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101. 发明专利

GB1475644A SUBSTITUTED AMIDES OF 3-METHYL-4-PHENYL-3-BUTENOIC ACID 未知
公开(公告)号：GB1475644A
公开(公告)日：1977-06-01
申请号：GB2482675
申请日：1975-06-10
申请人： LORENZINI SAS INST BIOCHIM
IPC分类号： A61K31/165 , A61P3/06 , C07C51/60 , C07C67/00 , C07C231/00 , C07C231/02 , C07C233/09 , C07C233/17 , C07D295/185 , G01N1/22 , C07C103/76 , A61K31/535 , C07C103/78 , C07D295/18 , C07C63/60
摘要： 1475644 3 - Methyl - 4 - phenyl - 3 - butenoic acid amides and their pharmaceutical compositions ISTITUTO BIOCHIMICO ITALIANO DI LOREDANA LORENZINI SAS 10 June 1975 [10 June 1974] 24826/75 Heading C2C The invention comprises amides of the general Formula III wherein R is hydrogen, C 1-6 alkyl, C 1-6 hydroxyalkyl or C 1-6 cycloalkyl and R 1 is C 1-6 alkyl, C 1-6 hydroxy alkyl or C 1-6 cycloalkyl or wherein R and R 1 together with the nitrogen atom to which they are attached form a morpholino ring which may be prepared by reaction of the acid chloride or a mixed anhydride of 3-methyl- 4-phenyl-3-butenoic acid with an amine of formula In exemplified compounds the amine is ethanolamine, diethanolamine, diethylamine, morpholine or cyclohexylamine. 3 - Methyl - 4 - phenyl - 3 - butenoylchloride is prepared by reaction of the parent acid with thionyl chloride. Pharmaceutical compositions having hypolipemizing activity comprise one or more compounds of Formula III together with a compatible pharmaceutically acceptable diluent.

102. 发明专利

NO135748C 未知
公开(公告)号：NO135748C
公开(公告)日：1977-05-25
申请号：NO299370
申请日：1970-08-03
申请人： BEECHAM GROUP LTD
发明人： BILLETT E H , MILLER D
IPC分类号： A61K31/19 , C07C29/147 , C07C51/00 , C07C51/38 , C07C57/42 , C07C59/64 , C07C67/00 , C07C63/60

103. 发明专利

ATA24676A 未知
公开(公告)号：ATA24676A
公开(公告)日：1977-05-15
申请号：AT24676
申请日：1976-01-15
申请人： HOFFMANN LA ROCHE
IPC分类号： A61K31/00 , C07C59/64 , C07C69/12 , C07C69/76 , C07D213/30 , C07D295/18 , C07D295/185 , C07C63/60 , C07C103/22

105. 发明专利

AU8378975A CINNAMAMIDES 未知
公开(公告)号：AU8378975A
公开(公告)日：1977-02-10
申请号：AU8378975
申请日：1975-08-08
申请人： WELLCOME FOUND
发明人： GRIVSKY EUGENE MICHAEL
IPC分类号： A61K31/165 , A61K20060101 , A61K31/16 , C07C20060101 , C07C67/00 , C07C69/76 , C07C231/00 , C07C231/02 , C07C233/09 , C07C233/11 , C07C103/58 , C07C103/133 , C07C63/60
摘要： Cinnamamide compounds of the formula where X is chloro, bromo or iodo and R is hydrogen or alkyl of 1 to 3 carbons AS PHARMACEUTICALS WHICH ARE USEFUL IN THE TREATMENT OR PROPHYLAXIS FOR CONVULSIONS.

106. 发明专利

AU8031775A 2-SUBSTITUTED-5-OXO-5H-DIBENZO %A,D<-CYCLOHEPTENES, THE SALTSAND ESTERS THEREOF, HAVING PHARMACEUTICAL ACTIVITY, AND METHODS AND COMPOSITIONS FOR THE USE THEREOF 未知
公开(公告)号：AU8031775A
公开(公告)日：1976-10-21
申请号：AU8031775
申请日：1975-04-18
申请人： SYNTEX INC
发明人： NELSON PETER H , UNTCH KARL G
IPC分类号： C07C69/73 , C07C51/00 , C07C51/41 , C07C59/86 , C07C62/38 , C07C63/331 , C07C63/66 , C07C65/36 , C07C65/38 , C07C67/00 , C07C213/00 , C07C219/10 , C07C63/50 , C07C63/60 , C07C97/10 , C07D49/34 , C07D27/04 , C07D29/24 , C07D51/20 , C07D51/72 , C07D87/36 , A61K27/00
摘要： 2-Substituted-5-oxo-5H-dibenzo[a,d]cycloheptenes represented by the following formula: where R' is hydrogen, alkyl having 1 to 12 carbon atoms, or where n is an integer from 2 to 4, inclusive, and R4 and R5 are independently lower alkyl having 1 to 6 carbon atoms or together R4 and R5 and the nitrogen atom to which they are attached form a heterocyclic ring having 5 or 6 total ring atoms; one of R2 and R3 is hydrogen and the other is hydrogen, methyl, or ethyl, or together R2 and R3 are methylene; and the pharmaceutically acceptable salts thereof. The compounds have anti-inflammatory, analgesic, and antipyretic activities and, accordingly, are useful in the treatment of inflammation, pain and/or pyrexia.

107. 发明专利

FR2285864A1 未知
公开(公告)号：FR2285864A1
公开(公告)日：1976-04-23
申请号：FR7529226
申请日：1975-09-24
申请人： HOFFMANN LA ROCHE
发明人： BOLLAG WERNER , RUEGG RUDOLF , RYSER GOTTLIEB
IPC分类号： C07C215/68 , A61K31/20 , A61K31/215 , A61P17/00 , A61P29/00 , A61P35/00 , A61P37/08 , C07C11/21 , C07C17/23 , C07C27/00 , C07C37/045 , C07C45/00 , C07C45/51 , C07C59/64 , C07C67/00 , C07C205/12 , C07C205/22 , C07C205/37 , C07C217/76 , C07C217/84 , C07C219/32 , C07C223/06 , C07C229/44 , C07C233/11 , C07C235/32 , C07C237/20 , C07F9/54 , C07F9/547 , A61K31/00 , C07C33/06 , C07C47/48 , C07C63/60

108. 发明专利

FR2218881B1 未知
公开(公告)号：FR2218881B1
公开(公告)日：1976-03-05
申请号：FR7306273
申请日：1973-02-22
申请人： UNICLER FR
IPC分类号： C07C69/76 , A61K27/00 , C07C63/60

109. 发明专利

DE2531456A1 未知
公开(公告)号：DE2531456A1
公开(公告)日：1976-02-05
申请号：DE2531456
申请日：1975-07-14
申请人： TAISHO PHARMA CO LTD
发明人： AMANO TAKEHIRO , SEKI TERUYA , SASAJIMA MICHITADA
IPC分类号： A61K31/185 , A61K31/19 , C07C45/68 , C07C49/796 , C07C49/813 , C07C51/00 , C07C51/08 , C07C57/42 , C07C57/60 , C07C59/64 , C07C67/00 , C07C69/618 , C07C69/76 , C07D295/194 , C07C63/60

110. 发明专利

GB1422181A SUBSTITUTED PHENYL DERIVATIVES 未知
公开(公告)号：GB1422181A
公开(公告)日：1976-01-21
申请号：GB2221373
申请日：1973-05-09
申请人： CIBA GEIGY AG
IPC分类号： C07C69/734 , A01N33/06 , A01N37/10 , A01N37/18 , A01N37/34 , A01N37/36 , A01N37/44 , A01N39/02 , A01N49/00 , C07C45/51 , C07C49/255 , C07C51/00 , C07C59/58 , C07C59/60 , C07C59/68 , C07C67/00 , C07C69/712 , C07C69/736 , C07C69/738 , C07C213/00 , C07C217/84 , C07C229/30 , C07C233/02 , C07C233/16 , C07C233/46 , C07C235/28 , C07C235/34 , C07C237/16 , C07C253/00 , C07C255/15 , C07C255/30 , C07C255/34 , C07D295/08 , C07D295/185 , C07C69/76 , C07C43/20 , C07C49/84 , C07C63/60 , C07C69/95 , C07C101/453 , C07C103/46 , C07C103/76 , C07C121/70 , C07D295/18
摘要： 1422181 Aromatic derivatives of but-2- enoic acid CIBA-GEIGY AG 9 May 1973 [10 May 1972 29 Sept 1972 29 March 1973] 22213/73 Heading C2C The invention comprises a compound of Formula I wherein R 1 represents a cyclohexyl or cyclohexyloxy group or a group of Formula Ia in which n represents 0 or 1, Y represents an oxygen atom or a group of formula and R 6 represents a hydrogen or halogen atom or a C 1-5 alkyl or alkoxy group and R 7 represents a C 1-3 alkyl, formyl or acetyl group; R 2 represents a hydrogen or halogen atom, CH 3 or C 2 H 5 ; R 3 represents H, CH 3 or C 2 H 5 ; R 4 represents a hydrogen atom or a C 1-3 alkyl group; R 5 represents a carboxyl, (C 1-5 alkoxy)carbonyl, unsubstituted or halosubstituted (C 3-5 alkenyloxy)carbonyl, (C 3-5 alkynyloxy)carbonyl, cyclohexyloxycarbonyl, phenoxycarbonyl or cyano group or a group of Formula Ib in which R 8 represents a hydrogen atom or a C 1-5 alkyl, C 3-5 alkenyl, or C 3-5 alkynyl group and R 9 represents a C 1-5 alkyl, C 3-5 alkenyl or C 3-5 alkynyl group or R 8 and R 9 together with their attached nitrogen represent a saturated heterocyclic group having 5 or 6 ring atoms which atoms may comprise an oxygen, sulphur or further nitrogen atom; Z represents -O-, -NH-, -NR 7 - or -CH(R 10 )O- the latter being carbon linked to the phenyl nucleus and R 10 being H or C 1-3 alkyl. The compounds of Formula I may be prepared by reacting (a) a compound of Formula II in the presence of a base with a compound of Formula III (III) X-CHR 3 -CR 4 = CH-R 5 in which R 1 to R 5 and z are as defined above and x-halogen, (b) a compound of Formula V with a compound of Formula VIII R 1 to R 5 and z being as defined above, R 11 represents a C 1-5 alkyl, phenyl or p-chlorophenyl group and Me represents an alkali or alkaline earth metal of valency n, (c) a compound of Formula IX (i) in the presence of an acid catalyst with a compound of formula R 12 OH or (ii) in the presence of a base with a compound of formula R 12 X wherein R 12 represents a C 1-5 alkyl, C 3 to C 5 alkenyl, C 3 to C 5 alkynyl or cyclohexyl group and X is halogen to obtain compounds of Formula I in which R 1 to R 4 and z are as defined above and R 5 represents a (C 1-5 alkoxy)carbonyl, (C 3-5 alkenyloxy)carbonyl, (C 3-5 alkynyloxy)- carbonyl or cyclohexyloxycarbonyl groups or (d) a compound of Formula I in which Y and/or Z represents -NH- with an alkylating or acylating agent to obtain compounds of Formula I in which Y and/or Z represents -NR 7 - R 7 being as defined above other than hydrogen. 1 - [4 - Benzylphenoxy]propan - 2 - one, 1 - [4 - phenoxyphenoxy] - propan - 2 - one, 1 - [4 - benzoylphenoxy]propan - 2 - one and 2 - [4 - phenoxyphenoxy] - butan - 3 - one are prepared by hydrolysis of their dimethyl ketals. 1 - [4 - Benzylphenoxy] - propan - 2 - ondimethylketal is prepared by reacting 4- benzylpropargyloxybenzene with a mixture of HgO, CCl 3 CO 2 H, BF 3 .(C 2 H 5 ) 2 O and CH 3 OH. Pesticidal compositions comprise a compound of Formula I together with a solid extender, a solid extender and a surface active agent or a liquid diluent and a surface active agent.

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