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101. 发明专利

DE69828692T2 未知
公开(公告)号：DE69828692T2
公开(公告)日：2006-01-12
申请号：DE69828692
申请日：1998-06-26
申请人： NOVARTIS AG
发明人： DOSENBACH CORNELIA , GRASSBERGER MAXIMILIAN , HARTMANN OTTO , HORVATH AMARYLLA , MUTZ JEAN-PAUL , PENN GERHARD , PFEFFER SABINE , WIECKHUSEN DIERK
IPC分类号： C07D498/18 , A61K20060101 , A61K31/33 , A61K31/4353 , A61K31/436 , A61K31/439 , A61K31/55 , A61K31/695 , A61P29/00 , A61P37/00 , A61P37/06 , A61P43/00 , C07B20060101 , C07D20060101 , C07D498/16
摘要： 33-Epichloro-33-desoxyascomycin of formula Iand various tautomeric or forms thereof, in crystalline form, such as Form A and Form B.Their preparation involves appropriately converting amorphous compound of formula I, or compound of formula I in other than Form A, or compound of formula I in other than Form B, respectively, from a solution thereof under crystallization-inducing conditions or conditions inducing preferential crystallization of Form A or B, respectively.Such crystals are particularly indicated for use in the preparation of topical galenical forms of the compound for pharmaceutical use, e.g. creams, emulsions and ointments.

102. 发明专利

PL376525A1 Sposób modyfikacji pokroju kryształów substancji leczniczej 未知
公开(公告)号：PL376525A1
公开(公告)日：2006-01-09
申请号：PL37652504
申请日：2004-01-19
申请人： NOVARTIS AG
发明人： PFEFFER SABINE , WIECKHUSEN DIERK
IPC分类号： A61K9/14 , A61K9/28 , C07D307/88

103. 发明专利

CO5580738A2 PROCEDIMIENTO PARA MODIFICAR LA FORMACION DE CRISTAL DE FARMACO 未知
公开(公告)号：CO5580738A2
公开(公告)日：2005-11-30
申请号：CO05072728
申请日：2005-07-25
申请人： NOVARTIS AG
发明人： PFEFFER SABINE , WIECKHUSEN DIERK
IPC分类号： A61K9/14 , A61K9/28 , A61K31/05 , C07D307/88
摘要： 1.- Un procedimiento para modificar el hábito de cristal de una sustancia de fármaco acicular, que comprende suspender dicha sustancia de fármaco cristalina en un sistema de solvente que tiene un efecto sobre el hábito de cristal, y someter dicha suspensión a una oscilación de temperatura.2.- Un procedimiento para la recristalización de una sustancia de fármaco acicular, que comprende suspender dichos cristales en un sistema de solvente que tiene un efecto sobre el hábito de cristal, y someter dicha suspensión a una oscilación de temperatura.3.- El procedimiento de acuerdo con la reivindicación 1 ó 2, en donde el hábito de cristal es modificado ya que la relación de aspecto media de los cristales procesados es menor que aproximadamente 10:1.4.- El procedimiento de acuerdo con cualquiera de las reivindicaciones 1 a 3, en donde la sustancia del fármaco después de la oscilación de temperatura tiene una densidad aparente por arriba de aproximadamente 200 kg/m3.5.- El procedimiento de acuerdo con cualquiera de las reivindicaciones precedentes, en donde la oscilación de temperatura está en la forma de una curva de zigzag.

104. 发明专利

NO20053846A 未知
公开(公告)号：NO20053846A
公开(公告)日：2005-08-16
申请号：NO20053846
申请日：2005-08-16
申请人： NOVARTIS AG
发明人： PFEFFER SABINE , WIECKHUSEN DIERK
IPC分类号： A61K9/14 , A61K9/28 , C07D307/88
CPC分类号： C07D307/88 , A61K9/14 , A61K9/2866

105. 发明专利

NO20052244L 未知
公开(公告)号：NO20052244L
公开(公告)日：2005-07-07
申请号：NO20052244
申请日：2005-05-06
申请人： NOVARTIS AG
发明人： SEDELMEIER GOTTFRIED , PFEFFER SABINE , BLATTER FRITZ , MATHES CHRISTIAN , GRIMLER DOMINIQUE
IPC分类号： A61P25/08 , C07D223/24 , C07F15/00 , A61K31/55
摘要： The invention relates to a novel process for the manufacture of substituted enantiopure 10hydroxy-dihydrodibenz[b,f]azepines (Ia), (Ib) wherein each of R 1 and R 2 , independently, are hydrogen, halogen, amino or nitro; and each of R 3 and R 4 , independently, are hydrogen or C 1 -C 6 alkyl; by transfer hydrogenation of 10-oxo-dihydrodibenz[b,f]azepines; and to novel catalysts of formula (III'a) and (III'b) wherein M is Ru, Rh, Ir, Fe, Co or Ni; L 1 is hydrogen; L 2 represents an aryl or aryl-aliphatic residue; and the further radicals have the meanings as defined herein; and to new crystal forms of both enantiomers of 10,11-dihydro-10 hydroxy-5Hdibenz[b,f]azepine-5-carboxamide, obtainable by the new processes, their usage in the production of pharmaceutical preparations, new pharmaceutical preparations comprising these new crystal forms and/or the use of these new crystal forms in the treatment of disorders such as epilepsy, or in the production of pharmaceutical formulations which are suitable for this treatment.

106. 发明专利

PE02532005A1 MODIFICACIONES ESTABLES DE MALEATO DE HIDROGENO DE TEGASEROD 未知
公开(公告)号：PE02532005A1
公开(公告)日：2005-06-03
申请号：PE0007062004
申请日：2004-07-22
申请人： NOVARTIS AG
发明人： PFEFFER SABINE , VITZLING CHRISTIAN
IPC分类号： A61K31/404 , C07D209/14
CPC分类号： A61K31/404 , C07D209/14
摘要： REFERIDA A UNA MODIFICACION ESENCIALMENTE PURA DEL CRISTAL A DE MALEATO DE H DE TEGASEROD PRESENTANDO DETERMINADOS VALORES EN EL ANALISIS DE CRISTAL DE RAYOS X, UN PATRON DE DIFRACCIONDE POLVOS DE RAYOS X CUYOS VALORES q SON: 5.4 ± 0.3°, 6.4 ± 0.3°, 10.8 ± 0.3°, 16.2 ± 0.3°, ENTRE OTROS; UNA SENAL ENDORTERMICA DE APROX. 190°C EN EL TERMOGRAMA EN CALORIMETRIA DE EXPLORACION DIFERENCIAL. TAMBIEN REFERIDA A UNA PROCESO DE PREPARACION Y A UNA COMPOSICION FARMACEUTICA QUE COMPRENDA UN VEHICULO ADEMAS. DICHO MEDICAMENTO ES UTIL PARA EL TRATAMIENTO DE SINDROME DE INTESTINO IRRITABLE, REFLUJO GASTROESOFAGICO, CONSTIPACION CRONICA, DIARREA, ENTRE OTROS

107. 发明专利

DE69828692D1 未知
公开(公告)号：DE69828692D1
公开(公告)日：2005-02-24
申请号：DE69828692
申请日：1998-06-26
申请人： NOVARTIS AG
发明人： DOSENBACH CORNELIA , GRASSBERGER MAXIMILIAN , HARTMANN OTTO , HORVATH AMARYLLA , MUTZ JEAN-PAUL , PENN GERHARD , PFEFFER SABINE , WIECKHUSEN DIERK
IPC分类号： C07D498/18 , A61K20060101 , A61K31/33 , A61K31/4353 , A61K31/436 , A61K31/439 , A61K31/55 , A61K31/695 , A61P29/00 , A61P37/00 , A61P37/06 , A61P43/00 , C07B20060101 , C07D20060101 , C07D498/16
摘要： 33-Epichloro-33-desoxyascomycin of formula Iand various tautomeric or forms thereof, in crystalline form, such as Form A and Form B.Their preparation involves appropriately converting amorphous compound of formula I, or compound of formula I in other than Form A, or compound of formula I in other than Form B, respectively, from a solution thereof under crystallization-inducing conditions or conditions inducing preferential crystallization of Form A or B, respectively.Such crystals are particularly indicated for use in the preparation of topical galenical forms of the compound for pharmaceutical use, e.g. creams, emulsions and ointments.

108. 发明专利

AU2004206731A8 Process for modifying drug crystal formation 未知
公开(公告)号：AU2004206731A8
公开(公告)日：2004-08-05
申请号：AU2004206731
申请日：2004-01-19
申请人： NOVARTIS AG
发明人： PFEFFER SABINE , WIECKHUSEN DIERK
IPC分类号： A61K9/14 , A61K9/28 , C07D307/88
摘要： Process for modifying the crystal habit of an acicular drug crystal wherein the acicular drug substance is a mycophenolate sodium salt, comprising suspending said crystalline drug substance in a methanol/water solvent and subjecting said suspension to a temperature oscillation, wherein the crystal habit is modified in that the mean aspect ratio of the processed crystals is smaller than 10:1 and the bulk density is above 200 kg/m 3 .

109. 发明专利

NO312765B1 未知
公开(公告)号：NO312765B1
公开(公告)日：2002-07-01
申请号：NO995909
申请日：1999-12-02
申请人： NOVARTIS AG
发明人： DOSENBACH CORNELIA , GRASSBERGER MAXIMILLAN , HARTMANN OTTO , HORVATH AMARYLLA , MUTZ JEAN-PAUL , PENN GERHARD , PFEFFER SABINE , WIECHUSEN DIERK
IPC分类号： C07D498/18 , A61K20060101 , A61K31/33 , A61K31/4353 , A61K31/436 , A61K31/439 , A61K31/55 , A61K31/695 , A61P29/00 , A61P37/00 , A61P37/06 , A61P43/00 , C07B20060101 , C07D20060101 , C07D498/16
摘要： 33-Epichloro-33-desoxyascomycin of formula Iand various tautomeric or forms thereof, in crystalline form, such as Form A and Form B.Their preparation involves appropriately converting amorphous compound of formula I, or compound of formula I in other than Form A, or compound of formula I in other than Form B, respectively, from a solution thereof under crystallization-inducing conditions or conditions inducing preferential crystallization of Form A or B, respectively.Such crystals are particularly indicated for use in the preparation of topical galenical forms of the compound for pharmaceutical use, e.g. creams, emulsions and ointments.

110. 发明专利

HK1028597A1 Crystalline macrolides and process for their preparation. 未知
公开(公告)号：HK1028597A1
公开(公告)日：2001-02-23
申请号：HK00106806
申请日：2000-10-25
申请人： NOVARTIS AG
发明人： DOSENBACH CORNELIA , GRASSBERGER MAXIMILIAN , HARTMANN OTTO , HORVATH AMARYLLA , MUTZ JEAN-PAUL , PENN GERHARD , PFEFFER SABINE , WIECKHUSEN DIERK
IPC分类号： C07D498/18 , A61K20060101 , A61K31/33 , A61K31/4353 , A61K31/436 , A61K31/439 , A61K31/55 , A61K31/695 , A61P29/00 , A61P37/00 , A61P37/06 , A61P43/00 , C07B20060101 , C07D20060101 , C07D498/16 , C07D
摘要： 33-Epichloro-33-desoxyascomycin of formula Iand various tautomeric or forms thereof, in crystalline form, such as Form A and Form B.Their preparation involves appropriately converting amorphous compound of formula I, or compound of formula I in other than Form A, or compound of formula I in other than Form B, respectively, from a solution thereof under crystallization-inducing conditions or conditions inducing preferential crystallization of Form A or B, respectively.Such crystals are particularly indicated for use in the preparation of topical galenical forms of the compound for pharmaceutical use, e.g. creams, emulsions and ointments.

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