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111. 发明专利

IL272939D0 Vinylheterocycles as rho-associated coiled-coil kinase (rock) inhibitors 未知
公开(公告)号：IL272939D0
公开(公告)日：2020-04-30
申请号：IL27293920
申请日：2020-02-27
申请人： ANGION BIOMEDICA CORP
IPC分类号： C07D20060101
摘要： The present invention provides compounds having formula (I): and pharmaceutically acceptable salts thereof, wherein Cy1, Cy2, Cy3, R, R1, R2, R3, A1 and A2 are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof for the treatment of any of a number of conditions or diseases in which inhibiting ROCK1, ROCK2, or ROCK1/2 has a therapeutically useful role.

112. 发明专利

ES2748873T3 Compuestos antifibróticos y usos de los mismos 未知
公开(公告)号：ES2748873T3
公开(公告)日：2020-03-18
申请号：ES13740566
申请日：2013-01-26
申请人： ANGION BIOMEDICA CORP
发明人： PANICKER BIJOY , MISHRA RAMA , JUNG DAWOON , OEHLEN LAMBERTUS , LIM DONG SUNG
IPC分类号： C07D471/04 , A61K31/437 , A61P9/00 , A61P13/00
摘要： Un compuesto que tiene la estructura de la siguiente Fórmula (II):**Fórmula** o una sal farmacéuticamente aceptable del mismo; en la que R1 es -COOR5; R2 es H; R3 y R4 son independientemente H, arilo seleccionado del grupo que consiste en fenilo; naftilo; tetrahidronaftilo; indanilo; e indenilo, o heteroarilo que tiene de 5 a 10 átomos en el anillo, de los que un átomo del anillo se selecciona entre S, O y N, en los que el arilo o heteroarilo no está sustituido o está sustituido independientemente con uno o más fracciones alquilo C1-6, halógeno, OR6, NO2, CN, NH2, NR6R7, NR6COR7 o NR6SO2R7; R5 es un grupo alquilo que tiene 1-6 átomos de carbono; R6 y R7 son independientemente hidrógeno o alquilo C1-6, cicloalquilo C3-10, heteroarilo que tiene de 5 a 10 átomos en el anillo, de los que un átomo del anillo se selecciona entre S, O y N, cicloalquil C3-10-alquilo C1-6, alquil C1-6-cicloalquil C3-10-alquilo C1-6, o un heterocicloalquilo o heterocicloalquilo de alquilo C1-6, en donde el heterocicloalquilo tiene de 5 a 16 átomos en el anillo, de los que al menos un átomo del anillo se selecciona entre S, O y N, que puede estar opcionalmente sustituido con fracciones alquilo C1-6, OR8, COOR8, NR8R9 o NCOR8; R8 y R9 son independientemente H o un grupo alquilo que tiene 1-6 átomos de carbono; y B es O o S.

113. 发明专利

AU2015301891B2 Cytochrome P450 inhibitors and uses thereof 未知
公开(公告)号：AU2015301891B2
公开(公告)日：2019-12-05
申请号：AU2015301891
申请日：2015-08-11
申请人： ANGION BIOMEDICA CORP
发明人： PANICKER BIJOY
IPC分类号： C07D417/06 , A61K31/428 , A61P1/16 , A61P3/10 , A61P9/10 , A61P9/12 , A61P11/00 , A61P13/12 , A61P17/00 , A61P19/02 , A61P25/28 , A61P35/00 , A61P43/00
摘要： The present invention provides compounds having the general structural formula (I) (I) and pharmaceutically acceptable derivatives thereof, as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof for the treatment of any of a number of conditions or diseases involving fibrosis and proliferation, and where anti-fibrotic or anti-proliferative activity is beneficial.

114. 发明专利

AU2013211888B2 Antifibrotic compounds and uses thereof 未知
公开(公告)号：AU2013211888B2
公开(公告)日：2017-08-31
申请号：AU2013211888
申请日：2013-01-26
申请人： ANGION BIOMEDICA CORP
发明人： PANICKER BIJOY , MISHRA RAMA K , JUNG DAWOON , OEHLEN LAMBERTUS J W M , LIM DONG SUNG
IPC分类号： C07D471/04 , A61K31/437 , A61P9/00 , A61P13/00
摘要： The present invention provides compounds having the general structural formula (I), and pharmaceutically acceptable derivatives thereof, as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof for the treatment of any of a number of conditions or diseases involving abnormal or excessive fibrosis.

115. 发明专利

HUE030700T2 Hepatocita növekedési faktor (scatter faktor) modulátor pirazol-származékok 未知
公开(公告)号：HUE030700T2
公开(公告)日：2017-05-29
申请号：HUE10011181
申请日：2003-12-19
申请人： ANGION BIOMEDICA CORP
发明人： ZEMBOWER DAVID E , EINZHAMER DAVID
IPC分类号： A61K31/4155 , C07D231/12 , C07D401/06 , C07D403/06 , C07D405/06 , C07D405/14 , C07D409/06 , C07D409/14

116. 发明专利

IL250506D0 Cytochrome p450 inhibitors and uses thereof 未知
公开(公告)号：IL250506D0
公开(公告)日：2017-03-30
申请号：IL25050617
申请日：2017-02-08
申请人： ANGION BIOMEDICA CORP
IPC分类号： C07D20060101
摘要： The present invention provides compounds having the general structural formula (I) (I) and pharmaceutically acceptable derivatives thereof, as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof for the treatment of any of a number of conditions or diseases involving fibrosis and proliferation, and where anti-fibrotic or anti-proliferative activity is beneficial.

117. 发明专利

IL210544D0 METHODS AND COMPOSITIONS OF SMALL MOLECULE MODULATORS OF HEPATOCYTE GROWTH FACTOR (SCATTER FACTOR) ACTIVITY 未知
公开(公告)号：IL210544D0
公开(公告)日：2011-03-31
申请号：IL21054411
申请日：2011-01-10
申请人： ANGION BIOMEDICA CORP
IPC分类号： A61K20060101
摘要： The present invention provides compositions and formulations of compounds having formula (I) and pharmaceutically acceptable derivatives thereof, wherein p, R1, R2 and B are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof for the treatment of any of a number of injuries, conditions or diseases in which HGF/SF or the activities thereof, or agonists or antagonists thereof have a therapeutically useful role. In addition, methods are provided for treating such diseases or diseases starting at a time after the onset of the injury, condition or disease.

118. 发明专利

AU2005289560A1 Small molecule modulators of cytokine activity 未知
公开(公告)号：AU2005289560A1
公开(公告)日：2006-04-06
申请号：AU2005289560
申请日：2005-09-28
申请人： ANGION BIOMEDICA CORP
发明人： SINGH JASBIR , ZEMBOWER DAVID E , MISHRA RAMA K
IPC分类号： A61K31/502 , A61P35/00 , C07D237/32 , C07D401/10 , C07D403/10 , C07D403/14

119. 发明专利

AU2020257075B2 Methods and agents for treating disease 未知
公开(公告)号：AU2020257075B2
公开(公告)日：2022-06-16
申请号：AU2020257075
申请日：2020-10-21
申请人： ANGION BIOMEDICA CORP
发明人： PANICKER BIJOY , OEHLEN LAMBERTUS J W M
IPC分类号： C07D213/26 , A61K31/427 , A61K31/4439 , A61P5/40 , A61P9/10 , A61P37/06 , C07D277/64
摘要： The present invention provides compounds having the general structural formula (I) K-NL (I) and pharmaceutically acceptable derivatives thereof, as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof for the treatment of any of a number of conditions or diseases involving elevated levels of aldosterone or abnormal or excessive fibrosis, such as kidney disease and hypertension.

120. 发明专利

SG11202110406SA SOLID FORMS OF (E)-3-[2-(2-THIENYL)VINYL]-1H-PYRAZOLE 未知
公开(公告)号：SG11202110406SA
公开(公告)日：2021-10-28
申请号：SG11202110406S
申请日：2020-04-10
申请人： ANGION BIOMEDICA CORP
发明人： LI AN-HU , SAKILAM SATISH KUMAR , LIM DONG SUNG
IPC分类号： C07D409/02 , C07D231/12 , C07D409/06
摘要： The present disclosure provides solid forms of (E)-3-[2-(2-thienyl)vinyl]-1H-pyrazole, compositions thereof, and methods of making and using the same.

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