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101. 发明申请

US20050182097A1 Methods and compositions using thalidomide for the treatment and management of central nervous system disorders or diseases 审中-公开
标题翻译：使用沙利度胺治疗和治疗中枢神经系统疾病或疾病的方法和组合
公开(公告)号：US20050182097A1
公开(公告)日：2005-08-18
申请号：US11022065
申请日：2004-12-23
申请人： Jerome Zeldis , Herbert Faleck , Peter Schafer
发明人： Jerome Zeldis , Herbert Faleck , Peter Schafer
IPC分类号： A61K31/454
CPC分类号： A61K31/445 , A61K31/00 , A61K31/425 , A61K45/06 , A61K2300/00
摘要： Methods of treating, preventing and/or managing central nervous system disorders, such as Amyotrophic Lateral Sclerosis (ALS or Lou Gehrig's Disease) and related syndromes are disclosed. Specific methods encompass the administration of thalidomide, or a pharmaceutically acceptable salt, solvate, hydrate, or stereoisomer thereof, alone or in combination with a second active ingredient. Pharmaceutical compositions, single unit dosage forms, and kits suitable for use in methods of the invention are also disclosed.
摘要翻译：公开了治疗，预防和/或控制中枢神经系统疾病如肌萎缩性侧索硬化症（ALS或Lou Gehrig's disease）及相关综合征的方法。具体方法包括单独或与第二活性成分组合施用沙利度胺或其药学上可接受的盐，溶剂合物，水合物或立体异构体。还公开了适用于本发明方法的药物组合物，单一单位剂型和试剂盒。

102. 发明授权

US6057269A Benzylhydroxylamines and intermediates used to prepare them 失效
公开(公告)号：US6057269A
公开(公告)日：2000-05-02
申请号：US973780
申请日：1998-01-05
申请人： Ralf Klintz , Gerhard Hamprecht , Elisabeth Heistracher , Peter Schafer , Cyrill Zagar , Karl-Otto Westphalen , Helmut Walter , Ulf Misslitz , Olaf Menke , Markus Menges
发明人： Ralf Klintz , Gerhard Hamprecht , Elisabeth Heistracher , Peter Schafer , Cyrill Zagar , Karl-Otto Westphalen , Helmut Walter , Ulf Misslitz , Olaf Menke , Markus Menges
IPC分类号： A01N43/54 , A01N47/12 , A01N47/24 , A01N47/30 , A01N53/00 , C07C239/08 , C07C239/10 , C07C239/16 , C07C239/20 , C07C265/12 , C07C271/22 , C07C271/28 , C07C271/54 , C07C271/58 , C07C275/32 , C07C275/40 , C07D239/54 , C07D405/12
CPC分类号： C07D239/54 , A01N43/54 , A01N47/12 , A01N47/24 , A01N47/30 , A01N53/00 , C07C239/08 , C07C239/10 , C07C265/12 , C07C271/22 , C07C271/28 , C07C271/54 , C07C271/58 , C07C275/40
摘要： Benzylhydroxylamines I ##STR1## (X=--N(R.sup.7)--O--; Y=O, S; R.sup.1 =halogen, CN, NO.sub.2, CF.sub.3 ; R.sup.2 =H, halogen; R.sup.3 =H, NH.sub.2, CH.sub.3 ;R.sup.4 =H, halogen, C.sub.1 -C.sub.6 -alkyl, C.sub.1 -C.sub.6 -haloalkyl, C.sub.1 -C.sub.6 -alkylthio, C.sub.1 -C.sub.6 -alkylsulfinyl or C.sub.1 -C.sub.6 -alkylsulfonyl;R.sup.5 =H, halogen, C.sub.1 -C.sub.6 -alkyl;R.sup.6 =H, C.sub.1 -C.sub.6 -alkyl, C.sub.1 -C.sub.6 -haloalkyl, C.sub.3 -C.sub.6 -cycloalkyl, C.sub.2 -C.sub.6 -alkenyl;R.sup.7 =H, C.sub.1 -C.sub.6 -alkyl, C.sub.3 -C.sub.8 -cycloalkyl, C.sub.1 -C.sub.6 -haloalkyl, C.sub.3 -C.sub.6 -alkenyl, C.sub.3 -C.sub.6 -alkynyl, C.sub.1 -C.sub.6 -alkylcarbonyl, C.sub.3 -C.sub.6 -alkenylcarbonyl, C.sub.3 -C.sub.6 -alkynylcarbonyl, C.sub.1 -C.sub.6 -alkoxycarbonyl, C.sub.2 -C.sub.8 -alkenyloxycarbonyl, C.sub.2 -C.sub.6 -alkynyloxycarbonyl, C.sub.1 -C.sub.6 -alkylthiocarbonyl, C.sub.1 -C.sub.6 -alkylsulfonyl, C.sub.1 -C.sub.6 -alkylcarbamoyl, it being possible for the 14 last-mentioned radicals to have attached to them 1-3 substituents:NO.sub.2, CN, halogen, C.sub.3 -C.sub.8 -cycloalkyl, OH, C.sub.1 -C.sub.6 -alkoxy, C.sub.3 -C.sub.8 -cycloalkoxy, C.sub.3 -C.sub.6 -alkenyloxy, C.sub.3 -C.sub.6 -alkynyloxy, C.sub.1 -C.sub.6 -alkoxy-C.sub.1 -C.sub.6 -alkoxy, C.sub.1 -C.sub.6 -alkylthio, C.sub.1 -C.sub.6 -alkylcarbonyl, C.sub.1 -C.sub.6 -alkylcarbonyloxy, C.sub.1 -C.sub.6 -alkylsulfinyl, C.sub.1 -C.sub.6 -alkylsulfonyl, C.sub.1 -C.sub.6 -alkylideneaminoxy, C.sub.1 -C.sub.6 -alkylcarbamoyl,unsubstituted or substituted phenyl, phenoxy or phenylsulfonyl,a 3- to 7-membered heterocyclyl or heterocyclyloxy group having 1-3 hetero atoms, it being possible for this group to be saturated, unsaturated or aromatic and to have attached to it 1-3 substituents,--CO--Z.sup.1 R.sup.9, --OCO--Z.sup.1 R.sup.9, --N(R.sup.9)R.sup.10 orR.sup.7 =unsubstituted or substituted cycloalkylcarbonyl, phenylcarbonyl, phenylsulfonyl, phenylcarbamoyl;R.sup.8 =H, C.sub.1 -C.sub.6 -alkyl, C.sub.3 -C.sub.8 -cycloalkyl, C.sub.1 -C.sub.6 -haloalkyl, C.sub.3 -C.sub.6 -alkenyl or C.sub.3 -C.sub.6 -alkynyl, it being possible for each of the 5 last-mentioned radicals to have attached to it 1-3 substituents:NO.sub.2, CN, halogen, C.sub.3 -C.sub.8 -cycloalkyl, OH, C.sub.1 -C.sub.6 -alkoxy, C.sub.3 -C.sub.8 -cycloalkoxy, C.sub.3 -C.sub.6 -alkenyloxy, C.sub.3 -C.sub.6 -alkynyloxy, C.sub.1 -C.sub.6 -alkoxy-C.sub.1 -C.sub.6 -alkoxy, C.sub.1 -C.sub.6 -alkylthio, C.sub.1 -C.sub.6 -alkylsulfinyl, C.sub.1 -C.sub.6 -alkylsulfonyl, C.sub.1 -C.sub.6 -alkylideneaminoxy,unsubstituted or substituted phenyl- [sic], phenoxy-[sic] or phenylsulfonyl,a 3- to 7-membered heterocyclyl or heterocyclyloxy group having 1-3 hetero atoms, it being possible for this group to be saturated, unsaturated or aromatic and to have attached to it 1-3 substituents,--CO--Z.sup.2 R.sup.11, --OCO--Z.sup.2 R.sup.11, --N(R.sup.11)R.sup.12 ;Z.sup.1 a chemical bond, oxygen, sulfur or --N(R.sup.10)--;Z.sup.2 =a chemical bond, oxygen, sulfur or --N(R.sup.12)--;R.sup.9, R.sup.11 =H, C.sub.1 -C.sub.6 -alkyl, C.sub.1 -C.sub.6 -haloalkyl, C.sub.3 -C.sub.8 -cycloalkyl, C.sub.3 -C.sub.6 -alkenyl, C.sub.3 -C.sub.6 -alkynyl, C.sub.1 -C.sub.6 -alkoxy-C.sub.1 -C.sub.6 -alkyl, (C.sub.1 -C.sub.6 -alkoxy)carbonyl-C.sub.1 -C.sub.6 -alkyl, unsubstituted or substituted phenyl or phenyl-C.sub.1 -C.sub.6 -alkyl,orZ.sup.1 and R.sup.9 and/or Z.sup.2 and R.sup.11 together=a 3- to 7-membered heterocycle having 1-3 hetero atoms and bonded via nitrogen, it being possible for this heterocycle to be saturated, unsaturated or aromatic and, if desired, to have attached to it one to three substituents,R.sup.10, R.sup.12 =H, OH, C.sub.1 -C.sub.6 -alkyl, C.sub.3 -C.sub.8 -cycloalkyl, C.sub.1 -C.sub.6 -alkoxy)and the salts of I where R.sup.3, R.sup.7 and/or R.sup.8 =hydrogenare used as herbicides and for the desiccation/defoliation of plants.

103. 发明授权

US5885934A Substituted triazolinones as crop protection agents 失效
标题翻译：取代三唑啉酮作为作物保护剂
公开(公告)号：US5885934A
公开(公告)日：1999-03-23
申请号：US793152
申请日：1997-02-18
申请人： Elisabeth Heistracher , Christoph Sweder von dem Bussche-Hunnefeld , Gerhard Hamprecht , Ralf Klintz , Peter Schafer , Karl-Otto Westphalen , Matthias Gerber , Helmut Walter
发明人： Elisabeth Heistracher , Christoph Sweder von dem Bussche-Hunnefeld , Gerhard Hamprecht , Ralf Klintz , Peter Schafer , Karl-Otto Westphalen , Matthias Gerber , Helmut Walter
IPC分类号： A01N43/653 , C07D249/12
CPC分类号： A01N43/653 , C07D249/12
摘要： Substituted triazolinones I ##STR1## where R.sup.1 and R.sup.2 are each H, C.sub.1 -C.sub.6 -alkyl or C.sub.1 -C.sub.6 -haloalkyl,R.sup.3 is H or halogen,R.sup.4 is CN, halogen, C.sub.1 -C.sub.6 -alkyl, C.sub.1 -C.sub.6 -haloalkyl, C.sub.1 -C.sub.6 -alkoxy or C.sub.1 -C.sub.6 -haloalkoxy,R.sup.5 is NO.sub.2, CN or halogen,R.sup.6 is --OR.sup.7, --SR.sup.7, --N(R.sup.8)--R.sup.9 or --N(R.sup.8)--OR.sup.10,R.sup.7 is H, C.sub.1 -C.sub.6 -alkyl, C.sub.3 -C.sub.6 -alkenyl, C.sub.3 -C.sub.6 -alkynyl, C.sub.3 -C.sub.6 -cycloalkyl, C.sub.1 -C.sub.6 -haloalkyl, cyano-C.sub.1 -C.sub.6 -alkyl, C.sub.1 -C.sub.6 -alkoxy-C.sub.1 -C.sub.6 -alkyl, C.sub.1 -C.sub.6 -alkylthio-C.sub.1 -C.sub.6 -alkyl, C.sub.1 -C.sub.6 -alkoxycarbonyl-C.sub.1 -C.sub.6 -alkyl, C.sub.1 -C.sub.6 -alkylaminocarbonyl-C.sub.1 -C.sub.6 -alkyl, di-(C.sub.1 -C.sub.6 -alkyl)aminocarbonyl-C.sub.1 -C.sub.6 -alkyl, C.sub.1 -C.sub.6 -alkoximino-C.sub.1 -C.sub.6 -alkyl, di-(C.sub.1 -C.sub.6 -alkoxy)-C.sub.2 -C.sub.6 -alkyl, di-(C.sub.1 -C.sub.6 -alkylthio)-C.sub.2 -C.sub.6 -alkyl, C.sub.3 -C.sub.6 -haloalkenyl or unsubstituted or substituted phenyl or benzyl,R.sup.8, R.sup.9 and R.sup.10 are each C.sub.1 -C.sub.6 -alkylcarbonyl or C.sub.1 -C.sub.6 -haloalkyl-carbonyl or each have one of the meanings stated for R.sup.7,R.sup.8 and R.sup.9 together form a 4- to 6-membered carbon chain in which one methylene unit may be replaced by oxygen or C.sub.1 -C.sub.4 -alkylimino, and the salts of I are used as herbicides or for the desiccation/defoliation of plants.
摘要翻译： PCT No.PCT / EP95 / 02167 Sec。 371日期1997年2月18日 102（e）日期1997年2月18日PCT Filed June 7，1995 PCT Pub。公开号WO96 / 05179 日期1996年2月22日三取代三唑啉酮I其中R 1和R 2各自为H，C 1 -C 6烷基或C 1 -C 6卤代烷基，R 3为H或卤素，R 4为CN，卤素，C 1 -C 6烷基， C1-C6-卤代烷基，C1-C6-烷氧基或C1-C6-卤代烷氧基，R5是NO2，CN或卤素，R6是-OR7，-SR7，-N（R8）-R9或-N（R8）-OR10， R7是H，C1-C6-烷基，C3-C6-烯基，C3-C6-炔基，C3-C6-环烷基，C1-C6-卤代烷基，氰基-C1-C6-烷基，C1-C6-烷氧基C1- C 1 -C 6烷基，C 1 -C 6烷基硫基-C 1 -C 6烷基，C 1 -C 6烷氧基羰基-C 1 -C 6烷基，C 1 -C 6烷基氨基羰基-C 1 -C 6烷基，二（C 1 -C 6烷基）氨基羰基 -C 1 -C 6 - 烷基，C 1 -C 6 - 烷氧基-C 1 -C 6 - 烷基，二 - （C 1 -C 6 - 烷氧基）-C 2 -C 6烷基，二 - （C 1 -C 6 - 烷硫基）-C 2 -C 6烷基，C 3 -C 6 - 卤代链烯基或未取代或取代的苯基或苄基，R 8，R 9和R 10各自为C 1 -C 6 - 烷基羰基或C 1 -C 6卤代烷基 - 羰基，或者各自具有R7，R8和R9所述的含义其中一个亚甲基单元可被氧或C 1 -C 4烷基亚氨基取代的4-至6-元碳链，其中I ar e用作除草剂或用于植物的干燥/脱叶。

104. 发明授权

US5700805A Substituted 1-amino-3-phenyluracils 失效
标题翻译：取代的1-氨基-3-苯基尿嘧啶
公开(公告)号：US5700805A
公开(公告)日：1997-12-23
申请号：US596215
申请日：1996-02-15
申请人： Peter Schafer , Ralf Klintz , Gerhard Hamprecht , Elisabeth Heistracher , Karl-Otto Westphalen , Matthias Gerber , Helmut Walter
发明人： Peter Schafer , Ralf Klintz , Gerhard Hamprecht , Elisabeth Heistracher , Karl-Otto Westphalen , Matthias Gerber , Helmut Walter
IPC分类号： A01N43/54 , C07D239/54 , C07D239/56 , C07D405/10 , C07D409/10 , C07D411/10
CPC分类号： C07D239/54 , A01N43/54 , C07D405/10 , C07D409/10 , C07D411/10
摘要： Substituted 1-amino-3-phenyluracils I ##STR1## where the variables have the following meanings: R.sup.1 =H, F, Cl; Y=O, S; Z=--CH=N--OH, --CH=N--O--(alkyl), --CH=N--O--(alkylene)--O--(alkyl), --CH=N--O--CH.sub.2 --COOH, --CH=N--O--CH(alkyl)--COOH, --CH=N--O--CH.sub.2 --CO--O--(alkyl), --CH=N--O--CH(alkyl)--CO--O--(alkyl), --CH=N--O--CH.sub.2 --CO--O=O-- (alkylene)--O--(alkyl), --CH=N--O--CH(alkyl)--CO--O-- (alkylene)--O--(alkyl), --CH=CH--CO--O--(alkyl), --CH=CH-- CO--O--(alkylene)--O--(alkyl), --CH=C(Cl)--CO--O--(alkyl), --CH=C(Br)--CO--O--(alkyl), --CH=C(Cl)--CO--O--(alkylene)--O--(alkyl), --CH=C(Br)--CO--O--(alkylene)--O--(alkyl), --CH=C(CH.sub.3)--CO--O--(alkyl), --CH=C(CH.sub.3)--CO--O--(alkylene)--O--(alkyl), --CH�X.sup.1 -(alkyl)! �X.sup.2 -(alkyl)! or a radical ##STR2## X.sup.1 -X.sup.6 =O, S; R.sup.2 -R.sup.11 =H, alkyl, vinyl, alkoxycarbonyl are described. Use: herbicides; desiccation/defoliation of plants.
摘要翻译： PCT No.PCT / EP94 / 02821 Sec。 371日期：1996年2月15日 102（e）日期1996年2月15日PCT 1994年8月25日PCT公布。公开号WO95 / 06641 日期1995年3月9日取代的1-氨基-3-苯基尿嘧啶I，其中变量具有以下含义：R1 = H，F，Cl; Y = O，S; Z = -CH = N-OH，-CH = NO-（烷基），-CH = NO-（亚烷基）-O-（烷基），-CH = NO-CH 2 -COOH，-CH = ）-COOH，-CH = NO-CH 2 -CO-O-（烷基），-CH = NO-CH（烷基）-CO-O-（烷基），-CH = NO-CH 2 -CO-O = O- （亚烷基）-O-（烷基），-CH = NO-CH（烷基）-CO-O-（亚烷基）-O-（烷基），-CH = CH-CO-O-（烷基） CH-CO-O-（亚烷基）-O-（烷基），-CH = C（C1）-CO-O-（烷基），-CH = C（Br）-CO-O- = C（Cl）-CO-O-（亚烷基）-O-（烷基），-CH = C（Br）-CO-O-（亚烷基）-O-（烷基），-CH = C（CH 3） CO-O-（烷基），-CH = C（CH3）-CO-O-（亚烷基）-O-（烷基），-CH [X1-（烷基）] [X2-（烷基）图像> X1-X6 = O，S; 描述了R2-R11 = H，烷基，乙烯基，烷氧基羰基。用途：除草剂; 植物的干燥/脱叶。

105. 发明授权

US5319313A Power coupler with adjustable coupling factor for accelerator cavities 失效
标题翻译：具有可调耦合系数的加速器腔的功率耦合器
公开(公告)号：US5319313A
公开(公告)日：1994-06-07
申请号：US677112
申请日：1991-03-29
申请人： Hanspeter Vogel , Dietmar Kiehlmann , Peter Schafer , Ernst Haebel , John McGill
发明人： Hanspeter Vogel , Dietmar Kiehlmann , Peter Schafer , Ernst Haebel , John McGill
IPC分类号： H01P5/04 , H01P5/08 , H05H7/02 , H05H7/20
CPC分类号： H05H7/02 , Y10S505/866
摘要： An accelerator includes a beam tube having a cavity with a central axis along which particles can be accelerated. A radio frequency power coupling device couples the cavity to a high frequency power source. The coupling device includes a coaxial waveguide having a central axis, an outer conductor and an inner conductor. The outer conductor is fixed relative to the cavity defining an angle between the central axis of the cavity and the central axis of the coaxial waveguide. An external drive moves the inner conductor along the central axis of the coaxial waveguide.
摘要翻译：加速器包括具有中空轴的空腔的射束管，颗粒可沿着中心轴加速。射频功率耦合装置将空腔耦合到高频电源。耦合装置包括具有中心轴的同轴波导，外部导体和内部导体。外部导体相对于空腔固定，该空腔限定腔的中心轴线和同轴波导的中心轴线之间的角度。外部驱动器沿着同轴波导的中心轴移动内部导体。

106. 发明申请

US20070190070A1 Methods of using and compositions comprising selective cytokine inhibitory drugs for the treatment and management of disorders of the central nervous system 审中-公开
标题翻译：使用方法和包含选择性细胞因子抑制药物的组合物用于治疗和控制中枢神经系统疾病
公开(公告)号：US20070190070A1
公开(公告)日：2007-08-16
申请号：US10590575
申请日：2004-09-03
申请人： Jerome Zeldis , Peter Schafer
发明人： Jerome Zeldis , Peter Schafer
IPC分类号： A61K31/4704 , A61K31/425 , A61K31/4035
CPC分类号： A61K31/4035 , A61K31/425 , A61K31/4704
摘要： Methods of treating, preventing and/or managing central nervous system disorders, such as Parkinson disease, Alzheimer disease, mild cognitive impairment, Huntington disease, Amytophic Lateral Sclerosis, depression and defective long-term memory, and related syndromes are disclosed. Specific methods encompass the administration of a selective cytokine inhibitory drug, or a pharmaceutically acceptable salt, solvate, hydrate, stereoisomer, clathrate, or prodrug thereof, alone or in combination with a second active ingredient. Pharmaceutical compositions, single unit dosage forms, and kits suitable for use in methods of the invention are also disclosed.
摘要翻译：公开了治疗，预防和/或控制中枢神经系统疾病如帕金森病，阿尔茨海默病，轻度认知障碍，亨廷顿舞蹈症，扁桃腺侧索硬化，抑郁症和有缺陷的长期记忆的方法和相关综合征。具体方法包括单独或与第二活性成分组合施用选择性细胞因子抑制药物或其药学上可接受的盐，溶剂合物，水合物，立体异构体，包合物或前药。还公开了适用于本发明方法的药物组合物，单一单位剂型和试剂盒。

107. 发明申请

US20060102600A1 Laser welding device and method 有权
标题翻译：激光焊接装置及方法
公开(公告)号：US20060102600A1
公开(公告)日：2006-05-18
申请号：US11281265
申请日：2005-11-17
申请人： Peter Schafer , Frank Faisst , Martin Huonker , Richard Petersen
发明人： Peter Schafer , Frank Faisst , Martin Huonker , Richard Petersen
IPC分类号： B23K26/20 , B23K26/14
CPC分类号： B23K26/0648 , B23K26/123 , B23K26/142 , B23K26/1436 , B23K26/1437 , B23K26/1464 , B23K26/16 , B23K26/21 , B23K26/702
摘要： A laser welding device includes a laser that generates a laser beam, an optics, and a limiting apparatus. The optics has a focal length of at least 200 nm and being configured to focus the laser beam onto a processing zone of a workpiece. The limiting apparatus limits a mixture of welding gases and heated ambient air, produced during laser welding, within the laser beam to a region that is less than the focal length from a surface of the workpiece.
摘要翻译：激光焊接装置包括产生激光束的激光器，光学器件和限制装置。光学元件具有至少200nm的焦距，并被配置为将激光束聚焦到工件的处理区域上。限制装置将激光焊接期间产生的焊接气体和加热的环境空气的混合物限制在小于来自工件表面的焦距的区域内。

108. 发明申请

US20050143344A1 Methods and compositions using immunomodulatory compounds for the treatment and management of central nervous system disorders or diseases 审中-公开
标题翻译：使用免疫调节化合物治疗和治疗中枢神经系统疾病或疾病的方法和组合物
公开(公告)号：US20050143344A1
公开(公告)日：2005-06-30
申请号：US11022075
申请日：2004-12-23
申请人： Jerome Zeldis , Herbert Faleck , Peter Schafer
发明人： Jerome Zeldis , Herbert Faleck , Peter Schafer
IPC分类号： A61K31/00 , A61K31/454 , A61K31/724
CPC分类号： A61K31/454 , A61K31/00
摘要： Methods of treating, preventing and/or managing central nervous system disorders, such as Amyotrophic Lateral Sclerosis (ALS or Lou Gehrig's Disease) and related syndromes are disclosed. Specific methods encompass the administration of an immunomodulatory compound of the invention, or a pharmaceutically acceptable salt, solvate, hydrate, stereoisomer, clathrate, or prodrug thereof, alone or in combination with a second active ingredient. Pharmaceutical compositions, single unit dosage forms, and kits suitable for use in methods of the invention are also disclosed.
摘要翻译：公开了治疗，预防和/或控制中枢神经系统疾病如肌萎缩性侧索硬化症（ALS或Lou Gehrig's disease）及相关综合征的方法。具体方法包括单独或与第二活性成分组合施用本发明的免疫调节化合物或其药学上可接受的盐，溶剂合物，水合物，立体异构体，包合物或前药。还公开了适用于本发明方法的药物组合物，单一单位剂型和试剂盒。

109. 发明授权

US6150303A Substituted 3-phenylisoxazolines 失效
公开(公告)号：US6150303A
公开(公告)日：2000-11-21
申请号：US463246
申请日：2000-01-21
申请人： Olaf Menke , Markus Menges , Gerhard Hamprecht , Robert Reinhard , Peter Schafer , Cyrill Zagar , Karl-Otto Westphalen , Ulf Misslitz , Helmut Walter
发明人： Olaf Menke , Markus Menges , Gerhard Hamprecht , Robert Reinhard , Peter Schafer , Cyrill Zagar , Karl-Otto Westphalen , Ulf Misslitz , Helmut Walter
IPC分类号： A01N43/80 , C07D261/04 , A01N43/72
CPC分类号： C07D261/04
摘要： Substituted 3-phenylisoxazolines I, and their salts and enol ethers, are described as herbicides ##STR1## where X.dbd.--O--, --S--, --N(R.sup.9)--;R.sup.1 .dbd.CN, C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 -haloalkyl, C.sub.1 -C.sub.4 -haloalkoxy, C.sub.1 -C.sub.4 -alkylsulfonyl;R.sup.2 .dbd.H or unsubstituted or substituted C.sub.1 -C.sub.6 -alkyl, (C.sub.1 -C.sub.6 -alkyl)carbonyl, C.sub.1 -C.sub.6 -alkylsulfonyl, C.sub.2 -C.sub.6 -alkenyl, (C.sub.2 -C.sub.6 -alkenyl)carbonyl, C.sub.2 -C.sub.6 -alkynyl, (C.sub.2 -C.sub.6 -alkynyl)carbonyl;R.sup.3 .dbd.H, halogen;R.sup.4 .dbd.CN, halogen, C.sub.1 -C.sub.3 -haloalkyl;R.sup.5 .dbd.H, CN, halogen, C.sub.1 -C.sub.3 -haloalkyl;R.sup.6 .dbd.H, CN, halogen, C.sub.1 -C.sub.3 -haloalkyl or unsubstituted or substituted C.sub.1 -C.sub.6 -alkoxy;R.sup.7 .dbd.CN, halogen;R.sup.8 in position .alpha., R.sup.7 in this case being in position .beta., or in position .beta., R.sup.7 in this case being in position .alpha., is1) H, OH, SH, CN, NO.sub.2, halogen, C.sub.1 -C.sub.6 -alkyl, C.sub.1 -C.sub.6 -haloalkyl, C.sub.1 -C.sub.6 -haloalkoxy, C.sub.1 -C.sub.6 -haloalkylthio, C.sub.1 -C.sub.6 -alkylthio-(C.sub.1 -C.sub.6 -alkyl)carbonyl, (C.sub.1 -C.sub.6 -alkyl)iminooxycarbonyl, C.sub.1 -C.sub.6 -alkoxy-C.sub.1 -C.sub.6 -alkyl, C.sub.1 -C.sub.6 -alkoxyamino-C.sub.1 -C.sub.6 -alkyl, C.sub.1 -C.sub.6 -alkoxy-C.sub.1 -C.sub.6 -alkylamino-C.sub.1 -C.sub.6 -alkyl,2) unsubstituted or substituted C.sub.1 -C.sub.6 -alkoxy, C.sub.1 -C.sub.6 -alkylthio, C.sub.3 -C.sub.6 -cycloalkoxy, C.sub.3 -C.sub.6 -cycloalkylthio, C.sub.2 -C.sub.6 -alkenyloxy, C.sub.2 -C.sub.6 -alkenylthio, C.sub.2 -C.sub.6 -alkynyloxy, C.sub.2 -C.sub.6 -alkynylthio, (C.sub.1 -C.sub.6 -alkyl)carbonyloxy, (C.sub.1 -C.sub.6 -alkyl)carbonylthio, (C.sub.1 -C.sub.6 -alkoxy)carboxyloxy, (C.sub.2 -C.sub.6 -alkenyl)carbonyloxy, (C.sub.2 -C.sub.6 -alkenyl)carbonylthio, (C.sub.2 -C.sub.6 -alkynyl)carbonyloxy, (C.sub.2 -C.sub.6 -alkynyl)carbonylthio, C.sub.1 -C.sub.6 -alkylsulfonyloxy or C.sub.1 -C.sub.6 -alkylsulfonyl,3) 29 further radicals;R.sup.9 .dbd.H, C.sub.1 -C.sub.6 -alkyl, C.sub.3 -C.sub.6 -cycloalkyl, C.sub.3 -C.sub.6 -alkenyl, C.sub.3 -C.sub.6 -alkynyl, C.sub.1 -C.sub.6 -alkoxy-C.sub.1 -C.sub.6 -alkyl, (C.sub.1 -C.sub.6 -alkoxy)carbonyl-C.sub.1 -C.sub.6 -alkyl, (C.sub.3 -C.sub.6 -alkenyloxy)carbonyl-C.sub.1 -C.sub.6 -alkyl, unsubstituted or substituted phenyl or phenyl-C.sub.1 -C.sub.6 -alkyl.

110. 发明授权

US6013606A Substituted cinnamic oxime and hydroxamide derivatives 失效
标题翻译：取代的肉桂肟和羟基酰胺衍生物
公开(公告)号：US6013606A
公开(公告)日：2000-01-11
申请号：US765180
申请日：1997-06-30
申请人： Ralf Klintz , Gerhard Hamprecht , Elisabeth Heistracher , Peter Schafer , Christoph-Sweder von dem Bussche-Hunnefeld , Peter Munster , Reinhard Kirstgen , Albrecht Harreus , Karl-Otto Westphalen , Matthias Gerber , Helmut Walter
发明人： Ralf Klintz , Gerhard Hamprecht , Elisabeth Heistracher , Peter Schafer , Christoph-Sweder von dem Bussche-Hunnefeld , Peter Munster , Reinhard Kirstgen , Albrecht Harreus , Karl-Otto Westphalen , Matthias Gerber , Helmut Walter
IPC分类号： C07D239/52 , A01N37/32 , A01N37/50 , A01N43/38 , A01N43/54 , C07C251/40 , C07C259/06 , C07C265/14 , C07C271/28 , C07C271/58 , C07C331/28 , C07D209/48 , C07D239/54 , C07D239/56 , C07D239/58 , C07D413/10 , A01N43/50 , C07D223/10 , C07D235/26
CPC分类号： C07D209/48 , A01N37/32 , A01N37/50 , A01N43/54 , C07C251/40 , C07C259/06 , C07C265/14 , C07C271/28 , C07C271/58 , C07C331/28 , C07D239/54
摘要： Substituted cinnamic oxime derivatives I and cinnamic hydroxamide derivatives II ##STR1## (R.sup.1= halogen, NO.sub.2, CN, CF.sub.3 ; R.sup.2 =H, halogen; R.sup.3= H, halogen, C.sub.1 -C.sub.6 -alkyl, C.sub.1 -C.sub.6 -haloalkyl, C.sub.3 -C.sub.6 -cycloalkyl, C.sub.3 -C.sub.6 -alkenyl, C.sub.3 -C.sub.6 -alkynyl, hydroxy-C.sub.1 -C.sub.6 -alkyl;R.sup.4= H, halogen, CN, C.sub.1 -C.sub.6 -alkyl, C.sub.1 -C.sub.6 -haloalkyl orR.sup.3 +R.sup.4 =chemical bond;Y=--O--, --S--, --O--CO--, --O--SO.sub.2 -- or chemical bond;Y'=--O-- or --S--;R.sup.5= unsubst. or subst. C.sub.1 -C.sub.6 -alkyl or C.sub.1 -C.sub.6 -haloalkyl; C.sub.3 -C.sub.6 -cycloalkyl, C.sub.3 -C.sub.6 -alkenyl, C.sub.3 -C.sub.6 -alkynyl, unsubst. or subst. phenyl or phenyl-C.sub.1 -C.sub.6 -alkyl, or, if Y is --O--, --S-- or a chemical bond, is (C.sub.1 -C.sub.6 -alkyl)carbonyl or (C.sub.1 -C.sub.6 -alkoxy)carbonyl; or, if Y is a chemical bond, is hydrogen or halogen;R.sup.5 '=R.sup.5, H or (C.sub.1 -C.sub.6 -haloalkyl)carbonyl;R.sup.6= H, C.sub.1 -C.sub.6 -alkyl, C.sub.1 -C.sub.6 -haloalkyl, C.sub.3 -C.sub.6 -cycloalkyl, C.sub.3 -C.sub.6 -alkenyl, C.sub.3 -C.sub.6 -alkynyl, hydroxy-C.sub.1 -C.sub.6 -alkyl, C.sub.1 -C.sub.6 -alkoxy-C.sub.1 -C.sub.6 -alkyl, C.sub.1 -C.sub.6 -alkylthio-C.sub.1 -C.sub.6 -alkyl, cyano-C.sub.1 -C.sub.6 -alkyl, (C.sub.1 -C.sub.6 -alkoxy) carbonyl-C.sub.1 -C.sub.6 -alkyl, (C.sub.1 -C.sub.6 -alkyl) carbonyl-C.sub.1 -C.sub.6 -alkyl, (C.sub.1 -C.sub.6 -alkyl)carbonyloxy-C.sub.1 -C.sub.6 -alkyl or unsubst. or subst. phenyl-C.sub.1 -C.sub.6 -alkyl;or, if Y is oxygen or sulfur, R.sup.5 +R.sup.6 together=unsubst. or subst. C.sub.1 -C.sub.3 -alkylene;Cyc=N-(3,4,5,6-tetrahydrophthalimido) or ##STR2## X.sup.1, X.sup.2 =oxygen or sulfur; R.sup.7 =H, C.sub.1 -C.sub.6 -alkyl, C.sub.1 -C.sub.6 -haloalkyl, NH.sub.2 ;R.sup.8, R.sup.9 =H, halogen, C.sub.1 -C.sub.6 -alkyl, C.sub.1 -C.sub.6 -haloalkyl or unsubst. or subst. phenyl);and salts of I and II.Use: herbicides; desiccation/defoliation of plants.
摘要翻译： PCT No.PCT / EP95 / 02584第 371日期：1997年6月30日 102（e）日期1997年6月30日PCT提交1995年7月4日PCT公布。第WO96 / 02518号公报日期1996年2月1日取代肉桂肟衍生物I和肉桂酸羟基酰胺衍生物II（R1 =卤素，NO2，CN，CF3; R2 = H，卤素; R3 = H，卤素，C1-C6-烷基，C1-C6-卤代烷基， C3-C6-环烷基，C3-C6-烯基，C3-C6-炔基，羟基-C1-C6-烷基; R4 = H，卤素，CN，C1-C6-烷基，C1-C6-卤代烷基或R3 + R4 = 化学键; Y = -O-，-S-，-O-CO-，-O-SO2-或化学键; Y'= -O-或-S-; R5 =未取代或未取代的C1-C6- 烷基或C 1 -C 6 - 卤代烷基; C 3 -C 6 - 环烷基，C 3 -C 6 - 烯基，C 3 -C 6炔基，未取代或取代的苯基或苯基-C 1 -C 6烷基，或者如果Y是-O- （C 1 -C 6烷基）羰基或（C 1 -C 6 - 烷氧基）羰基;或者如果Y是化学键，则是氢或卤素; R 5'= R 5，H或（C 1 -C 6 - -C 6 - 卤代烷基）羰基; R 6 = H，C 1 -C 6烷基，C 1 -C 6卤代烷基，C 3 -C 6环烷基，C 3 -C 6 - 烯基，C 3 -C 6炔基，羟基-C 1 -C 6烷基， C 1 -C 6烷氧基-C 1 -C 6烷基，C 1 -C 6烷硫基-C 1 -C 6烷基，氰基-C 1 -C 6烷基，（C 1 -C 6 - 烷氧基）羰基-C 1 -C 6烷基，（C 1 -C 6 - 烷基）羰基-C 1 -C 6 - 烷基，（C 1 -C 6 - 烷基）羰基氧基 -C 1 -C 6 - 烷基或未取代基。或subst。苯基-C 1 -C 6 - 烷基; 或者如果Y是氧或硫，则R5 + R6一起=不成立。或subst。 C1-C3-亚烷基; Cyc = N-（3,4,5,6-四氢邻苯二甲酰亚氨基）或X1，X2 =氧或硫; R7 = H，C1-C6-烷基，C1-C6-卤代烷基，NH2; R8，R9 = H，卤素，C1-C6-烷基，C1-C6-卤代烷基或未取代基。或subst。苯基）; 和I和II的盐。用途：除草剂; 植物的干燥/脱叶。

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