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101. 发明申请

US20100322872A1 NOVEL METHODS AND MEDICAMENT FOR TREATING INFECTIOUS DISEASES INVOLVING MICROBIAL BIOFILMS 审中-公开
标题翻译：治疗涉及微生物生物膜的感染性疾病的新方法和药物
公开(公告)号：US20100322872A1
公开(公告)日：2010-12-23
申请号：US12849288
申请日：2010-08-03
申请人： Jean-Paul Perraudin
发明人： Jean-Paul Perraudin
IPC分类号： A61K8/64 , A61K38/00 , A61K38/47 , A61K39/395 , A61K38/18 , A61K38/40 , A61K38/44 , A61K38/22 , A61K38/46 , A61P1/02 , A61P31/04 , A61P31/12 , A61P33/02 , A61P33/00
CPC分类号： A61K38/443 , A61K38/1808 , A61K38/1825 , A61K38/1841 , A61K38/1858 , A61K38/1891 , A61K38/40 , A61K38/44 , A61K38/47 , A61K39/395 , C12Y101/03004 , C12Y111/01007 , C12Y302/01017 , A61K2300/00
摘要： The present invention provides a method for prophylaxis and therapy of infectious diseases caused by microorganisms present in biofilms adherent to cell surfaces comprising the step of administering to an individual in need thereof a composition comprising a combination of at least one compound chosen from the group of peroxidase, lactoferrin, lactoferrin peptides, lysozyme and immunoglobulins and at least one growth factor.
摘要翻译：本发明提供了一种用于预防和治疗由存在于细胞表面附着的生物膜中的微生物引起的感染性疾病的方法，包括向有需要的个体施用包含至少一种选自过氧化物酶，乳铁蛋白，乳铁蛋白肽，溶菌酶和免疫球蛋白以及至少一种生长因子。

102. 发明申请

US20070116698A1 Novel methods and medicament for treating infectious diseases involving microbial biofilms 审中-公开
标题翻译：用于治疗涉及微生物生物膜的传染病的新方法和药物
公开(公告)号：US20070116698A1
公开(公告)日：2007-05-24
申请号：US11480676
申请日：2006-07-03
申请人： Jean-Paul Perraudin
发明人： Jean-Paul Perraudin
IPC分类号： A61K39/40 , A61K38/47 , A61K38/40 , A61K38/18 , A61K35/20 , A61K31/44 , A61K33/00
CPC分类号： A61K38/443 , A61K38/1808 , A61K38/1825 , A61K38/1841 , A61K38/1858 , A61K38/1891 , A61K38/40 , A61K38/44 , A61K38/47 , A61K39/395 , C12Y101/03004 , C12Y111/01007 , C12Y302/01017 , A61K2300/00
摘要： The present invention provides a method for prophylaxis and therapy of infectious diseases caused by microorganisms present in biofilms adherent to cell surfaces comprising the step of administering to an individual in need thereof a composition comprising a combination of at least one compound chosen from the group of peroxidase, lactoferrin, lactoferrin peptides, lysozyme and immunoglobulins and at least one growth factor.
摘要翻译：本发明提供了一种预防和治疗由存在于细胞表面附着的生物膜中的微生物引起的感染性疾病的方法，其包括向有需要的个体施用包含至少一种选自过氧化物酶，乳铁蛋白，乳铁蛋白肽，溶菌酶和免疫球蛋白以及至少一种生长因子。

103. 发明授权

US06998267B1 Method for manufacturing glycoproteins having human-type glycosylation 有权
标题翻译：制备具有人型糖基化的糖蛋白的方法
公开(公告)号：US06998267B1
公开(公告)日：2006-02-14
申请号：US09857651
申请日：1999-12-08
申请人： Tatsuji Seki , Kazuhito Fujiyama
发明人： Tatsuji Seki , Kazuhito Fujiyama
IPC分类号： A01H1/00 , A01H5/00 , C12N15/82
CPC分类号： C12N9/0065 , C12N9/1051 , C12N15/8242 , C12N15/8245 , C12N15/8257 , C12P21/005 , C12Y111/01007 , C12Y204/01038
摘要： The present invention provides a method for manufacturing a glycoprotein having a mammalian-type or human-type sugar chain comprising a step in which a transformed plant cell is obtained by introducing to a plant cell a gene encoding a glycosyltransferase enzyme and a gene encoding an exogenous glycoprotein, and a step in which the obtained transformed plant cell is cultivated.
摘要翻译：本发明提供一种具有哺乳动物型或人型糖链的糖蛋白的制造方法，其特征在于，包括通过向植物细胞导入编码糖基转移酶的基因和编码外源基因的基因而获得转化的植物细胞的步骤糖蛋白，以及培养获得的转化植物细胞的步骤。

104. 发明申请

US20050238635A1 Use of hyrogen peroxide producting enzyme for treatment of otitis media 审中-公开
标题翻译：使用过氧化氢产生酶治疗中耳炎
公开(公告)号：US20050238635A1
公开(公告)日：2005-10-27
申请号：US10508590
申请日：2003-03-06
申请人： Krister Tano
发明人： Krister Tano
IPC分类号： A61K9/00 , A61K33/40 , A61K38/44 , A61K38/47 , A61P31/04
CPC分类号： A61K33/40 , A61K9/0043 , A61K38/44 , A61K38/443 , A61K38/47 , C12Y101/03004 , C12Y111/01001 , C12Y111/01007 , C12Y302/01 , A61K2300/00
摘要： The present invention relates to the use of hydrogen peroxide producing enzyme for manufacturing of a medicament for treatment and/or prevention of otitis media (inflammation in the middle ear), preferably in children. This enzyme is preferably NADH oxidase. The medicament is intended to be administered with lactoperoxidase into the nasal cavity.
摘要翻译：本发明涉及过氧化氢生产酶在制备用于治疗和/或预防中耳炎（中耳炎），优选儿童的药物中的用途。该酶优选为NADH氧化酶。药物旨在与乳过氧化物酶一起施用于鼻腔。

105. 发明申请

US20050203166A1 Indole-3-acetic acid derivatives 审中-公开
标题翻译：吲哚-3-乙酸衍生物
公开(公告)号：US20050203166A1
公开(公告)日：2005-09-15
申请号：US11124132
申请日：2005-05-09
申请人： Peter Wardman , Lisa Folkes , Gabriele Dachs , Sharon Rossiter , Olga Greco
发明人： Peter Wardman , Lisa Folkes , Gabriele Dachs , Sharon Rossiter , Olga Greco
IPC分类号： A61K31/405 , A61K38/44 , A61K47/48
CPC分类号： B82Y5/00 , A61K31/405 , A61K38/44 , A61K47/6899 , C12Y111/01007 , A61K2300/00
摘要： Compounds of formula (I), or physiologically functional derivatives thereof, wherein: R1, R2, R3 and R′3 are independently selected from H or lower alkyl; and R4, R5, R6 and R7 are independently selected from H, electron withdrawing groups (such as F, Cl, Br, I, OCF3, carboxyl groups, acetal groups, electron deficient aryl groups), lower alkyl groups, lower alkoxy groups, aryl groups or aryloxy groups, wherein at least one of R4, R5, R6 and R7 is selected from an electron withdrawing group, may be used in methods of therapy, particular in treating neoplastic diseases in methods of GDEPT, ADPET, PDEPT and PDT.
摘要翻译：式（I）化合物或其生理功能衍生物，其中：R 1，R 2，R 3和R' 3个独立地选自H或低级烷基; 和R 4，R 5，R 6和R 7均独立地选自H，吸电子基团（例如F，Cl，Br，I，OCF 3，羧基，缩醛基，缺电子基团），低级烷基，低级烷氧基，芳基或芳氧基，其中至少一个 R 4，R 5，R 6和R 7选自吸电子基团，可以是用于治疗方法，特别是在GDEPT，ADPET，PDEPT和PDT方法中治疗肿瘤疾病。

106. 发明授权

US06866869B2 Liquid antimicrobial compositions 失效
标题翻译：液体抗菌组合物
公开(公告)号：US06866869B2
公开(公告)日：2005-03-15
申请号：US10250566
申请日：2002-01-04
申请人： Walter Graham Guthrie , Mohammed Shoaib Qureshi , Lawrence Alan Staniforth , Darren Michael Hodgkinson , David Wilson Ashworth
发明人： Walter Graham Guthrie , Mohammed Shoaib Qureshi , Lawrence Alan Staniforth , Darren Michael Hodgkinson , David Wilson Ashworth
IPC分类号： A61K8/30 , A01N25/02 , A01N47/48 , A01N59/12 , A01N59/24 , A61K8/20 , A61K8/22 , A61K8/66 , A61K8/96 , A61K31/095 , A61K33/18 , A61K33/40 , A61K38/44 , A61K45/06 , A61L2/00 , A61L2/18 , A61K33/00
CPC分类号： A61L2/18 , A01N59/24 , A61K31/095 , A61K33/18 , A61K33/40 , A61K38/44 , A61K45/06 , A61L2/0088 , C12Y111/01007 , A01N61/00 , A01N59/12 , A01N37/46 , A01N2300/00 , A61K2300/00
摘要： A liquid antimicrobial composition comprises: (1) a mixture of iodide anions and thiocyanate anions; (2) periodic acid or an alkali metal salt thereof; and (3) optionally, a peroxidase. The composition may be used as a microbicide, disinfectant or for suppressing or killing viruses or spores.
摘要翻译：液体抗微生物组合物包括：（1）碘阴离子和硫氰酸根阴离子的混合物;（2）高碘酸或其碱金属盐; 和（3）任选的过氧化物酶。组合物可以用作杀微生物剂，消毒剂或用于抑制或杀死病毒或孢子。

107. 发明申请

US20040009285A1 Stable oil in water emulsion 失效
标题翻译：稳定的水包油乳液
公开(公告)号：US20040009285A1
公开(公告)日：2004-01-15
申请号：US10457789
申请日：2003-06-10
申请人： UNILEVER PATENT HOLDING
发明人： Willem Antheunisse , Elisabeth Cornelia Bouwens , Yvonne Evelien Bruggeman
IPC分类号： A23D007/00
CPC分类号： C12Y110/03002 , A23C9/154 , A23D7/001 , A23D7/003 , A23D7/011 , A23D7/013 , A23D7/015 , A23L27/60 , A23L29/231 , C12Y111/01007
摘要： The invention relates to a method of preparing stable oil in water emulsions wherein a ferulyolated compound is at least partly oxidized during or after formation of the oil in water emulsion.
摘要翻译：本发明涉及一种制备稳定的水包油乳液的方法，其中在水包油乳液中形成期间或之后，至少部分氧化铁化合物。

108. 发明授权

US06174549B1 Gel products from plant matter 失效
标题翻译：植物物质的凝胶产品
公开(公告)号：US06174549B1
公开(公告)日：2001-01-16
申请号：US09411888
申请日：1999-10-04
申请人： Roderick Greenshields , Artis L. Rees
发明人： Roderick Greenshields , Artis L. Rees
IPC分类号： A01K916
CPC分类号： C08B37/006 , A23L7/115 , A23L29/262 , A61L15/28 , A61L15/40 , A61L26/0023 , A61L26/0057 , C08B37/0057 , C12Y111/01007 , C08L5/14
摘要： Gels are produced from an aqueous soluble hemicellulosic starting medium which is free of glucans and obtainable from testaceous plant material. The starting medium is extracted with a non-acidic reagent and reacted with an oxidizing system comprising a peroxide, together with an oxygenase. The gel material is substantially free of glucans and pectins, and comprises a polysaccharide network comprising a matrix of polysaccharide chain segments with a multiplicity of cross-linking ferulate bridges at regularly spaced intervals along the cross-linked chain segments.
摘要翻译：凝胶由不含葡聚糖的水溶性半纤维素起始培养基产生并可从试验植物材料获得。起始培养基用非酸性试剂萃取并与包含过氧化物的氧化体系一起加氧酶。凝胶材料基本上不含葡聚糖和果胶，并且包含多糖网络，其包含多糖链段的基质，沿着交联链段以规则间隔的间隔形成多个交联的阿魏酸桥。

109. 发明授权

US5888505A Method for selectively inhibiting the growth of microbes using a haloperoxidase-halide-peroxide system 失效
标题翻译：使用卤代过氧化物酶 - 卤化物 - 过氧化物体系选择性抑制微生物生长的方法
公开(公告)号：US5888505A
公开(公告)日：1999-03-30
申请号：US480357
申请日：1995-06-07
申请人： Robert Charles Allen
发明人： Robert Charles Allen
IPC分类号： A01N63/00 , A61K38/44 , A61L12/08 , A61L12/12 , A61L15/38 , A61L15/46 , A61P31/00 , C07G17/00 , C12N9/08
CPC分类号： A61L15/46 , A01N63/00 , A61K33/00 , A61K33/20 , A61K33/40 , A61K38/44 , A61L12/082 , A61L12/126 , A61L15/38 , C12Y111/01007 , C12Y111/02002
摘要： Haloperoxidases are used to selectively bind to and, in the presence of peroxide and halide, inhibit the growth of target microbes without eliminating desirable microbes or significantly damaging other components, such as host cells, in the environment of the target microbe. When a target microbe, e.g., a pathogenic microbe, has a binding capacity for haloperoxidase greater than that of a desired microbe, e.g., members of the normal flora, the target microbe selectively binds the haloperoxidase with little or no binding of the haloperoxidase by the desired microbe. In the presence of peroxide and halide, the target bound haloperoxidase catalyzes halide oxidation and facilitates the disproportionation of peroxide to singlet molecular oxygen at the surface of the target microbe. The lifetime of singlet molecular oxygen restricts damage to the surface resulting in selective killing of the target microbe with a minimum of collateral damage to the desired microbe or physiological medium. The methods and compositions of the invention are highly useful in the therapeutic or prophylactic antiseptic treatment of human or animal subjects, since their use can be designed to be highly effective in combatting bacterial or fungal infections without significant damage to normal flora or host cells. Suitable haloperoxidases include myeloperoxidase (MPO), eosinophil peroxidase (EPO), lactoperoxidase (LPO), chloroperoxidase (CPO) and derivatives thereof capable of selective binding to target microbes.
摘要翻译：卤过氧化物酶用于选择性结合并且在过氧化物和卤化物的存在下，抑制靶微生物的生长，而不消除所需的微生物或显着损害目标微生物环境中的其它成分，例如宿主细胞。当目标微生物例如致病微生物具有比所需微生物（例如正常菌群成员）更大的卤代过氧化物酶的结合能力时，目标微生物选择性地结合卤代过氧化物酶，其中卤代过氧化物酶与所需的微生物。在过氧化物和卤化物的存在下，目标结合的卤代过氧化物酶催化卤化物氧化，促进过氧化物在目标微生物表面的单分子氧的歧化。单线态分子氧的寿命限制了对表面的损伤，导致对目标微生物的选择性杀伤，对所需的微生物或生理介质具有最小的附带损伤。本发明的方法和组合物在人或动物受试者的治疗或预防性消毒治疗中是非常有用的，因为它们的使用可被设计为在对正常菌群或宿主细胞没有显着损伤的情况下对抗细菌或真菌感染是非常有效的。合适的过氧化氢酶包括能够选择性结合靶微生物的髓过氧化物酶（MPO），嗜酸性粒细胞过氧化物酶（EPO），乳过氧化物酶（LPO），氯过氧化物酶（CPO）及其衍生物。

110. 发明授权

US5516675A Separation of lactoperoxidase, secretory component and lactoferrin from milk or whey with a cation exchange resin 失效
标题翻译：用乳酸或乳清与阳离子交换树脂分离乳过氧化物酶，分泌成分和乳铁蛋白
公开(公告)号：US5516675A
公开(公告)日：1996-05-14
申请号：US214012
申请日：1994-03-15
申请人： Toshiaki Uchida , Kaoru Sato , Yoshihiro Kawasaki , Shun'ichi Dosako
发明人： Toshiaki Uchida , Kaoru Sato , Yoshihiro Kawasaki , Shun'ichi Dosako
IPC分类号： A23J1/20 , A23K1/16 , A23K1/165 , A61K8/64 , A61K8/66 , A61K8/96 , A61K38/16 , A61K38/44 , A61K39/395 , A61P3/00 , A61P7/00 , A61P31/04 , A61P31/12 , C07K1/16 , C07K1/18 , C07K14/00 , C07K14/79 , C12N9/08 , C12N9/52 , A23C23/00 , A23J1/00 , C07K3/00
CPC分类号： C12Y111/01007 , A23J1/20 , C07K1/18 , C07K14/79 , C12N9/0065 , C12N9/52 , Y10S435/815
摘要： Lactoperoxidase, secretory component and lactoferrin are separated in high purity from milk and related materials such as whey with a single cation exchange resin. After adsorption on the cation exchange resin, elution is carried out with an aqueous solution having an ionic strength and pH selected to elute each separately. Lactoperoxidase is eluted first, secretory component second and lactoferrin last. Each is obtained in a purity of about 80% or greater. The cation exchange resin can be a cross-linked polysaccharide, cellulose or an acrylamide resin having carboxyl, sulfonic acid or phosphoric acid functional groups which may be attached with a spacer. The separated lactoperoxidase, secretory component and lactoferrin are biologically active and can be used in pharmaceuticals, cosmetics, foods, drinks and feeds.
摘要翻译：乳糖过氧化物酶，分泌成分和乳铁蛋白以高纯度与牛奶和相关材料如乳清与单一阳离子交换树脂分离。在阳离子交换树脂上吸附后，用离子强度和pH选择的水溶液进行洗脱，以分别洗脱。乳交酯酶首先被洗脱，最后分泌成分第二和乳铁蛋白。获得的纯度约为80％或更高。阳离子交换树脂可以是具有羧基，磺酸或磷酸官能团的交联多糖，纤维素或丙烯酰胺树脂，其可以与隔离物连接。分离的乳过氧化物酶，分泌组分和乳铁蛋白具有生物活性，可用于药物，化妆品，食品，饮料和饲料中。

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