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101. 发明申请

US20210407677A1 FATTY ACID AND KREBS CYCLE METABOLOMIC MEASURES FOR TREATMENT OF HEAD INJURY 有权
公开(公告)号：US20210407677A1
公开(公告)日：2021-12-30
申请号：US17352045
申请日：2021-06-18
申请人： Northwestern University , The Penn State Research Foundation
发明人： Hans C. BREITER , Semyon SLOBOUNOV , Nicole VIKE , Sumra BARI
IPC分类号： G16H50/20 , G16B25/10 , G16B20/20 , G16H50/70 , G16H10/60 , G16H10/40
摘要： Methods relating to treatment and diagnosis of head injury are provided herein.

102. 发明申请

US20210395149A1 THREE-DIMENSIONAL PRINTING OF CEMENTITIOUS COMPOSITIONS 有权
公开(公告)号：US20210395149A1
公开(公告)日：2021-12-23
申请号：US17353628
申请日：2021-06-21
申请人： THE PENN STATE RESEARCH FOUNDATION
发明人： Ali M. Memari , Maryam Hojati , Jose Manuel Pinto Duarte , Shadi Nazarian , Aleksandra Radlinska , Sven Bilen , Nicholas Meisel
IPC分类号： C04B28/04 , C04B14/10 , C04B18/14 , C04B22/12 , C04B14/14 , B33Y70/00
摘要： Embodiments of the disclosure provide a printable cementitious composition comprising a cement binder, an aggregate, at least one pozzolanic additive, an accelerator, water, and nanoclay.

103. 发明申请

US20210383924A1 METHODS AND MACHINE LEARNING FOR DISEASE DIAGNOSIS 有权
公开(公告)号：US20210383924A1
公开(公告)日：2021-12-09
申请号：US17288399
申请日：2019-10-25
申请人： QUADRANT BIOSCIENCES INC. , THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK , THE PENN STATE RESEARCH FOUNDATION
发明人： Alexander RAJAN , Steven D. HICKS , Frank A. MIDDLETON
IPC分类号： G16H50/20 , G16H10/60 , G16H10/40 , G16H10/20 , G16B40/00
摘要： A machine learning classifier that diagnoses autism spectrum disorder (ASD) is described that transforms data obtained from a patient medical history and a patients saliva into data that correspond to a test panel of features, the data for the features including human microtranscriptome and microbial transcriptome data, wherein the transcriptome data are associated with respective RNA categories for ASD. The classifier classifies the transformed data by applying the data to the classifier that has been trained to detect ASD using training data associated with the features of the test panel. The trained classifier includes vectors that define a classification boundary and predicts a probability of ASD based on results of the classifying.

104. 发明申请

US20210382371A1 Molding Free-Space Light with Guided-Wave-Driven Metasurfaces 有权
公开(公告)号：US20210382371A1
公开(公告)日：2021-12-09
申请号：US17303741
申请日：2021-06-07
申请人： The Penn State Research Foundation
发明人： Xingjie Ni , Xuexue Guo , Yimin Ding , Yao Duan , Xi Chen
IPC分类号： G02F1/295
摘要： Embodiments relate to a photonic component having a metasurface. The metasurface includes a substrate with a thin-layer of meta-atoms disposed thereon. The photonic component includes a waveguide having a top surface, wherein the metasurface is disposed on at least a portion of the top surface such that the meta-atoms form an array on the top surface. The photonic component includes a sandwich nano-bar antenna formed in or on the metasurface.

105. 发明申请

US20210372948A1 VERSATILE DISPLAY SCAFFOLDS FOR PROTEINS 有权
公开(公告)号：US20210372948A1
公开(公告)日：2021-12-02
申请号：US17399492
申请日：2021-08-11
申请人： THE PENN STATE RESEARCH FOUNDATION
发明人： Scott Eugene Lindner , Susan Hafenstein
IPC分类号： G01N23/04 , C07K1/00 , C07K14/47
摘要： Provided are processes and materials for solving biological or structural information about proteins or other organic molecules. The processes capitalize on a rigid multimeric nanocage formed from self-assembling substructure proteins. The processes and materials allow for recognition and tight, optionally covalent, bonding of any protein molecule with a tag complementary to a capture sequence on the nanocage. The processes and materials may be used to obtain biological or structural information by cryo-electron microscopy and overcome prior limitations of target protein size or salt concentration.

106. 发明授权

US11173227B2 Wound dressings and applications thereof 有权
公开(公告)号：US11173227B2
公开(公告)日：2021-11-16
申请号：US14891862
申请日：2014-05-21
申请人： THE PENN STATE RESEARCH FOUNDATION , BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
发明人： Jian Yang , Kytai T. Nguyen , Zhiwei Xie
IPC分类号： A61L15/22 , A61L15/44 , A61L15/28 , A61L15/42 , A61L15/26 , A61L15/64 , A61L31/14 , A61L31/04 , A61L31/16 , A61L31/06 , A61L31/12 , C08L67/04
摘要： In one aspect, compositions and wound dressings are described herein. In some embodiments, a composition or wound dressing described herein comprises a mesh formed from a plurality of biodegradable polymer fibers; a first active agent dispersed in the biodegradable polymer fibers; a plurality of biodegradable polymer particles disposed in the mesh; and a second active agent dispersed in the biodegradable polymer particles. The particles can be disposed within the interiors of the fibers of the mesh or between the fibers of the mesh. In another aspect, a composition or wound dressing described herein comprises a first perforated mesh formed from a first plurality of biodegradable polymer fibers; and a second perforated mesh formed from a second plurality of biodegradable polymer fibers, wherein the second perforated mesh is disposed on the first perforated mesh in a stacked configuration and the first and second perforated meshes have different degrees of perforation.

107. 发明申请

US20210347804A1 COMPOUNDS, COMPOSITIONS AND METHOD FOR COLORING EDIBLE MATERIALS 有权
公开(公告)号：US20210347804A1
公开(公告)日：2021-11-11
申请号：US17301711
申请日：2021-04-12
申请人： The Penn State Research Foundation
发明人： Gregory Ray Ziegler , Joshua David Lambert , Rachel Marie Shegog , Emmanouil Chatzakis , Deepti Dabas
IPC分类号： C07H15/26 , A23L5/47 , A23L5/42 , C09B61/00
摘要： The present invention provides compounds isolated from avocado seeds for use as a natural colorant in edible materials. The compounds of the invention are useful for coloring edible materials red, orange or yellow. The invention also provides compositions and methods for coloring edible materials to a desired color such as red, orange or yellow.

108. 发明申请

US20210324337A1 GENERATION OF PANCREATIC PROGENITOR CELLS AND BETA CELLS FROM HUMAN PLURIPOTENT STEM CELLS 有权
公开(公告)号：US20210324337A1
公开(公告)日：2021-10-21
申请号：US17269233
申请日：2019-08-22
申请人： The Penn State Research Foundation
发明人： Xiaojun LIAN , Chuanxin CHEN
IPC分类号： C12N5/071 , A61K35/39
摘要： Provided are methods, compositions and kits for generating beta cells from pluripotent stem cells under growth-factor free, defined culture conditions. The beta cells can be generated under conditions that are free of animal products. The generated beta cells secrete insulin, not glucagon, and the amount of insulin secreted is dependent upon the level of glucose stimulus.

109. 发明申请

US20210322984A1 DEVICES, SYSTEMS, AND METHODS FOR SINGLE CELL BACTERIA ANALYSIS 有权
公开(公告)号：US20210322984A1
公开(公告)日：2021-10-21
申请号：US17259136
申请日：2019-07-11
申请人： The Penn State Research Foundation
发明人： Pak Kin WONG , Hui LI
IPC分类号： B01L3/00 , C12Q1/04 , C12Q1/18 , C12Q1/689
摘要： Provided are devices and methods for detecting the presence, absence, and/or characteristics of bacteria. A microfluidic device for characterizing bacteria is provided. The device contains one or more bacteria trapping channels, and one or more pneumatic channels in contact with the bacteria trapping channels, wherein the one or more pneumatic channels are configured to reduce the height of the one or more bacteria trapping channels to thereby trap bacteria in the one or more bacteria trapping channels if said bacteria are present in a liquid biological sample that is introduced into the microfluidic device. Also provides is a method for identifying bacteria that may be used with the microfluidic device. The method includes contacting a sample that contains bacteria with a carbon nanotube and microwave energy such that a probe is introduced into the bacteria. The probe is a double strand polynucleotide probe having a first strand that includes a detectable label, and a second strand having a quencher moiety that quenches a signal from the detectable label when the probe is double stranded. The method includes allowing hybridization between the labeled strand with a polynucleotide in the bacteria if bacteria are present, and if bacteria are present, detecting a signal from the labeled strand that is hybridized to a polynucleotide in the bacteria to thereby identify the presence of, and/or the type of bacteria in the sample, and if the bacteria are not present, determining a lack of a signal from the labeled strand.

110. 发明授权

US11141419B1 Use of iminosugars as prophylactic and therapy against COVID-19 / SARS-CoV-2 有权
公开(公告)号：US11141419B1
公开(公告)日：2021-10-12
申请号：US17241894
申请日：2021-04-27
申请人： The Penn State Research Foundation
发明人： Suresh Kuchipudi
IPC分类号： A61K31/702 , A61K31/445 , A61P31/14 , A61K31/706 , A61K31/437
摘要： Provided are methods for prophylaxis or treatment of SARS-CoV-2 by administering a composition comprising one or more iminosugars to an individual in need thereof. The compositions may be administered to an individual who is at risk of becoming infected by SARS-CoV-2, or has been diagnosed with a SARS-CoV-2 infection. The iminosugars can inhibit SARS-CoV-2 cell entry and replication. The iminosugars potentiate co-administered antiviral agents, such as nucleoside analogs.

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