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101. 发明专利

EA017389B1 ГЕТЕРОЦИКЛИЧЕСКИЕ СОЕДИНЕНИЯ И ИХ ПРИМЕНЕНИЕ 未知
公开(公告)号：EA017389B1
公开(公告)日：2012-12-28
申请号：EA200901276
申请日：2008-03-24
申请人： AMGEN INC
发明人： CHEN YI , CUSHING TIMOTHY D , DUQUETTE JASON A , GONZALEZ LOPEZ DE TURISO FELIX , HAO XIAOLIN , HE XIAO , LUCAS BRIAN , MCGEE LAWRENCE R , REICHELT ANDREAS , RZASA ROBERT M , SEGANISH JENNIFER , SHIN YOUNGSOOK , ZHANG DAWEI
IPC分类号： C07D473/30 , A61K31/519 , A61K31/52 , A61P29/00 , A61P35/00 , C07D473/34 , C07D487/04
摘要： Изобретениеотноситсяк соединениямс приведенныминижеформуламиилиихфармацевтическиприемлемымсолям, атакжефармацевтическимкомпозициям, содержащимэтисоединенияи фармацевтическиприемлемыйразбавительилиноситель. Соединениянастоящегоизобретенияполезныдлялеченияобщеговоспаления, артрита, ревматизма, остеоартрита, воспалительныхзаболеванийкишечника, воспалительныхзаболеванийглаз, воспаленийилинестабильныхзаболеваниймочевогопузыря, псориаза, заболеванийкожис воспалительнымиэлементами, хроническихвоспалительныхзаболеваний, включающих, нонеограничивающихсяэтим, аутоиммунныезаболевания, такиекаксистемнаякраснаяволчанка (SLE), кинестезия, ревматоидныйартрит, острыйрассеянныйэнцефаломиелит, идиопатическаятромбоцитопеническаяпурпура, болезньШарко-Вюльпиана, синдромШегренаи аутоиммуннаягемолитическаяанемия, аллергическихсостояний, включающихвсеформыгиперчувствительности, раковыхзаболеваний, опосредованных, зависящихилисвязанныхс p110δактивностью, которыевключают, нонеограничиваютсяэтим, лейкемии, такиекакостраялейкемия, миелоиднуюлейкемию (AML), миелодиспластическийсиндром (MDS), миелопролиферативныезаболевания (MPD), хроническуюмиелоиднуюлейкемию (CML), Т-клеточныйострыйлимфобластныйлейкоз (T-ALL), В-клеточнуюлимфобластнуюлейкемию (B-ALL), неходжкинскуюлимфому (NHL), В-клеточнуюлимфомуи твердыеопухоли, такиекакракмолочнойжелезы.

102. 发明专利

AU2011261263A1 Piperidinone derivatives as MDM2 inhibitors for the treatment of cancer 未知
公开(公告)号：AU2011261263A1
公开(公告)日：2012-12-13
申请号：AU2011261263
申请日：2011-06-03
申请人： AMGEN INC
发明人： BARTBERGER MICHAEL DAVID , GONZALEZ BUENROSTRO ANA , BECK HILARY PLAKE , CHEN XIAOQI , CONNORS RICHARD VICTOR , DEIGNAN JEFFERY , DUQUETTE JASON , EKSTEROWICZ JOHN , FISHER BENJAMIN , FOX BRIAN MATTHEW , FU JIASHENG , FU ZICE , GONZALEZ LOPEZ DE TURISO FELIX , GRIBBLE JR MICHAEL WILLIAM , GUSTIN DARIN JAMES , HEATH JULIE ANNE , HUANG XIN , JIAO XIANYUN , JOHNSON MICHAEL , KAYSER FRANK , KOPECKY DAVID JOHN , LAI SUJEN , LI YIHONG , LI ZHIHONG , LIU JIWEN , LOW JONATHAN DANTE , LUCAS BRIAN STUART , MA ZHIHUA , MCGEE LAWRENCE , MCINTOSH JOEL , MCMINN DUSTIN , MEDINA JULIO CESAR , MIHALIC JEFFREY THOMAS , OLSON STEVEN HOWARD , REW YOSUP , ROVETO PHILIP MARLEY , SUN DAQING , WANG XIAODONG , WANG YINGCAI , YAN XUELEI , YU MING , ZHU JIANG
IPC分类号： C07D211/40 , A61K31/4412 , A61P35/00 , C07D279/02 , C07D401/04 , C07D401/06 , C07D401/12 , C07D407/04 , C07D407/06 , C07D409/04 , C07D413/06 , C07D417/06 , C07D471/20 , C07D498/08 , C07D498/20
摘要： The present invention provides MDM2 inhibitor compounds of Formula (I), wherein the variables are defined above, which compounds are useful as therapeutic agents, particularly for the treatment of cancers. The present invention also relates to pharmaceutical compositions that contain an MDM2 inhibitor.

104. 发明专利

AU2010265974A1 Polycyclic derivatives of pyridine and their use in the treatment of (inter alia) rheumatoid arthritis and similar diseases 未知
公开(公告)号：AU2010265974A1
公开(公告)日：2012-01-19
申请号：AU2010265974
申请日：2010-06-25
申请人： AMGEN INC
发明人： BUI MINNA HUE THANH , CHEN YI , CUSHING TIMOTHY D , DUQUETTE JASON A , FISHER BENJAMIN , GONZALEZ LOPEZ DE TURISO FELIX , HAO XIAOLIN , HE XIAO , JOHNSON MICHAEL G , LUCAS BRIAN
IPC分类号： C07D401/12 , A61K31/4375 , A61K31/444 , A61P19/02 , C07D401/14 , C07D471/04 , C07D487/04
摘要： Substituted bicyclic heteroaryls and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (SLE), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, Sjoegren's syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity, The present invention also enables methods for treating cancers that are mediated, dependent on or associated with p110 activity, including but not restricted to leukemias, such as Acute Myeloid leukaemia (AML) Myelo-dysplastic syndrome (MDS) myelo-proliferative diseases (MPD) Chronic Myeloid Leukemia (CML) T-cell Acute Lymphoblastic leukaemia ( T-ALL) B-cell Acute Lymphoblastic leukaemia (B-ALL) Non Hodgkins Lymphoma (NHL) B-cell lymphoma and solid tumors, such as breast cancer.

105. 发明专利

CA2681136A1 HETEROCYCLIC COMPOUNDS AND THEIR USES 未知
公开(公告)号：CA2681136A1
公开(公告)日：2008-10-02
申请号：CA2681136
申请日：2008-03-24
申请人： AMGEN INC
发明人： HAO XIAOLIN , MCGEE LAWRENCE R , HE XIAO , LUCAS BRIAN , SEGANISH JENNIFER , SHIN YOUNGSOOK , ZHANG DAWEI , CUSHING TIMOTHY D , CHEN YI , GONZALEZ LOPEZ DE TURISO FELIX , DUQUETTE JASON A , REICHELT ANDREAS , RZASA ROBERT M
IPC分类号： C07D473/30 , A61K31/519 , A61K31/52 , A61P29/00 , A61P35/00 , C07D473/34 , C07D487/04
摘要： Substituted bicyclic heteroaryls and compositions containing them, for th e treatment of general inflammation, arthritis, rheumatic diseases, osteoart hritis, inflammatory bowel disorders, inflammatory eye disorders, inflammato ry or unstable bladder disorders, psoriasis, skin complaints with inflammato ry components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (SLE), myesteni a gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopa thic thrombocytopenic purpura, multiples sclerosis, Sjoegren's syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hype rsensitivity. The present invention also enables methods for treating cancer s that are mediated, dependent on, or associated with p110 activity, includi ng but not restricted to leukemias, such as acute myeloid leukaemia (AML), m yelo-dysplastic syndrome (MDS), myelo-proliferative diseases (MPD), chronic myeloid leukemia (CML), T-cell acute lymphoblastic leukaemia (T-ALL), B-cell acute lymphoblastic leukaemia (B-ALL), non Hodgkins lymphoma (NHL), B-cell lymphoma and solid tumors, such as breast cancer.

106. 发明专利

CA3060703C COMPOUNDS CONTAINING THE PENTANOATE MOIETY 未知
公开(公告)号：CA3060703C
公开(公告)日：2022-08-02
申请号：CA3060703
申请日：2011-06-03
申请人： AMGEN INC
发明人： BARTBERGER MICHAEL DAVID , GONZALEZ BUENROSTRO ANA , CHEN XIAOQI , CONNORS RICHARD VICTOR , DEIGNAN JEFFREY , DUQUETTE JASON , EKSTEROWICZ JOHN , FISHER BENJAMIN , FOX BRIAN MATTHEW , FU JIASHENG , FU ZICE , GONZALEZ LOPEZ DE TURISO FELIX , GRIBBLE MICHAEL WILLIAM , GUSTIN DARIN JAMES , HEATH JULIE ANNE , HUANG XIN , JOHNSON MICHAEL , KAYSER FRANK , KOPECKY DAVID JOHN , LAI SUJEN , LI YIHONG , LI ZHIHONG , LIU JIWEN , LOW JONATHAN DANTE , LUCAS BRIAN STUART , MA ZHIHUA , MCGEE LAWRENCE , MCINTOSH JOEL , MCMINN DUSTIN , MEDINA JULIO CESAR , MIHALIC JEFFREY THOMAS , REW YOSUP , ROVETO PHILIP MARLEY , SUN DAQING , WANG XIAODONG , WANG YINGCAI , YAN XUELEI , YU MING , ZHU JIANG , BECK HILARY PLAKE , JIAO XIANYUN , OLSON STEVEN HOWARD
IPC分类号： C07D309/30 , C07C69/73 , C07C69/738 , C07D498/04
摘要： The present invention provides intermediates for making MDM2 inhibitor compounds of Formula (I), wherein the MDM2 inhibitor compounds are useful as therapeutic agents, particularly for the treatment of cancers. (see formula I)

107. 发明专利

CL2020000610A1 Compuestos de bisamida que activan el sarcómero y sus usos. 未知
公开(公告)号：CL2020000610A1
公开(公告)日：2020-11-13
申请号：CL2020000610
申请日：2020-03-10
申请人： AMGEN INC , CYTOKINETICS INC
发明人： BOEZIO ALESSANDRO , ASHCRAFT LUKE , BUTLER JOHN , CHANDRA AROOP , CHUANG CHIHYUAN , COLLIBEE SCOTT E , DEBENEDETTO MIKKEL , DIMASSA VINCENT , GRACEFFA RUSSELL , MALINOWSKI JUSTIN , MOEBIUS DAVID , MORGAN BRADLEY P , PAYETTE JOSHUA , ROMERO ANTONIO , ST JEAN DAVID JR , VARGAS RICHARD , YEOMAN JOHN , ZHANG HANMO , CHENG ALAN , GONZALEZ LOPEZ DE TURISO FELIX , JOHNSON MICHAEL GARRETT
IPC分类号： C07D207/16 , C07D209/02 , C07D401/06 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D413/12 , C07D413/14 , C07D417/14
摘要： La presente invención provee un compuesto de fórmula (I) o una sal farmacéuticamente aceptable de este, composiciones farmacéuticas que comprenden un compuesto de la invención, un método para fabricar compuestos de la invención y usos terapéuticos de estos.

110. 发明专利

JOP20200059A1 مركبات تنشيط القسيم العضلي ثنائي الأميد واستخداماتها 未知
公开(公告)号：JOP20200059A1
公开(公告)日：2019-03-13
申请号：JOP20200059
申请日：2020-03-12
申请人： AMGEN INC , CYTOKINETICS INC
发明人： CHENG ALAN , MALINOWSKI JUSTIN , JOHNSON MICHAEL GARRETT , DIMASSA VINCENT , ASHCRAFT LUKE , BUTLER JOHN , ZHANG HANMO , DEBENEDETTO MIKKEL , CHANDRA AROOP , YEOMAN JOHN , GRACEFFA RUSSELL , COLLIBEE SCOTT E , MORGAN BRADLEY P , ROMERO ANTONIO , GONZALEZ LOPEZ DE TURISO FELIX , MOEBIUS DAVID , ST JEAN DAVID JR , PAYETTE JOSHUA , BOEZIO ALESSANDRO , CHUANG CHIHYUAN , VARGAS RICHARD
摘要： يتعلقالاختراعالحاليبتوفيرمركبلهالصيغة (I) أوملحمنهمقبولصيدليًا،تركيباتصيدليةتشتملعلىمركبالاختراع،طريقةتصنيعمركباتالاختراعواستخداماتعلاجيةلها. صورةالصيغة I

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