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101. 发明专利

NZ580341A SALTS OF ISOPHOSPHORAMIDE MUSTARD AND ANALOGS THEREOF 未知
公开(公告)号：NZ580341A
公开(公告)日：2012-06-29
申请号：NZ58034108
申请日：2008-04-04
申请人： ZIOPHARM ONCOLOGY INC
发明人： AMEDIO JOHN C , WALLNER BARBARA P , KOMARNITSKY PHILIP B
IPC分类号： C07C229/26 , A61K31/13 , A61K31/133 , A61K31/198 , A61K31/4409 , A61K31/664 , A61P35/00 , C07C211/35 , C07C215/10 , C07C279/14 , C07D213/74 , C07F9/24
摘要： Disclosed is a crystalline compound having a structure of formula (I) wherein A+ is the conjugate acid of a hydroxylated aliphatic amine; and X and Y independently represent leaving groups. Examples of A+ are conjugate acid of mono-, bis- or tris-(2-hydroxyethyl)amine, 2-hydroxy-tertbutylamine, N,N-dimethyl-N-(2-hydroxyethyl)amine, and tris(hydroxymethyl)aminomethane (Tris). Also disclosed is a method for preparing a composition comprising a compound of formula (I) and a saline solution; a pharmaceutical composition or lyophilisate comprising a compound of formula (I) and the use of a compound of formula (I) in the manufacture of a medicament for treating a hyperproliferative disorder is selected from acute leukaemia, chronic leukemias, polycythaemia vera, lymphoma, Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, Waldenstrom's macroglobulinemia, heavy chain disease, myelodysplastic syndrome, hairy cell leukemia, myelodysplasia, sarcomas and carcinomas, synovioma, mesothelioma, Ewing's tumour, leiomyosarcoma, rhabdomyosarcoma, colon carcinoma, lymphoid malignancy, pancreatic cancer, breast cancer, lung cancers, ovarian cancer, prostate cancer, hepatocellular carcinoma, squamous cell carcinoma, basal cell carcinoma, adenocarcinoma, sweat gland carcinoma, sebaceous gland carcinoma, papillary carcinoma, papillary adenocarcinomas, medullary carcinoma, bronchogenic carcinoma, renal cell carcinoma, hepatoma, bile duct carcinoma, choriocarcinoma, Wilms' tumour, cervical cancer, testicular tumour, bladder carcinoma, and CNS tumours or cyclophosphamide (CPA) resistant condition.

102. 发明专利

ZA201100878B SYNTHESIS AND FORMULATIONS OF SALTS OF ISOPHOSPHORAMIDE MUSTARD AND ANALOGS THEREOF 未知
公开(公告)号：ZA201100878B
公开(公告)日：2011-10-26
申请号：ZA201100878
申请日：2011-02-02
申请人： ZIOPHARM ONCOLOGY INC
发明人： WALIGORA FRANK WALTER , AMEDIO JOHN C JR
IPC分类号： A61K20060101 , A61P20060101 , C07F20060101

103. 发明专利

IL210921D0 SYNTHESIS AND FORMULATIONS OF SALTS OF ISOPHOSPHORAMIDE MUSTARD AND ANALOGS THEREOF 未知
公开(公告)号：IL210921D0
公开(公告)日：2011-04-28
申请号：IL21092111
申请日：2011-01-27
申请人： ZIOPHARM ONCOLOGY INC
IPC分类号： A61K20060101

104. 发明专利

SK287533B6 Medicament for the treatment of multidrug-resistant tumors or angiogenesis and metastasis inhibition 未知
公开(公告)号：SK287533B6
公开(公告)日：2011-01-04
申请号：SK4072002
申请日：2000-09-26
申请人： ZIOPHARM ONCOLOGY INC
发明人： NICKEL BERND , KLENNER THOMAS , BACHER GERALD , BECKERS THOMAS , EMIG PETER , ENGEL JURGEN , BRUYNEEL ERIK , KAMP GUNTER , PETERS KIRSTEN
IPC分类号： A61K31/00 , C07D401/12 , A61K31/404 , A61K31/4439 , A61P35/00
摘要： Use of N-substituted indol-3-glyoxylamides of general formula (1) and pharmaceutically acceptable acid addition salts thereof for the manufacture of a medicament for the treatment of multidrug-resistant tumors and angiogenesis and metastasis inhibition. In the general formula (1) R represents hydrogen atom; R1 represents 4-pyridyl group or 4-fluorophenyl group; R2 represents benzyl group, 4-chlorobenzyl group, 4-fluorobenzyl group, 3-pyridylmethyl group or 4-bromobenzyl group; R3 and R4 represent hydrogen atom and Z represents oxygen atom. The preferred compound for that use is N-(pyridin-4-yl)-[1-(4- chlorobenzyl)indol-3-yl]glyoxylamide (indibulin).

105. 发明专利

ZA200907722B SALTS OF ISOPHOSPHORAMIDE MUSTARD AND ANALOGS THEREOF 未知
公开(公告)号：ZA200907722B
公开(公告)日：2010-11-24
申请号：ZA200907722
申请日：2009-11-03
申请人： ZIOPHARM ONCOLOGY INC
发明人： AMEDIO JOHN C , WALLNER BARBARA P , KOMARNITSKY PHILIP B
IPC分类号： A61K20060101 , A61P20060101 , C07C20060101 , C07D20060101 , C07F20060101
摘要： Disclosed herein are crystalline compounds of formula (I), wherein A + represents a hydroxylated aliphatic ammonium species; and X and Y independently represent leaving groups.

106. 发明专利

ES2342042T3 DERIVADOS DEL ACIDO INDOLIL-3-GLIOXILICO CON VALIOSAS PROPIEDADES TERAPEUTICAS. 未知
公开(公告)号：ES2342042T3
公开(公告)日：2010-07-01
申请号：ES00967789
申请日：2000-09-26
申请人： ZIOPHARM ONCOLOGY INC
发明人： NICKEL BERND , KLENNER THOMAS , BACHER GERALD , BECKERS THOMAS , EMIG PETER , ENGEL JURGEN
IPC分类号： A61K31/4439 , C07D401/12 , A61K31/404 , A61P9/00 , A61P35/00 , A61P35/02 , A61P35/04
摘要： Indol-3-glioxilamidas sustituidas en N de la Fórmula 1 siguiente, o bien sus sales de adición fisiológicamente tolerables, para emplear en el tratamiento de tumores resistentes a fármacos antitumorales **(Ver fórmula)** en donde los radicales R, R1, R2, R3, R4 y Z tienen los significados siguientes: Res hidrógeno. R1es una estructura de piridina de Fórmula 2 **(Ver fórmula)** en donde la estructura de piridina está unida a los átomos de carbono 2, 3 ó 4 en el anillo y puede estar sustituida opcionalmente con los sustituyentes R5 y R6, en donde los radicales R5 y R6 pueden ser iguales o distintos y ser alquilo (C1-C6), cicloalquilo (C3-C7), alcoxi (C1-C6), nitro, amino, hidroxi, halógeno, trifluorometilo, etoxicarbonilamino y carboxialquiloxi en el que el grupo alquilo puede tener 1-4 átomos de C, R2es un grupo alquilo (C1-C6), en donde el grupo alquilo está monosustituido o polisustituido con halógeno y fenilo, el cual, por otro lado, puede estar monosustituido o polisustituido con halógeno, alquilo (C1-C6), cicloalquilo (C3-C7), un grupo carboxilo, un grupo carboxilo esterificado con alcanol (C1-C6), un grupo trifluorometilo, un grupo hidroxilo, un grupo metoxi, un grupo etoxi, un grupo benciloxi, un grupo 2-quinolilo o un grupo 2-piridilo, 3-piridilo o 4-piridilo, en donde los grupos 2-piridilo, 3-piridilo o 4-piridilo pueden estar en cada caso, monosustituidos o polisustituidos con halógeno, un grupo alquilo (C1-C4) o un grupo alcoxi (C1-C4), R3 y R4 pueden ser idénticos o diferentes, y representan hidrógeno, alquilo (C1-C6), cicloalquilo (C3-C7), alcanoilo (C1-C6), alcoxi (C1-C6), halógeno y benciloxi, un grupo nitro, un grupo amino, un grupo amino sustituido con monoalquilo o dialquilo (C1-C4), un grupo alcoxi (C1-C6)-carbonilamino y un grupo alcoxi (C1-C6)-carbonilamino-alquilo (C1-C6), Zes O y S.

107. 发明专利

IL201424D0 SALTS OF ISOPHOSPHORAMIDE MUSTARD AND ANALOGS THEREOF 未知
公开(公告)号：IL201424D0
公开(公告)日：2010-05-31
申请号：IL20142409
申请日：2009-10-11
申请人： ZIOPHARM ONCOLOGY INC
IPC分类号： C07D20100101
摘要： Disclosed herein are crystalline compounds of formula (I), wherein A + represents a hydroxylated aliphatic ammonium species; and X and Y independently represent leaving groups.

108. 发明专利

AU2009282972A1 Organoarsenic compounds and methods for the treatment of cancer 未知
公开(公告)号：AU2009282972A1
公开(公告)日：2010-02-25
申请号：AU2009282972
申请日：2009-08-14
申请人： ZIOPHARM ONCOLOGY INC
发明人： SCHWARTZ BRIAN ERIC , LEWIS JONATHAN , KOMARNITSKY PHILIP B
IPC分类号： A61P35/00 , A61K31/285 , A61K31/455 , A61K31/60 , A61K38/06
摘要： The present invention provides organic arsenicals useful for the treatment of lymphoma.

109. 发明专利

CA2732290A1 SYNTHESIS AND FORMULATIONS OF SALTS OF ISOPHOSPHORAMIDE MUSTARD AND ANALOGS THEREOF 未知
公开(公告)号：CA2732290A1
公开(公告)日：2010-02-04
申请号：CA2732290
申请日：2009-07-30
申请人： ZIOPHARM ONCOLOGY INC
发明人： WALIGORA FRANK WALTER , AMEDIO JOHN C JR
IPC分类号： A61K31/675 , A61K31/66 , A61P35/00 , C07F9/22
摘要： Disclosed herein are formulations and methods of manufacture of compounds of formula (E):wherein X and Y independently represent leaving groups; and A+ is an ammonium cation.

110. 发明专利

ES2319929T3 FORMULACION FARMACEUTICA SOLIDA ORAL DEL INHIBIDOR DE TUBULINA INDIBULINA. 未知
公开(公告)号：ES2319929T3
公开(公告)日：2009-05-14
申请号：ES06761981
申请日：2006-06-07
申请人： ZIOPHARM ONCOLOGY INC
发明人： ROESSLER BERTHOLD , RAAB GERHARD , REISSMANN THOMAS
IPC分类号： A61K9/16 , A61K31/4439
摘要： Formulación farmacéutica de indibulina para la administración oral que comprende un granulado que contiene indibulina micronizada con un tamaño de partícula inferior a 20 µm en como mínimo un 99% en volumen de las partículas, como mínimo un agente tensioactivo hidrófilo y uno o más excipientes de encapsulación.

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