(公告)号：CA2732628A1
公开(公告)日：2010-02-04
申请号：CA2732628
申请日：2009-07-31
申请人： BIOCRYST PHARM INC
发明人： BABU YARLAGADDA S , CHAND POORAN , KOTIAN PRAVIN L , KUMAR V SATISH
IPC分类号： C07D471/04 , A61K31/53 , A61P37/06 , C07D487/04 , C07D491/048 , C07D495/04 , C07D513/04
摘要： The invention provides a compound of formula (I):wherein W is a bicyclic heteroaromatic group; or a salt thereof. The compounds and salts thereof have beneficial therapeutic properties (e.g. immunosuppressant properties).

114. 发明专利

PE20091727A1 AGENTES TERAPEUTICOS ANTIVIRALES 未知
公开(公告)号：PE20091727A1
公开(公告)日：2009-12-04
申请号：PE2009000334
申请日：2009-03-05
申请人： BIOCRYST PHARM INC
发明人： BABU YARLAGADDA S , CHAND POORAN , KOTIAN PRAVIN L , WU MINWAN , KUMAR V SATISH
IPC分类号： A61K31/7042 , A61K31/7052 , A61P31/00 , A61P31/12 , A61P35/00 , C07H7/00 , C12N9/99
摘要： REFERIDA A UN COMPUESTO HETEROCICLICO DE FORMULA (I), DONDE B ES UN ANILLO CARBOCICLICO O HETEROCICLICO DE 5, 6, 7 U 8 ELEMENTOS QUE COMPRENDE UNO O MAS ENLACES DOBLES Y QUE ESTA OPCIONALMENTE SUSTITUIDO CON OXO, Br, CN, ENTRE OTROS; R1 ES H, F, NraRb, ENTRE OTROS; Ra Y Rb SON H, ALQUILO C1-C6, ALQUINILO C2-C10, ENTRE OTROS; R2 ES UN GRUPO NUCLEOSIDO DE AZUCAR TAL COMO RIBOSA, ARABINOSA, 2,3-DESOXIRIBOSA, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: (88e), (93f), ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE POLIMERASAS VIRALES DEL ADN Y EL ARN Y SON UTILES PARA EL TRAMIENTO DE INFECCIONES VIRALES TALES COMO HCV, HIV Y HBV, O PARA EL TRATAMIENTO DEL CANCER

115. 发明专利

CA2315262C SUBSTITUTED CYCLOPENTANE AND CYCLOPENTENE COMPOUNDS USEFUL AS NEURAMINIDASE INHIBITORS 未知
公开(公告)号：CA2315262C
公开(公告)日：2009-11-10
申请号：CA2315262
申请日：1998-12-17
申请人： BIOCRYST PHARM INC
发明人： BABU YARLAGADDA S , CHAND POORAN , MONTGOMERY JOHN A
IPC分类号： C07D261/20 , A61K20060101 , A61K31/195 , A61K31/196 , A61K31/215 , A61K31/27 , A61K31/385 , A61K31/4164 , A61K31/42 , A61K31/423 , A61P31/12 , A61P31/16 , A61P43/00 , C07C20060101 , C07C229/32 , C07C229/48 , C07C233/47 , C07C233/52 , C07C247/14 , C07C271/24 , C07C279/16 , C07C279/24 , C07C309/66 , C07C323/41 , C07C323/43 , C07C323/59 , C07C323/60 , C07D20060101 , C07D233/54 , C07D233/56 , C07D339/08 , C07D521/00
摘要： Compounds represented by the formulae: (see formula I), (see formula II), or (see formula III) wherein U is CH, O, or S; Z is -C(R2)(R3), -CH-N(R2)(R3), C(R3)[(CH2)n R2], CH-C(R3)(R8)(CH2)n R2, C[(CH2)n R2]-[CH(R3)(R8)], C[(R3)][CH[(CH2)n R2](R8)]; R1 is H, (CH2)n OH, (CH2)n NH2, (CH2)n NR10R11, (CH2)n OR11, (CH2)n SR11, o r (CH2)n halogen R9 is (CH2)n CO2H, (CH2)n SO3H, (CH2)n PO3H2, (CH2)n NO2, CH(SCH3)3, esters thereof, or salts thereof; or R1 R9 together represent = O, or (see formula IV) R2 is H, NHC(O)R5, NHC(S)R5, NHSO2R5, C(O)NHR5, SO2NHR5, CH2S(O)R5, or CH2SO2R5 R3 and R8 individually is H, (CH2)n C(O)R10, (CH2)n CO2R10, (CH2)m OR10, CH(OR10)CH(R10)m, C(O)N(R10)m, C(O)N(OR10)R10, (CH2)n N(R10)m, CH(R10)m, (CH2)n(R10)m, , CH2CH(OR10)CH2OR10, CH(OR10)CH(OR10)CH2OR10, CH2OR10, CH(OR10)CH2NHR10, CH2CH(OR10)CH2NHR10, CH(OR10)CH(OR10)CH2NHR10, C(=NR10)N(R10)m, NHR10, NHC(=NR10)N(R10)m, (CH2)m-X-W-Y, CH2CH(X-W- Y)CH2OR10, CH(X-W-Y)CH(OR10)CH2OR10, CH(X-W-Y)CH2(OR10), CH(OR10)CH(X-W-Y)CH2OR10, CH(OR10)CH2(X-W-Y), CH2CH(X-W- Y)CH2NHR10, CH(X-W-Y)CH(OR10)CH2NHR10, CH(X-W-Y)CH2(NHR10), CH(OR10)CH(X-W-Y)CH2NHR10, or CH(NHR10)CH2(X-W-Y); provided that at least one of R2, R3, and R8 is other than H; R4 is H, (CH2)n OH, (CH2)n OR11, (CH2)n OC(O)R11, (CH2)n NHC(NR11)NHR11, (CH2)n NR10R11, (CH2)n NH2, (CH2)n C(=NH)(NH2), (CH2)n NHC(=NR11)NH2, (CH2)n NHC(=NR7)NH2, (CH2)n CN, (CH2)n N3, C(=NH)NH2, C(NR7)NH2, or C(NR11)NH2; R5 is H, lower alkyl, cyclo alkyl, halogen substituted alkyl, aryl, substituted aryl, or CF3; R7 is H, (CH2)n OH, (CH2)n CN, (CH2)n NH2, or (CH2)n NO2; R10 is H, lower alkyl, lower alkylene, branched alkyl, cyclic alkyl, (CH2)n aromatic, (CH2)n substituted aromatic, or when m is 2 both R10 groups can also be interconnected to form an N substituted heterocyclic ring, or other 5 or 6 membered heterocyclic ring; R11 is lower alkyl, branched alkyl, (CH2)m aromatic, SO2R10, C(O)R10, or C(O)OR10; R12 and R13 is H, (CH2)n OH, (CH2)n NH2, (CH2)n NR10R11, (CH2)n OR11, (CH2)n F, (CH2)n OC(O)R11, (CH2)n NHC(O)R11, or X-W-Y; m is 1 or 2; n is 0-4; p is 0 or 1; X is O, S, CH2, or NH; W is a spacer group made up of a chain of 1 to 100 atoms, and optionally als o comprising of substituted carbon and/ or nitrogen atoms and optionally including oxygen or sulphur atoms; and Y is H, OH, SH, NH2, CH=O, CH=CH2, CO2H, CONHNH2, or a protected form of one of these end functionalities; and pharmaceutically aceptable salts thereof and their method of preparation are provided. Compounds of the above formula are influenza virus nueraminidase inhibitors and can be used in treating patients infected with influenza viru s. Also provided are intermediates represented by the formulae:. Another aspect of the present invention relates to intermediates represented by the following formulae: (see formula V) Wherein R4 and R9 are the same as defined above; and (see formula VI) Wherein each R14 individually is H, O, (CH2)n CO2H, (CH2)n SO3H, (CH2)n PO3H , (CH2)n NO2, CH(SCH3)3, (see formula IV) esters thereof or salts thereof, and provided at least one of R14 is H, and R3 and R4 are as defined above.

116. 发明专利

CA2881035A1 METHODS OF TREATING HEMATOLOGIC CANCERS 未知
公开(公告)号：CA2881035A1
公开(公告)日：2009-06-18
申请号：CA2881035
申请日：2008-12-10
申请人： BIOCRYST PHARM INC
发明人： BANTIA SHANTA , BREITFELD PHILIP , BABU YARLAGADDA S
IPC分类号： A61K31/519 , A61K31/4184 , A61P35/00 , A61P35/02
摘要： The present application relates to treatment of hematologic cancers, which treatments can include, e.g., administration of a purine nucleoside phosphorylase (PNP) inhibitor, an alkylating agent and/or an anti-CD20 agent, and related compositions and kits.

117. 发明专利

AU2007215156A1 Intravenous antiviral treatments 未知
公开(公告)号：AU2007215156A1
公开(公告)日：2007-08-23
申请号：AU2007215156
申请日：2007-02-12
申请人： BIOCRYST PHARM INC
发明人： KILPATRICK JOHN MICHAEL , CHAND POORAN , ARNOLD SHANE , BABU YARLAGADDA SUDHAKARA , BANTIA SHANTA
IPC分类号： A61K31/196 , A61P31/16
摘要： The invention provides unit dosage forms, kits, and methods useful for treating viral infections.

118. 发明专利

DE69735634T2 未知
公开(公告)号：DE69735634T2
公开(公告)日：2007-05-03
申请号：DE69735634
申请日：1997-06-13
申请人： BIOCRYST PHARM INC
发明人： BABU S , CHAND POORAN , MONTGOMERY A
IPC分类号： A01N37/12 , C07D295/18 , A01N37/18 , A01N37/52 , A01N47/44 , A61K31/00 , A61K31/04 , A61K31/045 , A61K31/08 , A61K31/155 , A61K31/16 , A61K31/18 , A61K31/19 , A61K31/195 , A61K31/275 , A61K31/395 , A61K31/397 , A61K31/40 , A61K31/445 , A61P31/00 , A61P31/16 , C07C61/04 , C07C61/06 , C07C62/02 , C07C69/757 , C07C233/00 , C07C233/47 , C07C237/22 , C07C279/14 , C07C279/16 , C07C281/00 , C07D205/04 , C07D211/16 , C07D211/70 , C07D295/185
摘要： Compounds represented by formula (I), and pharmaceutically acceptacle salts thereof; and their method of preparation are provided. Compounds of the above formula are influenza virus neuraminidase inhibitors and can be used in treating patients infected with influenza virus.

119. 发明专利

SI0933993T1 SUBSTITUIRANE SESTAVINE CIKLOPENTANA UPORABNE KOTNEURAMINIDAZNI INHIBITORJI 未知
公开(公告)号：SI0933993T1
公开(公告)日：2006-10-31
申请号：SI9730737
申请日：1997-06-13
申请人： BIOCRYST PHARM INC
发明人： BABU YARLAGADDA S , CHAND POORAN , MONTGOMERY JOHN A
IPC分类号： A01N37/00 , C07C61/00 , C07C233/00 , C07C281/00

120. 发明专利

CA2602533A1 HEPATITIS C THERAPIES 未知
公开(公告)号：CA2602533A1
公开(公告)日：2006-10-05
申请号：CA2602533
申请日：2006-03-23
申请人： BIOCRYST PHARM INC
发明人： KOTIAN PRAVIN L , LIN TSU-HSING , KUMAR V SATISH , WU MINWAN , GHOSH AJIT K , EL-KATTAN YAHYA , CHAND POORAN , BABU YARLAGADDA S
IPC分类号： A61K31/7064 , A61P31/12

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