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101. 发明申请

US20080214442A1 Anti-Viral Effect of an Extract of Ganoderma Lucidum 审中-公开
标题翻译：灵芝提取物的抗病毒作用
公开(公告)号：US20080214442A1
公开(公告)日：2008-09-04
申请号：US11859729
申请日：2007-09-21
申请人： Alice Yu , Chi-Huey Wong , Jia Tsrong Jan , Y.-S. Edmond Cheng
发明人： Alice Yu , Chi-Huey Wong , Jia Tsrong Jan , Y.-S. Edmond Cheng
IPC分类号： A61K38/16 , C07K14/00 , A61P31/12
CPC分类号： C07K2/00 , A61K36/074 , A61K38/00
摘要： Compositions and methods for the treatment viral infections in organisms, particularly flu virus. The methods and compositions of the disclosure involve the administration to mammals and immune cells of a fucose-containing glycoprotein fraction from Reishi. An extract of G. lucidum induces immune responses that are shown to induce increase survivability in mice injected with lethal does of influenza virus. The effect is increased when the G. lucidum extract is dosed prior to injection of the lethal dose of influenza virus.
摘要翻译：用于治疗生物体中的病毒感染的组合物和方法，特别是流感病毒。本公开的方法和组合物涉及向来自Reishi的含岩藻糖的糖蛋白部分的哺乳动物和免疫细胞施用。灵芝的提取物诱导免疫应答，显示其在注射致死性流感病毒的小鼠中诱导增加的存活能力。当在注射致死剂量的流感病毒之前配制灵芝提取物时，效果增加。

102. 发明申请

US20080064059A1 In Vivo Site-Specific Incorporation of N-Acetyl-Galactosamine Amino Acids in Eubacteria 审中-公开
标题翻译：体内位点特异性引入N-乙酰基半乳糖胺氨基酸在细菌中
公开(公告)号：US20080064059A1
公开(公告)日：2008-03-13
申请号：US11664898
申请日：2005-10-20
申请人： Peter Schultz , Sarah Hanson , Ran Xu , Zhiwen Zhang , Chi-Huey Wong
发明人： Peter Schultz , Sarah Hanson , Ran Xu , Zhiwen Zhang , Chi-Huey Wong
IPC分类号： C12N9/22 , C12N1/00 , C12N1/21 , C12P21/02 , C12N15/52 , C12N15/70
CPC分类号： C12P21/005 , C12N9/93 , C12N15/67
摘要： Methods and compositions for making glycoproteins, both in vitro and in vivo, are provided. One method involves incorporating an unnatural amino acid having a N-acetylgalactosamine moiety into a protein; optionally, the N-acetylgalactosamine-containing unnatural amino acid can be further modified with additional sugars.
摘要翻译：提供了体外和体内制备糖蛋白的方法和组合物。一种方法包括将具有N-乙酰半乳糖胺部分的非天然氨基酸掺入蛋白质中; 任选地，含N-乙酰半乳糖胺的非天然氨基酸可以进一步用另外的糖进行改性。

103. 发明授权

US07323176B2 Immuno-modulating antitumor activities of ganoderma lucidum (reishi) polysaccharides 有权
标题翻译：灵芝多糖的免疫调节抗肿瘤活性
公开(公告)号：US07323176B2
公开(公告)日：2008-01-29
申请号：US11553402
申请日：2006-10-26
申请人： Yuan-Yuan Wang , Kay-Hooi Khoo , Shui-Tein Chen , Chun-Cheng Lin , Chi-Huey Wong , Chun-Hung Lin , Hong-Sen Chen , Yow-Fu Tsai
发明人： Yuan-Yuan Wang , Kay-Hooi Khoo , Shui-Tein Chen , Chun-Cheng Lin , Chi-Huey Wong , Chun-Hung Lin , Hong-Sen Chen , Yow-Fu Tsai
IPC分类号： A01N65/00 , A61K9/00 , A61K47/00 , A23K1/17
CPC分类号： A61K36/074 , A23L33/105
摘要： The present invention provides medicinally active extracts and fractions, and a method for preparing the same by extracting and fractioning constituents from the tissue of components of Ganoderma lucidum. These active extracts and fractions are useful for inhibiting tumor growth, modulating immune response, and increasing hematopoietic activity.
摘要翻译：本发明提供药物活性提取物和级分，以及通过从灵芝组分的组织提取和分馏成分的方法制备该提取物和级分。这些活性提取物和级分可用于抑制肿瘤生长，调节免疫应答和增加造血活性。

104. 发明申请

US20070213297A1 Arrays with cleavable linkers 审中-公开
公开(公告)号：US20070213297A1
公开(公告)日：2007-09-13
申请号：US11645188
申请日：2006-12-22
申请人： Chi-Huey Wong
发明人： Chi-Huey Wong
IPC分类号： A61K31/716 , C40B40/12
CPC分类号： G01N33/54353 , A61K31/716 , C07H3/06 , G01N33/56972 , G01N33/56988 , G01N33/57415 , G01N2400/02 , G01N2400/14
摘要： The invention provides arrays of molecules where the molecules (e.g., glycans) are attached to the arrays by cleavable linkers. The invention also provides methods for using these arrays, methods for identifying the structural elements of molecules bound to these arrays by using the cleavable linkers, especially the structural elements that are important for binding to test samples. The invention further provides methods for evaluating whether test samples and test molecules can bind to distinct glycans on the arrays and useful glycans identified using the methods and arrays provided herein.

105. 发明申请

US20070015260A1 Synthesis of synthons for the manufacture of bioactive compounds 审中-公开
标题翻译：用于生产生物活性化合物的合成子的合成
公开(公告)号：US20070015260A1
公开(公告)日：2007-01-18
申请号：US11481653
申请日：2006-07-05
申请人： Chi-Huey Wong , Junjie Liu , Grace DeSantis , Mark Burk
发明人： Chi-Huey Wong , Junjie Liu , Grace DeSantis , Mark Burk
IPC分类号： C08B37/00 , C12P19/02 , C12N9/24
CPC分类号： C12P19/02 , C12N9/88 , C12P17/06 , C12R1/19
摘要： The present invention is based on the discovery that 2-deoxyribose-5-phosphate aldolase (DERA, EC 4.1.2.4) and variants thereof can be used to catalyze sequential asymmetric aldol reactions between a wide variety of donor and acceptor aldehydes. The reaction products typically contain at least two new stereogenic centers and can be produced in enantiomerically pure form. As such, DERA catalyzed asymmetric aldol chemistry can be exploited to produce synthons for the synthesis of a variety of bioactive molecules.
摘要翻译：本发明基于以下发现：2-脱氧核糖-5-磷酸醛缩酶（DERA，EC 4.1.2.4）及其变体可用于催化多种供体和受体醛之间的顺序不对称醛醇反应。反应产物通常含有至少两个新的立体中心并且可以以对映体纯的形式制备。因此，DERA催化的不对称醛醇化学可以被利用来产生用于合成各种生物活性分子的合成物。

106. 发明授权

US07018824B2 Mannosyl transfer with regeneration of GDP-mannose 失效
公开(公告)号：US07018824B2
公开(公告)日：2006-03-28
申请号：US11145810
申请日：2005-06-06
申请人： Chi-Huey Wong
发明人： Chi-Huey Wong
IPC分类号： C12N9/10 , C12N15/54 , C12N15/70
CPC分类号： C12N9/1051 , C12P19/18 , C12P19/32 , C12P21/005
摘要： A one-pot glycosylation reaction is disclosed in which a mannosyl (Man) group is enzymatically transferred to an acceptor molecule. The starting glycoside is a mannosyl 1-phosphate that is enzymatically converted to its GDP derivative via UTP and a pyrophorylase. The formed GDP derivative is used in the enzyme-catalyzed glycosyl transfer. That enzyme-catalyzed glycosyl transfer to an acceptor releases GDP that is enzymatically converted to GTP for further conversion of mannosyl 1-phosphate into its GDP derivative. Also disclosed are a recombinant α1,2-mannosyltransferase that is enzymatically active, is dispersible in an aqueous reaction medium, and free of the transmembrane portion of the native enzyme, as well as DNA encoding that transferase, an expression vector containing exogenous DNA that encodes that enzyme and E. coli cells containing that vector.

107. 发明授权

US06900238B1 HIV protease inhibitors 失效
标题翻译： HIV蛋白酶抑制剂
公开(公告)号：US06900238B1
公开(公告)日：2005-05-31
申请号：US09077712
申请日：1996-12-09
申请人： Chi-Huey Wong , Deborah H. Slee , Karen Laslo
发明人： Chi-Huey Wong , Deborah H. Slee , Karen Laslo
IPC分类号： G01N33/15 , A61K31/00 , A61K31/40 , A61K45/00 , A61P31/00 , A61P31/18 , C07B61/00 , C07D207/08 , C07D207/16 , C12N9/99 , C12Q1/02 , C12Q1/37 , A01N43/36 , C07D207/00 , C07F9/02
CPC分类号： C12Q1/37 , C07D207/08 , C07D207/12 , C07D207/16 , C07D211/60 , C12Q1/18 , C40B40/04 , G01N2333/16
摘要： Combinatorial libraries of HIV and FIV protease inhibitors are characterized by α-keto amide or hydroxyethylamine core structures flanked by on one side by substituted pyrrolidines, piperidines, or azasugars and on the other side by phenylalanine, tyrosine, or substituted tyrosines. The libraries are synthesized via a one step coupling reaction. Highly efficacious drug candidates are identified by screening the libraries for binding and inhibitory activity against both HIV and FIV protease. Drug candidates displaying clinically useful activity against both HIV and FIV protease are identified as being potentially resistive against a loss of inhibitory activity due to development of resistant strains of HIV.
摘要翻译：艾滋病病毒和FIV蛋白酶抑制剂的组合文库的特征在于α-酮酰胺或羟乙胺核心结构，其侧面为取代的吡咯烷酮，哌啶或氮杂环庚烷，另一侧为苯丙氨酸，酪氨酸或取代的酪氨酸。文库通过一步偶联反应合成。通过筛选文库对HIV和FIV蛋白酶的结合和抑制活性来鉴定高效药物候选物。鉴于HIV和FIV蛋白酶对临床有用的活性的候选药物被鉴定为可能阻止由于HIV的抗性株的发展而导致的抑制活性丧失。

108. 发明授权

US06774140B1 Iminocyclitol inhibitors of hexoaminidase and glycosidase 失效
标题翻译：己糖胺苷酶和糖苷酶的咪嗪环醇抑制剂
公开(公告)号：US06774140B1
公开(公告)日：2004-08-10
申请号：US09980869
申请日：2002-02-12
申请人： Chi-Huey Wong , Jungie Liu
发明人： Chi-Huey Wong , Jungie Liu
IPC分类号： A61K3140
CPC分类号： C07D207/12 , A61K31/40 , A61K31/4025 , A61K31/445
摘要： Designed iminocylitols that have potent inhibition activity with respect to hexominidases and glycosides are disclosed.
摘要翻译：公开了相对于己糖苷酶和糖苷具有有效抑制活性的设计的亚氨基二醇。

109. 发明授权

US06664235B1 Medicaments comprising sialic acid derivatives as active ingredients 失效
标题翻译：包含唾液酸衍生物作为活性成分的药物
公开(公告)号：US06664235B1
公开(公告)日：2003-12-16
申请号：US09640776
申请日：2000-08-18
申请人： Osamu Kanie , Chi-Huey Wong , Yasuo Suzuki
发明人： Osamu Kanie , Chi-Huey Wong , Yasuo Suzuki
IPC分类号： A61K317028
CPC分类号： A61K31/7012
摘要： A medicament for treatment of a viral infection which comprises as an active ingredient a compound represented by the following formula (I) or its Pharmaceutically acceptable salt, or a hydrate thereof or a solvate thereof. wherein R1 represents hydrogen atom or a C1-6 alkyl group; R2 represents an optionally substituted phenyl group, a C1-20 alkyl group, a C1-20 alkenyl group, or—(CH2)k—[NH—(CH2)m—NH]n—Y or —(CH2)k—[NH—(CH2CH2O)m-1—CH2CH2NH]n—Y in which Y represents phosphatidylethanolamine residue or polyglutamic acid residue, k and m independently represent an integer of from 2 to 10, n represents 0 or 1, provided that when n represents 1, Y represents phosphatidylethyl group; R3 represents hydrogen atom or an optionally substituted hydroxyl group; R4 represents hydrogen atom, a halogen atom, azide group, an optionally substituted amino group, or an optionally substituted hydroxyl group; and R5, R6, R7 and R8 independently represent an optionally substituted hydroxyl group.
摘要翻译：一种用于治疗病毒感染的药物，其包含作为活性成分的由下式（I）表示的化合物或其药学上可接受的盐或其水合物或其溶剂合物。其中R 1表示氢原子或C1 -6烷基; R 2表示任选取代的苯基，C 1-20烷基，C 1-20链烯基或 - （CH 2）k - [NH-（CH 2）m -NH] n Y或 - （CH 2） [NH-（CH2CH2O）m-1-CH2CH2NH] nY其中Y表示磷脂酰乙醇胺残基或聚谷氨酸残基，k和m独立地表示2至10的整数，n表示0或1，条件是当n表示1时， Y表示磷脂酰乙基; R 3表示氢原子或任选取代的羟基; R 4表示氢原子，卤素原子，叠氮基，任选取代的氨基或任选取代的羟基; R 5，R 6，R 7和R 8独立地表示任选取代的羟基。

110. 发明授权

US06462193B1 Hydroxyazepanes as inhibitors of glycosidase and HIV protease 失效
标题翻译：羟基氮芥作为糖苷酶和HIV蛋白酶的抑制剂
公开(公告)号：US06462193B1
公开(公告)日：2002-10-08
申请号：US09367919
申请日：1999-08-23
申请人： Chi-Huey Wong , Francisco Moris-Varas
发明人： Chi-Huey Wong , Francisco Moris-Varas
IPC分类号： C07D22308
CPC分类号： G11C11/22 , C07D233/08 , H01L27/11502 , H01L27/11585 , H01L27/1159
摘要： Hydroxyazepanes display inhibitory activity with respect to glycosidase, with Ki values from-moderate to low micromolar range. Benzyl and 3,6-dibenzyl derivatives of hydroxyazepanes display inhibitory activity with respect to HIV protease. These compounds are synthesized either by chemoenzymatic or chemical methodologies.
摘要翻译：羟基氮芥对糖苷酶显示抑制活性，Ki值从中到低微摩尔范围。羟基氮杂环庚烷的苄基和3,6-二苄基衍生物对HIV蛋白酶表现出抑制活性。这些化合物通过化疗或化学方法合成。

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