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101. 发明申请

WO2014047398A1 MODULATION OF ASYMMETRIC PROLIFERATION 审中-公开
标题翻译：不对称增殖的调制
公开(公告)号：WO2014047398A1
公开(公告)日：2014-03-27
申请号：PCT/US2013/060842
申请日：2013-09-20
申请人： THE GENERAL HOSPITAL CORPORATION , RAMASWAMY, Sridhar
发明人： RAMASWAMY, Sridhar
IPC分类号： A61K31/352 , A61K31/437 , A61K31/495 , A61K31/5025 , A61P35/00
CPC分类号： A61K31/69
摘要： Provided herein are methods and compositions related to modulation of the rate of asymmetric proliferation of cancer cells. In some embodiments, the methods described herein relate to the treatment of cancer, at least in part, via the modulation of the rate of asymmetric proliferation of cancer cells.
摘要翻译：本文提供了与调节癌细胞不对称增殖速率有关的方法和组合物。在一些实施方案中，本文所述的方法涉及至少部分地通过调节癌细胞的不对称增殖速率来治疗癌症。

102. 发明申请

WO2014022749A1 POROUS ELECTROLYTIC POLYMER CRYOGELS FOR ENHANCED ELECTRICAL COLLAPSIBILITY 审中-公开
标题翻译：用于增强电解性的多孔电解聚合物晶体
公开(公告)号：WO2014022749A1
公开(公告)日：2014-02-06
申请号：PCT/US2013/053367
申请日：2013-08-02
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE
发明人： KENNEDY, Stephen Michael , BENCHERIF, Side Ahmed , MOONEY, David, J.
IPC分类号： C08J3/075 , C08J9/00 , C08F20/10 , A61K47/48 , A61K9/06
CPC分类号： C08J9/286 , A61K9/0009 , A61K9/06 , C08F220/06 , C08F220/56 , C08F2222/1013 , C08J9/28 , C08J2201/0484 , C08J2205/022 , C08J2207/10 , C08J2333/02 , C08J2333/26 , C08J2343/00 , C08J2347/00
摘要： The invention provides cryogels whose porosity, pore size, pore connectivity, swelling agent concentration, and/or specific volume undergoes a change from a first value to a second value in response to an electrical stimulus. The cryogels have interconnected macropores which greatly enhance their ability to rapidly undergo volumetric collapse when subjected to moderate electric fields. The cryogels of the invention can be easily integrated into arrays capable of rapid configurational and chromatic optical modulations, and when loaded with drugs, are able to coordinate the delivery profile of multiple drugs. The cryogel can be prepared by polymerizing an aqueous solution of charged monomers and cross-linker monomers at a temperature below the freezing temperature of the solvent.
摘要翻译：本发明提供了冷冻凝胶，其孔隙率，孔径，孔连通性，溶胀剂浓度和/或比体积响应于电刺激而经历从第一值到第二值的变化。冷冻凝胶具有相互连接的大孔，当其受到中等电场的影响时，它们能够迅速地发生体积崩溃的能力。本发明的冷冻凝胶可以容易地集成到能够进行快速配置和彩色光学调制的阵列中，并且当装载有药物时，能够协调多种药物的递送特征。可以在低于溶剂冷冻温度的温度下聚合带电荷单体和交联剂单体的水溶液来制备冷冻凝胶。

103. 发明申请

WO2014004465A1 TARGETED THERAPEUTICS 审中-公开
标题翻译：目标治疗
公开(公告)号：WO2014004465A1
公开(公告)日：2014-01-03
申请号：PCT/US2013/047550
申请日：2013-06-25
申请人： THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
发明人： LEE, Richard, T. , PATWARI, Parth , LOFFREDO, Francesco , PANCOAST, James
IPC分类号： C07K19/00 , C07K14/00 , C12N15/63 , C12N5/10 , A61K38/16 , A61P19/00 , A61P25/00 , A61P27/00
CPC分类号： C07K14/65 , A61K38/00 , A61K38/16 , A61K38/29 , A61K38/30 , C07K14/47 , C07K14/635 , C07K2319/00 , C07K2319/01 , C07K2319/33
摘要： The present invention relates to compositions, methods and kits for delivery of active agents (X) to cells or tissues that express proteoglycans. More specifically, the present invention relates to conjugates comprising (HB-linker) n -X m -(linker-HB) o , where HB is a heparin binding protein, X is an active agents such as a therapeutic protein (including a functional fragment or variant thereof), or a therapeutic small molecule, linker is a linker entity and m is an integer of at least 1, and n+o is an integer of at least 1. Other aspects relate to use of a HB-X conjugate in methods to deliver active agents to cartilage for the treatment of cartilage related disease and disorders, the use of the HB-X conjugate in methods to deliver active agents to neuronal tissues (e.g., brain and spinal cord) for the treatment of neurological disorders, and the use of the HB-X conjugates in methods for the treatment of eye conditions and disorders and inflammatory conditions and disorders.
摘要翻译：本发明涉及用于将活性剂（X）递送至表达蛋白聚糖的细胞或组织的组合物，方法和试剂盒。更具体地说，本发明涉及包含（HB-接头）n-Xm-（接头-HB）o的缀合物，其中HB是肝素结合蛋白，X是活性剂，例如治疗性蛋白质（包括功能片段或变体）或治疗性小分子，接头是连接体实体，m是至少为1的整数，n + o是至少为1的整数。其它方面涉及在方法中使用HB-X缀合物将软骨中的活性剂递送到软骨相关疾病和病症的治疗中，在将神经元组织（例如脑和脊髓）递送活性剂用于治疗神经障碍的方法中使用HB-X缀合物，以及在治疗眼部疾病和病症以及炎性疾病和病症的方法中使用HB-X缀合物。

104. 发明申请

WO2013169739A1 NOVEL COMPOSITIONS AND USES OF ANTI-HYPERTENSION AGENTS FOR CANCER THERAPY 审中-公开
标题翻译：新型组合物和抗高血压药物用于癌症治疗的用途
公开(公告)号：WO2013169739A1
公开(公告)日：2013-11-14
申请号：PCT/US2013/039901
申请日：2013-05-07
申请人： THE GENERAL HOSPITAL CORPORATION , XTUIT PHARMACEUTICALS, INC. , JAIN, Rakesh, Kumar , BOUCHER, Yves , CHAUHAN, Vikash, Pal, Singh , DIOP-FRIMPONG, Benjamin , KRANE, Stephen
发明人： JAIN, Rakesh, Kumar , BOUCHER, Yves , CHAUHAN, Vikash, Pal, Singh , DIOP-FRIMPONG, Benjamin , KRANE, Stephen , CRANE, Alane, L. , LANGER, Robert, Samuel
IPC分类号： A61K9/14
CPC分类号： A61K31/4178 , A61K9/51 , A61K45/06 , A61K2300/00
摘要： Methods and compositions for improving the delivery and/or efficacy of a therapy ( e.g ., a cancer therapy) are disclosed. In one embodiment, methods and compositions for treating or preventing a cancer (e.g., a solid tumor such as a desmoplastic tumor) by administering to a subject an anti-hypertensive agent, as a single agent or in combination with a microenvironment modulator and/or a therapy, e.g., a cancer therapy (for example, a therapeutic agent or therapy, including immunotherapy ( e.g ., antibodies, vaccine, cell-based), nanotherapeutics, radiation therapy, photodynamic therapy, low molecular weight chemotherapeutics, molecularly targeted therapeutics and/or oxygen radical) are disclosed.
摘要翻译：公开了用于改善治疗的递送和/或功效的方法和组合物（例如，癌症治疗）。在一个实施方案中，通过向受试者施用抗高血压剂作为单一试剂或与微环境调节剂组合施用治疗或预防癌症的方法和组合物（例如，实体肿瘤，例如，致瘤性肿瘤），和/或治疗，例如癌症治疗（例如，治疗剂或治疗，包括免疫治疗（例如抗体，疫苗，基于细胞的），纳米治疗剂，放射疗法，光动力疗法，低分子量化学治疗剂，分子靶向治疗剂和/ 或氧自由基）。

105. 发明申请

WO2013163512A1 AGENTS AND METHODS FOR TREATING AND PREVENTING SEBORRHEIC KERATOSIS 审中-公开
标题翻译：用于治疗和预防SEBORRHEIC KERATOSIS的代理和方法
公开(公告)号：WO2013163512A1
公开(公告)日：2013-10-31
申请号：PCT/US2013/038358
申请日：2013-04-26
申请人： THE GENERAL HOSPITAL CORPORATION
发明人： MANDINOVA, Anna I. , LEE, Sam W. , NEEL, Victor A.
IPC分类号： A61K31/712 , A61K39/395 , A61P17/08
CPC分类号： C12N5/0629 , A61K31/352 , A61K31/353 , A61K31/437 , A61K31/4439 , A61K31/4745 , A61K31/475 , A61K31/496 , A61K31/7076 , A61K31/713 , A61K45/06 , A61K2039/505 , C07K16/40 , C12N15/1137 , C12N2310/14 , C12N2501/734 , C12Y207/11001 , C12Y304/21004 , C12Y304/24004 , G01N33/5044 , G01N2333/912 , G01N2500/10 , G01N2510/00
摘要： Provided herein are methods and assays for isolating and culturing seborrheic keratosis cells ex vivo. Also provided herein are screening assays using cultured seborrheic keratosis cells and methods for treating seborrheic keratosis in a subject.
摘要翻译：本文提供了离体分离和培养脂溢性角化病细胞的方法和测定法。本文还提供使用培养的脂溢性角化病细胞的筛选测定法和用于治疗受试者的脂溢性角化病的方法。

106. 发明申请

WO2013163407A1 SILK MICROSPHERES AND METHODS FOR SURFACE LUBRICATION 审中-公开
标题翻译： SILK微球和表面润滑方法
公开(公告)号：WO2013163407A1
公开(公告)日：2013-10-31
申请号：PCT/US2013/038186
申请日：2013-04-25
申请人： TRUSTEES OF TUFTS COLLEGE , THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND
发明人： KAPLAN, David L. , WANG, Xiaoqin , JOHN, Vijay , PESIKA, Noshir , ZHENG, Rubo
IPC分类号： A61K47/42 , A61K47/30 , A61K9/16
CPC分类号： A61K47/42 , A61K9/1617 , A61K45/06 , A61L27/227 , A61L27/28 , A61L27/3645 , A61L27/50 , A61L27/54 , A61L2300/622 , A61L2400/10 , A61L2430/24
摘要： Provided herein relates to compositions and methods for lubrication of a surface. The surface amenable to the compositions and methods described herein can be a non-biological surface, a biological surface, or a combination thereof. In some embodiments, the composition comprising a phospholipid-coated silk microsphere can be used for lubrication of a surface. In some embodiments, the composition comprising a phospholipid-coated silk microsphere can be used for joint lubrication, e.g., for treatment of joint disorders such as arthritis.
摘要翻译：本文涉及用于润滑表面的组合物和方法。适用于本文所述的组合物和方法的表面可以是非生物表面，生物表面或其组合。在一些实施方案中，包含磷脂涂覆的丝微球的组合物可用于润滑表面。在一些实施方案中，包含磷脂包被的丝微球的组合物可用于关节润滑，例如用于治疗关节疾病如关节炎。

107. 发明申请

WO2013134464A1 TISSUE CONSTRUCTS AND USES THEREOF 审中-公开
标题翻译：组织结构及其用途
公开(公告)号：WO2013134464A1
公开(公告)日：2013-09-12
申请号：PCT/US2013/029517
申请日：2013-03-07
申请人： CHILDREN'S MEDICAL CENTER CORPORATION
发明人： SANCHEZ-SCHMITZ, Guzman , LEVY, Ofer , STEVENS, Chad
IPC分类号： A61K38/39 , A61K38/19 , A61K38/20 , A61P7/02 , A61P17/00
CPC分类号： C12N5/0639 , A61K35/14 , A61K35/44 , A61K2035/124 , C12N2500/98 , C12N2502/28 , C12N2506/115 , C12N2533/54 , C12N2533/90
摘要： Artificial tissue constructs (TCs), methods of making the TCs, uses thereof, and kits comprising the TCs are provided. TCs are useful for vaccine evaluation for human adult, human non-newborn, and newborns.
摘要翻译：提供人造组织构建体（TC），制备TC的方法及其用途，以及包含TC的试剂盒。 TC可用于人类成年人，人类非新生儿和新生儿的疫苗评估。

108. 发明申请

WO2013130937A1 ENDOVASCULAR SILK-PROTEIN BASED EMBOLIZATION OF BLOOD VESSELS 审中-公开
标题翻译：基于丝状蛋白的血管内皮生长因子
公开(公告)号：WO2013130937A1
公开(公告)日：2013-09-06
申请号：PCT/US2013/028543
申请日：2013-03-01
申请人： TUFTS UNIVERSITY , TUFTS MEDICAL CENTER, INC.
发明人： MALEK, Adel , LEISK, Gary , LO, Tim J. , KAPLAN, David L.
IPC分类号： A61M25/06 , A61B17/12 , A61F2/82 , A61L27/04
CPC分类号： A61B17/1215 , A61B17/12113 , A61B17/1214 , A61B17/12172 , A61B17/12177 , A61B17/1219 , A61B2017/12054
摘要： Disclosed herein are novel silk-based embolizing compositions and methods using the compositions for causing embolism in blood vessels. The silk-based compositions comprise silk proteins in the form of an aqueous silk fibroin solution, powdered silk foam or powdered dried silk gel. Also disclosed are microcatheter systems for delivering the silk-based compositions to target sites of blood vessels and inducing silk solidification or silk foam or powdered expansion in situ on demand.
摘要翻译：本文公开了新颖的丝状栓塞组合物和使用组合物引起血管栓塞的方法。丝状组合物包含丝素蛋白水溶液形式的丝蛋白，丝状泡沫粉末或粉状干燥的丝凝胶。还公开了用于将丝基组合物递送到血管的靶位置并根据需要诱导丝凝固或丝绸泡沫或原位膨胀的微导管系统。

109. 发明申请

WO2013022927A2 TREATMENT OF UTERINE LEIOMYOMATA 审中-公开
标题翻译：子宫肌瘤的治疗
公开(公告)号：WO2013022927A2
公开(公告)日：2013-02-14
申请号：PCT/US2012/049922
申请日：2012-08-08
申请人： THE BRIGHAM AND WOMEN'S HOSPITAL, INC. , MORTON, Cynthia C. , EGGERT, Stacey L.
发明人： MORTON, Cynthia C. , EGGERT, Stacey L.
CPC分类号： C12N15/1137 , A61K31/00 , A61K31/713 , C12N15/113 , C12N2310/14 , C12N2320/30 , C12Q1/6827
摘要： Embodiments herein provide a therapy for uterine leiomyomata (UL) in women using a fatty acid synthase (FAS) inhibitor. Additionally, an analysis method for evaluating the likelihood of women developing UL during their lifetime is provided.
摘要翻译：本文的实施方案提供了使用脂肪酸合成酶（FAS）抑制剂的妇女中的子宫平滑肌瘤（UL）的治疗。另外，提供了一种用于评估在其寿命期间发展UL的妇女的可能性的分析方法。

110. 发明申请

WO2012177997A1 TREATMENT OF PROTEINOPATHIES 审中-公开
标题翻译：治疗病史
公开(公告)号：WO2012177997A1
公开(公告)日：2012-12-27
申请号：PCT/US2012/043732
申请日：2012-06-22
申请人： THE GENERAL HOSPITAL CORPORATION , KRAINC, Dmitri , MAZZULLI, Joseph, R.
发明人： KRAINC, Dmitri , MAZZULLI, Joseph, R.
IPC分类号： A61K47/00 , A61P25/28 , G01N33/573
CPC分类号： C07D487/04 , C12Q1/34 , C12Q1/44 , G01N33/5008 , G01N33/573 , G01N2333/924 , G01N2500/10 , Y02A50/57
摘要： The present disclosure provides technologies relating to lysosomal activation. The disclosure provides several strategies for increasing level and/or activity of lysosomal enzyme, and furthermore demonstrates the surprising applicability of such strategies in the treatment and/or prophylaxis of certain proteinopathies. Among other things, the present invention provides methods and compositions for the treatment and/or prophylaxis of proteinopathies other than lysosomal storage diseases through lysosomal activation. In particular, the present disclosure provides methods and compositions for the treatment and/or prophylaxis of neurodegenerative proteinopathies, and in particular those associated with accumulation of α-synuclein. The present disclosure specifically provides methods and compositions for the treatment and/or prophylaxis of Parkinson's disease.
摘要翻译：本公开提供了涉及溶酶体激活的技术。本公开提供了用于增加溶酶体酶的水平和/或活性的几种策略，并且进一步证实了这些策略在治疗和/或预防某些蛋白病中的惊人的适用性。除其他之外，本发明提供了用于通过溶酶体激活治疗和/或预防除溶酶体贮积疾病之外的蛋白质病症的方法和组合物。特别地，本公开提供了用于治疗和/或预防神经变性蛋白病的方法和组合物，特别是与α-突触核蛋白的积累相关的那些。本公开专门提供了用于治疗和/或预防帕金森病的方法和组合物。

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