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101. 发明授权

US07674416B2 Hybrid intravascular stent 有权
标题翻译：混合血管内支架
公开(公告)号：US07674416B2
公开(公告)日：2010-03-09
申请号：US11020826
申请日：2004-12-22
申请人： James Hong , Rahul Bhagat , Syed Hossainy , Santosh Prabhu , K. T. Venkateswara Rao , Ashok Shah , Srinivasan Sridharan
发明人： James Hong , Rahul Bhagat , Syed Hossainy , Santosh Prabhu , K. T. Venkateswara Rao , Ashok Shah , Srinivasan Sridharan
IPC分类号： B32B38/08
CPC分类号： A61F2/915 , A61F2/07 , A61F2/91 , A61F2002/072 , A61F2002/91533 , A61F2002/91558 , A61F2002/91575 , A61F2220/0058 , A61F2230/0013 , A61F2230/0054 , A61L31/10 , A61L31/16 , Y10S623/901
摘要： A hybrid stent is formed which exhibits both high flexibility and high radial strength. The expandable hybrid stent for implantation in a body lumen, such as a coronary artery, consists of radially expandable cylindrical rings generally aligned on a common longitudinal axis and interconnected by one or more links. In one embodiment, a dip-coated covered stent is formed by encapsulating cylindrical rings within a polymer material. In other embodiments, at least some of the rings and links are formed of a polymer material which provides longitudinal and flexural flexibility to the stent. These polymer rings and links are alternated with metallic rings and links in various configurations to attain sufficient column strength along with the requisite flexibility in holding open the target site within the body lumen. Alternatively, a laminated, linkless hybrid stent is formed by encapsulating cylindrical rings within a polymer tube.
摘要翻译：形成具有高柔性和高径向强度的混合支架。用于植入体腔（例如冠状动脉）中的可扩张混合支架由径向可扩展的圆柱形环构成，其通常在公共纵向轴线上对齐并且由一个或多个连杆相互连接。在一个实施例中，通过将圆柱形环封装在聚合物材料内而形成浸涂的覆盖支架。在其它实施例中，至少一些环和链节由聚合物材料形成，该聚合物材料向支架提供纵向和弯曲的柔性。这些聚合物环和链环与金属环和各种结构的链接交替，以获得足够的柱强度以及在体腔内保持打开靶部位所需的灵活性。或者，通过在聚合物管内封装圆柱形环来形成层压的无环式混合支架。

102. 发明授权

US07641643B2 Methods and compositions to treat myocardial conditions 有权
标题翻译：治疗心肌病症的方法和组合物
公开(公告)号：US07641643B2
公开(公告)日：2010-01-05
申请号：US10414767
申请日：2003-04-15
申请人： Eugene T. Michal , Evgenia Mandrusov , Charles D. Claude , Nadine Ding , Murthy Simhambhatla , Syed Faiyez Ahmed Hossainy , Srinivasan Sridharan , Paul Consigny
发明人： Eugene T. Michal , Evgenia Mandrusov , Charles D. Claude , Nadine Ding , Murthy Simhambhatla , Syed Faiyez Ahmed Hossainy , Srinivasan Sridharan , Paul Consigny
IPC分类号： A61M31/00
CPC分类号： A61N1/3625 , A61K9/0024 , A61K31/00 , A61K31/728 , A61K31/732 , A61K31/734 , A61K31/78 , A61K31/79 , A61K36/886 , A61K38/40 , A61K41/0042 , A61K45/06 , A61K47/02 , A61K47/34 , A61K47/60 , A61K47/62 , A61K49/0404 , A61L24/043 , A61L27/20 , A61L27/50 , A61L27/54 , A61L2430/20 , A61N1/36521 , A61K2300/00
摘要： Methods, devices, kits and compositions to treat a myocardial infarction. In one embodiment, the method includes the prevention of remodeling of the infarct zone of the ventricle. In other embodiments, the method includes the introduction of structurally reinforcing agents. In other embodiments, agents are introduced into a ventricle to increase compliance of the ventricle. In an alternative embodiment, the prevention of remodeling includes the prevention of thinning of the ventricular infarct zone. In another embodiment, the prevention of remodeling and thinning of the infarct zone involves the cross-linking of collagen and prevention of collagen slipping. In other embodiments, the structurally reinforcing agent may be accompanied by other therapeutic agents. These agents may include but are not limited to pro-fibroblastic and angiogenic agents.
摘要翻译：用于治疗心肌梗塞的方法，装置，试剂盒和组合物。在一个实施例中，该方法包括防止脑室梗死区的重塑。在其它实施方案中，该方法包括引入结构上增强剂。在其它实施方案中，将药剂引入心室以增加心室的依从性。在替代实施例中，预防重塑包括防止心室梗塞区变薄。在另一个实施方案中，预防梗塞区的重塑和变薄包括胶原蛋白的交联和预防胶原蛋白滑脱。在其它实施方案中，结构上增强剂可以伴随其它治疗剂。这些药剂可以包括但不限于前成纤维细胞和血管生成剂。

103. 发明授权

US07638156B1 Apparatus and method for selectively coating a medical article 有权
标题翻译：用于选择性地涂敷医疗制品的装置和方法
公开(公告)号：US07638156B1
公开(公告)日：2009-12-29
申请号：US11312149
申请日：2005-12-19
申请人： Syed F. A. Hossainy , Gordon Stewart , Srinivasan Sridharan , Arkady Kokish , Klaus Kleine , Benjamyn Serna , Bjorn G. Svensson
发明人： Syed F. A. Hossainy , Gordon Stewart , Srinivasan Sridharan , Arkady Kokish , Klaus Kleine , Benjamyn Serna , Bjorn G. Svensson
IPC分类号： A61L33/00
CPC分类号： B05D1/32 , B05B12/20 , B05B13/0442 , B05D1/02 , Y10T428/13
摘要： Masking apparatus and methods of masking a medical article, such as stent, for selective application of a coating composition on the article are disclosed.
摘要翻译：公开了掩模设备和掩蔽诸如支架之类的医疗用品的选择性施用涂料组合物的方法。

104. 发明申请

US20090232700A1 Sterilization of Biosensors 审中-公开
标题翻译：生物传感器的灭菌
公开(公告)号：US20090232700A1
公开(公告)日：2009-09-17
申请号：US12464488
申请日：2009-05-12
申请人： Javier Alarcon , Kristin Weidemaier , David M. Kurisko , Srinivasan Sridharan
发明人： Javier Alarcon , Kristin Weidemaier , David M. Kurisko , Srinivasan Sridharan
IPC分类号： A61L2/08
CPC分类号： A61L2/082 , A61B5/1486 , A61L2/0011 , A61L2/0035 , A61L2/0094 , A61L2/022 , A61L2/081 , A61L2/087 , A61L2/10 , A61L2/206 , A61L2/208
摘要： The present invention relates to methods of making a sterilized biosensor, where the biosensor comprises at least one binding reagent, which comprises at least one non-enzyme proteinaceous binding domain. Certain embodiments of the methods described herein comprise partially assembling the components of the biosensor, except for the binding reagent, and separately sterilizing this partial assemblage and the binding reagent. The sterilized binding reagent and the sterilized partial assemblage are then aseptically assembled to produce the sterilized biosensor. Other embodiments of the methods described herein comprise assembling substantially all of the components of the biosensor, including the binding reagent, and sterilizing the assembled biosensor to produce a sterilized biosensor.
摘要翻译：本发明涉及制造无菌生物传感器的方法，其中生物传感器包括至少一种包含至少一个非蛋白质结合结构域的结合试剂。本文描述的方法的某些实施方案包括部分组装除了结合试剂之外的生物传感器的组分，并且对该部分组合物和结合试剂进行单独灭菌。灭菌的结合试剂和灭菌的部分组合物然后无菌组装以产生无菌生物传感器。本文描述的方法的其它实施方案包括组装生物传感器的基本上所有组分，包括结合试剂，并对组装的生物传感器进行灭菌以产生无菌生物传感器。

105. 发明申请

US20080113081A1 Methods for Modifying Balloon of a Catheter Assembly 审中-公开
标题翻译：改造导管组装气球的方法
公开(公告)号：US20080113081A1
公开(公告)日：2008-05-15
申请号：US12018122
申请日：2008-01-22
申请人： Syed Hossainy , Srinivasan Sridharan
发明人： Syed Hossainy , Srinivasan Sridharan
IPC分类号： B05D5/00
CPC分类号： A61M25/1029 , A61M2025/1031 , A61M2025/105
摘要： Methods for modifying a balloon of a catheter assembly are disclosed.
摘要翻译：公开了用于修改导管组件的球囊的方法。

106. 发明申请

US20080041516A1 INFUSION TREATMENT AGENTS, CATHETERS, FILTER DEVICES, AND OCCLUSION DEVICES, AND USE THEREOF 有权
标题翻译：输液治疗剂，过滤器，过滤器和消毒装置及其用途
公开(公告)号：US20080041516A1
公开(公告)日：2008-02-21
申请号：US11923258
申请日：2007-10-24
申请人： Jessica Chiu , Gregory Chan , Gabriel Asongwe , Robert Esselstein , Douglas Gesswein , Srinivasan Sridharan , Nianjiong Bei , William Webler , Stephen Schaible , Mina Chow , Yan Shen , Hongzhi Bai , Mark Bly , Thomas Hatten
发明人： Jessica Chiu , Gregory Chan , Gabriel Asongwe , Robert Esselstein , Douglas Gesswein , Srinivasan Sridharan , Nianjiong Bei , William Webler , Stephen Schaible , Mina Chow , Yan Shen , Hongzhi Bai , Mark Bly , Thomas Hatten
IPC分类号： B29C53/60
CPC分类号： A61M25/10 , A61M25/1002 , A61M2025/1052
摘要： Embodiments include an infusion-occlusion system having a delivery catheter, a guide catheter adapted to receive the delivery catheter, and a guidewire with an occlusion device adapted to be received within the guide catheter. The guide catheter of the catheter kit may be provided with an occlusion device at the distal end of the guide catheter. The delivery catheter may have an accessory lumen, coaxial or co-linear lumen, a supporting mandrel, or an occlusion device at its distal end. Moreover, according to some embodiments, occlusion devices may be a single material or a composite balloon having an inner liner and an outer layer of different materials, a high compliance low pressure balloon, or a filter device that restricts particles from passing through but does not restrict fluid, such as blood. An inflation device with a large volume and low volume syringe can be used to inflate the balloon.
摘要翻译：实施例包括具有输送导管的输液阻塞系统，适于接收输送导管的引导导管，以及具有适于容纳在引导导管内的闭塞装置的导丝。导管套件的引导导管可以在引导导管的远端处设置有闭塞装置。输送导管可以具有附件腔，同轴或共线腔，支撑心轴或其远端处的闭塞装置。此外，根据一些实施例，闭塞装置可以是具有内衬和不同材料外层的单一材料或复合球囊，高顺应性低压气球或限制颗粒通过但不限制的过滤装置限制流体，如血液。可以使用具有大体积和低体积注射器的充气装置来使气囊膨胀。

107. 发明申请

US20070138694A1 CATHETER BALLOON 审中-公开
标题翻译：导管气球
公开(公告)号：US20070138694A1
公开(公告)日：2007-06-21
申请号：US11680027
申请日：2007-02-28
申请人： Srinivasan Sridharan
发明人： Srinivasan Sridharan
IPC分类号： B29C65/00
CPC分类号： A61M25/104 , A61M2025/1075
摘要： An expandable medical device or component thereof including a tubular body formed of a wrapped sheet of porous polymeric material fused together, the tubular body having a fused seam at an angle relative to the longitudinal axis of the tubular body which changes along the length of the tubular body from a first angle to a second angle greater than the first angle. The sheet of porous polymeric material is wound and then fused together such that the winding angle is less in a first longitudinal section of the tubular body compared with the winding angle in a second longitudinal section of the tubular body, in order to provide the second section with greater resistance to expansion (i.e., lower compliance) than the first section.
摘要翻译：一种可扩张的医疗装置或其部件，包括一个管状体，该管状体由一层多孔聚合物材料形成，该多孔聚合物材料熔合在一起，该管状体具有相对于该管状体的纵向轴线成一定角度的熔融接缝，主体从第一角度到大于第一角度的第二角度。多孔聚合物材料片被卷绕并熔合在一起，使得与管状体的第二纵向部分中的缠绕角度相比，在管状体的第一纵向部分中卷绕角度较小，以便提供第二部分与第一部分相比，具有更大的抗膨胀性（即较低的柔顺性）。

108. 发明申请

US20070111196A1 Sterilization of Biosensors 审中-公开
标题翻译：生物传感器的灭菌
公开(公告)号：US20070111196A1
公开(公告)日：2007-05-17
申请号：US11465857
申请日：2006-08-21
申请人： Javier Alarcon , Kristin Weidemaier , David Kurisko , Srinivasan Sridharan
发明人： Javier Alarcon , Kristin Weidemaier , David Kurisko , Srinivasan Sridharan
IPC分类号： C12Q1/00
CPC分类号： A61L2/082 , A61B5/1486 , A61L2/0011 , A61L2/0035 , A61L2/0094 , A61L2/022 , A61L2/081 , A61L2/087 , A61L2/10 , A61L2/206 , A61L2/208
摘要： The present invention relates to methods of making a sterilized biosensor, where the biosensor comprises at least one binding reagent, which comprises at least one non-enzyme proteinaceous binding domain. Certain embodiments of the methods described herein comprise partially assembling the components of the biosensor, except for the binding reagent, and separately sterilizing this partial assemblage and the binding reagent. The sterilized binding reagent and the sterilized partial assemblage are then aseptically assembled to produce the sterilized biosensor. Other embodiments of the methods described herein comprise assembling substantially all of the components of the biosensor, including the binding reagent, and sterilizing the assembled biosensor to produce a sterilized biosensor.
摘要翻译：本发明涉及制造无菌生物传感器的方法，其中生物传感器包括至少一种包含至少一个非酶蛋白质结合结构域的结合试剂。本文描述的方法的某些实施方案包括部分组装除了结合试剂之外的生物传感器的组分，并且对该部分组合物和结合试剂进行单独灭菌。灭菌的结合试剂和灭菌的部分组合物然后无菌组装以产生无菌生物传感器。本文描述的方法的其它实施方案包括组装生物传感器的基本上所有组分，包括结合试剂，并对组装的生物传感器进行灭菌以产生无菌生物传感器。

109. 发明申请

US20070108423A1 Lead-Free And Cadmium-Free Conductive Copper Thick Film Pastes 有权
标题翻译：无铅和无镉导电铜厚膜
公开(公告)号：US20070108423A1
公开(公告)日：2007-05-17
申请号：US11609998
申请日：2006-12-13
申请人： Orville Brown , Srinivasan Sridharan
发明人： Orville Brown , Srinivasan Sridharan
IPC分类号： H01B1/12
CPC分类号： C03C8/02 , C03C3/064 , C03C3/066 , C03C8/04 , C03C8/18 , C03C8/22 , C04B41/009 , C04B41/5127 , C04B41/88 , C04B2111/00844 , H01B1/22 , H05K1/092 , Y10T428/24909 , Y10T428/24926 , C04B35/10 , C04B41/4539 , C04B41/5022 , C04B41/5049
摘要： Thick film conductive copper pastes that are lead-free and cadmium-free. The inventive copper pastes possess desirable characteristics, including good solderability, good wire bondability, a low firing temperature, and a wide temperature processing window, and provide excellent adhesion to a variety of substrates, including alumina and glass coated stainless steel substrates, as well as low resistivity, and a microstructure after firing that is dense and substantially free of pores.
摘要翻译：厚膜导电铜浆，无铅，无镉。本发明的铜浆具有所需的特性，包括良好的可焊性，良好的线焊接性，低的烧制温度和宽的温度加工窗口，并且对各种基材（包括氧化铝和玻璃涂层的不锈钢基材）以及对低电阻率和烧结后的微观结构是致密的并且基本上没有孔。

110. 发明申请

US20070106258A1 RETROGRADE PRESSURE REGULATED INFUSION 有权
标题翻译：改变压力调节性输注
公开(公告)号：US20070106258A1
公开(公告)日：2007-05-10
申请号：US11609143
申请日：2006-12-11
申请人： Jessica Chiu , Gregory Chan , Hongzhi Bai , Nianjiong Bei , Mark Bly , Srinivasan Sridharan , Tom Hatten
发明人： Jessica Chiu , Gregory Chan , Hongzhi Bai , Nianjiong Bei , Mark Bly , Srinivasan Sridharan , Tom Hatten
IPC分类号： A61M31/00
CPC分类号： A61M25/10 , A61M25/1002 , A61M2025/1052
摘要： A delivery catheter that includes a flexible shaft having a proximal end and a distal end, the distal end having an outer diameter less than about 13 mm; a delivery lumen having a proximal end and a distal end, the delivery lumen within the flexible shaft, the delivery lumen having at least an outlet port or at least one side hole at the distal end of the delivery lumen, the delivery lumen having a cross-sectional area at least about 5 mm2; a pressure monitoring lumen having a proximal end and a distal end, the pressure monitoring lumen within the flexible shaft; a pressure port adjacent to and connected to the distal end of the pressure monitoring lumen; a balloon inflation lumen having a proximal end and a distal end, the balloon inflation lumen within the flexible shaft; a soft tip at the distal end of the flexible shaft; a balloon at the distal end of the flexible shaft, the balloon connected to the distal end of the balloon inflation lumen, the balloon includes at least one of the following materials, polyether block amide resin, polyetheramide, polyurethane, silicone, natural latex, or synthetic latex; wherein the balloon is adapted to inflate to a diameter range of about 4 to about 15 mm.
摘要翻译：输送导管，其包括具有近端和远端的柔性轴，所述远端具有小于约13mm的外径; 输送腔，其具有近端和远端，所述输送腔在所述柔性轴内，所述输送腔至少具有出口端口或至少一个在所述输送腔的远端处的侧孔，所述输送腔具有交叉至少约5毫米2的截面积; 具有近端和远端的压力监测管腔，所述柔性轴内的所述压力监测腔; 与所述压力监视管腔的远端相邻并连接的压力口; 具有近端和远端的球囊充气腔，所述气囊膨胀腔在所述柔性轴内; 在柔性轴的远端处的软尖端; 在柔性轴的远端处的气囊，气囊连接到球囊充气腔的远端，气囊包括以下材料中的至少一种：聚醚嵌段酰胺树脂，聚醚酰胺，聚氨酯，硅氧烷，天然胶乳或合成胶乳其中所述气囊适于膨胀至约4至约15mm的直径范围。

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