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101. 发明申请

WO2003058065A1 HYDRAULIC AMPLIFIER PUMP 审中-公开
标题翻译：液压放大器泵
公开(公告)号：WO2003058065A1
公开(公告)日：2003-07-17
申请号：PCT/US2002/035392
申请日：2002-11-05
申请人： WATERS INVESTMENTS LIMITED , GERHARDT, Geoff , COMPTON, Bruce, J.
发明人： GERHARDT, Geoff , COMPTON, Bruce, J.
IPC分类号： F04B9/08
CPC分类号： F04B9/1178 , F04B9/113 , F04B9/1174 , F04B13/00 , F04B23/06 , F04B49/065 , G01N30/22 , G01N30/32 , G01N30/34 , G01N30/36 , G01N2030/324 , G01N2030/326
摘要： A hydraulic amplifier system for an ultra-high pressure liquid chromatography system. The hydraulic amplifier system includes a hydraulic cylinder (14) comprising a primary piston chamber (20) in which a primary piston (22) is disposed and a secondary piston chamber (30) in which a secondary piston (26) is disposed. The cross-sectional area of the primary piston (22) is larger than the cross-sectional area of the secondary piston (26). The difference in the cross-sectional areas of the pistons (22, 26) creates an amplification of the pressure in the primary piston chamber (20) and a reduction in flow rate.
摘要翻译：一种用于超高压液相色谱系统的液压放大器系统。液压放大器系统包括液压缸（14），其包括主活塞室（20），其中设置有主活塞（22），以及辅助活塞室（30），其中设置有二级活塞（26）。主活塞（22）的横截面面积大于第二活塞（26）的横截面面积。活塞（22,26）的横截面积的差异产生了主活塞室（20）中的压力的放大和流量的降低。

102. 发明申请

WO2002097392A2 SAMPLE CONCENTRATION MALDI PLATES FOR MALDI MASS SPECTROMETRY 审中-公开
标题翻译：用于MALDI质谱的样品浓度MALDI板
公开(公告)号：WO2002097392A2
公开(公告)日：2002-12-05
申请号：PCT/US2002/016613
申请日：2002-05-24
申请人： WATERS INVESTMENTS LIMITED , LEE, Peter, Jeng, Jong
发明人： LEE, Peter, Jeng, Jong
IPC分类号： G01N
CPC分类号： H01J49/0418 , G01N1/405
摘要： A novel Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry (MALDI-MS) sample support plate is described. The plate comprises a top sample presentation surface and a lower surface, wherein the top sample presentation surface comprises at least one aperture for receiving a sample. The aperture extends through and between the top sample presentation surface and the bottom surface, and contains a porous material that retains and concentrates at the target spot analyte and matrix molecules contained in the sample on the surface of the aperture. Methods for making and using the sample support plate in conventional and automated MALDI-MS are also described.
摘要翻译：描述了一种新型的矩阵辅助激光解吸/电离质谱（MALDI-MS）样品支撑板。板包括顶部样品呈现表面和下表面，其中顶部样品呈现表面包括用于接收样品的至少一个孔。孔径延伸穿过顶部样品呈现表面和底部表面之间并且包含多孔材料，其保留并集中在靶点分析物和包含在孔的表面上的样品中的基质分子。还描述了在常规和自动化的MALDI-MS中制备和使用样品支持板的方法。

103. 发明申请

WO1997039347A1 CHROMATOGRAPHIC PATTERN ANALYSIS SYSTEM EMPLOYING CHROMATOGRAPHIC VARIABILITY CHARACTERIZATION 审中-公开
标题翻译：使用色谱变异特征的色谱图分析系统
公开(公告)号：WO1997039347A1
公开(公告)日：1997-10-23
申请号：PCT/US1997006135
申请日：1997-04-14
申请人： WATERS INVESTMENTS LIMITED
发明人： WATERS INVESTMENTS LIMITED , GORENSTEIN, Marc, V.
IPC分类号： G01N30/86
CPC分类号： G01N30/8665 , G01N30/8624 , G01N30/8641 , G01N30/88 , G01N2030/8804 , G01N2030/8809
摘要： A Chromatographic Pattern Analysis System (CPAS) (100) determines chromatographic variability due to a plurality of sources without requiring identification or characterization of peaks or other chromatographic features, receives data indicative of a standard chromatogram and a first sample chromatogram generated from a first mixture by a High Pressure Liquid Chromatography (HPLC) device (102) and data indicative of a plurality of additional sample chromatograms generated by the HPLC device (102) from a plurality of different mixtures. The CPAS (100) generates from the standard chromatogram a plurality of sets of chromatographic variability data, each set being indicative of a different effect of the chromatographic variability of the HPLC. The standard chromatogram is modified as a function of the variability data, and a residual value, indicative of a difference between the modified standard chromatograms and the first sample chromatogram is generated. Residual values are generated for the additional sample chromatograms and are used to determine differences between the corresponding mixtures and the first mixture.
摘要翻译：色谱图样分析系统（CPAS）（100）由于多个来源而确定色谱变异性，而不需要鉴定或表征峰或其他色谱特征，接收指示标准色谱图的数据和从第一混合物产生的第一样品色谱图高压液相色谱（HPLC）装置（102）和指示由HPLC装置（102）从多种不同混合物产生的多个附加样品色谱图的数据。 CPAS（100）从标准色谱图产生多组色谱变异性数据，每组色谱变异性数据指示HPLC的色谱变异性的不同影响。标准色谱被修改为变异性数据的函数，并且生成表示修改的标准色谱图与第一样品色谱图之间的差异的残留值。为附加样品色谱图生成残留值，并用于确定相应混合物和第一混合物之间的差异。

104. 发明申请

WO1997032192A2 THREE CAPILLARY FLOW-THROUGH VISCOMETER 审中-公开
标题翻译：三毛毛虫流量测量仪
公开(公告)号：WO1997032192A2
公开(公告)日：1997-09-04
申请号：PCT/US1997003162
申请日：1997-02-28
申请人： WATERS INVESTMENTS LIMITED , DE CORRAL, Jose, Luis
发明人： WATERS INVESTMENTS LIMITED
IPC分类号： G01N11/08
CPC分类号： G01N11/08
摘要： A method and apparatus for measuring the viscosity of a sample solution which comprises an input tube for transporting a sample solution flow towards a splitter for diverting input flow into two distinct flows streams where three capillary tubes are located in the two flow streams placed downstream from the flow splitter, where each flow stream has one or two capillary tubes a delay volume, and a flow-through transducer having hydraulic connections placed in one stream or in two streams used for measuring the pressure difference across the capillary tubes.
摘要翻译：一种用于测量样品溶液的粘度的方法和装置，其包括用于将样品溶液流输送到分流器的输入管，用于将输入流转向两个不同的流动流，其中三个毛细管位于放置在下游的两个流动流中流动分流器，其中每个流动流具有一个或两个毛细管和延迟体积，以及具有放置在一个流中的液压连接的流通换能器或用于测量跨越毛细管的压力差的两个流中的流通换能器。

105. 发明申请

WO1995023966A1 METHOD FOR DETECTING POLYMERS IN A SOLUTION, DETECTOR SYSTEM AND CHROMATOGRAPHY APPARATUS CONTAINING SUCH A DETECTOR SYSTEM 审中-公开
标题翻译：用于检测解决方案中的聚合物的方法，检测器系统和包含这种检测器系统的色谱装置
公开(公告)号：WO1995023966A1
公开(公告)日：1995-09-08
申请号：PCT/NL1995000084
申请日：1995-03-06
申请人： WATERS INVESTMENTS LIMITED , STAAL, Willem, Jacob
发明人： WATERS INVESTMENTS LIMITED
IPC分类号： G01N30/84
CPC分类号： G01N33/442 , G01N21/82 , G01N30/34 , G01N30/74 , G01N30/84 , G01N2030/027 , G01N2030/8441 , G01N21/53
摘要： A method of quantitatively detecting a polymer in a solution of the polymer in a solvent is provided, which method comprises the steps of (a) adding to the solution a non-solvent for said polymer in a sufficient amount to make the resulting liquid turbid and (b) measuring the turbidity of the resulting liquid. A detecting device for detecting a polymer in a polymer-containing solution is also provided, which device comprises a line for supplying polymer-containing solution, a line for supplying non-solvent, a mixing chamber, a line connected to said mixing chamber for conveying the mixed liquid, and a detector for measuring turbidity in the mixed liquid, as well as an HPLC apparatus comprising a liquid separation system, especially a Gradient Polymer Elution Chromatography (GPEC)3 system, connected to said detecting device.
摘要翻译：提供了一种定量检测聚合物在溶剂中的溶液中的聚合物的方法，该方法包括以下步骤：（a）向溶液中加入足够量的所述聚合物的非溶剂以使所得液体浑浊，（b）测量所得液体的浊度。还提供了用于检测含聚合物溶液中的聚合物的检测装置，该装置包括用于提供含聚合物的溶液的管线，用于供给非溶剂的管线，混合室，连接到所述混合室的管线，用于输送混合液体和用于测量混合液体中的浊度的检测器，以及包括液体分离系统，特别是连接到所述检测装置的梯度聚合物洗脱色谱（GPEC）3系统）的HPLC装置。

106. 发明申请

WO2008153913A1 SYSTEM AND METHOD FOR THERMAL ANALYSIS USING VARIABLE THERMAL RESISTANCE 审中-公开
标题翻译：使用可变耐热性进行热分析的系统和方法
公开(公告)号：WO2008153913A1
公开(公告)日：2008-12-18
申请号：PCT/US2008/007087
申请日：2008-06-05
申请人： WATERS INVESTMENTS LIMITED
发明人： DANLEY, Robert, L.
IPC分类号： G01C3/20
CPC分类号： G01N25/4833
摘要： A thermal measurement apparatus and method for performing heat flux differential scanning calorimetry (DSC) is disclosed. A variable thermal resistor is used to couple a measurement assembly to a heat sink in the thermal measurement apparatus, such that samples can be rapidly heated and rapidly cooled. The apparatus can be configured with a highly conductive sample assembly enclosure. The enclosure can include a high emissivity coating. In one embodiment, the enclosure extends along a longitudinal direction that is about the same as that of an infrared lamp assembly used to heat the enclosure, thereby increasing the efficiency of heating the sample enclosure. In one configuration, the variable thermal resistor comprises a gap whose gas composition can be varied during a sample measurement to independently optimize sample heating and cooling rates.
摘要翻译：公开了一种用于执行热通量差示扫描量热法（DSC）的热测量装置和方法。可变热敏电阻器用于将测量组件耦合到热测量设备中的散热器，使得样品可以被快速加热并快速冷却。该装置可以配置有高度导电的样品组件外壳。外壳可以包括高发射率涂层。在一个实施例中，外壳沿着与用于加热外壳的红外灯组件大致相同的纵向方向延伸，从而提高加热样品外壳的效率。在一种配置中，可变热敏电阻器包括间隙，其气体组成可以在样品测量期间变化以独立地优化样品加热和冷却速率。

107. 发明申请

WO2008150766A1 CHROMATOGRAPHY COLUMN 审中-公开
标题翻译：色谱柱
公开(公告)号：WO2008150766A1
公开(公告)日：2008-12-11
申请号：PCT/US2008/064864
申请日：2008-05-27
申请人： WATERS INVESTMENTS LIMITED , BOUVIER, Edouard, S.p. , BELANGER, Johnathan
发明人： BOUVIER, Edouard, S.p. , BELANGER, Johnathan
IPC分类号： B01D15/22
CPC分类号： B01D15/22 , B01J2220/82 , G01N30/6065 , G01N2030/528
摘要： A device for chromatographically separating compounds held in a fluid sample. The device comprises a tube means having an inlet aperture for receiving a fluid sample, an outlet aperture and an internal wall. The internal wall defines a passage for receiving a monolithic separation medium. The passage has a first end and a second end, spaced from each other along a length, and a plurality of cross-sectional areas along the length. The inlet aperture is at the first end and the outlet aperture at the second end. A monolithic separation medium is positioned in said passage. Each of the cross-sectional areas of the passage decreases with each cross sectional area in a continuous or stepwise manner between the first end and the second end, such that a flow of a fluid sample through the passage from the inlet aperture to the outlet aperture pushes the monolithic separation medium against the internal wall.
摘要翻译：用于色谱分离保留在流体样品中的化合物的装置。该装置包括具有用于接收流体样品的入口孔，出口孔和内壁的管装置。内壁限定用于接收单片分离介质的通道。通道具有沿着长度彼此间隔开的第一端和第二端以及沿着该长度的多个横截面区域。入口孔位于第一端，第二端处的出口孔。整体式分离介质定位在所述通道中。通道的每个横截面面积以第一端部和第二端部之间的连续或分步方式的每个横截面面积减小，使得流体样品从入口孔到出口孔的流动将整体式分离介质推向内壁。

108. 发明申请

WO2008124264A2 DEVICE, APPARATUS AND METHODS FOR MASS SPECTROMETRY 审中-公开
标题翻译：装置，装置和方法用于质谱分析
公开(公告)号：WO2008124264A2
公开(公告)日：2008-10-16
申请号：PCT/US2008/057505
申请日：2008-03-19
申请人： WATERS INVESTMENTS LIMITED , TOMANY, Michael, J. , JARRELL, Joseph, A. , KOZIOL, Stanislaw , LEVEILLE, Wade, P.
发明人： TOMANY, Michael, J. , JARRELL, Joseph, A. , KOZIOL, Stanislaw , LEVEILLE, Wade, P.
IPC分类号： A61M11/04
CPC分类号： G01N30/724 , H01J49/0445 , Y10T29/49718 , Y10T137/85938
摘要： The invention comprises apparatus for use with atmospheric pressure ionization sources in which an aerosol is formed from a solution of a sample. The aerosol is received in a hollow member and discharged outside the chamber of the ionization source in order to reduce contamination of the ionization source itself by involatile material in the solution and by previously analysed samples. The hollow member is easily removable from the ionization source to facilitate cleaning and replacement. Ionization sources, mass spectrometers, and ion mobility spectrometers comprising the apparatus are also described.
摘要翻译：本发明包括与大气压电离源一起使用的装置，其中气溶胶由样品溶液形成。气溶胶被容纳在中空构件中并且排出到电离源的室外，以便通过溶液中的非挥发性材料和先前分析的样品来减少电离源本身的污染。中空构件容易从电离源移除，以便于清洁和更换。还描述了包括该装置的电离源，质谱仪和离子迁移谱仪。

109. 发明申请

WO2008121453A3 DEVICE, APPARATUS AND METHOD FOR PERFORMING SEPARATIONS 审中-公开
公开(公告)号：WO2008121453A3
公开(公告)日：2008-10-09
申请号：PCT/US2008/054237
申请日：2008-02-19
申请人： WATERS INVESTMENTS LIMITED , BELANGER, Jonathan , WATT, Micah, Inglis , SHINER, Stephen, J. , FISK, Raymond, P.
发明人： BELANGER, Jonathan , WATT, Micah, Inglis , SHINER, Stephen, J. , FISK, Raymond, P.
IPC分类号： B01D15/08
摘要： Embodiment of the present invention feature a device having a body, a separation media and a frit element. The exterior surface of the body has a first attachment means positioned radially about at least one of the media chamber and the frit section to form a compact assembly.

110. 发明申请

WO2008103423A1 POROUS INORGANIC/ORGANIC HYBRID PARTICLES HAVING HIGH ORGANIC CONTENT AND ENHANCED PORE GEOMETRY FOR CHROMATOGRAPHIC SEPARATIONS 审中-公开
标题翻译：具有高有机含量的多孔无机/有机杂化颗粒和用于色谱分离的增强孔几何
公开(公告)号：WO2008103423A1
公开(公告)日：2008-08-28
申请号：PCT/US2008/002312
申请日：2008-02-21
申请人： WATERS INVESTMENTS LIMITED , WYNDHAM, Kevin, D. , O'GARA, John, E. , LAWRENCE, Nicole, L.
发明人： WYNDHAM, Kevin, D. , O'GARA, John, E. , LAWRENCE, Nicole, L.
IPC分类号： B32B5/16
CPC分类号： B01J20/283 , B01J20/103 , B01J20/28004 , B01J20/28019 , B01J20/28042 , B01J20/28057 , B01J20/28069 , B01J20/28078 , B01J20/284 , B01J20/3064 , B01J20/3085 , B01J20/3092 , B01J20/3206 , B01J20/3219 , B01J20/3225 , B01J20/3259 , B01J20/3268 , B01J2220/82 , Y10T428/2982
摘要： Novel particles and materials for chromatographic separations, processes for preparation and separations devices containing the chromatographic particles and materials are provided by the instant invention. In particular, the invention provides a porous inorganic/organic hybrid particle, wherein the inorganic portion of the hybrid particle is present in an amount ranging from about 0 molar % to not more than about 49 molar %, wherein the pores of the particle are substantially disordered. The invention also provides a porous inorganic/organic hybrid particle, wherein the inorganic portion of the hybrid particle is present in an amount ranging from about 25 molar % to not more than about 50 molar %, wherein the pores of the particle are substantially disordered and wherein the particle has a chromatographically enhancing pore geometry (CEPG). Methods for producing the hybrid particles, separations devices comprising the hybrid particles and kits are also provided.
摘要翻译：用于色谱分离的新型颗粒和材料，含有色谱颗粒和材料的制备方法和分离装置由本发明提供。特别地，本发明提供一种多孔无机/有机杂化颗粒，其中杂化颗粒的无机部分以约0摩尔％至不大于约49摩尔％的量存在，其中颗粒的孔基本上无序。本发明还提供一种多孔无机/有机杂化颗粒，其中杂化颗粒的无机部分以约25摩尔％至不大于约50摩尔％的量存在，其中颗粒的孔基本无序，其中所述颗粒具有色谱增强孔几何形状（CEPG）。还提供了制备混合颗粒的方法，包括混合颗粒和试剂盒的分离装置。

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