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101. 发明授权

EP0226266B1 Use of a tetrahydrocarbazolone derivative for the manufacture of medicaments 失效
标题翻译：四氢咔唑酮衍生物用于制造药物的用途
公开(公告)号：EP0226266B1
公开(公告)日：1996-02-28
申请号：EP86304831.0
申请日：1986-06-24
申请人： GLAXO GROUP LIMITED
发明人： Tyers, Michael Brian c/o Glaxo Research Limited , Coates, Ian Harold , Humber, David Cedric , Ewan, George Blanch , Bell, James Angus
IPC分类号： A61K31/415
CPC分类号： A61K31/415 , Y10S514/872 , Y10S514/917 , Y10S514/922 , A61K31/34 , A61K2300/00

102. 发明公开

EP0683669A1 METHODS AND COMPOSITIONS OF A POLYMER (POLOXAMER) FOR CELL REPAIR 失效
标题翻译：方法和组合物的基于聚合物（泊洛沙姆）细胞再生。
公开(公告)号：EP0683669A1
公开(公告)日：1995-11-29
申请号：EP93905944.0
申请日：1993-02-12
申请人： ARCH DEVELOPMENT CORPORATION
发明人： LEE, Raphael C.
IPC分类号： A61K31 , A61P39
CPC分类号： A61K31/785 , A61K31/77 , Y10S424/13 , Y10S514/917 , Y10S514/975 , A61K31/70 , A61K31/685 , A61K2300/00
摘要： Novel methods for prophylaxis and treatment of tissue damage resulting from cell membrane permeabilization are disclosed. Compositions comprising a surface active copolymer are employed to prevent permeabilization or to promote membrane repair. Methods for enhancement of cell survival following membrane permeabilization in vitro are also disclosed, along with methods for increasing the efficacy of transfection of cells with foreign exogenous macromolecules, in particular DNA, also involving treatment of permeabilized cells with a surface active copolymer. Also disclosed are novel methods for prophylaxis and treatment of tissue damage, and for enhancement of cell survival and transfection efficacy, using a surface active copolymer in combination with high energy phosphate compounds which are capable of recharging cellular energy stores and thereby potentiating cell repair and survival. Compositions comprising surface active copolymers for intravenous, intramuscular, and topical use are also disclosed, along with novel compositions comprising a combination of a surface active copolymer and a high energy phosphate compound.

103. 发明公开

EP0633767A4 METHOD AND COMPOSITIONS FOR ENHANCING WHITE BLOOD CELL FUNCTIONING ON A MUCOSAL OR CUTANEOUS SURFACE. 失效
标题翻译：方法和组合物改善白血球的功能。在黏膜或皮肤表面。
公开(公告)号：EP0633767A4
公开(公告)日：1995-06-07
申请号：EP93908579
申请日：1993-03-25
申请人： CYTOLOGICS INC
发明人： RUDY MICHAEL A
IPC分类号： A61K9/00 , A61K33/14 , A61K45/08 , A61K9/08 , A61K9/10 , A61K31/70 , A61K31/715 , A61K33/00 , A61K33/06 , A61K33/10
CPC分类号： A61K33/14 , Y10S514/866 , Y10S514/885 , Y10S514/887 , Y10S514/917 , Y10S514/921 , Y10S514/925 , Y10S514/926 , Y10S514/927 , Y10S514/928 , Y10S514/931 , Y10S514/932 , Y10S514/933 , Y10S514/934 , A61K33/06 , A61K33/00 , A61K31/715 , A61K31/19 , A61K2300/00

104. 发明授权

EP0425821B1 The use of human ADF (=Adult T-cell leukemia-derived factor) for producing a medicament 失效
标题翻译：使用人类ADF（=成人T细胞白血病衍生因子）用于药物制剂。
公开(公告)号：EP0425821B1
公开(公告)日：1994-08-10
申请号：EP90118695.7
申请日：1990-09-28
申请人： AJINOMOTO CO., INC. , Yodoi, Junji
发明人： Yodoi, Junji , Uchida, Atsushi , Tagaya, Yutaka, Rokko Takaha Urban Life 107 , Mitsui, Akira, c/o Central Research Laboratories , Hirakawa, Tadashi, c/o Central Research Lab.
IPC分类号： C07K13/00 , A61K37/02
CPC分类号： C12N9/0036 , A61K38/00 , C12Y108/01008 , Y02A50/473 , Y10S514/824 , Y10S514/886 , Y10S514/917
摘要： Human adult T cell leukemia-derived factor (human ADF) is used for producing a radioprotective composition, an antiinflammatory composition, a composition for the treatment of rheumatism, a composition for the treatment of autoimmune diseases, a composition for the treatment of ischemic damage of organs, a composition for the treatment of drug toxicity, and a composition for the treatment of arteriosclerosis.

105. 发明授权

EP0417238B1 SILICON-CONTAINING ENVIRONMENT-PROTECTIVE AGENT ADSORBING RADIOACTIVE METAL ISOTOPES AND TOXIC HEAVY METALS AND A PHARMACEUTICAL COMPOSITION CONTAINING SAME 失效
标题翻译：含有环境保护剂的放射性金属同位素和毒性重金属和含有其的药物组合物
公开(公告)号：EP0417238B1
公开(公告)日：1993-08-11
申请号：EP90904923.1
申请日：1990-03-21
申请人： Agromen Agrármenedzseri Részvénytársaság , ORSZAGOS "FREDERIC JOLIOT-CURIE" SUGARBIOLOGIA ES SUGAREGESZSEGUGYI KUTATO INTEZET , MAGYAR KÜLKERESKEDELMI BANK RT.
发明人： VARGA, László , Töröcsik, Mihály , SZTANYIK, Bálint, László , Juhasz, Imre L.
IPC分类号： B09B3/00 , G21F9/00 , A61K33/06 , B01J20/12
CPC分类号： G21F9/12 , A61K33/06 , B01J39/14 , B09B3/0008 , B09C1/08 , Y10S514/917 , Y10S514/951
摘要： The invention relates to an environment-protective agent consisting of silicon-containing minerals for adsorbing radioactive metal isotopes and toxic heavy metals, which comprises as silicon-containing minerals with a particle size of 0.001 to 0.5 mm, a natural diatomaceous earth and at least two natural zeolite minerals of the general formula: MxO.Al2O3.YSiO2.ZH2O, wherein M stands for sodium, potassium or calcium; x is a number between 1 and 2 inclusive of both extreme values; Y is 3 or 10; and Z is 6 or 7 treated by dilute acid, washed to neutral, dried to a constant weight at a temperature up to 115°C and then heat-treated at 150 to 350°C, preferably at 250°C, where the amount of each mineral ingredient independently of each other is at least 0.1 % by weight up to 99.8 % by weight calculated to the total weight of the agent. The invention further relates to pharmaceutical compositions and animal foods containing the above agent according to the invention as active ingredient.

106. 发明公开

EP0425821A1 The use of human ADF (=Adult T-cell leukemia-derived factor) for producing a medicament 失效
标题翻译： Verwendung von Human-ADF（= Adult T-cell leukemia-derived factor）zur Herstellung von Medikamenten。
公开(公告)号：EP0425821A1
公开(公告)日：1991-05-08
申请号：EP90118695.7
申请日：1990-09-28
申请人： AJINOMOTO CO., INC. , Yodoi, Junji
发明人： Yodoi, Junji , Uchida, Atsushi , Tagaya, Yutaka, Rokko Takaha Urban Life 107 , Mitsui, Akira, c/o Central Research Laboratories , Hirakawa, Tadashi, c/o Central Research Lab.
IPC分类号： C07K13/00 , A61K37/02
CPC分类号： C12N9/0036 , A61K38/00 , C12Y108/01008 , Y02A50/473 , Y10S514/824 , Y10S514/886 , Y10S514/917
摘要： Human adult T cell leukemia-derived factor (human ADF) is used for producing a radioprotective composition, an antiinflammatory composition, a composition for the treatment of rheumatism, a composition for the treatment of autoimmune diseases, a composition for the treatment of ischemic damage of organs, a composition for the treatment of drug toxicity, and a composition for the treatment of arteriosclerosis.
摘要翻译：人成人T细胞白血病衍生因子（人ADF）用于制备放射防护组合物，抗炎组合物，治疗风湿病的组合物，治疗自身免疫性疾病的组合物，治疗缺血性损伤的组合物器官，用于治疗药物毒性的组合物和用于治疗动脉硬化的组合物。

107. 发明公开

EP0152945A3 Pharmaceutical multicomponent systems and process for their preparation 失效
标题翻译：药物多药体系及其制备方法
公开(公告)号：EP0152945A3
公开(公告)日：1987-05-20
申请号：EP85101809
申请日：1985-02-20
申请人： Müller, Bernd Willy Werner, Prof. Dr.
发明人： Müller, Bernd Willy Werner, Prof.Dr. , Franzky, Hans-Jürgen , Kölln, Claus-Jürgen
IPC分类号： A61K09/10
CPC分类号： A61K9/0014 , A61K9/1075 , A61K47/14 , Y10S514/917 , Y10S514/938 , Y10S514/941 , Y10S514/942 , Y10S514/943 , Y10S514/962 , Y10S514/966

108. 发明公开

KR1020130012417A 감태 추출물 유래의 후코이단을 함유하는 방사선 방호능을 가진 면역증강용 조성물 无效
标题翻译：具有包含来自ECKLONIA CAVA提取物的FUCOIDANE的放射性保护作用的免疫增强组合物
公开(公告)号：KR1020130012417A
公开(公告)日：2013-02-04
申请号：KR1020110073612
申请日：2011-07-25
申请人： 아쿠아그린텍(주) , 제주대학교 산학협력단
发明人： 전유진 , 지영흔 , 제종선 , 장지태 , 안긴내
IPC分类号： A61K31/737 , A61K36/03 , A61P37/00
CPC分类号： A61K31/737 , A61K36/03 , A61K2121/00 , Y10S514/885 , Y10S514/917
摘要： PURPOSE: A composition containing Ecklonia cava-derived fucoidan for enhancing immunity is provided to ensure a radiation protecting ability and to be used as a material for enhancing immunity. CONSTITUTION: A composition with a radiation protecting ability contains Ecklonia cava extract-derived fucoidan. The fucoidan is prepared by extracting pulverized Ecklonia cava by enzyme extraction using saccharolytic enzyme, protease, or a mixture thereof. The saccharolytic enzyme includes celluclast, AMG, viscozyme, or a mixture thereof. The protease is alkalase, neutrase, flavourzyme, protamex, or a mixture thereof. The fucoidan is prepared by treating a fucoidan crude extract with potassium chloride and removing alginic acid. The fucoidan contains 45-55 wt% of polysaccharides and 15-20 wt% of a sulfate group. [Reference numerals] (AA) Ecklonia cava; (BB,JJ) Freeze-drying; (CC) Adding enzyme and reacting for 24 hours; (DD) Enzyme extract; (EE) Forming fractions using a membrane separator; (FF) Fractions by molecular weight; (GG) Separating fucoidan crude extract after removing low molecular products and pigment using ethanol; (HH) Removing alginic acid using calcium chloride; (II) Refining fucoidan without the alginic acid; (KK) Investigating characteristic
摘要翻译：目的：提供含有Ecklonia cava来源的岩藻依聚糖用于增强免疫力的组合物，以确保辐射防护能力，并用作增强免疫力的材料。构成：具有辐射防护能力的组合物含有Ecklonia cava提取物衍生的岩藻依聚糖。岩藻依聚糖通过使用蔗糖分解酶，蛋白酶或其混合物的酶提取提取粉碎的埃克氏杆菌来制备。蔗糖酶包括celluclast，AMG，粘蛋白酶或其混合物。蛋白酶是碱性酶，中性酶，flavourzyme，protamex或它们的混合物。通过用氯化钾处理岩藻依聚糖粗提物并除去海藻酸制备岩藻依聚糖。岩藻依聚糖含有45-55wt％的多糖和15-20wt％的硫酸根。（AA）Ecklonia cava; （BB，JJ）冷冻干燥; （CC）加酶并反应24小时; （DD）酶提取物; （EE）使用膜分离器形成级分; （FF）分子量分数; （GG）使用乙醇除去低分子产物和颜料后分离岩藻依聚糖粗提物; （HH）使用氯化钙去除海藻酸; （II）不含藻酸的精制岩藻多糖; （KK）调查特征

109. 发明公开

KR20100092616A Pharmaceutical composition for the prevention and treatment of disease caused oxidative stress containing hesperidin or pharmaceutically acceptable salt thereof as an active ingredient 审中-公开
标题翻译：用于预防和治疗含有依他汀或其药物可接受的盐的疾病引起的氧化应激作为活性成分的药物组合物
公开(公告)号：KR20100092616A
公开(公告)日：2010-08-23
申请号：KR20090011822
申请日：2009-02-13
申请人： KOREA ATOMIC ENERGY RES
发明人： PARK SANG HYUN , KO KYONG CHEOL , PRADEEP KANNAMPALLI
IPC分类号： A61K31/7048 , A61P39/06
CPC分类号： A61K31/7048 , A23L2/52 , A23L29/035 , Y10S514/811 , Y10S514/824 , Y10S514/825 , Y10S514/866 , Y10S514/894 , Y10S514/912 , Y10S514/917
摘要： PURPOSE: A pharmaceutical composition containing hesperidin is provided to prevent and treat disease caused by oxidative stress induced by radiation exposure. CONSTITUTION: A pharmaceutical composition for preventing and treating diseases caused by oxidative stress contains hesperidin of chemical formula 1 and pharmaceutically acceptable salt thereof as an active ingredient. The radiation is X ray, alpha ray, beta ray, or gamma ray. The cell is cardiac cell or renal cell. The composition recovers activation of blood serum marker enzyme. The marker enzyme is aspartate transaminase(AST), alanine transaminase(ALT), alkaline phosphatase(ALP), or lactate dehydrogenase(LDH).
摘要翻译：目的：提供含有橙皮苷的药物组合物，用于预防和治疗由辐射暴露引起的氧化应激引起的疾病。构成：用于预防和治疗由氧化应激引起的疾病的药物组合物含有化学式1的橙皮苷及其药学上可接受的盐作为活性成分。辐射是X射线，α射线，β射线或γ射线。细胞是心脏细胞或肾细胞。该组合物恢复血清标记酶的活化。标记酶是天冬氨酸转氨酶（AST），丙氨酸转氨酶（ALT），碱性磷酸酶（ALP）或乳酸脱氢酶（LDH）。

110. 发明授权

KR100245482B1 활성 산소 소거제 失效
标题翻译：活性氧气扫描仪
公开(公告)号：KR100245482B1
公开(公告)日：2000-03-02
申请号：KR1019920025653
申请日：1992-12-26
申请人： 소고 세이야꾸 가부시끼가이샤
发明人： 가즈마따마나부 , 가우찌게이꼬 , 다시로도모야스 , 우찌꾸가사부로
IPC分类号： A61K31/185
CPC分类号： A61K31/195 , A61K8/466 , A61K31/185 , A61Q17/04 , Y10S514/86 , Y10S514/886 , Y10S514/917
摘要： 본 발명은 활성 성분이 하기 화학식 1로 나타내어지는 화합물이고, 유해한 자외선으로 인한 광독성 및 산소 독성으로 부터의 안정하고 효과적인 보호제로서 유용한 활성 산소 소거제, 피부용 제제 또는 활성 산소 및 자유 라디칼에 의해 야기된 질환에 대한 억제제 및/또는 치료제에 관한 것이다.

(상기에서, R
1 및 R
2 는 동일 또는 상이할 수 있으며, 각각 수소 원자, 탄소수 1-22의 포화 또는 불포화 직쇄 또는 촉쇄 알킬기, 아실기 또는 아미디노기를 나타내고; R
3 은 수소원자 또는 -COOR
4 (여기에서, R
4 는 수소 원자, 탄소수 1-22의 포화 또는 불포화 직쇄 또는 측쇄 알킬기 또는 알칼리 금속 또는 알칼리 토금속을 나타낸다)를 나타내며; n은 0 또는 1을 나타낸다).

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