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101. 发明申请

WO1995023151A1 PYRROLO(2,3-D)PYRIMIDINE DERIVATIVES AS ANTIVIRALS 审中-公开
标题翻译：吡咯（2,3-D）吡啶衍生物作为抗病毒剂
公开(公告)号：WO1995023151A1
公开(公告)日：1995-08-31
申请号：PCT/US1995002287
申请日：1995-02-23
申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN
发明人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN , TOWNSEND, Leroy, B. , DRACH, John, C. , RENAU, Thomas, E.
IPC分类号： C07D487/04
CPC分类号： C07D487/04
摘要： This invention relates to a novel class of 4,5,6,7-substituted non-nucleoside, non-phosphorylatable pyrrolo[2,3-d]pyrimidines which exhibit both significantly lower levels of cytotoxicity and superior antiviral activity than known nucleoside, non-nucleoside, and non-nucleoside, non-phosphorylatable pyrrolo[2,3-d]pyrimidine derivatives, particularly against human DNA viruses such as cytomegalovirus (HCMV) and herpes simplex virus type 1 (HSV-1). These compounds are represented by formula (I) wherein R is -NH2 or -NHCH3; R is -CN, -CSNH2, or -CSeNH2; R is -H or -NH2; and R is selected from the group consisting of aryls and aralkyls having 6 to 30 carbon atoms; aliphatic oxy-hydrocarbyls having 2 to 15 carbon atoms, lacking free hydroxyl groups and further lacking acyl or acyl derivatized groups; and oxy-hydrocarbyls having 6 to 30 carbon atoms, at least one aryl or aralkyl group, and only one oxy-group; with the proviso that if R is -CN and R is -H, then R is -NH2 and R is -CH2C6H4-2-CH3.
摘要翻译：本发明涉及一类新颖的4,5,6,7-取代的非核苷，不可磷酸化的吡咯并[2,3-d]嘧啶，其显示出比已知的核苷非特异性的显着更低的细胞毒性水平和更好的抗病毒活性核苷和非核苷，不可磷酸化的吡咯并[2,3-d]嘧啶衍生物，特别是针对人DNA病毒如巨细胞病毒（HCMV）和1型单纯疱疹病毒（HSV-1）。这些化合物由式（I）表示，其中R 4是-NH 2或-NHCH 3; R 5是-CN，-CSNH 2或-CSeNH 2; R 6是-H或-NH 2; R 7选自具有6〜30个碳原子的芳基和芳烷基; 具有2至15个碳原子的脂族烃基，缺少游离羟基并进一步缺乏酰基或酰基衍生基团; 和具有6至30个碳原子的烃基，至少一个芳基或芳烷基和仅一个氧基; 条件是如果R 5是-CN且R 6是-H，那么R 4是-NH 2，R 7是-CH 2 C 6 H 4 -2-CH 3。

102. 发明申请

WO1995022611A2 METHODS AND COMPOSITIONS FOR STIMULATING BONE CELLS 审中-公开
标题翻译：刺激骨细胞的方法和组合物
公开(公告)号：WO1995022611A2
公开(公告)日：1995-08-24
申请号：PCT/US1995002251
申请日：1995-02-21
申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN
发明人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN
IPC分类号： C12N15/12
CPC分类号： A61K9/0024 , A61K38/29 , A61K47/6953 , A61K48/00 , C07K14/47 , C07K14/51 , C07K14/635 , C07K14/72 , C07K14/78 , C07K2319/00 , C12N15/87 , C12N2799/022
摘要： Disclosed are methods, compositions, kits and devices for use in transferring nucleic acids into bone cells in situ and/or for stimulating bone progenitor cells. Type II collagen and, particularly, osteotropic genes, are shown to stimulate bone progenitor cells and to promote bone growth, repair and regeneration in vivo. Gene transfer protocols are disclosed for use in transferring various nucleic acid materials into bone, as may be used in treating various bone-related diseases and defects including fractures, osteoporosis, osteogenesis, imperfecta and in connection with bone implants.
摘要翻译：公开了用于将核酸转移到原位骨髓细胞和/或刺激骨祖细胞中的方法，组合物，试剂盒和装置。 II型胶原，特别是成骨基因，显示出刺激骨祖细胞并促进骨生长，体内修复和再生。公开了用于将各种核酸材料转移到骨中的基因转移方案，可用于治疗各种与骨相关的疾病和缺陷，包括骨折，骨质疏松，成骨，不完全以及与骨植入物的关系。

103. 发明申请

WO1995011301A1 P53-MEDIATED APOPTOSIS 审中-公开
标题翻译： P53介导的APOPTOSIS
公开(公告)号：WO1995011301A1
公开(公告)日：1995-04-27
申请号：PCT/US1994011923
申请日：1994-10-19
申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN
发明人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN , CLARKE, Michael, F. , RYAN, James, Joseph , NUNEZ, Gabriel , WICHA, Max, S.
IPC分类号： C12N15/12
CPC分类号： A61K38/1709 , A61K48/00 , C07K14/4746 , C07K14/82 , C12N2799/022
摘要： The invention is directed to methods of reducing the viability of a proliferating mammalian cells such as cancer cells. In one method cells deficient in p53 activity and in p53 suppressor activity of one or more p53-interacting regulatory proteins cell viability is reduced by increasing the level or activity of p53 in the cell. In another method viability of cells exhibiting p53 activity and p53 suppressor activity of one or more p53-interacting regulatory proteins is reduced by reducing the suppressor activity of the one or more p53-interacting regulatory proteins. Further, cell viability is reduced in cells deficient in p53 activity and exhibiting p53 suppressor activity of one or more p53-interacting regulatory proteins by a method that includes: (a) increasing the level or activity of p53 in the cell, and (b) reducing the suppressor activity of the one or more p53-interacting regulatory proteins. Also, included are methods of selectively reducing the viability of proliferating cancer cells compared to nonproliferating normal cells within a mixed population of cells and to methods of selectively reducing the viability of chronic granulocytic leukemia cells within a sample of proliferating bone marrow cells.
摘要翻译：本发明涉及减少增殖的哺乳动物细胞如癌细胞的活力的方法。在一种方法中，一种或多种p53相互作用的调节蛋白的p53活性和p53抑制活性缺乏的细胞通过增加细胞中p53的水平或活性来降低细胞活力。在另一种方法中，通过降低一种或多种p53相互作用的调节蛋白的抑制活性来降低表现出一种或多种p53相互作用调节蛋白的p53活性和p53抑制活性的细胞的存活力。此外，通过包括以下方法的一种或多种p53相互作用的调节蛋白的p53抑制活性表现出p53活性缺陷的细胞的细胞活力降低，（a）增加细胞中p53的水平或活性，（b）降低一种或多种p53相互作用的调节蛋白的抑制活性。此外，包括与混合细胞群体内的非增殖性正常细胞相比选择性降低增殖性癌细胞的存活力的方法以及选择性降低增殖性骨髓细胞样品内慢性粒细胞白血病细胞活力的方法。

104. 发明申请

WO1995004067A1 MARKERS FOR DETECTION OF CHROMOSOME 16 REARRANGEMENTS 审中-公开
标题翻译：检测染色体16重新标记的标记
公开(公告)号：WO1995004067A1
公开(公告)日：1995-02-09
申请号：PCT/US1994008530
申请日：1994-07-26
申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN , THE BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM
发明人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN , THE BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM , LIU, Pu , COLLINS, Francis, S. , SICILIANO, Michael, J. , CLAXTON, David
IPC分类号： C07H21/02
CPC分类号： G01N33/57426 , C07K14/4705 , C07K14/4716 , C07K2319/00 , C12Q1/6886 , C12Q2600/158 , G01N2800/382 , Y10S530/828 , Y10S530/841
摘要： The breakpoints of the pericentric inversion of chromosome 16 have been cloned. Two genes, one at each breakpoint, have also been identified, as well as several forms of the inversion 16 fusion gene. Diagnostic applications for chromosome 16 abnormalities and, particularly acute myeloid leukemia, are also within the scope of the present invention. The figure is a diagrammatic representation of the locations of the human genomic chromosome 16p content of hybrid cells and recombinant clones.
摘要翻译： 16号染色体的中心倒置的断点已被克隆。两个基因，每个断点一个，也已被鉴定，以及几种形式的倒置16融合基因。染色体16异常特别是急性骨髓性白血病的诊断应用也在本发明的范围内。该图是杂交细胞和重组克隆的人基因组染色体16p含量的位置的图示。

105. 发明申请

WO1994007542A3 LABELLED MONOCYTE CHEMOATTRACTANT PROTEIN MATERIAL AND MEDICAL USES THEREOF 审中-公开
公开(公告)号：WO1994007542A3
公开(公告)日：1994-04-14
申请号：PCT/US1993009417
申请日：1993-10-04
申请人： MALLINCKRODT MEDICAL, INC. , THE REGENTS OF THE UNIVERSITY OF MICHIGAN
发明人： MALLINCKRODT MEDICAL, INC. , THE REGENTS OF THE UNIVERSITY OF MICHIGAN , KUNKEL, Steven, L. , LYLE, Leon, R.
IPC分类号： A61K49/02

106. 发明申请

WO1994002616A1 CLONING AND EXPRESSION OF A HUMAN 'alpha'(1,3)FUCOSYLTRANSFERASE, FUCT-VI 审中-公开
标题翻译：人类α（1,3）FUCOSYRTRANSFERASE，FUCT-VI的克隆和表达
公开(公告)号：WO1994002616A1
公开(公告)日：1994-02-03
申请号：PCT/US1993006703
申请日：1993-07-20
申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN
发明人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN , LOWE, John, B.
IPC分类号： C12N15/54
CPC分类号： C07K16/40 , C07K2319/00 , C07K2319/05 , C07K2319/705 , C12N9/1051 , C12N15/62 , C12Q1/6813
摘要： A method for isolating a gene, comprising: (i) isolating a cell possessing a post-translational characteristic of interest, said post-translational characteristic being the presence of a membrane-bound oligosaccharide or polysaccharide of interest on the surface of said cell, the presence of a soluble oligosaccharide or polysaccharide of interest in an extract of said cell, or the presence of a particularly glycosyltransferase activity in an extract of said cell; (ii) creating a genetic library of either cDNA or genomic DNA from the genetic material of said isolated cell; (iii) transforming host cells with said genetic library; and (iv) screening said transformed host cells for a host cell containing said post-translational characteristic, thereby obtaining a cell containing said gene, is disclosed. The method can be used to obtain genes encoding glycosyltransferases.
摘要翻译：一种用于分离基因的方法，包括：（i）分离具有翻译后特征的细胞，所述翻译后特征是所述细胞表面上存在膜结合的寡糖或目标多糖，在所述细胞的提取物中存在感兴趣的可溶性寡糖或多糖，或在所述细胞的提取物中存在特别的糖基转移酶活性; （ii）从所述分离的细胞的遗传物质中产生cDNA或基因组DNA的遗传文库; （iii）用所述遗传文库转化宿主细胞; 和（iv）筛选所述转化的宿主细胞用于含有所述翻译后特征的宿主细胞，从而获得含有所述基因的细胞。该方法可用于获得编码糖基转移酶的基因。

107. 发明申请

WO1993023073A1 THYROID PEROXIDASE EPITOPIC REGIONS 审中-公开
标题翻译：甲状腺过氧化物酶
公开(公告)号：WO1993023073A1
公开(公告)日：1993-11-25
申请号：PCT/US1993003837
申请日：1993-04-22
申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN , BAKER, James, R., Jr. , KOENIG, Ronald, J.
发明人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN
IPC分类号： A61K37/50
CPC分类号： C12N9/0065 , A61K38/00 , A61K39/00 , G01N33/564 , G01N33/573 , G01N2800/24 , Y10S435/975 , Y10S436/811 , Y10S530/854
摘要： Specific eptitopic regions of thyroid peroxidase (TPO), a thyroid-specific membrane autoantigen, have been identified from amino acid 456 to 933, with distinct epitopic regions from amino acid 517 to 630 and from 633 to 933 of the TPO molecule, the former region having at least one distinct binding region therewithin located from aminoacid 592 to 613. The identification and production of these localized epitopes/epitopic regions provide specific diagnostic reagents for autoimmune thyroid disease. As a thyroid-specific immunogenic structure, the TPO epitope/epitopic regions identified can be used for immunotherapy of thyroid disease and thyroid cancer.
摘要翻译：甲状腺过氧化物酶（TPO），甲状腺特异性膜自身抗原的特异性顶点区域已经从氨基酸456至933鉴定出来，其中TPO分子的氨基酸517至630和633至933的不同表位区域，前区其中位于氨基酸592至613中的至少一个不同的结合区。这些局部表位/表位区的鉴定和产生提供了用于自身免疫性甲状腺疾病的特异性诊断试剂。作为甲状腺特异性免疫原性结构，鉴定的TPO表位/表位区域可用于甲状腺疾病和甲状腺癌的免疫治疗。

108. 发明申请

WO1993018009A1 ANTIVIRAL NUCLEOSIDE ANALOGUES 审中-公开
标题翻译：抗病毒核苷酸类似物
公开(公告)号：WO1993018009A1
公开(公告)日：1993-09-16
申请号：PCT/GB1993000479
申请日：1993-03-08
申请人： THE WELLCOME FOUNDATION LIMITED , THE REGENTS OF THE UNIVERSITY OF MICHIGAN , TOWNSEND, Leroy, B. , DRACH, John, Charles , GOOD, Steven, Spencer , DALUGE, Susan, Mary , MARTIN, Michael, Tolar
发明人： THE WELLCOME FOUNDATION LIMITED , THE REGENTS OF THE UNIVERSITY OF MICHIGAN
IPC分类号： C07D235/06
CPC分类号： C07D235/06 , C07D235/08 , C07D235/24 , C07D235/26 , C07D235/28 , C07D235/30
摘要： Antiviral nucleoside analogues contain a substituted benzimidazole base attached to a carbocyclic ring in a place of the conventional sugar residue. Particularly preferred compounds include those in which the 2-,5- and 6- positions of the benzimidazole base are substituted by halogen. The compounds have activity against herpes virus especially cytomegalovirus and also hepatitis B virus infections.
摘要翻译：抗病毒核苷类似物在常规糖残基的位置含有连接到碳环上的取代的苯并咪唑碱。特别优选的化合物包括其中苯并咪唑碱的2-，5-和6-位被卤素取代的化合物。该化合物具有抗疱疹病毒特异性巨细胞病毒和乙型肝炎病毒感染的活性。

109. 发明申请

WO1993009808A1 METHODS FOR DETECTING AND ISOLATING uPA-R AND INHIBITING THE BINDING OF uPA TO uPA-R 审中-公开
标题翻译：检测和分离uPA-R并抑制uPA与uPA-R结合的方法
公开(公告)号：WO1993009808A1
公开(公告)日：1993-05-27
申请号：PCT/US1992008977
申请日：1992-10-27
申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN
发明人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN , MIZUKAMI, Ikuko, F. , TODD, Robert, F., III
IPC分类号： A61K39/00
CPC分类号： G01N33/573 , A61K38/00 , C07K14/705 , C07K16/2896
摘要： Antibodies specific for Mo3 are capable of binding to uPA-R and may be used to detect or isolate uPA-R or to inhibit the binding of uPA to uPA-R.
摘要翻译：对Mo3特异性的抗体能够结合uPA-R，可用于检测或分离uPA-R或抑制uPA与uPA-R的结合。

110. 发明申请

WO1993003750A1 PROTEINS USEFUL IN THE REGULATION OF 'kappa'B-CONTAINING GENES, CORRESPONDING DNA AND RNA SEQUENCES 审中-公开
标题翻译：蛋白质可用于调节含κB的基因，相关DNA和RNA序列
公开(公告)号：WO1993003750A1
公开(公告)日：1993-03-04
申请号：PCT/US1992006888
申请日：1992-08-21
申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN
发明人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN , NABEL, Gary, Jan , SCHMID, Roland, Michael , PERKINS, Neil, Donald
IPC分类号： A61K37/02
CPC分类号： C07K14/4702
摘要： Proteins, and corresponding DNA and RNA sequences, useful for the regulation of expression of kappa B-containing genes are disclosed. These proteins are useful to either stimulate or inhibit the expression of kappa B-containing genes. Proteins stimulating the expression of kappa B-containing genes have an amino acid sequence at least 80 % identical to the amino acid sequence of from position 1 to position 374 of p100 [SEQ ID NO: 2]. Proteins having an inhibitory effect on the expression of kappa B-containing genes have sequences either at least 80 % identical to the amino acid sequence of from position 407 to the carboxyl end of p100 [SEQ ID NO: 2] or having an amino acid sequence at least 80 % identical to the amino sequence of either from position 1 to 100 or from position 101 to position 374 of p100 [SEQ ID NO: 2].
摘要翻译：公开了可用于调节含κB基因表达的蛋白质和相应的DNA和RNA序列。这些蛋白质可用于刺激或抑制含κB的基因的表达。刺激含κB基因表达的蛋白质具有与p100 [SEQ ID NO：2]的位置1至位置374的氨基酸序列至少80％相同的氨基酸序列。具有对含κB基因表达的抑制作用的蛋白质具有与位置407至p100 [SEQ ID NO：2]的羧基末端的氨基酸序列至少80％相同或具有氨基酸序列的序列与p100 [SEQ ID NO：2]的位置1至100的氨基酸序列或位置101至位置374至少80％相同。

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