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101. 发明授权

US08124341B2 Genes and polypeptides relating to hepatocellular or colorectal carcinoma 有权
标题翻译：与肝细胞癌或结肠直肠癌相关的基因和多肽
公开(公告)号：US08124341B2
公开(公告)日：2012-02-28
申请号：US12699711
申请日：2010-02-03
申请人： Yusuke Nakamura , Yoichi Furukawa
发明人： Yusuke Nakamura , Yoichi Furukawa
IPC分类号： C12Q1/68 , G01N33/53
CPC分类号： C07K16/303 , A61K38/00 , C07K14/4748 , C07K16/3046 , G01N33/57419 , G01N33/57438 , G01N33/6893 , G01N2500/00
摘要： The present application provides novel human genes WDRPUH and KRZFPUH, and PPIL1 whose expression is markedly elevated in a great majority of HCCs and colorectal cancers, respectively, compared to corresponding non-cancerous tissues, as well as novel human gene APCDD1 whose expression is elevated in primary colon cancers and down-regulated in response to the transduction of wild-type APC1 into colon-cancer cells. The genes and polypeptides encoded by the genes can be used, for example, in the diagnosis of a cell proliferative disease, and as target molecules for developing drugs against the disease.
摘要翻译：本申请提供了新的人类基因WDRPUH和KRZFPUH，和PPIL1，其表达在大多数HCC和结肠直肠癌中分别与相应的非癌组织相比显着升高，以及新型人基因APCDD1，其表达升高原发性结肠癌并且响应于野生型APC1转导入结肠癌细胞而下调。由该基因编码的基因和多肽可用于例如细胞增殖性疾病的诊断，以及用于开发针对该疾病的药物的靶分子。

102. 发明申请

US20120028262A1 GENES AND POLYPEPTIDES RELATING TO HUMAN PANCREATIC CANCERS 审中-公开
标题翻译：与人胰腺癌相关的基因和多肽
公开(公告)号：US20120028262A1
公开(公告)日：2012-02-02
申请号：US13079274
申请日：2011-04-04
申请人： Yusuke Nakamura , Toyomasa Katagiri
发明人： Yusuke Nakamura , Toyomasa Katagiri
IPC分类号： C12Q1/68 , C12Q1/02 , G01N33/566
CPC分类号： G01N33/57438 , A61K38/00 , C07K14/47 , C07K14/82 , C12Q1/6837 , C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Q2600/158 , Y02A90/26
摘要： The present application provides novel human genes C1958V1 or C1958V2 whose expression is markedly elevated in pancreatic cancers compared to corresponding non-cancerous tissues. The genes and polypeptides encoded by the genes can be used, for example, in the diagnosis of pancreatic cancer, and as target molecules for developing drugs against the disease.
摘要翻译：本申请提供了新的人基因C1958V1或C1958V2，与相应的非癌组织相比，其在胰腺癌中的表达显着升高。由该基因编码的基因和多肽可用于例如胰腺癌的诊断，以及作为用于开发针对该疾病的药物的靶分子。

103. 发明申请

US20120022128A1 PKIB and NAALADL2 for Target Genes of Prostate Cancer Therapy and Diagnosis 审中-公开
标题翻译： PKIB和NAALADL2用于前列腺癌治疗和诊断的靶基因
公开(公告)号：US20120022128A1
公开(公告)日：2012-01-26
申请号：US12674664
申请日：2008-08-20
申请人： Yusuke Nakamura , Hidewaki Nakagawa , Shuichi Nakatsuru
发明人： Yusuke Nakamura , Hidewaki Nakagawa , Shuichi Nakatsuru
IPC分类号： A61K31/713 , C12N15/63 , C12Q1/68 , A61P35/00 , C40B30/04 , C07K16/44 , C07K16/18 , G01N33/566 , C12N15/113 , G01N33/574
CPC分类号： A61K31/70 , A61K48/00 , C07K14/47 , C12N15/113 , C12N2310/111 , C12N2310/14
摘要： The invention features methods for detecting prostate cancer, especially hormone-refractory prostate cancer (HRPC) or castration-resistant prostate cancer (CRPC), by detecting over-expression of PKIB or NAALADL2 compared the normal organs. Also disclosed are methods of identifying compounds for treating and preventing prostate cancer including HRPC, based on the over-expression of PKIB or NAALADL2 in the prostate cancer, the cell proliferation function of PKIB or NAALADL2, the intracellular localization of PKIB or NAALADL2 or the interaction between PKIB and PKA-C. Also, provided are a method for treating prostate cancer by administering a double-stranded molecule against the PKIB or NAALADL2 gene. The invention also provides products, including the double-stranded molecules and vectors encoding them, as well as compositions comprising the molecules or vectors, useful in the provided methods.
摘要翻译：本发明通过检测PKIB或NAALADL2的过表达来检测前列腺癌，特别是激素难治性前列腺癌（HRPC）或去势抗性前列腺癌（CRPC）的方法。还公开了基于前列腺癌中PKIB或NAALADL2的过度表达，PKIB或NAALADL2的细胞增殖功能，PKIB或NAALADL2的细胞内定位或相互作用的鉴定，鉴定用于治疗和预防前列腺癌包括HRPC的化合物的方法 PKIB和PKA-C之间。此外，提供了通过对PKIB或NAALADL2基因施用双链分子来治疗前列腺癌的方法。本发明还提供了包括双链分子和编码它们的载体的产物，以及可用于所提供的方法中的包含分子或载体的组合物。

104. 发明申请

US20120021945A1 Hypoxia-Inducible Protein 2 (HIG2), a Diagnostic Marker for Clear Cell Renal Cell Carcinoma 审中-公开
标题翻译：低氧诱导蛋白2（HIG2），清除细胞肾细胞癌的诊断标记
公开(公告)号：US20120021945A1
公开(公告)日：2012-01-26
申请号：US13224102
申请日：2011-09-01
申请人： Yusuke Nakamura , Toyomasa Katagiri
发明人： Yusuke Nakamura , Toyomasa Katagiri
IPC分类号： C40B30/04 , C12Q1/02 , G01N33/53 , C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/136 , C12Q2600/158
摘要： The present invention provides a method for inhibiting growth of a cancer cell, particularly a renal cell carcinoma, by contacting the cell with a composition composed of an HIG2 siRNA or HIG2 antibody. Methods of diagnosing renal cell cancer are also provided within the present invention.
摘要翻译：本发明提供了通过使细胞与由HIG2 siRNA或HIG2抗体构成的组合物接触来抑制癌细胞，特别是肾细胞癌生长的方法。本发明还提供了诊断肾细胞癌的方法。

105. 发明申请

US20120004172A1 SCREENING METHOD OF ANTI-LUNG OR ESOPHAGEAL CANCER COMPOUNDS 审中-公开
标题翻译：抗肺癌或食管癌化合物的筛选方法
公开(公告)号：US20120004172A1
公开(公告)日：2012-01-05
申请号：US13125549
申请日：2009-08-24
申请人： Yusuke Nakamura , Yataro Daigo , Takuya Tsunoda
发明人： Yusuke Nakamura , Yataro Daigo , Takuya Tsunoda
IPC分类号： A61K38/17 , C12N15/63 , A61K31/7105 , C12N1/21 , C12N1/19 , C07K14/435 , C12N15/11 , C12N5/10
CPC分类号： F28F9/0226 , F01M5/002 , F01P11/08 , F28D2021/0089 , F28D2021/0094 , F28F9/0209 , F28F9/0234 , F28F27/02
摘要： Disclosed herein is a method for determining a kinase activity of ERK for CDCA5 and methods of screening for modulators of this kinase activity. Also disclosed are methods and pharmaceutical compositions for preventing and/or treating lung cancer or esophageal cancer that use or include such modulators.
摘要翻译：本文公开了用于测定CDCA5的ERK的激酶活性的方法和筛选该激酶活性的调节剂的方法。还公开了用于预防和/或治疗使用或包括这种调节剂的肺癌或食管癌的方法和药物组合物。

106. 发明申请

US20110319280A1 ECT2 ONCOGENE AS A THERAPEUTIC TARGET AND PROGNOSTIC INDICATOR FOR LUNG AND ESOPHAGEAL CANCER 审中-公开
标题翻译： ECT2 ONCOGENE作为肺癌和食管癌的治疗目标和预防指标
公开(公告)号：US20110319280A1
公开(公告)日：2011-12-29
申请号：US13002977
申请日：2009-07-16
申请人： Yusuke Nakamura , Yataro Daigo , Akira Togashi
发明人： Yusuke Nakamura , Yataro Daigo , Akira Togashi
IPC分类号： C40B30/04 , G01N33/566 , C12Q1/68 , G01N33/53
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Q2600/158 , G01N33/57423 , G01N2800/50
摘要： The invention features methods for detecting lung cancer or esophageal cancer, by detecting over-expression of ECT2 compared the normal organs. Also disclosed are methods of identifying compounds for treating and preventing lung cancer or esophageal cancer, based on the over-expression of ECT2 in the lung cancer or esophageal cancer, the cell proliferation function of ECT2. Also, provided are a method for treating lung cancer or esophageal cancer by administering a double-stranded molecule against the ECT2 gene or an antibody against ECT2 protein. The invention also provides products, including the double-stranded molecules and vectors encoding them, as well as compositions comprising the molecules or vectors, useful in the provided methods.
摘要翻译：本发明特征在于检测肺癌或食管癌的方法，通过检测ECT2与正常器官的过表达。还公开了基于ECT2在肺癌或食管癌中的过表达，ECT2的细胞增殖功能，鉴定用于治疗和预防肺癌或食管癌的化合物的方法。此外，提供了通过对ECT2基因施用双链分子或针对ECT2蛋白的抗体来治疗肺癌或食管癌的方法。本发明还提供了包括双链分子和编码它们的载体的产物，以及可用于所提供的方法中的包含分子或载体的组合物。

107. 发明授权

US08067153B2 Genes and polypeptides relating to prostate cancers 失效
标题翻译：与前列腺癌相关的基因和多肽
公开(公告)号：US08067153B2
公开(公告)日：2011-11-29
申请号：US11913233
申请日：2006-07-19
申请人： Yusuke Nakamura , Hidewaki Nakagawa , Shuichi Nakatsuru
发明人： Yusuke Nakamura , Hidewaki Nakagawa , Shuichi Nakatsuru
IPC分类号： C12Q1/00
CPC分类号： G01N33/57434 , A61K38/1709 , C07K14/4748 , C12Q1/48 , G01N33/573 , G01N2333/91051 , G01N2500/00
摘要： The present application provides novel human gene ELOVL7 whose expression is markedly elevated in prostate cancers. The gene and polypeptide encoded by the gene can be used, for example, in the diagnosis of prostate cancers, as target molecules for developing drugs against the disease, and for attenuating cell growth of prostate cancer.
摘要翻译：本申请提供了新型人类基因ELOVL7，其表达在前列腺癌中显着升高。由该基因编码的基因和多肽可用于例如前列腺癌的诊断中，作为用于开发针对该疾病的药物的靶分子，以及用于减轻前列腺癌的细胞生长。

108. 发明申请

US20110263012A1 SCREENING AND THERAPEUTIC METHOD FOR NSCLC TARGETING CDCA1-KNTC2 COMPLEX 审中-公开
标题翻译：用于NSCLC靶向CDCA1-KNTC2复合物的筛选和治疗方法
公开(公告)号：US20110263012A1
公开(公告)日：2011-10-27
申请号：US13080461
申请日：2011-04-05
申请人： Yusuke Nakamura , Yataro Daigo , Shuichi Nakatsuru
发明人： Yusuke Nakamura , Yataro Daigo , Shuichi Nakatsuru
IPC分类号： C12N15/63 , C07H21/02
CPC分类号： G01N33/57423 , G01N2500/02
摘要： The present invention is based on the observation that the co-activation of CDCA1 and KNTC2, and their cognate interactions, play significant roles in lung-cancer progression and that methods of inhibiting the complex can be used to treat non-small-cell lung cancer.
摘要翻译：本发明是基于CDCA1和KNTC2的共激活及其同源相互作用在肺癌进展中起重要作用的观察，并且抑制复合物的方法可用于治疗非小细胞肺癌。

109. 发明申请

US20110251090A1 PANCREATIC CANCER RELATED GENE TTLL4 审中-公开
标题翻译：胰腺癌相关基因TTLL4
公开(公告)号：US20110251090A1
公开(公告)日：2011-10-13
申请号：US13061071
申请日：2009-08-21
申请人： Yusuke Nakamura , Hidewaki Nakagawa , Akira Togashi
发明人： Yusuke Nakamura , Hidewaki Nakagawa , Akira Togashi
IPC分类号： C40B30/04 , C07K16/40 , C12Q1/68 , C07H21/00 , C12Q1/25 , G01N33/53
CPC分类号： G01N33/57438 , C12N9/93 , C12N15/1137 , C12N2310/14 , C12Q1/6886 , C12Q2600/136 , C12Q2600/154 , C12Q2600/158 , C12Y603/02025
摘要： The present invention relates to the roles played by TTLL4 genes in pancreatic cancer carcinogenesis and features a method for treating or preventing pancreatic cancer by administering a double-stranded molecule against one or more of the TTLL4 genes or a composition, vector or cell containing such a double stranded molecule. Also, disclosed are methods of identifying compounds for treating and preventing pancreatic cancer, using as an index their effect on the over-expression of TTLL4 in the pancreatic cancer cell.
摘要翻译：本发明涉及TTLL4基因在胰腺癌发生中的作用，其特征在于通过对一种或多种TTLL4基因施用双链分子或含有这样一种或多种的TTLL4基因的组合物，载体或细胞来治疗或预防胰腺癌的方法双链分子。此外，公开了鉴定用于治疗和预防胰腺癌的化合物的方法，其作为对胰腺癌细胞中TTLL4的过表达的影响的指标。

110. 发明申请

US20110224878A1 SHIFT CONTROL APPARATUS OF AUTOMATIC TRANSMISSION 有权
标题翻译：自动变速箱换档控制装置
公开(公告)号：US20110224878A1
公开(公告)日：2011-09-15
申请号：US13020847
申请日：2011-02-04
申请人： Yusuke Nakamura , Hiroyuki Sato
发明人： Yusuke Nakamura , Hiroyuki Sato
IPC分类号： F16H59/68
CPC分类号： F16H61/66259 , F16H59/20 , F16H2061/0227
摘要： There is provided a shift control apparatus of an automatic transmission in a vehicle including a constant speed traveling apparatus, which has a detecting device detecting a surrounding situation of the vehicle and operates according to the detected situation, and an automatic transmission capable of steplessly changing a transmission ratio, the shift control apparatus controlling the automatic transmission according to a shift map for changing the transmission ratio according to a traveling state. The shift control apparatus includes a plurality of shift maps, and a switching and selecting unit selecting and switching to one of the shift maps based on a shift-down request signal or a requested acceleration, which is outputted by a constant speed traveling control device of the constant speed traveling apparatus, according to the situation detected by the detecting device.
摘要翻译：本发明提供一种车辆中的自动变速器的变速控制装置，其包括：恒速行驶装置，其具有检测车辆的周围状况的检测装置，并根据检测到的情况进行动作;以及自动变速器，其能够无级变更传动比，变速控制装置根据行驶状态根据用于改变传动比的换档图来控制自动变速器。变速控制装置包括多个位移图，以及切换选择单元，基于由减速请求信号或所请求的加速度来选择和切换到其中一个换档图，所述减速请求信号或所请求的加速度由恒速行驶控制装置输出恒速行驶装置，根据检测装置检测到的情况。

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