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101. 发明授权

US10336754B2 Pyrimidinones as factor XIa inhibitors 有权
公开(公告)号：US10336754B2
公开(公告)日：2019-07-02
申请号：US15903671
申请日：2018-02-23
申请人： Bristol-Myers Squibb Company
发明人： Andrew K. Dilger , James R. Corte , Indawati De Lucca , Tianan Fang , Wu Yang , Yufeng Wang , Kumar Balashanmuga Pabbisetty , William R. Ewing , Yeheng Zhu , Ruth R. Wexler , Donald J. P. Pinto , Michael J. Orwat , Leon M. Smith, II
IPC分类号： C07F7/08 , C07D519/00 , C07D471/18 , C07D487/08 , C07D471/08
摘要： The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective factor XIa inhibitors or dual inhibitors of FXIa and plasma kallikrein. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.

102. 发明授权

US10287312B2 Cyclic peroxides as prodrugs for selective delivery of agents 有权
公开(公告)号：US10287312B2
公开(公告)日：2019-05-14
申请号：US15118268
申请日：2015-02-13
申请人： The Regents of the University of California
发明人： Adam R. Renslo , Erica M. W. Lauterwasser , Shaun D. Fontaine , Benjamin B. Spangler , James A. Wells
IPC分类号： C07D323/02 , A61K31/357 , C07H19/16 , C07F7/18 , C07D407/12 , C07D405/14 , C07D405/12 , C07D417/12 , C07D417/14 , C07D471/14 , C07D493/04 , C07D519/04 , C07F9/655 , C07H19/06 , C07H19/167 , A61K31/4025 , A61K31/404 , A61K31/4192 , A61K31/427 , A61K31/435 , A61K31/437 , A61K31/444 , A61K31/4709 , A61K31/4745 , A61K31/496 , A61K31/4985 , A61K31/513 , A61K31/662 , A61K31/7072 , A61K31/7076 , A61K31/7135 , A61K51/04 , C07D487/04 , C07D491/107 , C07D491/113 , C07D491/153 , C07D493/14 , C07K7/06 , A61K47/64 , A61K47/68
摘要： Disclosed herein, inter alia, are prodrug compositions and methods of using the same for treatment and detection of disease. Specifically, disclosed herein is a compound of formula (I) having spiro-fused 1,2,4-trioxolane and piperidine rings, namely, 1,2,4-trioxa-8-azaspiro[4.5]decane. Also disclosed is a pharmaceutical composition containing the compound and a pharmaceutically acceptable carrier.

103. 外观设计

USD832710S1 Cosmetic vessel 有权
公开(公告)号：USD832710S1
公开(公告)日：2018-11-06
申请号：US29589863
申请日：2017-01-05
申请人： LG HOUSEHOLD & HEALTH CARE LTD.
设计人： Joung Eun Kim

104. 发明授权

US09994595B2 Catalyst and battery components derived from condensation reactions with carba-closo-dodecaborate amines 有权
公开(公告)号：US09994595B2
公开(公告)日：2018-06-12
申请号：US15126245
申请日：2015-03-16
申请人： THE REGENTS OF THE UNVERSITY OF CALIFORNIA
发明人： Vincent Lavallo , Ahmad El Hellani , Allen Chan
IPC分类号： C07F5/02 , C07F15/00 , C07F15/04 , C07F1/00 , C07F1/08 , C07F1/10 , C07F3/02 , B01J31/22 , B01J31/24 , C07C2/76 , C07C5/333 , H01M10/0565 , H01M10/0568
CPC分类号： C07F5/027 , B01J31/2265 , B01J31/2295 , B01J31/2404 , B01J2231/46 , B01J2231/766 , B01J2531/16 , B01J2531/17 , B01J2531/824 , B01J2531/827 , B01J2531/847 , C07C2/76 , C07C5/3335 , C07C5/3337 , C07C2531/22 , C07F1/00 , C07F1/08 , C07F1/10 , C07F3/02 , C07F5/02 , C07F15/0033 , C07F15/006 , C07F15/04 , C07F15/045 , H01M10/0565 , H01M10/0568 , H01M2300/0025 , H01M2300/0085
摘要： Described herein is the fusion of two families of unique carbon-containing molecules that readily disregard the tendency of carbon to form four chemical bonds, namely N-heterocyclic carbenes (NHCs) and carborane anions. Deprotonation of an anionic imidazolium salt with lithium diisopropylamide at room temperature leads to a mixture of lithium complexes of C-2 and C-5 dianionic NHC constitutional isomers as well as a trianionic (C-2, C-5) adduct. Judicious choice of the base and reaction conditions allows for the selective formation of all three stable polyanionic carbenes. In solution, the so-called abnormal C-5 NHC lithium complex slowly isomerizes to the normal C-2 NHC, and the process can be proton catalyzed by the addition of the anionic imidazolium salt. These results indicate that the combination of two unusual forms of carbon atoms can lead to unexpected chemical behavior, and that this strategy paves the way for the development of a broad new generation of NHC ligands for catalysis.

105. 发明授权

US09951104B2 Peptides and methods of using same 有权
公开(公告)号：US09951104B2
公开(公告)日：2018-04-24
申请号：US14370815
申请日：2013-01-07
申请人： Serpin Pharma, LLC
发明人： Soren Mogelsvang , Cohava Gelber
IPC分类号： C07K7/08 , C07K14/81 , A61K38/00
CPC分类号： C07K7/08 , A61K38/00 , C07K14/8125
摘要： We describe peptides and their uses for the treatment of autoimmune, inflammatory and metabolic diseases.

106. 发明授权

US09909107B2 Brassica AHAS genes and gene alleles that provide resistance to imidazolinone herbicides 有权
公开(公告)号：US09909107B2
公开(公告)日：2018-03-06
申请号：US14502263
申请日：2014-09-30
申请人： VITERRA INC.
发明人： Kening Yao , Derek A. Potts , Bradley D. Leibel , Daryl R. Males
IPC分类号： A01H5/10 , C12N9/10 , C12N15/82 , C12N9/88
CPC分类号： C12N9/1022 , A01H5/10 , C12N9/88 , C12N15/8274
摘要： Plants, plant parts and plant seeds that are resistant to imidazolinone herbicides are provided. Plants are disclosed that contain a mutation in an AHAS gene. Specifically, plants are disclosed that contain a mutant AHAS gene allele of the Brassica juncea B genome. Two B. juncea AHAS gene sequences (BjAHAS-a and BjAHAS-b) and one B. nigra AHAS gene sequence (BngrAHAS) are disclosed. The sequence of the mutant allele, BjAHAS-bR, is also disclosed. Various methods are disclosed that include creation of mutant B. juncea lines, selection for herbicide resistant lines and determining the presence of the BjAHAS-bR mutant allele after crosses.

107. 发明授权

US09735332B2 Thermoelectric power generation system for vehicle 有权
公开(公告)号：US09735332B2
公开(公告)日：2017-08-15
申请号：US14685708
申请日：2015-04-14
申请人： Hyundai Motor Company
发明人： Kyung Beom Jeon
IPC分类号： H02J7/00 , H01L35/30 , H01M10/46 , B60L11/18 , H02J7/35 , F25B9/04 , F25B21/02
CPC分类号： H01L35/30 , B60L11/1816 , B60L11/1861 , F25B9/04 , F25B21/02 , H01M10/46 , H02J7/35
摘要： A thermoelectric power generation system for a vehicle is provided. The system includes an air compressor that is configured to compress and discharge air and a vortex tube that is configured to receive the compressed air discharged from the air compressor and separate and discharge the compressed air into two groups of air having a temperature difference. In addition, a thermoelectric module is provided that includes a thermoelectric element having a channel formed at a first side thereof introduced with any one of the two groups of air and a channel formed at a second side thereof introduced with the other of the two groups of air to generate an electromotive force due to a temperature difference of the two groups of air.

108. 发明授权

US09076796B2 Interconnection structure for package and fabrication method thereof 有权
标题翻译：封装的互连结构及其制造方法
公开(公告)号：US09076796B2
公开(公告)日：2015-07-07
申请号：US13894687
申请日：2013-05-15
申请人： Siliconware Precision Industries Co., Ltd.
发明人： Chun-Hung Lin , Chun-Hung Lu , Guang-Hwa Ma , Hsiao-Chun Huang , Kuang-Hsin Chen
IPC分类号： H01L23/532 , H01L21/768 , H01L23/498
CPC分类号： H01L23/53295 , H01L21/76802 , H01L21/76808 , H01L23/49894 , H01L23/53238 , H01L23/5329 , H01L2221/1031 , H01L2924/0002 , H01L2924/00
摘要： An interconnection structure for a package is disclosed. The interconnection structure includes a substrate body having a conductive portion formed on a surface thereof; a first photosensitive dielectric layer formed on the surface of the substrate body and having a via for exposing the conductive potion; a conductive via formed in the via; a second photosensitive dielectric layer formed on the first photosensitive dielectric layer and having a opening for exposing the conductive via and a portion of the first photosensitive dielectric layer; and a conductive trace layer formed in the opening of the second photosensitive dielectric layer so as to be electrically connected to the conductive portion through the conductive via, thereby simplifying the fabrication process and reducing the fabrication cost and time.
摘要翻译：公开了一种用于封装的互连结构。互连结构包括在其表面上形成有导电部分的基板主体; 形成在所述基板主体的表面上并且具有用于使所述导电部暴露的通孔的第一光敏介电层; 在通孔中形成的导电通孔; 形成在所述第一光敏介电层上并具有用于使所述导电通孔和所述第一光敏介电层的一部分暴露的开口的第二光敏介电层; 以及形成在第二感光介电层的开口中的导电迹线层，以便通过导电通孔电连接到导电部分，从而简化制造工艺并降低制造成本和时间。

109. 发明授权

US08934393B2 Local selection of retransmitting device in cooperative cluster to enhance cellular multicast 有权
标题翻译：协同集群中重传设备的本地选择，以增强蜂窝多播
公开(公告)号：US08934393B2
公开(公告)日：2015-01-13
申请号：US13704520
申请日：2010-06-17
申请人： Sami-Jukka Hakola , Timo Kalevi Koskela , Zhenhong Li , Haifeng Wang
发明人： Sami-Jukka Hakola , Timo Kalevi Koskela , Zhenhong Li , Haifeng Wang
IPC分类号： H04H20/71 , H04L1/18 , H04W24/04 , H04W4/06 , H04W72/00 , H04W36/18 , H04L1/00
CPC分类号： H04W4/06 , H04L1/1867 , H04L2001/0093 , H04W24/04 , H04W36/18 , H04W72/005
摘要： A method for local selection of a retransmitting user equipment within a cluster comprises: selecting first retransmission indication information according to a first pre-defined criterion, in response to receipt of non-acknowledgement information from at least one non-acknowledgement user equipment at which a data packet from a network node is decoded incorrectly; performing a local selection of a retransmitting user equipment within a cluster based at least in part on the first retransmission indication least one non-acknowledgement user equipment, and at least one acknowledgement user equipment at which the data packet is decoded correctly; and determining whether or not to retransmit the data packet to the at least one non-acknowledgement user equipment, based at least in part on the local selection of the retransmitting user equipment.
摘要翻译：用于本地选择群集内的重传用户设备的方法包括：响应于从至少一个非确认用户设备接收到非确认信息，根据第一预定义准则选择第一重传指示信息，其中，来自网络节点的数据分组被解码不正确; 至少部分地基于所述第一重传指示至少一个非确认用户设备以及至少一个所述数据分组被正确解码的确认用户设备来执行群集内的重传用户设备的本地选择; 以及至少部分地基于所述重传用户设备的本地选择来确定是否向所述至少一个非确认用户设备重传所述数据分组。

110. 发明授权

US08886177B2 Measurement reporting of inter-rat cells of more than one rat in GERAN 有权
标题翻译： GERAN中多只大鼠的大鼠间细胞测量报告
公开(公告)号：US08886177B2
公开(公告)日：2014-11-11
申请号：US13521972
申请日：2011-01-26
申请人： Guillaume Jacques Sebire , Harri Aatos Jokinen , Leonardo Provvedi
发明人： Guillaume Jacques Sebire , Harri Aatos Jokinen , Leonardo Provvedi
IPC分类号： H04W4/00 , H04W36/00 , H04W36/14
CPC分类号： H04W36/0094 , H04W36/14
摘要： Methods and apparatus, including computer program products, are provided for measurement reporting In one aspect there is provided a method. The method may include receiving, at a user equipment from a base station, a first message providing one or more parameters for measurement reporting, selecting one or more first cells from among a plurality of cells, wherein the selecting is based on at least one comparison value determined based on at least one reporting threshold defined for at least one of a plurality of radio access technologies being used by at least one of the plurality of cells, wherein the at least one reporting threshold is further defined based on at least one measurement quantity used for the at least one of a plurality of radio access technologies, and sending, by the user equipment to the base station, one or more measurement results for the selected one or more first cells, the one or more measurement results included m the measurement report message, when the measurement report message lacks capacity to report valid measurement results for each of the plurality of cells, wherein the one or more results are included based on the at least one comparison value including the at least one reporting threshold. Related apparatus, systems, methods, and articles are also described.
摘要翻译：提供了包括计算机程序产品在内的方法和装置用于测量报告。一方面，提供了一种方法。该方法可以包括在来自基站的用户设备处接收提供用于测量报告的一个或多个参数的第一消息，从多个小区中选择一个或多个第一小区，其中所述选择基于至少一个比较基于为多个小区中的至少一个小区使用的多个无线电接入技术中的至少一个定义的至少一个报告阈值确定的值，其中至少一个报告阈值基于至少一个测量量进一步定义用于多个无线电接入技术中的至少一个，并且由用户设备向基站发送所选择的一个或多个第一小区的一个或多个测量结果，所述一个或多个测量结果包括在测量中报告消息，当所述测量报告消息缺乏报告所述多个小区中的每个小区的有效测量结果的能力时，其中所述一个或多个结果基于包括至少一个报告阈值的至少一个比较值被包括。还描述了相关装置，系统，方法和制品。

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