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101. 发明申请

WO2005079208A9 UNCOOLED CANTILEVER MICROBOLOMETER FOCAL PLANE ARRAY WITH MK TEMPERATURE RESOLUTIONS AND METHOD OF MANUFACTURING MICROCANTILEVER 审中-公开
标题翻译：具有MK温度分辨率的不可控CANILEVER MICROBOLOMETER FOCAL PLANE ARRAY阵列和制造微处理器的方法
公开(公告)号：WO2005079208A9
公开(公告)日：2005-10-06
申请号：PCT/US2004039339
申请日：2004-11-22
申请人： UNIV BOSTON , FRAUNHOFER USA INC , LI BIAO , ZHANG XIN , BIFANO THOMAS , SHARON ANDRE
发明人： LI BIAO , ZHANG XIN , BIFANO THOMAS , SHARON ANDRE
IPC分类号： G01J5/40 , G01N15/06 , H01L27/146
CPC分类号： G01J5/40 , H01L27/14649 , H01L27/14683
摘要： A microbolometer sensor has a first cantilever supported above a substrate and formed of a bimaterial so as to deform in a first direction in response to incident radiation, and a second cantilever supported above the substrate and formed of a bimaterial so oriented as to cause the second cantilever to deflect oppositely to the first cantilever in response to radiation. The first and second cantilevers have a spacing therebetween that varies as a function of radiation incident on said first and second cantilevers. Means for sensing the deflection of the first and second cantilevers to provide an indication of the incident radiation is provided. A process of forming a micromechanical cantilever structure is also providing by irradiating a cantilever with an ion beam, whereby the cantilever is flattened. Also, the cantilever can be annealed in a rapid thermal annealing process to flatten the cantilever.
摘要翻译：微辐射热计传感器具有支撑在基板上并由双材料形成的第一悬臂，以响应于入射辐射在第一方向上变形;以及第二悬臂，其支撑在基板上方并由双重材料形成，以便导致第二悬臂悬臂以响应于辐射而相反地偏转到第一悬臂。第一和第二悬臂在它们之间具有随入射在所述第一和第二悬臂上的辐射的函数而变化的间隔。提供了用于感测第一和第二悬臂的偏转以提供入射辐射的指示的装置。通过用离子束照射悬臂也提供了形成微机械悬臂结构的工艺，由此使悬臂平坦化。此外，悬臂可以在快速热退火工艺中退火以使悬臂平坦化。

102. 发明申请

WO2005069997A2 ENHANCED DETECTION OF ACOUSTO-PHOTONIC EMISSIONS IN OPTICALLY TURBID MEDIA USING A PHOTO-REFRACTIVE CRYSTAL-BASED DETECTION SYSTEM 审中-公开
标题翻译：使用基于光电晶体的检测系统增强光学涡轮介质中的光电子发射的检测
公开(公告)号：WO2005069997A2
公开(公告)日：2005-08-04
申请号：PCT/US2005002226
申请日：2005-01-20
申请人： UNIV NORTHEASTERN , UNIV BOSTON , DIMARZIO CHARLES A , ROY RONALD A , MURRAY TODD W , BLONIGEN FLORIAN J , NIEVA LUIS A , SUI LEI , MAGULURI GOPI
发明人： DIMARZIO CHARLES A , ROY RONALD A , MURRAY TODD W , BLONIGEN FLORIAN J , NIEVA LUIS A , SUI LEI , MAGULURI GOPI
IPC分类号： G01N21/47 , G01N29/24 , G01N29/34
CPC分类号： G01N21/4795 , G01N29/0672 , G01N29/2418 , G01N29/346 , G01N2291/02466 , G01N2291/02872 , G01N2291/0427
摘要： A system and method of detecting acousto-photonic emissions in optically turbid media that provide increased levels of detection sensitivity. The detection system includes an ultrasonic transducer, a laser, a photo-detector for detecting ultrasound-modulated laser light, and circuitry for processing the detected signals for subsequent analysis. The ultrasonic transducer generates an ultrasonic wave that propagates within an optically turbid medium. The laser generates a coherent light beam, which is split to form signal and reference beams. The signal beam is sent through the turbid medium, where it is phase modulated by the ultrasound. The ultrasound-modulated signal beam is provided to a photo-refractive crystal for subsequent interference with the reference beam to convert the phase modulation to intensity modulation. The DC offset of the signal beam intensity provides a measure of the magnitude of the mean phase shift induced by the ultrasound on the multiply scattered optical field within the turbid medium.
摘要翻译：一种在光学混浊介质中检测声光发射的系统和方法，其提供更高水平的检测灵敏度。检测系统包括超声波换能器，激光器，用于检测超声调制激光的光检测器，以及用于处理检测信号以用于后续分析的电路。超声波换能器产生在光学混浊介质内传播的超声波。激光产生相干光束，其被分离以形成信号和参考光束。信号光束通过混浊介质传送，在那里它被超声波相位调制。超声调制信号光束被提供给光折射晶体，用于随后与参考光束的干涉，以将相位调制转换成强度调制。信号光束强度的直流偏移提供了在混浊介质内的多重散射光场上由超声引起的平均相移幅度的量度。

103. 发明申请

WO2004046321A3 CIS/TRANS RIBOREGULATORS 审中-公开
标题翻译： CIS / TRANS RIBOREGULATORS
公开(公告)号：WO2004046321A3
公开(公告)日：2005-02-03
申请号：PCT/US0336506
申请日：2003-11-14
申请人： UNIV BOSTON , COLLINS JAMES J , ISAACS FARREN J , DWYER DANIEL J , CANTOR CHARLES R
发明人： COLLINS JAMES J , ISAACS FARREN J , DWYER DANIEL J , CANTOR CHARLES R
IPC分类号： C12N15/11 , C12N15/67 , C12Q1/68 , C07H21/04 , A01K67/00
CPC分类号： C12N15/67 , C12N15/11 , C12N2310/53 , C12Q1/6897
摘要： The present invention provides nucleic acid molecules, DNA constructs, plasmids, and methods for post-transcriptional regulation of gene expression using RNA molecules to both repress and activate translation of an open reading frame. Repression of gene expression is achieved through the presence of a regulatory nucleic acid element (the cis-repressive RNA or crRNA) within the 5' untranslated region (5' UTR) of an mRNA molecule. The nucleic acid element forms a hairpin (stem/loop) structure through complementary base pairing. The hairpin blocks access to the mRNA transcript by the ribosome, thereby preventing translation. In particular, in embodiments of the invention designed to operate in prokaryotic cells, the stem of the hairpin secondary structure sequesters the ribosome binding site (RBS). In embodiments of the invention designed to operate in eukaryotic cells, the stem of the hairpin is positioned upstream of the start codon, anywhere within the 5' UTR of an mRNA. A small RNA (trans-activating RNA, or taRNA), expressed in trans, interacts with the crRNA and alters the hairpin structure. This alteration allows the ribosome to gain access to the region of the transcript upstream of the start codon, thereby activating transcription from its previously repressed state.
摘要翻译：本发明提供核酸分子，DNA构建体，质粒和用于转录后调节基因表达的方法，其使用RNA分子抑制和激活开放阅读框的翻译。通过在mRNA分子的5'非翻译区（5'UTR）内存在调节性核酸元件（顺式抑制性RNA或crRNA）来实现基因表达的抑制。核酸元件通过互补碱基配对形成发夹（茎/环）结构。发夹阻止核糖体进入mRNA转录物，从而阻止翻译。特别地，在设计用于在原核细胞中操作的本发明的实施方案中，发夹二级结构的茎螯合核糖体结合位点（RBS）。在设计用于在真核细胞中操作的本发明的实施方案中，发夹的茎位于起始密码子的上游，位于mRNA的5'UTR内的任何位置。以反式表达的小RNA（反式激活RNA或taRNA）与crRNA相互作用并改变发夹结构。这种改变允许核糖体进入起始密码子上游的转录物区域，从而从其先前的抑制状态激活转录。

104. 发明申请

WO2004089926A8 GENIPIN DERIVATIVES AND USES THEREOF 审中-公开
标题翻译： GENIPIN衍生物及其用途
公开(公告)号：WO2004089926A8
公开(公告)日：2005-01-20
申请号：PCT/US2004009957
申请日：2004-03-31
申请人： BETH ISRAEL HOSPITAL , UNIV BOSTON , ZHANG CHEN-YU , LOWELL BRADFORD B , PORCO JOHN A JR , SHEN RUICHAO , LIN CHENG TING , KRAUSS STEFAN
发明人： ZHANG CHEN-YU , LOWELL BRADFORD B , PORCO JOHN A JR , SHEN RUICHAO , LIN CHENG TING , KRAUSS STEFAN
IPC分类号： A61K31/352 , C07D211/90 , C07D221/04 , C07D309/32 , C07D311/94 , C07D491/04 , C07D493/04 , C07D493/06
CPC分类号： C07D221/04 , A61K31/352 , A61K31/353 , A61K31/365 , A61K31/4741 , A61K31/7048 , C07D211/90 , C07D309/32 , C07D311/94 , C07D491/04 , C07D493/04 , C07D493/06
摘要： Genipin derivatives and pharmaceutical compositions thereof that inhibit the activity of uncoupling protein-2 (UCP2) and are useful in treating deficient first-phase insulin secretion, non-insulin dependent diabetes mellitus, and ischemia in a mammal are disclosed.
摘要翻译：公开了抑制解偶联蛋白-2（UCP2）活性并且可用于治疗哺乳动物的缺陷性第一相胰岛素分泌，非胰岛素依赖性糖尿病和局部缺血的京尼平衍生物及其药物组合物。

105. 发明申请

WO2004083820A9 RESONANT CAVITY BIOSENSOR 审中-公开
标题翻译：谐振腔生物传感器
公开(公告)号：WO2004083820A9
公开(公告)日：2004-11-11
申请号：PCT/US2004008558
申请日：2004-03-19
申请人： UNIV BOSTON , UNLU SELIM M , BERGSTEIN DAVID A , RUANE MICHAEL F , GOLDBERG BENNETT B
发明人： UNLU SELIM M , BERGSTEIN DAVID A , RUANE MICHAEL F , GOLDBERG BENNETT B
IPC分类号： G01N20060101 , G01N21/64 , G01N
CPC分类号： G01N21/7746 , B01L3/5027 , G01N21/0303 , G01N21/253
摘要： An assay system having a channel (16) bounded by first and second reflective surfaces (14, 15) adapted to accommodate a fluid material therebetween and defining a plurality of regions in an array between those surfaces.
摘要翻译：测定系统具有由第一和第二反射表面（14,15）限定的通道（16），其适于在其间容纳流体材料并且在这些表面之间限定阵列中的多个区域。

106. 发明申请

WO03087411A8 METHOD TO INHIBIT CELL GROWTH USING OLIGONUCLEOTIDES 审中-公开
标题翻译：使用寡核苷酸抑制细胞生长的方法
公开(公告)号：WO03087411A8
公开(公告)日：2004-11-11
申请号：PCT/US0311393
申请日：2003-04-11
申请人： UNIV BOSTON , GILCHRIST BARBARA A , ELLER MARK S , YAAR MINA
发明人： ELLER MARK S , YAAR MINA
IPC分类号： C12N15/09 , A61K9/12 , A61K31/7088 , A61K38/00 , A61K41/00 , A61K47/10 , A61K48/00 , A61P1/18 , A61P7/00 , A61P15/00 , A61P17/00 , A61P19/00 , A61P21/00 , A61P35/00 , A61P35/02 , C12Q1/68 , A01N43/04 , A61K31/07 , C07H21/04
CPC分类号： A61K31/711 , A61K31/7088 , A61K31/7125 , A61K31/713
摘要： Described are methods for treating hyperproliferative disorders, including cancers, by administering to the affected mammal (e.g.,human) an effective amount of a composition comprising pTT or a composition comprising one or more oligonucleotides which share at least 50% nucleotide sequence identity with the human telomere overhang repeat. Methods of treatment or prevention of hyperproliferative diseases or pre-cancerous conditions affecting epithelial cells, such as psoriasis, atopic dermatitis, or hyperproliferative diseases of other epithelia and methods for reducing photoaging, or oxidative stress or for prophylaxis against or reduction in the likelihood of the development of skin cancer, are also disclosed.
摘要翻译：描述了通过向受影响的哺乳动物（例如，人）施用有效量的包含pTT的组合物或包含与人类共享至少50％核苷酸序列同一性的一种或多种寡核苷酸的组合物来治疗过度增殖性疾病（包括癌症）的方法端粒突出重复。治疗或预防影响上皮细胞的过度增殖性疾病或癌前病症的方法，例如牛皮癣，特应性皮炎或其他上皮细胞的过度增殖性疾病，以及降低光老化或氧化应激或预防或降低其发生可能性的方法皮肤癌的发展也被公开。

107. 发明申请

WO0236128A9 NEUROACTIVE STEROID DERIVATIVES AND METHODS OF USE 审中-公开
标题翻译：神经甾体衍生物及其使用方法
公开(公告)号：WO0236128A9
公开(公告)日：2003-11-13
申请号：PCT/US0143975
申请日：2001-11-06
申请人： UNIV BOSTON , FARB DAVID H , SADRI-VAKILI GHAZALEH , PIERCE ROBERT CHRISTOPHER , JOHNSON DAVID W , GIBBS TERRELL T
发明人： FARB DAVID H , SADRI-VAKILI GHAZALEH , PIERCE ROBERT CHRISTOPHER , JOHNSON DAVID W , GIBBS TERRELL T
IPC分类号： A61K31/57 , A61K31/573 , A61K31/56
CPC分类号： A61K31/57
摘要： The invention relates to neuroactive steroid compounds that are useful in modulating CNS effects, diseases or disease symptoms. The invention also relates to use of the compounds in methods of treating or preventing disease or disease symptoms, and methods of modulating or mediating CNS effects or processes.
摘要翻译：本发明涉及可用于调节CNS作用，疾病或疾病症状的神经活性类固醇化合物。本发明还涉及该化合物在治疗或预防疾病或疾病症状的方法中的应用，以及调节或介导CNS作用或过程的方法。

108. 发明申请

WO0209726A9 METHODS OF TREATING CONDITIONS ASSOCIATED WITH INSULIN RESISTANCE WITH AICAR, (5-AMINO-4-IMIDAZOLE CARBOXAMIDE RIBOSIDE) AND RELATED COMPOUNDS 审中-公开
标题翻译：治疗与胰岛素抗药性相关的病症的方法（5-氨基-4-咪唑烷酰胺酰胺）及相关化合物
公开(公告)号：WO0209726A9
公开(公告)日：2003-09-12
申请号：PCT/US0124194
申请日：2001-07-31
申请人： UNIV BOSTON , GARVAN INST , RUDERMAN NEIL , KRAEGEN EDWARD W , IDO YASUO
发明人： RUDERMAN NEIL , KRAEGEN EDWARD W , IDO YASUO
IPC分类号： A61K31/00 , A61K31/7056 , C12Q1/48 , A61K31/70
CPC分类号： C12Q1/485 , A61K31/00 , A61K31/7056
摘要： The long-term usage of AICAR (5-amino, 4-imidazole carboxamide riboside) to produce sustained metabolic and biological changes in mammals that overcome insulin resistance, i.e., increase insulin sensitivity, and result in benefits in diseases and conditions such as diabetes, hypertension, atherosclerosis, polycystic ovary syndrome and gallstones is described. Long-term usage of AICAR, particularly intermittent administration, e.g., three days per week, appears to have some of the positive offects of exercise, having an impact on the amount of food consumed by a subject and resulting in reduced fat build-up and increase in muscle mass. Therefore, AICAR administration has a positive impact in reducing obesity. AICAR can also prove useful in preventing or treating vascular diseases associated with hyperglycemia, high plasma levels of free fatty acids (FFA)and triglyceride, and insulin resistance by virtue of the fact that this agent activates fatty acid oxidation. Animal tests have shown that chronic intermittent treatment with AICAR has not resulted in any noticeable toxic effects. AICAR and related compounds are activators of AMP-activated protein kinase (AMPK) and, furthermore, are effective at decreasing malonyl CoA levels in the animal.
摘要翻译： AICAR（5-氨基，4-咪唑甲酰胺核苷）长期使用可以克服胰岛素抵抗的哺乳动物产生持续的代谢和生物学变化，即增加胰岛素敏感性，并导致疾病和病症如糖尿病，描述了高血压，动脉粥样硬化，多囊卵巢综合征和胆结石。 AICAR的长期使用，特别是间歇性给药，例如每周三天，似乎具有一些积极的运动成分，对受试者消耗的食物量产生影响，并导致脂肪堆积减少，肌肉量增加因此，AICAR管理对减少肥胖有积极的影响。 AICAR也可用于预防或治疗与高血糖，游离脂肪酸（FFA）和甘油三酸酯的高血浆水平以及胰岛素抵抗相关的血管疾病，这是因为该药物能够激活脂肪酸氧化。动物实验表明，AICAR慢性间歇性治疗并未产生明显的毒性作用。 AICAR和相关化合物是AMP活化蛋白激酶（AMPK）的活化剂，此外，在降低动物中丙二酰辅酶A水平方面是有效的。

109. 发明申请

WO03005836A3 MODIFIED-FAT NUTRITIONAL PRODUCTS USEFUL FOR PREVENTING OR TREATING OBESITY 审中-公开
标题翻译：用于预防或治疗肥胖症的改良脂肪营养产品
公开(公告)号：WO03005836A3
公开(公告)日：2003-09-04
申请号：PCT/US0221908
申请日：2002-07-10
申请人： UNIV BOSTON , CORKEY BARBARA E , GUO WEN , JIANRONG HAN
发明人： CORKEY BARBARA E , GUO WEN , JIANRONG HAN
IPC分类号： A23C15/14 , A23D9/00 , A23L1/30 , A61K47/00
CPC分类号： A23C15/14 , A23D9/00 , A23L33/115 , A23L33/12 , A23L33/40 , A23V2002/00 , A23V2250/1944 , A23V2250/1868 , A23V2250/1882 , A23V2200/332
摘要： The present invention provides dietary products for infant, child and adult nutrition which possess adequate levels and ratios of medium chain fatty acids and n-polyunsaturated fatty acids. Consumption of these dietary products can contribute to the prevention of obesity in developing individuals and can contribute to a reduction in body fat mass in individuals who are trying to loose weight or reduce body fat mass (e.g., obese individuals). A first preferred product is a dairy supplement or formulated dairy product for consumption by infants or children to prevent development of obesity. A second preferred product is a dietary suppplement for persons combating unwanted weight gain or obesity. Also featured are methods for formulating these dietary products (see Figure 12A).
摘要翻译：本发明提供具有足够水平和比例的中链脂肪酸和n-多不饱和脂肪酸的用于婴儿，儿童和成人营养的膳食产品。这些膳食产品的消费可以有助于预防发展中的个体的肥胖，并且可以有助于减轻体重或减少体重脂肪量（例如肥胖个体）的个体的身体脂肪量。第一优选产品是乳制品补充剂或配制的乳制品，用于婴儿或儿童消费以预防肥胖症的发展。第二个优选的产品是用于防止不想要的体重增加或肥胖的人的膳食补充剂。还特征在于制备这些膳食产品的方法（参见图12A）。

110. 发明申请

WO03005836A9 MODIFIED-FAT NUTRITIONAL PRODUCTS USEFUL FOR PREVENTING OR TREATING OBESITY 审中-公开
标题翻译：用于预防或治疗肥胖症的改良脂肪营养产品
公开(公告)号：WO03005836A9
公开(公告)日：2003-04-10
申请号：PCT/US0221908
申请日：2002-07-10
申请人： UNIV BOSTON , CORKEY BARBARA E , GUO WEN , JIANRONG HAN
发明人： CORKEY BARBARA E , GUO WEN , JIANRONG HAN
IPC分类号： A23C15/14 , A23D9/00 , A23L1/30 , A23L
CPC分类号： A23C15/14 , A23D9/00 , A23L33/115 , A23L33/12 , A23L33/40 , A23V2002/00 , A23V2250/1944 , A23V2250/1868 , A23V2250/1882 , A23V2200/332
摘要： The present invention provides dietary products for infant, child and adult nutrition which possess adequate levels and ratios of medium chain fatty acids and omega -polyunsaturated fatty acids. Consumption of these dietary products can contribute to the prevention of obesity in developing individuals and can contribute to a reduction in body fat mass in individuals who are trying to loose weight or reduce body fat mass (e.g., obese individuals). A first preferred product is a dairy supplement or formulated dairy product for consumption by infants or children to prevent development of obesity. A second preferred product is a dietary suppplement for persons combating unwanted weight gain or obesity. Also featured are methods of formulating these dietary products.
摘要翻译：本发明提供了具有足够水平和比例的中链脂肪酸和ω-多不饱和脂肪酸的用于婴儿，儿童和成人营养的膳食产品。这些膳食产品的消费可以有助于预防发展中的个体的肥胖，并且可以有助于减轻体重或减少体重脂肪量（例如肥胖个体）的个体的身体脂肪量。第一优选产品是乳制品补充剂或配制的乳制品，用于婴儿或儿童消费以预防肥胖症的发展。第二个优选的产品是用于防止不想要的体重增加或肥胖的人的膳食补充剂。还特征是配制这些膳食产品的方法。

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