专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

101. 发明授权

US06852739B1 Methods using proton pump inhibitors and nitric oxide donors 失效
标题翻译：使用质子泵抑制剂和一氧化氮供体的方法
公开(公告)号：US06852739B1
公开(公告)日：2005-02-08
申请号：US09512829
申请日：2000-02-25
申请人： David S. Garvey , L. Gordon Letts , Sang William Tam
发明人： David S. Garvey , L. Gordon Letts , Sang William Tam
IPC分类号： A61K31/00 , A61K31/4184 , A61K31/433 , A61K31/437 , A61K31/4439 , A61K31/444 , A61K31/4706 , A61K31/506 , A61K45/06 , C07D401/12
CPC分类号： C07D401/12 , A61K31/00 , A61K31/4184 , A61K31/433 , A61K31/437 , A61K31/4439 , A61K31/444 , A61K31/4706 , A61K31/506 , A61K45/06 , A61K2300/00
摘要： The present invention describes novel nitrosated and/or nitrosylated proton pump inhibitor compounds, and novel compositions comprising at least one proton pump inhibitor compound that is optionally substituted with at least one NO and/or N02 group, and, optionally, at least one compound that donates, transfers or releases nitric oxide, stimulates endogenous synthesis of nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor or is a substrate for nitric oxide synthase, and/or at least one nonsteroidal antiinflammatory drug, selective COX-2 inhibitor, antacid, bismuth-containing reagent, acid-degradable antibacterial compound, and mixtures thereof. The present invention also provides methods for treating and/or preventing gastrointestinal disorders; facilitating ulcer healing; decreasing the recurrence of ulcers; improving gastroprotective properties, anti-Helicobacter pylori properties or antacid properties of proton pump-inhibitors; decreasing or reducing the gastrointestinal toxicity associated with the use of nonsteroidal antiinflammatory compounds; treating Helicobacter pylori and viral infections. The compounds and/or compositions of the present invention can also be provided in the form of a pharmaceutical kit.
摘要翻译：本发明描述了新的亚硝化和/或亚硝化的质子泵抑制剂化合物，以及包含至少一种任选被至少一个NO和/或NO 2基团取代的至少一种质子泵抑制剂化合物的新组合物，和任选的至少一种化合物，捐赠，转移或释放一氧化氮，刺激一氧化氮的内源性合成，提高内源性内皮衍生的松弛因子水平，或是一氧化氮合酶的底物和/或至少一种非甾体抗炎药，选择性COX-2抑制剂，抗酸剂，含铋试剂，酸降解抗菌化合物及其混合物。本发明还提供了治疗和/或预防胃肠道疾病的方法; 促进溃疡愈合; 减少溃疡复发; 改善胃保护性质，抗幽门螺杆菌特性或质子泵抑制剂的抗酸性; 降低或减少与使用非甾体抗炎化合物相关的胃肠道毒性; 治疗幽门螺杆菌和病毒感染。本发明的化合物和/或组合物也可以以药物试剂盒的形式提供。

102. 发明授权

US06593347B2 Nitrosated and nitrosylated nonsteroidal antiinflammatory compounds, compositions and methods of use 失效
公开(公告)号：US06593347B2
公开(公告)日：2003-07-15
申请号：US09938560
申请日：2001-08-27
申请人： Upul K. Bandarage , Qing Dong , Xinqin Fang , David S. Garvey , Gregory J. Mercer , Stewart K. Richardson , Joseph D. Schroeder , Tiansheng Wang
发明人： Upul K. Bandarage , Qing Dong , Xinqin Fang , David S. Garvey , Gregory J. Mercer , Stewart K. Richardson , Joseph D. Schroeder , Tiansheng Wang
IPC分类号： A61K31445
CPC分类号： C07D207/08 , A61K45/06 , C07C381/00 , C07C2601/14 , C07D209/28 , C07D211/22 , C07D211/26 , C07D211/54 , C07D211/62 , C07D239/47 , C07D241/06 , C07D263/20 , C07D295/088 , C07D295/185 , C07D295/192 , C07D317/32 , C07F9/4006 , C07F9/4075
摘要： The present invention describes novel nitrosated and/or nitrosylated nonsteroidal antiinflammatory compounds, and novel compositions comprising at least one nitrosated and/or nitrosylated nonsteroidal antiinflammatory compound, and, optionally, at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase. The present invention also provides methods for treating, preventing and/or reducing inflammation, pain, and fever; decreasing or reversing the gastrointestinal, renal and other toxicities resulting from the use of nonsteroidal antiinflammatory drugs; treating and/or preventing gastrointestinal disorders; treating inflammatory disease states and disorders; and treating and/or preventing ophthalmic diseases or disorders.

103. 发明授权

US06579863B1 Nitrosated and nitrosylated compounds and compositions and their use for treating respiratory disorders 失效
标题翻译：亚硝化和亚硝化化合物及其组合物及其用于治疗呼吸系统疾病的用途
公开(公告)号：US06579863B1
公开(公告)日：2003-06-17
申请号：US09689851
申请日：2000-10-13
申请人： David S. Garvey , L. Gordon Letts , H. Burt Renfroe , Stewart K. Richardson
发明人： David S. Garvey , L. Gordon Letts , H. Burt Renfroe , Stewart K. Richardson
IPC分类号： A61K3156
CPC分类号： C07D451/06 , C07C313/36 , C07D311/22 , C07D451/10 , C07D471/04 , C07J5/00 , C07J7/00 , C07J31/00 , C07J71/00 , C07J71/0031
摘要： Disclosed are (i) compounds of a steroid, a &bgr;-agonist, an anticholinergic, a mast cell stabilizer and a phosphodiesterase (PDE) inhibitor directly or indirectly linked to a NO or NO2 group or a group which stimulates endogenous production of NO or EDRF in vivo; (ii) compositions of steroids, &bgr;-agonists, anticholinergics, mast cell stabilizers and PDE inhibitors, which can optionally be substituted with at least one NO or NO2 moiety or a group which stimulates endogenous production of NO or EDRF in vivo, and a compound that donates, transfers or releases nitric oxide as a charged species, i.e., nitrosonium (NO+) or nitroxyl (NO−), or as the neutral species, nitric oxide (NO•) or that stimulates endogenous production of NO or EDRF in vivo; and (iii) uses for them in preventing and/or treating respiratory disorders.
摘要翻译：公开的是（i）直接或间接连接到NO或NO 2基团或刺激NO或EDRF的内源性产生的基团的类固醇，β-激动剂，抗胆碱能药，肥大细胞稳定剂和磷酸二酯酶（PDE）抑制剂的化合物体内; （ii）类固醇，β-激动剂，抗胆碱能药物，肥大细胞稳定剂和PDE抑制剂的组合物，其可任选地被至少一个NO或NO 2部分或刺激体内NO或EDRF内源性产生的基团取代;以及化合物捐赠，转移或释放一氧化氮作为带电物质，即亚硝酸盐（NO +）或硝酰基（NO-），或作为中性物质，一氧化氮（NO））或刺激体内NO或EDRF的内源性产生; 和（iii）用于预防和/或治疗呼吸系统疾病。

104. 发明授权

US06433182B1 Nitrosated and nitrosylated &agr;-adrenergic receptor antagonist compounds, compositions and their uses 失效
标题翻译：亚硝化和亚硝酰化的α-肾上腺素能受体拮抗剂化合物，组合物及其用途
公开(公告)号：US06433182B1
公开(公告)日：2002-08-13
申请号：US09306805
申请日：1999-05-07
申请人： David S. Garvey , Joseph D. Schroeder , Inigo Saenz de Tejada
发明人： David S. Garvey , Joseph D. Schroeder , Inigo Saenz de Tejada
IPC分类号： C07D23500
CPC分类号： C07D459/00 , A61K45/06 , C07C381/00 , C07D211/62 , C07D233/24 , C07D239/95 , C07D401/04 , C07D405/12 , Y10S514/929 , Y10S514/968
摘要： The present invention is directed to nitrosated or nitrosylated &agr;-adrenergic receptor antagonists, compositions comprising &agr;-adrenergic receptor antagonists that are optionally substituted with at least one NO or NO2 moiety and compounds that donate, transfer or release nitric oxide or elevate levels of endogenous endothelium-derived relaxing factor, and methods for treating sexual dysfunctions in males and females.
摘要翻译：本发明涉及亚硝基化或亚硝基化的α-肾上腺素能受体拮抗剂，其包含任选被至少一个NO或NO 2部分取代的α-肾上腺素能受体拮抗剂的组合物和捐赠，转移或释放一氧化氮或升高内源性内皮水平的化合物来源的放松因子，以及治疗男性和女性性功能障碍的方法。

105. 发明授权

US06316457B1 Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses 失效
公开(公告)号：US06316457B1
公开(公告)日：2001-11-13
申请号：US09247323
申请日：1999-02-10
申请人： David S. Garvey , Inigo Saenz de Tejada
发明人： David S. Garvey , Inigo Saenz de Tejada
IPC分类号： C07D48704
CPC分类号： C07D487/04 , C07D405/14
摘要： Disclosed are nitrosated and/or nitrosylated phosphodiesterase inhibitors having the formula NOn-PDE inhibitor where n is 1 or 2. The invention also provides compositions comprising such compounds in a pharmaceutically acceptable carrier. The invention also provides a composition comprising a therapeutically effective amount of an phosphodiesterase inhibitor (PDE inhibitor), which can optionally be substituted with at least one NO or NO2 moiety, and one to ten fold molar excess of a compound that donates, transfers or releases nitrogen monoxide as a charged species, i. e., nitrosonium (NO+) or nitroxyl (NO−), or as the neutral species, nitric oxide (NO·) or which stimulates endogenous EDRF production. The invention also provides compositions comprising such compounds in a pharmaceutically acceptable carrier. The invention also provides methods for treating sexual dysfunctions in males and females.

106. 发明授权

US06297260B1 Nitrosated and nitrosylated nonsteroidal antiinflammatory compounds, compositions and methods of use 失效
标题翻译：亚硝化和亚硝化非甾体抗炎化合物，组合物和使用方法
公开(公告)号：US06297260B1
公开(公告)日：2001-10-02
申请号：US09429019
申请日：1999-10-29
申请人： Upul K. Bandarage , Qing Dong , Xinqin Fang , David S. Garvey , Gregory J. Mercer , Stewart K. Richardson , Joseph D. Schroeder , Tiansheng Wang
发明人： Upul K. Bandarage , Qing Dong , Xinqin Fang , David S. Garvey , Gregory J. Mercer , Stewart K. Richardson , Joseph D. Schroeder , Tiansheng Wang
IPC分类号： A61K31445
CPC分类号： C07D207/08 , A61K45/06 , C07C381/00 , C07C2601/14 , C07D209/28 , C07D211/22 , C07D211/26 , C07D211/54 , C07D211/62 , C07D239/47 , C07D241/06 , C07D263/20 , C07D295/088 , C07D295/185 , C07D295/192 , C07D317/32 , C07F9/4006 , C07F9/4075
摘要： The present invention describes novel nitrosated and/or nitrosylated nonsteroidal antiinflammatory compounds, and novel compositions comprising at least one nitrosated and/or nitrosylated nonsteroidal antiinflammatory compound, and, optionally, at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase. The present invention also provides methods for treating, preventing and/or reducing inflammation, pain, and fever; decreasing or reversing the gastrointestinal, renal and other toxicities resulting from the use of nonsteroidal antiinflammatory drugs; treating and/or preventing gastrointestinal disorders; treating inflammatory disease states and disorders; and treating and/or preventing ophthalmic diseases or disorders.
摘要翻译：本发明描述了新的亚硝化和/或亚硝基化的非甾族化合物抗炎化合物，以及包含至少一种亚硝化和/或亚硝基化的非甾族化合物抗炎化合物的新组合物，以及任选的至少一种捐赠，转移或释放一氧化氮的化合物，提高内源性水平的内皮衍生的松弛因子，刺激一氧化氮的内源性合成，或是一氧化氮合酶的底物。本发明还提供了治疗，预防和/或减轻炎症，疼痛和发烧的方法; 减少或逆转使用非甾体抗炎药物引起的胃肠道，肾脏和其他毒性; 治疗和/或预防胃肠道疾病; 治疗炎性疾病状态和障碍; 以及治疗和/或预防眼科疾病或病症。

107. 发明授权

US06211179B1 Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses 失效
公开(公告)号：US06211179B1
公开(公告)日：2001-04-03
申请号：US09347426
申请日：1999-07-06
申请人： David S. Garvey , Inigo Saenz de Tejada
发明人： David S. Garvey , Inigo Saenz de Tejada
IPC分类号： A61K31519
CPC分类号： C07D487/04 , C07D405/14
摘要： Disclosed are nitrosated and/or nitrosylated phosphodiesterase inhibitors having the formula NOn-PDE inhibitor where n is 1 or 2. The invention also provides compositions comprising such compounds in a pharmaceutically acceptable carrier. The invention also provides a composition comprising a therapeutically effective amount of an phosphodiesterase inhibitor (PDE inhibitor), which can optionally be substituted with at least one NO or NO2 moiety, and one to ten fold molar excess of a compound that donates, transfers or releases nitrogen monoxide as a charged species, i. e., nitrosonium (NO+) or nitroxyl (NO−), or as the neutral species, nitric oxide (NO•) or which stimulates endogenous EDRF production. The invention also provides compositions comprising such compounds in a pharmaceutically acceptable carrier. The invention also provides methods for treating sexual dysfunctions in males and females.

108. 发明授权

US06177428B1 Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses 失效
公开(公告)号：US06177428B1
公开(公告)日：2001-01-23
申请号：US09247321
申请日：1999-02-10
申请人： David S. Garvey , Inigo Saenz de Tejada
发明人： David S. Garvey , Inigo Saenz de Tejada
IPC分类号： A61K31501
CPC分类号： C07D487/04 , C07D405/14
摘要： Disclosed are nitrosated and/or nitrosylated phosphodiesterase inhibitors having the formula NOn-PDE inhibitor where n is 1 or 2. The invention also provides compositions comprising such compounds in a pharmaceutically acceptable carrier. The invention also provides a composition comprising a therapeutically effective amount of an phosphodiesterase inhibitor (PDE inhibitor), which can optionally be substituted with at least one NO or NO2 moiety, and one to ten fold molar excess of a compound that donates, transfers or releases nitrogen monoxide as a charged species, i.e., nitrosonium (NO+) or nitroxyl (NO−), or as the neutral species, nitric oxide (NO•) or which stimulates endogenous EDRF production. The invention also provides compositions comprising such compounds in a pharmaceutically acceptable carrier. The invention also provides methods for treating sexual dysfunctions in males and females.

109. 发明授权

US6057347A Compositions and methods to prevent toxicity induced by nonsteroidal antiinflammatory drugs 失效
公开(公告)号：US6057347A
公开(公告)日：2000-05-02
申请号：US931564
申请日：1997-09-16
申请人： David S. Garvey , L. Gordon Letts , H. Burt Renfroe , Sang William Tam
发明人： David S. Garvey , L. Gordon Letts , H. Burt Renfroe , Sang William Tam
IPC分类号： C07D417/04 , A61K31/00 , A61K31/19 , A61K31/403 , A61K31/404 , A61K31/405 , A61K31/54 , A61K31/541 , A61K38/00 , A61K45/00 , A61P1/00 , A61P1/04 , A61P29/00 , A61P43/00 , C07C203/00 , C07C327/28 , C07C381/00 , C07D209/28 , C07D417/12 , C07J41/00 , C07K5/02 , A61K31/12 , C07C207/00 , C07C207/02 , C07C207/04
CPC分类号： C07D417/12 , A61K31/343 , A61K31/60 , C07C203/00 , C07C327/28 , C07C381/00 , C07D209/28 , C07J41/0055 , C07K5/0215 , A61K38/00
摘要： Nonsteroidal antiinflammatory drugs which have been substituted with a nitrogen monoxide group; compositions comprising (i) a nonsteroidal antiinflammatory drug, which can optionally be substituted with a nitrogen monoxide group and (ii) a compound that directly donates, transfers or releases a nitrogen monoxide group (preferably as a charged species, particularly nitrosonium); and methods of treatment of inflammation, pain, gastrointestinal lesions and/or fever using the compositions are disclosed. The compounds and compositions protect against the gastrointestinal, renal and other toxicities that are otherwise induced by nonsteroidal antiinflammatory drugs.

110. 发明授权

US6051588A Nitroso esters of .beta.-oxo-amides and aryl propionic acid derivatives of non-steroidal antiinflammatory drugs 失效
标题翻译：非甾体抗炎药的β-氧代酰胺和芳基丙酸衍生物的亚硝基酯
公开(公告)号：US6051588A
公开(公告)日：2000-04-18
申请号：US425090
申请日：1995-04-19
申请人： David S. Garvey , L. Gordon Letts , H. Burt Renfroe , Sang William Tam
发明人： David S. Garvey , L. Gordon Letts , H. Burt Renfroe , Sang William Tam
IPC分类号： A61K38/00 , C07C203/00 , C07C327/28 , C07C381/00 , C07D209/28 , C07D417/12 , C07J41/00 , C07K5/02 , C07D403/02 , A61K31/38 , A61K31/40 , A61K31/405 , A61K31/42 , C07D263/30 , C07D333/02 , C07D403/14
CPC分类号： C07D417/12 , C07C203/00 , C07C327/28 , C07C381/00 , C07D209/28 , C07J41/0055 , C07K5/0215 , A61K38/00
摘要： A compound comprising a non-steroidal antiinflammatory agent to which is directly or indirectly linked an NO group, a pharmaceutical composition including the compounds and methods of treatment of pain and/or inflammation using the compounds and compositions are disclosed. Also disclosed is a composition comprising a non-steroidal antiinflammatory agent and a compound that donates, transfers or releases nitric oxide.
摘要翻译：公开了一种化合物，其包含直接或间接连接NO基团的非甾体抗炎剂，包含该化合物的药物组合物和使用该化合物和组合物治疗疼痛和/或炎症的方法。还公开了包含非甾体抗炎剂和捐赠，转移或释放一氧化氮的化合物的组合物。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式