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    • 104. 发明公开
    • Cartridge and dispenser
    • Kartusche und Abgabevorrichtung
    • EP2671534A1
    • 2013-12-11
    • EP12004304.7
    • 2012-06-06
    • Dentsply DeTrey GmbH
    • Evers, Markus
    • A61C5/06B65D83/00A61J1/20
    • A61M5/24A61C5/62A61C5/64A61J1/062A61J1/2089A61J7/0053A61M5/31558A61M2005/2407B65D83/005
    • Cartridge (10) for storing and dispensing a flowable composition, which comprises
      (a) a hollow elongated body (11) having a proximal end (110) and a distal end (111); said elongated body (11) forming a storage chamber (112) having a first opening (113) at the proximal end (110) and a second opening (114) at the distal end (111);
      (b) a piston (12) slidably inserted into the first opening (113) of the elongated body (11) for sealingly closing the storage chamber (112);
      (c) a discharge nipple (13) having an external thread (131), which is provided at the second opening (114), whereby the external thread has a handedness defining a first direction of rotation in which an internal thread (311) engaging the external thread (131) of the discharge nipple (13) moves away from the elongated body (11); wherein the elongated body (11) is provided with a sleeve (115) at the proximal end (110), said sleeve (115) having a rack of one or more asymmetrical teeth (116) provided on the circumference of the sleeve (115), with each tooth (116) having a steep slope (117) facing the first direction and a moderate slope (118) facing a second direction opposite to the first direction.
    • 用于存储和分配可流动组合物的盒(10),其包括(a)具有近端(110)和远端(111)的中空细长体(11); 所述细长体(11)形成在近端(110)处具有第一开口(113)并且在远端(111)处具有第二开口(114))的储存室(112) (b)可滑动地插入细长主体(11)的第一开口(113)中的活塞(12),用于密封地关闭储存室(112); (c)具有外螺纹(131)的排出接头(13),其设置在第二开口(114)处,由此外螺纹具有限定第一旋转方向的螺旋度,其中内螺纹(311)接合 放电接头(13)的外螺纹(131)远离细长体(11)移动; 其中所述细长体(11)在所述近端(110)处设置有套筒(115),所述套筒(115)具有设置在所述套筒(115)的圆周上的一个或多个不对称齿(116)的齿条, ,每个齿(116)具有面向第一方向的陡坡(117)和面向与第一方向相反的第二方向的中等斜率(118)。
    • 105. 发明公开
    • Device for accomodating a freeze-dried pharmaceutical product and method of manufacturing a sealed vessel accomodating a freeze-dried pharmaceutical product
    • 装置,用于接收一种制造密封容器用于容纳冷冻干燥药物产品的冷冻干燥药物产品和方法
    • EP2626097A1
    • 2013-08-14
    • EP12154661.8
    • 2012-02-09
    • Arte Corporation
    • The designation of the inventor has not yet been filed
    • A61M5/28A61M5/31
    • B65D83/005A61J1/20A61J3/00A61M5/284A61M2005/3123B65B3/003B65B7/2821B65B63/08B65B2220/14B65B2230/02
    • A device for accommodating a freeze-dried pharmaceutical product (S) for reconstitution, comprising: a vessel (1) having at its opening end (3) an opening edge (4) and an adjoining longitudinal portion (5) with an evenly formed inner cross section, a front plunger (2) to be positioned inside the vessel (1) at the longitudinal portion (5), wherein the front plunger (2) is configured to be positioned inside the vessel (1) in a sealing state, in which the front plunger (2) is fully inserted in the vessel (1), or in an exchange state, in which the front plunger (2) is inserted partly in the vessel (1) and partly protrudes over the opening edge (4) of the vessel (1), and wherein the front plunger (2) comprises sealing means that are configured to seal the inside of the vessel (1) against the outside when the front plunger (2) is positioned in the sealing state, and one or more communicating grooves (2i) that are configured to place the inside and outside of the vessel (1) in communication with each other when the front plunger (2) is positioned in the exchange state, is characterized in that the sealing means are dimensioned and/or structured in such a way that the front plunger (2), when an underpressure of predefined strength is applied to the outer environment of the vessel (1), is caused to move inside the vessel (1) toward its opening end (3). Furthermore, a method of manufacturing a sealed vessel (1) accommodating a freeze-dried pharmaceutical product (S) is disclosed.
    • 一种用于容纳冻干药物产品(S),用于重构的装置,包括:(1)具有在其开口端(3)至开口边缘(4)和上相邻纵向部分的容器(5),其具有均匀地形成帧内 横截面,前柱塞(2)在(5)的纵向部分的容器(1)内被定位,worin前柱塞(2)被配置在容器内,以被定位(1)在密封状态下,在 其中前柱塞(2)被完全插入在容器(1),或在交换状态中,其中所述前柱塞部分地插入在所述容器(1)(2)和部分地突出于开口边缘(4) 所述容器(1),和worin前柱塞(2)包括密封bedeutet,DASS被构造成密封所述容器(1)相对于外部的内侧当前柱塞(2)在密封状态定位,并且一个 或多个连通槽(2I)也被配置为放置容器(1)的内部和外部连通瓦特 第i个海誓山盟当前柱塞(2)在交换状态下被定位,在DASS特点模具密封装置的尺寸和/或构造在寻求一种方式做了前柱塞(2)当一个预定义的强度的压力下施加 到所述容器的外部环境(1)造成的容器(1)朝向其开口端部(3)内移动。 进一步,在制造(1)容纳冻干药物产品(S)的密封容器的制造方法是游离缺失光盘。