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101. 发明申请

US20140018688A1 DEVICE BASED CARDIAC MONITORING AND STRESS TEST 有权
标题翻译：基于设备的心脏监测和应力测试
公开(公告)号：US20140018688A1
公开(公告)日：2014-01-16
申请号：US13549983
申请日：2012-07-16
申请人： Zhendong Song , Xiaohong Zhou
发明人： Zhendong Song , Xiaohong Zhou
IPC分类号： A61B5/0205 , A61B5/0452
CPC分类号： A61B5/0452 , A61B5/02028 , A61B5/021 , A61B5/7275
摘要： A medical device and associated method establish an occurrence of a premature atrial contraction. The device senses a ventricular signal. A control unit is configured to determine a metric of the ventricular signal during an interval following the premature atrial contraction and detect a change in cardiac stress tolerance in response to the determined metric.
摘要翻译：医疗器械和相关方法建立了早发性心房收缩的发生。该装置感测到心室信号。控制单元被配置为在过早心房收缩之后的间隔期间确定心室信号的度量，并响应于所确定的度量来检测心脏应力容忍度的变化。

102. 发明授权

US08554314B2 Device and method to detect the severity of ischemia and heart attack risk 有权
标题翻译：检测缺血和心脏病发作风险严重程度的装置和方法
公开(公告)号：US08554314B2
公开(公告)日：2013-10-08
申请号：US12263383
申请日：2008-10-31
申请人： Xiaohong Zhou
发明人： Xiaohong Zhou
IPC分类号： A61B5/04
CPC分类号： A61N1/3702 , A61B5/01 , A61B5/0215 , A61B5/024 , A61B5/0452 , A61B5/11 , A61B7/00 , A61N1/3925
摘要： A device and method of detecting the severity of myocardial ischemia and heart attack risk is provided. The method includes obtaining an electrogram signal, determining T-wave measurements based on the electrogram signal, and determining ST segment measurements based on the electrogram signal. The method also includes identifying T-wave alternans based on the T-wave measurements and identifying ST segment changes based on the ST segment measurements. The method further includes correlating the T-wave alternans with the ST segment changes in order to detect a severity of ischemia.
摘要翻译：提供了一种检测心肌缺血严重程度和心脏病发作风险的方法。该方法包括获得电描记图信号，基于电描记图信号确定T波测量，以及基于电描记图信号确定ST段测量。该方法还包括基于T波测量识别T波交替，并基于ST段测量识别ST段变化。该方法还包括将T波交替与ST段变化相关联，以便检测局部缺血的严重程度。

103. 发明申请

US20120093931A9 Inhibition of Neovascularization by Cerium Oxide Nanoparticles 有权
标题翻译：通过氧化铈纳米颗粒抑制新血管形成
公开(公告)号：US20120093931A9
公开(公告)日：2012-04-19
申请号：US12429650
申请日：2009-04-24
申请人： James F. McGinnis , Lily L. Wong , Xiaohong Zhou , Sudipta Seal
发明人： James F. McGinnis , Lily L. Wong , Xiaohong Zhou , Sudipta Seal
IPC分类号： A61K33/24 , A61P29/00 , A61P17/00 , A61P9/00 , A61P19/02 , A61P1/00 , A61K9/14 , A61P27/02
CPC分类号： A61K9/14 , A61K33/24
摘要： The present invention provides methods for reducing, reversing or inhibiting neovascularization in a tissue of a mammalian subject having a pathological condition involving neovascularization by administration in vivo of nanoceria particles (cerium oxide nanoparticles) to the subject. The method of the invention is useful, for example, for reducing, treating, reversing or inhibiting neovascularization in ocular tissue such as the retina, macula or cornea; in skin; in synovial tissue; in intestinal tissue; or in bone. In addition, the method of the invention is useful for reducing or inhibiting neovascularization in a neoplasm (tumors), which can be benign or malignant and, where malignant, can be a metastatic neoplasm. As such, the invention provides compositions, which contain nanoceria particles and are useful for reducing, treating, reversing or inhibiting angiogenesis in a mammalian subject.
摘要翻译：本发明提供了通过在受试者体内施用纳米颗粒（氧化铈纳米颗粒）的体内，减少，逆转或抑制具有涉及新血管形成的病理状况的哺乳动物受试者的组织中的新生血管形成的方法。本发明的方法例如用于减少，治疗，逆转或抑制眼组织如视网膜，黄斑或角膜中的新生血管形成; 在皮肤上在滑膜组织中在肠组织中或在骨头。此外，本发明的方法可用于减少或抑制肿瘤（肿瘤）中的新生血管形成，其可以是良性或恶性的，并且恶性肿瘤可以是转移性肿瘤。因此，本发明提供了含有纳米颗粒并且可用于在哺乳动物受试者中减少，治疗，逆转或抑制血管生成的组合物。

104. 发明申请

US20120029600A1 NERVE SIGNAL DIFFERENTIATION IN CARDIAC THERAPY 有权
标题翻译：心脏病治疗中的神经信号差异
公开(公告)号：US20120029600A1
公开(公告)日：2012-02-02
申请号：US12848010
申请日：2010-07-30
申请人： Xiaohong Zhou , John Edward Burnes , Lilian Kornet , Richard N.M. Cornelussen
发明人： Xiaohong Zhou , John Edward Burnes , Lilian Kornet , Richard N.M. Cornelussen
IPC分类号： A61N1/00
CPC分类号： A61N1/36139 , A61B5/04001 , A61N1/36114 , A61N1/36514 , A61N1/3684 , A61N1/3686 , A61N1/3962
摘要： Methods of nerve signal differentiation, methods of delivering therapy using such nerve signal differentiation, and to systems and devices for performing such methods. Nerve signal differentiation may include locating two electrodes proximate nerve tissue and differentiating between efferent and afferent components of nerve signals monitored using the two electrodes.
摘要翻译：神经信号分化方法，使用这种神经信号分化的治疗方法，以及用于执行这些方法的系统和装置。神经信号分化可能包括将两个电极定位在神经组织附近，并使用两个电极来监测神经信号的传出和传入分量。

105. 发明申请

US20110015190A1 GAMMA SECRETASE MODULATORS 失效
标题翻译： GAMMA秘密调节器
公开(公告)号：US20110015190A1
公开(公告)日：2011-01-20
申请号：US12746041
申请日：2008-12-04
申请人： Xianhai Huang , Anandan Palani , Jun Qin , Robert Aslanian , Zhaoning Zhu , William Greenlee , Hubert Josien , Wei Zhou , Xiaohong Zhou , Chad E. Bennett , Dmitri Pissarnitski , Mihirbaran Mandal , Pawan Dhondi , Troy McCracken , Thomas Bara , Zhiqiang Zhao , Duane Burnett , John Clader
发明人： Xianhai Huang , Anandan Palani , Jun Qin , Robert Aslanian , Zhaoning Zhu , William Greenlee , Hubert Josien , Wei Zhou , Xiaohong Zhou , Chad E. Bennett , Dmitri Pissarnitski , Mihirbaran Mandal , Pawan Dhondi , Troy McCracken , Thomas Bara , Zhiqiang Zhao , Duane Burnett , John Clader
IPC分类号： A61K31/5383 , C07D471/04 , A61K31/437 , C07D487/04 , A61K31/519 , A61K31/5377 , C07D498/04 , C07D403/02 , A61K31/4178 , A61P25/28
CPC分类号： C07D471/04 , C07D403/10 , C07D487/04 , C07D498/04 , C07D513/04
摘要： This invention provides novel compounds that are modulators of gamma secretase. The compounds have the formula (I) wherein R2 is a fused bicyclic ring of the formula (II). Also disclosed are methods of modulating gamma secretase activity and methods of treating Alzheimer's disease using the compounds of formula (I).
摘要翻译：本发明提供了作为γ分泌酶调节剂的新型化合物。所述化合物具有式（I），其中R 2是式（II）的稠合双环。还公开了使用式（I）的化合物调节γ-分泌酶活性和治疗阿尔茨海默病的方法的方法。

106. 发明授权

US07825245B2 Substituted 4-anilinoquinazolines and their use in tumor treatment 失效
标题翻译：取代的4-苯胺基喹唑啉及其在肿瘤治疗中的应用
公开(公告)号：US07825245B2
公开(公告)日：2010-11-02
申请号：US11939265
申请日：2007-11-13
申请人： Wenlin Huang , Xiaohong Zhou
发明人： Wenlin Huang , Xiaohong Zhou
IPC分类号： C07D239/72
CPC分类号： C07D239/94
摘要： The present invention relates to quinazoline derivatives of formula I: wherein X, Y, Z, R1, R2, R3, and R4 are as defined herein. The invention also relates to a method of preparing these compounds, and use of these compounds for inhibiting tumor growth.
摘要翻译：本发明涉及式I的喹唑啉衍生物：其中X，Y，Z，R 1，R 2，R 3和R 4如本文所定义。本发明还涉及制备这些化合物的方法，以及这些化合物用于抑制肿瘤生长的用途。

107. 发明申请

US20100016919A1 METHOD AND APPARATUS FOR ELECTRICALLY STIMULATING THE NERVOUS SYSTEM TO IMPROVE VENTRICULAR DYSFUNCTION, HEART FAILURE, AND OTHER CARDIAC CONDITIONS 有权
标题翻译：用于电刺激神经系统以改善心脏功能障碍，心脏衰竭和其他心脏病症的方法和装置
公开(公告)号：US20100016919A1
公开(公告)日：2010-01-21
申请号：US12565910
申请日：2009-09-24
申请人： Michael R.S. Hill , Gary W. King , Thomas J. Mullen , Xiaohong Zhou
发明人： Michael R.S. Hill , Gary W. King , Thomas J. Mullen , Xiaohong Zhou
IPC分类号： A61N1/365
CPC分类号： A61N1/36114 , A61N1/3627
摘要： A method and apparatus are used to provide therapy to a patient experiencing ventricular dysfunction or heart failure. At least one electrode is located in a region associated with nervous tissue, such as nerve bundles T1-T4, in a patient's body. Electrical stimulation is applied to the at least one electrode to improve the cardiac efficiency of the patient's heart. One or more predetermined physiologic parameters of the patient are monitored, and the electrical stimulation is adjusted based on the one or more predetermined physiologic parameters.
摘要翻译：使用方法和装置为患有心室功能障碍或心力衰竭的患者提供治疗。至少一个电极位于与患者体内的神经组织如神经束T1-T4相关联的区域中。电刺激被施加到至少一个电极以改善患者心脏的心脏效率。监测患者的一个或多个预定生理参数，并且基于一个或多个预定生理参数来调整电刺激。

108. 发明授权

US07650190B2 Methods and apparatus for the regulation of hormone release 有权
标题翻译：用于调节激素释放的方法和装置
公开(公告)号：US07650190B2
公开(公告)日：2010-01-19
申请号：US11751813
申请日：2007-05-22
申请人： Xiaohong Zhou , Thomas J. Mullen , Gary W. King , Michael R. S. Hill
发明人： Xiaohong Zhou , Thomas J. Mullen , Gary W. King , Michael R. S. Hill
IPC分类号： A61N1/00
CPC分类号： A61N1/36071 , A61N1/205 , A61N1/36021
摘要： A method and apparatus for delivering corrective therapy through hormone regulation is provided. Inhibition of sympathetic fibers by spinal cord stimulation is used to regulate the levels of hormones such as catecholamines, renin, and calcitonin gene-related peptide. The invention utilizes a closed or open loop feedback system in which physiological parameters such as the concentrations of hormones and sympathetic indicators such as heart rate and urine production are monitored and used to determine the appropriate level of neurostimulation. The site of electrical stimulation includes, but is not limited to, the spinal cord at levels T7-L2 and the associated neural fibers within a region of the T7-L2 dermatomes.
摘要翻译：提供了一种通过激素调节进行矫正治疗的方法和装置。通过脊髓刺激抑制交感神经纤维用于调节激素水平，如儿茶酚胺，肾素和降钙素基因相关肽。本发明利用封闭或开环反馈系统，其中监测诸如心率和尿液产生之间的激素和交感神经指标的生理参数，并用于确定适当的神经刺激水平。电刺激部位包括但不限于在T7-L2皮层区域内的T7-L2级和相关神经纤维的脊髓。

109. 发明申请

US20090192398A1 METHOD AND APPARATUS FOR MONITORING T-WAVE ALTERNANS 有权
标题翻译：用于监测T波形变换器的方法和装置
公开(公告)号：US20090192398A1
公开(公告)日：2009-07-30
申请号：US11871405
申请日：2007-10-12
申请人： Xiaohong Zhou , Jeffrey M. Gillberg
发明人： Xiaohong Zhou , Jeffrey M. Gillberg
IPC分类号： A61B5/0452
CPC分类号： A61B5/0452 , A61B5/021 , A61N1/3702
摘要： An implantable medical device and associated method assess T-wave alternans by sensing a cardiac electrogram (EGM) signal and selecting a pair of consecutive T-wave signals from the EGM signal. A first amplitude and a second amplitude from each of the consecutive T-wave signals are determined. The differences between the first amplitudes and the second amplitudes of the consecutive T-wave signal pairs are used to compute a T-wave alternans metric.
摘要翻译：可植入医疗装置和相关方法通过感测心电图（EGM）信号和从EGM信号中选择一对连续的T波信号来评估T波交替。确定来自每个连续T波信号的第一幅度和第二幅度。使用连续T波信号对的第一幅度和第二幅度之间的差异来计算T波交替量度。

110. 发明申请

US20080167328A1 QUINAZOLINE DERIVATIVES 失效
标题翻译：喹诺酮衍生物
公开(公告)号：US20080167328A1
公开(公告)日：2008-07-10
申请号：US11939265
申请日：2007-11-13
申请人： Wenlin Huang , Xiaohong Zhou
发明人： Wenlin Huang , Xiaohong Zhou
IPC分类号： A61K31/517 , C07D239/94 , A61P35/00
CPC分类号： C07D239/94
摘要： The present invention relates to quinazoline derivatives of formula I: wherein X, Y, Z, R1, R2, R3, and R4 are as defined herein. The invention also relates to a method of preparing these compounds, and use of these compounds for inhibiting tumor growth.
摘要翻译：本发明涉及式I的喹唑啉衍生物：其中X，Y，Z，R 1，R 2，R 3和R 3 4 如本文所定义。本发明还涉及制备这些化合物的方法，以及这些化合物用于抑制肿瘤生长的用途。

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