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101. 发明专利

ES402578A1 PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE 4-(OMEGA-(CUMARIN-7-IL-OXI) ALCOHIL)-PIPERAZINA. 未知
公开(公告)号：ES402578A1
公开(公告)日：1975-04-01
申请号：ES402578
申请日：1972-05-09
申请人： BOEHRINGER MANNHEIM GMBH
发明人： WITTE ERNST-CHRISTIAN , STACH KURT , THIEL MAX , ROESCH ANDRONIKI , ROESCH EGON
IPC分类号： C07D309/16 , A61K31/35 , A61K31/351 , A61K31/352 , A61K31/495 , A61P3/00 , A61P29/00 , A61P37/08 , C07D309/32 , C07D311/16 , C07D , A61K

102. 发明专利

AU5880073A 1-%3-%5,6,7,8-TETRAHYDRONAPHTH-1-YLOXY<-PROPYL<-PIPERAZINE DERIVATIVES 未知
公开(公告)号：AU5880073A
公开(公告)日：1975-02-06
申请号：AU5880073
申请日：1973-08-01
申请人： BOEHRINGER MANNHEIM GMBH
发明人： SPONER GISBERT , STACH KURT , WITTE ERNST-CHRISTIAN , DIETMANN KARL
IPC分类号： C07C43/20 , C07D1/18 , A61K27/00 , C07D1/04 , C07D51/70

103. 发明专利

GB1335946A 4- W-COUMARIN-7-YLOXY- ALKYL- PIPERAZINE DERIVATIVES 未知
公开(公告)号：GB1335946A
公开(公告)日：1973-10-31
申请号：GB2207072
申请日：1972-05-11
申请人： BOEHRINGER MANNHEIM GMBH
发明人： WITTE ERNST-CHRISTIAN , STACH KURT , THIEL MAX , ROESCH ANDRONIKI , ROESCH EGON
IPC分类号： C07D309/16 , A61K31/35 , A61K31/351 , A61K31/352 , A61K31/495 , A61P3/00 , A61P29/00 , A61P37/08 , C07D309/32 , C07D311/16 , C07D7/28 , A61K27/00
摘要： 1335946 Coumarin-7-yloxyalkyl-piperazine derivatives BOEHRINGER MANNHEIM GmbH 11 May 1972 [14 May 1971] 22070/72 Heading C2C Novel compounds of the Formula (I) wherein R 1 is a hydrogen atom or a C 1-5 alkyl radical, R 2 is a C 1-5 alkyl radical, R 3 is an unsubstituted or substituted phenyl or benzyl radical, the substituents, when present, being halogen atoms or C 1-5 alkyl or C 1-5 alkoxy radicals, and n is 1, 2 or 3; and the pharmacologically compatible salts thereof, may be obtained by (a) condensing a compound of the Formula (II) in which X is a halogen atom, with a 7-hydroxy- 3 - R 1 - 4 - R 2 - substituted - coumarin, (b) condensation of a compound of the Formula (IV) with an R 3 -substituted-piperazine, (c) condensation of a compound of Formula (I), in which R 3 is H, with a compound of the formula X.R 3 , in which R 3 is an unsubstituted or substituted benzyl radical; or (d) condensation of a compound of the Formula (VII) with an amine of formula H 2 N-R 3 , and thereafter, if desired, converting the products into their physiologically compatible salts. Pharmaceutical compositions having antiinflammatory and anti-allergic action comprise at least one compound of the Formula (I) in admixture with a solid or liquid pharmaceutical diluent or carrier, for example in the form of tablets or dragees or suspended or dissolved in water or an oil.

104. 发明专利

AU4723372A PHENOXY-ALKYL-CARBOXYLIC ACID DERIVATIVES 未知
公开(公告)号：AU4723372A
公开(公告)日：1973-08-23
申请号：AU4723372
申请日：1972-09-28
申请人： BOEHRINGER MANNHEIM GMBH
发明人： WITTE ERNST-CHRISTIAN , STACH KURT , THIEL MAX , SCHMIDT FELIX HELMUT , STORK HARALD
IPC分类号： A61K31/215 , A61K20060101 , A61K31/16 , A61K31/19 , A61K31/195 , A61K31/22 , C07C20060101 , C07C67/00 , C07C231/00 , C07C231/02 , C07C231/12 , C07C233/73 , C07C235/48 , C07C103/78 , A61K27/00

105. 发明专利

ZA723167B NEW 4-(OMEGA-(COUMARIN-7-YLOXY)-ALKYL)-PIPERAZINE DERIVATIVES AND THE PREPARATION THEREOF 未知
公开(公告)号：ZA723167B
公开(公告)日：1973-03-28
申请号：ZA723167
申请日：1972-05-09
申请人： BOEHRINGER MANNHEIM GMBH
发明人： WITTE ERNST-CHRISTIAN , STACH KURT , THIEL MAX , ROESCH ANDRONIKI , ROESCH EGON
IPC分类号： A61K31/35 , C07D309/16 , A61K31/351 , A61K31/352 , A61K31/495 , A61P3/00 , A61P29/00 , A61P37/08 , C07D309/32 , C07D311/16 , C07D
摘要： 1335946 Coumarin-7-yloxyalkyl-piperazine derivatives BOEHRINGER MANNHEIM GmbH 11 May 1972 [14 May 1971] 22070/72 Heading C2C Novel compounds of the Formula (I) wherein R 1 is a hydrogen atom or a C 1-5 alkyl radical, R 2 is a C 1-5 alkyl radical, R 3 is an unsubstituted or substituted phenyl or benzyl radical, the substituents, when present, being halogen atoms or C 1-5 alkyl or C 1-5 alkoxy radicals, and n is 1, 2 or 3; and the pharmacologically compatible salts thereof, may be obtained by (a) condensing a compound of the Formula (II) in which X is a halogen atom, with a 7-hydroxy- 3 - R 1 - 4 - R 2 - substituted - coumarin, (b) condensation of a compound of the Formula (IV) with an R 3 -substituted-piperazine, (c) condensation of a compound of Formula (I), in which R 3 is H, with a compound of the formula X.R 3 , in which R 3 is an unsubstituted or substituted benzyl radical; or (d) condensation of a compound of the Formula (VII) with an amine of formula H 2 N-R 3 , and thereafter, if desired, converting the products into their physiologically compatible salts. Pharmaceutical compositions having antiinflammatory and anti-allergic action comprise at least one compound of the Formula (I) in admixture with a solid or liquid pharmaceutical diluent or carrier, for example in the form of tablets or dragees or suspended or dissolved in water or an oil.

106. 发明专利

ZA7203167B NEW 4-(OMEGA-(COUMARIN-7-YLOXY)-ALKYL)-PIPERAZINE DERIVATIVES AND THE PREPARATION THEREOF 未知
公开(公告)号：ZA7203167B
公开(公告)日：1973-03-28
申请号：ZA7203167
申请日：1972-05-09
申请人： BOEHRINGER MANNHEIM GMBH
发明人： WITTE ERNST-CHRISTIAN , STACH KURT , THIEL MAX , ROESCH ANDRONIKI , ROESCH EGON
IPC分类号： C07D309/16 , A61K31/35 , A61K31/351 , A61K31/352 , A61K31/495 , A61P3/00 , A61P29/00 , A61P37/08 , C07D309/32 , C07D311/16 , C07D
CPC分类号： C07D311/16 , Y10S514/87

107. 发明专利

NL7206456A 未知
公开(公告)号：NL7206456A
公开(公告)日：1972-11-16
申请号：NL7206456
申请日：1972-05-12
申请人： BOEHRINGER MANNHEIM GMBH
发明人： WITTE ERNST-CHRISTIAN , STACH KURT , THIEL MAX , ROESCH ANDRONIKI , ROESCH EGON
IPC分类号： C07D309/16 , A61K31/35 , A61K31/351 , A61K31/352 , A61K31/495 , A61P3/00 , A61P29/00 , A61P37/08 , C07D309/32 , C07D311/16 , C07D99/04 , A61K27/00
摘要： 1335946 Coumarin-7-yloxyalkyl-piperazine derivatives BOEHRINGER MANNHEIM GmbH 11 May 1972 [14 May 1971] 22070/72 Heading C2C Novel compounds of the Formula (I) wherein R 1 is a hydrogen atom or a C 1-5 alkyl radical, R 2 is a C 1-5 alkyl radical, R 3 is an unsubstituted or substituted phenyl or benzyl radical, the substituents, when present, being halogen atoms or C 1-5 alkyl or C 1-5 alkoxy radicals, and n is 1, 2 or 3; and the pharmacologically compatible salts thereof, may be obtained by (a) condensing a compound of the Formula (II) in which X is a halogen atom, with a 7-hydroxy- 3 - R 1 - 4 - R 2 - substituted - coumarin, (b) condensation of a compound of the Formula (IV) with an R 3 -substituted-piperazine, (c) condensation of a compound of Formula (I), in which R 3 is H, with a compound of the formula X.R 3 , in which R 3 is an unsubstituted or substituted benzyl radical; or (d) condensation of a compound of the Formula (VII) with an amine of formula H 2 N-R 3 , and thereafter, if desired, converting the products into their physiologically compatible salts. Pharmaceutical compositions having antiinflammatory and anti-allergic action comprise at least one compound of the Formula (I) in admixture with a solid or liquid pharmaceutical diluent or carrier, for example in the form of tablets or dragees or suspended or dissolved in water or an oil.

108. 发明专利

AU3091197A New process for preparing troglitazone 未知
公开(公告)号：AU3091197A
公开(公告)日：1997-12-05
申请号：AU3091197
申请日：1997-05-16
申请人： BOEHRINGER MANNHEIM GMBH
发明人： WOLFF HANS-PETER , WITTE ERNST-CHRISTIAN
IPC分类号： C07D417/12

109. 发明专利

AU3027297A New thiazolidinediones, process for preparing the same and medicaments containing the same 未知
公开(公告)号：AU3027297A
公开(公告)日：1997-12-05
申请号：AU3027297
申请日：1997-05-16
申请人： BOEHRINGER MANNHEIM GMBH
发明人： WOLFF HANS-PETER , WITTE ERNST-CHRISTIAN , KUHNLE HANS-FRIEDER
IPC分类号： C07D277/34 , C07D417/12 , C07D417/14 , A61K31/425

110. 发明专利

AT133404T 未知
公开(公告)号：AT133404T
公开(公告)日：1996-02-15
申请号：AT92906622
申请日：1992-03-19
申请人： BOEHRINGER MANNHEIM GMBH
发明人： WITTE ERNST-CHRISTIAN , WOLFF HANS PETER , DRESEL ALOIS
IPC分类号： A61K31/085 , A61K31/09 , A61K31/12 , A61K31/122 , A61P9/10 , C07C41/03 , C07C41/16 , C07C43/23 , C07C49/255

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