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101. 发明授权

US4890617A Dual chamber activity responsive pacer 失效
标题翻译：双室活动响应起搏器
公开(公告)号：US4890617A
公开(公告)日：1990-01-02
申请号：US125422
申请日：1987-11-25
申请人： H. Toby Markowitz , Kevin Prest-Berg , David L. Thompson
发明人： H. Toby Markowitz , Kevin Prest-Berg , David L. Thompson
IPC分类号： A61N1/365 , A61N1/368
CPC分类号： A61N1/36514 , A61N1/368
摘要： An activity responsive, rate adaptive pacer, which senses and paces in both the atrium and ventricle is disclosed. The pacing rate displayed by the pacer is determined by the sensed activity of the patient, the programmed lower rate, and the patient's atrial or sinus rate.
摘要翻译：公开了一种在心房和心室中感觉和起搏的活动响应速率自适应起搏器。起搏器显示的起搏速率由患者的感测活动，程序化的较低速率和患者的心房或窦速率决定。

102. 发明授权

US4421116A Heart pacemaker with separate A-V intervals for atrial synchronous and atrial-ventricular sequential pacing modes 失效
标题翻译：心脏起搏器，具有单独的A-V间隔，用于心房同步心房和心房间期起搏模式
公开(公告)号：US4421116A
公开(公告)日：1983-12-20
申请号：US356791
申请日：1982-03-10
申请人： H. Toby Markowitz
发明人： H. Toby Markowitz
IPC分类号： A61N1/368 , A61N1/36
CPC分类号： A61N1/368 , A61N1/3682
摘要： A dual chamber heart pacemaker has atrial and ventricular pulse generators (21, 22) and sense amplifiers (25, 26) which connect respectively to an atrial terminal (11) and a ventricular terminal (12) for connection to the heart. In an atrial synchronous mode, the pacemaker provides ventricular stimulating pulses in response to detected spontaneous atrial contractions, and spaced from them by an A-V interval determined by a timer (31). In an atrial-ventricular sequential mode, a timer (40) causes the pacemaker to deliver sequential atrial and ventricular stimulation pulses which are separated in time by an A-V interval determined by another timer (30). The atrial-ventricular intervals for atrial synchronous mode and atrial-ventricular sequential mode are independent of each other, permitting selection of different A-V intervals for the two modes of operation.
摘要翻译：双室心脏起搏器具有分别连接到心房终端（11）和心室终端（12）的心房和心室脉冲发生器（21,22）和感测放大器（25,26）。在心房同步模式中，起搏器响应于检测到的自发心房收缩而提供心室刺激脉冲，并且通过由定时器（31）确定的A-V间隔与心室起搏器间隔开。在心房 - 心室顺序模式中，定时器（40）使得起搏器输送顺序的心房和心室刺激脉冲，其在时间上被由另一定时器（30）确定的A-V间隔分开。心房同步模式和房室顺序模式的房室间隔彼此独立，允许为两种运作模式选择不同的A-V间隔。

103. 发明授权

US4411271A Body tissue depolarization evaluation system 失效
标题翻译：身体组织去极化评估系统
公开(公告)号：US4411271A
公开(公告)日：1983-10-25
申请号：US347522
申请日：1982-02-10
申请人： H. Toby Markowitz
发明人： H. Toby Markowitz
IPC分类号： A61N1/365 , A61N1/37
CPC分类号： A61N1/365 , A61N1/371
摘要： An evaluation system for use in conjunction with a body implantable body stimulator, the body stimulator including a stimulation delivering and depolarization sensing lead system. An input connects a digitizer to the lead system, the digitizer digitizing depolarization signals sensed by the lead system. A computing system identifies excursions in the digitized depolarization signals and evaluates identified excursions in accordance with preselected merit criteria. An output gives an indication of at least that excursion having the highest merit that satisfies said merit criteria.
摘要翻译：一种与身体可植入体刺激器结合使用的评估系统，身体刺激器包括刺激输送和去极化感测引线系统。输入端将数字转换器连接到引导系统，数字转换器将引导系统检测到的去极化信号数字化。计算系统识别数字化去极化信号中的偏移，并根据预选的优值标准评估所识别的偏移。输出给出至少具有满足所述优点标准的具有最高优点的偏移的指示。

104. 发明授权

US4344437A Pacemaker triggering coupling circuit 失效
标题翻译：起搏器触发耦合电路
公开(公告)号：US4344437A
公开(公告)日：1982-08-17
申请号：US145051
申请日：1980-04-30
申请人： H. Toby Markowitz
发明人： H. Toby Markowitz
IPC分类号： A61N1/368 , A61N1/30
CPC分类号： A61N1/368
摘要： An improved atrial synchronous pacemaker and control circuit therefor having a minimum ventricular rate backup mode includes circuitry for preventing occurrence of a closely coupled ventricular pulse which might otherwise occur during the vulnerable repolarization period of the ventricles. A triggering coupling circuit includes a variable or programmable upper rate limit/minimum escape interval timer and switching means therefor for switching to a relatively low maximum rate/minimum escape interval condition while pacing in the ventricular backup mode, and for switching to a higher programmed maximum rate/minimum escape interval limit value while pacing in atrial synchronous mode.
摘要翻译：具有最小心室率备用模式的改进的心房同步起搏器及其控制电路包括用于防止紧密耦合的心室脉搏的出现的电路，否则可能会在心室的易失性复极期间发生。触发耦合电路包括可变或可编程的上限速率限制/最小逃逸间隔定时器及其切换装置，用于在心室备用模式下切换到相对较低的最大速率/最小逃逸间隔条件，并切换到更高的编程最大值速率/最小逃逸间隔极限值，同时起搏在心房同步模式。

105. 发明申请

US20200281505A1 DEVICES AND METHODS FOR SIZING VALVE APERTURES AND LUMINAL ORGANS 审中-公开
公开(公告)号：US20200281505A1
公开(公告)日：2020-09-10
申请号：US16800970
申请日：2020-02-25
申请人： H. Toby Markowitz , 3DT Holdings, LLC
发明人： Ghassan S. Kassab , H. Toby Markowitz
IPC分类号： A61B5/107 , A61B5/053 , A61B5/00
摘要： Devices and methods for sizing valve apertures and luminal organs. In at least one embodiment of a device for obtaining measurements within a luminal organ of the present disclosure, the device comprises an elongated body having a distal end and at least two electrodes positioned at the distal end of the elongated body or to a portion of the device distal tot the distal end of the elongated body, the device configured to obtain data sufficient to determine a dimensional measurement within the mammalian luminal organ when positioned and operated therein.

106. 发明授权

US09131872B2 Multiple sensor input for structure identification 有权
标题翻译：用于结构识别的多个传感器输入
公开(公告)号：US09131872B2
公开(公告)日：2015-09-15
申请号：US13415335
申请日：2012-03-08
申请人： H. Toby Markowitz , Rogier Receveur , Koen Michels , Olaf Eick , Vincent Larik
发明人： H. Toby Markowitz , Rogier Receveur , Koen Michels , Olaf Eick , Vincent Larik
IPC分类号： A61B5/06 , A61B5/0432 , A61B5/044 , A61B5/042 , A61B5/053 , A61B19/00 , A61B5/0428 , A61B5/05 , A61B8/06 , A61B8/00 , A61B17/00 , A61B17/22
CPC分类号： A61B5/061 , A61B5/0422 , A61B5/04288 , A61B5/0432 , A61B5/044 , A61B5/05 , A61B5/053 , A61B5/0538 , A61B5/06 , A61B5/062 , A61B5/063 , A61B5/066 , A61B5/4836 , A61B5/742 , A61B8/06 , A61B8/4472 , A61B34/20 , A61B34/25 , A61B2017/00022 , A61B2017/00026 , A61B2017/00053 , A61B2017/00084 , A61B2017/00243 , A61B2017/00336 , A61B2017/22051 , A61B2034/105 , A61B2090/376 , A61B2090/378 , A61B2090/3983
摘要： A volume of a patient can be mapped with a system operable to identify a plurality of locations and save a plurality of locations of a mapping instrument. The mapping instrument can include one or more electrodes that can sense a voltage that can be correlated to a three dimensional location of the electrode at the time of the sensing or measurement. Therefore, a map of a volume can be determined based upon the sensing of the plurality of points without the use of other imaging devices. An implantable medical device can then be navigated relative to the mapping data.
摘要翻译：可以利用可操作以识别多个位置并且存储映射仪器的多个位置的系统来映射患者体积。映射仪器可以包括一个或多个电极，其可以感测在感测或测量时可以与电极的三维位置相关联的电压。因此，可以基于多个点的感测而不使用其它成像装置来确定体积的映射。然后可以相对于映射数据导航可植入医疗装置。

107. 发明授权

US08560042B2 Locating an indicator 有权
标题翻译：查找指标
公开(公告)号：US08560042B2
公开(公告)日：2013-10-15
申请号：US13424857
申请日：2012-03-20
申请人： H. Toby Markowitz , Pooja Mehta , Eduardo N. Warman , Phillip Falkner , Ioana Fleming
发明人： H. Toby Markowitz , Pooja Mehta , Eduardo N. Warman , Phillip Falkner , Ioana Fleming
IPC分类号： A61B5/04
CPC分类号： A61B5/061 , A61B5/0422 , A61B5/04288 , A61B5/0432 , A61B5/044 , A61B5/05 , A61B5/053 , A61B5/0538 , A61B5/06 , A61B5/062 , A61B5/063 , A61B5/066 , A61B5/4836 , A61B5/742 , A61B8/06 , A61B8/4472 , A61B34/20 , A61B34/25 , A61B2017/00022 , A61B2017/00026 , A61B2017/00053 , A61B2017/00084 , A61B2017/00243 , A61B2017/00336 , A61B2017/22051 , A61B2034/105 , A61B2090/376 , A61B2090/378 , A61B2090/3983
摘要： A system to determine and illustrate a location of position element within a volume is disclosed. The position element can be used to determine the position of a portion of an instrument. The instrument can include one or both of a cannulated member and a lead member passed through the cannula.
摘要翻译：公开了一种用于确定和说明体内位置元素的位置的系统。位置元件可用于确定仪器的一部分的位置。仪器可以包括穿过插管的插管构件和引导构件中的一个或两个。

108. 发明授权

US08494613B2 Combination localization system 有权
公开(公告)号：US08494613B2
公开(公告)日：2013-07-23
申请号：US12844061
申请日：2010-07-27
申请人： H. Toby Markowitz , Kenneth Gardeski , Jean Carver , Kendra Yasger , Michael R. Neidert , Laurent Verard , Steven L. Hartmann , Andrew Bzostek , Bradley A. Jascob
发明人： H. Toby Markowitz , Kenneth Gardeski , Jean Carver , Kendra Yasger , Michael R. Neidert , Laurent Verard , Steven L. Hartmann , Andrew Bzostek , Bradley A. Jascob
IPC分类号： A61B5/05 , A61B1/04
CPC分类号： A61B90/13 , A61B18/1492 , A61B34/20 , A61B34/25 , A61B2017/00026 , A61B2034/2051 , A61B2090/0818
摘要： A navigation system or combination of navigation systems can be used to provide two or more navigation modalities to navigate a single instrument in a volume. For example, both an Electromagnetic (EM) and Electropotential (EP) navigation system can be used to navigate an instrument within the volume. Image data can also be illustrated relative to a tracked position of the instrument in the volume for navigation.

109. 发明授权

US08494608B2 Method and apparatus for mapping a structure 有权
公开(公告)号：US08494608B2
公开(公告)日：2013-07-23
申请号：US12421364
申请日：2009-04-09
申请人： H. Toby Markowitz , Mustafa Karamanoglu , Pooja Mehta , Ioana Fleming , David Scanlon , Michael Kryger , Sean Campbell-Massa , Chad Giese , Steven L. Waldhauser , Shangqian Peter Zhang , Jeff Jannicke , Phillip Falkner , Don Hefner , Eduardo N. Warman , James Steeves , Rogier Receveur , Koen Michels , Olaf Eick , Vincent Larik
发明人： H. Toby Markowitz , Mustafa Karamanoglu , Pooja Mehta , Ioana Fleming , David Scanlon , Michael Kryger , Sean Campbell-Massa , Chad Giese , Steven L. Waldhauser , Shangqian Peter Zhang , Jeff Jannicke , Phillip Falkner , Don Hefner , Eduardo N. Warman , James Steeves , Rogier Receveur , Koen Michels , Olaf Eick , Vincent Larik
IPC分类号： A61B5/04
CPC分类号： A61B5/061 , A61B5/0422 , A61B5/04288 , A61B5/0432 , A61B5/044 , A61B5/05 , A61B5/053 , A61B5/0538 , A61B5/06 , A61B5/062 , A61B5/063 , A61B5/066 , A61B5/4836 , A61B5/742 , A61B8/06 , A61B8/4472 , A61B34/20 , A61B34/25 , A61B2017/00022 , A61B2017/00026 , A61B2017/00053 , A61B2017/00084 , A61B2017/00243 , A61B2017/00336 , A61B2017/22051 , A61B2034/105 , A61B2090/376 , A61B2090/378 , A61B2090/3983
摘要： An volume of a patient can be mapped with a system operable to identify a plurality of locations and save a plurality of locations of a mapping instrument. The mapping instrument can include one or more electrodes that can sense a voltage that can be correlated to a three dimensional location of the electrode at the time of the sensing or measurement. Therefore, a map of a volume can be determined based upon the sensing of the plurality of points without the use of other imaging devices. An implantable medical device can then be navigated relative to the mapping data.

110. 发明授权

US08421799B2 Illustrating a three-dimensional nature of a data set on a two-dimensional display 有权
标题翻译：说明二维显示器上的数据集的三维性质
公开(公告)号：US08421799B2
公开(公告)日：2013-04-16
申请号：US13358641
申请日：2012-01-26
申请人： H. Toby Markowitz , David Scanlon , Ioana Fleming , Mustafa Karamanoglu , Chad Giese , Karl Evan Nowak
发明人： H. Toby Markowitz , David Scanlon , Ioana Fleming , Mustafa Karamanoglu , Chad Giese , Karl Evan Nowak
IPC分类号： G06T15/00 , G06T15/10 , G06T15/20 , G09G5/00 , G06K9/00 , A61B5/04
CPC分类号： G06T19/003 , A61B5/0422 , A61B5/05 , A61B5/053 , A61B5/0538 , A61B5/063 , A61B5/066 , A61B5/068 , A61B8/06 , A61B34/20 , A61B34/25 , A61B2017/00022 , A61B2017/00026 , A61B2017/00053 , A61B2017/00084 , A61B2017/00243 , A61B2017/22051 , A61B2034/102 , A61B2034/105 , A61B2034/2051 , A61B2034/2068 , A61B2034/2072 , A61B2090/061 , A61B2090/063 , A61B2090/371 , A61B2090/376 , A61B2090/378
摘要： A volume of a patient can be mapped with a system operable to identify a plurality of locations and save a plurality of locations of a mapping instrument. The mapping instrument can include one or more electrodes that can sense a voltage that can be correlated to a three dimensional location of the electrode at the time of the sensing or measurement. Therefore, a map of a volume can be determined based upon the sensing of the plurality of points without the use of other imaging devices. An implantable medical device can then be navigated relative to the mapping data.
摘要翻译：可以利用可操作以识别多个位置并且存储映射仪器的多个位置的系统来映射患者体积。映射仪器可以包括一个或多个电极，其可以感测在感测或测量时可以与电极的三维位置相关联的电压。因此，可以基于多个点的感测而不使用其它成像装置来确定体积的映射。然后可以相对于映射数据导航可植入医疗装置。

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