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101. 发明授权

EP1663958B1 HALOALKYL CONTAINING COMPOUNDS AS CYSTEINE PROTEASE INHIBITORS 有权
标题翻译： HALOGENALKYLHALTIGE化合物作为半胱氨酸蛋白酶抑制剂
公开(公告)号：EP1663958B1
公开(公告)日：2015-02-25
申请号：EP04784332.1
申请日：2004-09-17
申请人： ViroBay, Inc.
发明人： LINK, John O. , MOSSMAN, Craig J. , WOO, Soon H. , ZIPFEL, Sheila M.
IPC分类号： C07C255/46 , C07C317/48 , C07C323/60 , C07D211/66 , C07D213/32 , C07D231/12 , C07D241/12 , C07D277/30 , C07D309/14 , C07D333/20 , C07D335/02 , A61K31/277 , A61K31/381 , A61K31/4402 , A61P11/06 , A61P17/06 , A61P19/02
CPC分类号： C07D333/20 , C07C255/46 , C07C317/48 , C07C323/60 , C07C2601/02 , C07C2601/08 , C07D211/66 , C07D213/32 , C07D231/12 , C07D241/12 , C07D277/30 , C07D309/14 , C07D335/02

102. 发明授权

EP1819667B1 SULFONAMIDE COMPOUNDS AS CYSTEINE PROTEASE INHIBITORS 有权
标题翻译：磺胺ALS抑制剂半胱氨酸
公开(公告)号：EP1819667B1
公开(公告)日：2012-10-17
申请号：EP05853104.7
申请日：2005-12-01
申请人： ViroBay, Inc.
发明人： WOO, Soon H. , VIVIAN, Randall W. , LINK, John O.
IPC分类号： C07C311/07 , C07C311/03 , C07C311/08 , C07D295/22 , C07D211/96 , C07D295/12 , C07D213/76 , C07D487/08 , C07D217/08 , C07D209/08 , C07D207/48 , C07D401/04 , C07D213/32 , A61K31/496 , A61P19/02
CPC分类号： C07D209/08 , C07C311/32 , C07C2601/02 , C07D207/48 , C07D211/96 , C07D213/32 , C07D213/76 , C07D217/08 , C07D295/13 , C07D295/26 , C07D401/04 , C07D487/08

103. 发明公开

EP2215076A4 COMPOUNDS THAT INHIBIT PROTEASE CATHEPSIN S AND HCV REPLICATION 审中-公开
标题翻译：组织蛋白酶S和HCV复制抑制化合物
公开(公告)号：EP2215076A4
公开(公告)日：2012-05-02
申请号：EP08841879
申请日：2008-10-22
申请人： VIROBAY INC
发明人： HOLSINGER LESLIE JEAN , ELROD KYLE , LINK JOHN O , GRAUPE MICHAEL , KIM IN JONG
IPC分类号： C07D401/12 , C07D241/02 , C07D401/02
CPC分类号： C07D403/12

104. 发明公开

EP2237793A1 INHIBITORS OF CATHEPSIN B 审中-公开
标题翻译：组织蛋白酶B-缝边
公开(公告)号：EP2237793A1
公开(公告)日：2010-10-13
申请号：EP09709414.8
申请日：2009-02-05
申请人： Virobay, Inc.
发明人： HOLSINGER, Leslie
IPC分类号： A61K38/00
CPC分类号： A61K38/05
摘要： The present invention is directed to a method of using compounds of Formula (I) to inhibit Cathepsin B. Specifically the compounds of the present invention are useful as therapeutic agents for the treatment of tumor invasion, metastasis, Alzheimer's Disease, arthritis, inflammatory diseases such as chronic and acute pancreatitis, inflammatory airway disease, and bone and joint disorders, including osteoporosis, osteoarthritis, rheumatoid arthritis, psoriasis, and other autoimmune disorders, liver fibrosis, including liver fibrosis associated with HCV, all types of steatosis (including non-alcoholic steatohepatitis) and alcohol-associated steatohepatitis, non-alcoholic fatty liver disease, forms of pulmonary fibrosis including idiopathic pulmonary fibrosis, pathological diagnosis of interstitial pneumonia following lung biopsy, renal fibrosis, cardiac fibrosis, retinal angiogenesis and fibrosis/gliosis in the eye, schleroderma, and systemic sclerosis. The compopunds of Formula (I) are also useful for treating subjects with both HCV and fibrosis in a mammal, particularly liver fibrosis, and subjects affirmatively diagnosed or at risk for bopth HCV and liver fibrosis.

105. 发明公开

EP2720692A2 CATHEPSIN INHIBITORS FOR TREATING MICROGLIA-MEDIATED NEURON LOSS IN THE CENTRAL NERVOUS SYSTEM 审中-公开
标题翻译： CATHEPSINHEMMER在中枢神经系统在处理小胶质细胞介导的神经元丢失
公开(公告)号：EP2720692A2
公开(公告)日：2014-04-23
申请号：EP12800202.9
申请日：2012-06-18
申请人： Virobay, Inc.
发明人： BOOTH, Robert
IPC分类号： A61K31/277 , A61K31/4406 , A61P25/28 , A61P25/16 , A61P25/00
CPC分类号： A61K31/277 , A61K9/0019 , A61K9/08 , A61K9/2054 , A61K31/4406 , A61K47/12 , A61K47/26
摘要： The present invention concerns methods of using Cathepsin S inhibitors and compounds of Formula I that are inhibitors of cathepsin S in treating CNS disorders, diseases, and injuries, particularly neurodegenerative conditions. The present invention is directed to pharmaceutical compositions comprising these compounds for treating CNS disorders.

106. 发明公开

EP2361243A4 HALOALKYL CONTAINING COMPOUNDS AS CYSTEINE PROTEASE INHIBITORS 有权
标题翻译：胆碱酯酶维生素A
公开(公告)号：EP2361243A4
公开(公告)日：2012-04-25
申请号：EP09826761
申请日：2009-11-12
申请人： VIROBAY INC
发明人： HART BARRY , GREEN MICHAEL , SETTI EDUARDO , ROEPEL MICHAEL
IPC分类号： C07C237/04 , A61K31/277 , A61P11/06 , A61P19/02 , C07C255/46 , C07C317/48 , C07C323/60 , C07D213/32
CPC分类号： C07C317/48 , C07C237/04 , C07C255/46 , C07C323/60 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07D213/32

107. 发明公开

EP2361243A2 HALOALKYL CONTAINING COMPOUNDS AS CYSTEINE PROTEASE INHIBITORS 有权
标题翻译： HALOGENALKYLHALTIGE化合物作为半胱氨酸蛋白酶抑制剂
公开(公告)号：EP2361243A2
公开(公告)日：2011-08-31
申请号：EP09826761.0
申请日：2009-11-12
申请人： Virobay, Inc.
发明人： HART, Barry , GREEN, Michael , SETTI, Eduardo , ROEPEL, Michael
IPC分类号： C07C317/28 , C07C255/48 , A61K31/277 , A61P11/06 , A61P19/02
CPC分类号： C07C317/48 , C07C237/04 , C07C255/46 , C07C323/60 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07D213/32
摘要： The present invention is directed to compounds that are inhibitors of cysteine proteases, in particular, cathepsins B, K, L, F, and S and are therefore useful in treating diseases mediated by these proteases. The present invention is directed to pharmaceutical compositions comprising these compounds and processes for preparing them.

108. 发明公开

EP1866277A4 SULFONYL CONTAINING COMPOUNDS AS CYSTEINE PROTEASE INHIBITORS 有权
标题翻译：磺酰基化合物作为半胱氨酸蛋白酶抑制剂
公开(公告)号：EP1866277A4
公开(公告)日：2011-02-16
申请号：EP06739439
申请日：2006-03-22
申请人： VIROBAY INC
发明人： MOSSMAN CRAIG J
IPC分类号： C07C233/00 , A61K31/16 , A61K31/42 , A61K31/44 , A61K31/47 , C07D211/30 , C07D211/82 , C07D261/06
CPC分类号： C07C317/46 , C07C2601/02 , C07C2601/04 , C07D213/32 , C07D213/70 , C07D261/08

109. 发明公开

EP2262370A1 DI-FLUORO CONTAINING COMPOUNDS AS CYSTEINE PROTEASE INHIBITORS 审中-公开
标题翻译：分离型维生素A
公开(公告)号：EP2262370A1
公开(公告)日：2010-12-22
申请号：EP08744863.5
申请日：2008-04-01
申请人： Virobay, Inc.
发明人： LINK, John, O. , MOSSMAN, Craig, J. , LIU, Jie , WOO, Soon Hyung
IPC分类号： A01N57/00 , A61K31/66
CPC分类号： C07C255/46 , C07C2601/02
摘要： The present invention is directed to compounds that are inhibitors of cysteine proteases, in particular, cathepsins B, K, L, F, and S, and are therefore useful in treating diseases mediated by these proteases. The present invention is directed to pharmaceutical compositions comprising these compounds and processes for preparing them.
摘要翻译：本发明涉及作为半胱氨酸蛋白酶抑制剂，特别是组织蛋白酶B，K，L，F和S的化合物，因此可用于治疗由这些蛋白酶介导的疾病。本发明涉及包含这些化合物的药物组合物及其制备方法。

110. 发明公开

EP1906945A4 HCV INHIBITORS 有权
标题翻译： HCV抑制剂
公开(公告)号：EP1906945A4
公开(公告)日：2009-07-15
申请号：EP06774467
申请日：2006-06-29
申请人： VIROBAY INC
发明人： GRAUPE MICHAEL , LINK JOHN O , VENKATARAMANI CHANDRASEKAR
IPC分类号： C07K5/06 , A61K31/00 , A61K31/74 , A61K47/00 , A61P31/14 , C07K5/08
CPC分类号： A61K38/05 , C07K5/06034

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