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101. 发明申请

US20100174224A1 HANDHELD TRANSDERMAL DRUG DELIVERY AND ANALYTE EXTRACTION 审中-公开
标题翻译：手持式药物传递和分析提取
公开(公告)号：US20100174224A1
公开(公告)日：2010-07-08
申请号：US12721030
申请日：2010-03-10
申请人： Ze'ev Sohn
发明人： Ze'ev Sohn
IPC分类号： A61N1/30 , A61F13/02
CPC分类号： A61N1/327 , A61B18/14 , A61B2018/00208 , A61B2018/00452 , A61B2018/1467 , A61B2018/1861 , A61M37/00 , A61N1/0424 , A61N1/044 , A61N1/0476 , A61N1/306
摘要： Apparatus is provided for facilitating delivery of a substance through skin of a subject. The apparatus includes a handle and a cartridge, removably coupled to the handle. The cartridge includes one or more electrodes and a patch comprising the substance, the electrodes adapted to be applied to a region of the skin, and the patch adapted to be applied to at least a portion of the region of the skin by removal of the electrodes therefrom.
摘要翻译：提供了用于促进物质通过受试者的皮肤递送的装置。该装置包括可拆卸地联接到手柄的手柄和盒。药筒包括一个或多个电极和包含该物质的贴片，适于施加到皮肤区域的电极，以及适于通过去除电极而被施加到皮肤区域的至少一部分的贴片由此。

102. 发明授权

US07558625B2 Combined micro-channel generation and iontophoresis for transdermal delivery of pharmaceutical agents 有权
标题翻译：组合的微通道产生和离子电渗疗法用于药物的透皮递送
公开(公告)号：US07558625B2
公开(公告)日：2009-07-07
申请号：US11749814
申请日：2007-05-17
申请人： Galit Levin , Amikam Gershonowitz , Meir Stern , Amir Sherman
发明人： Galit Levin , Amikam Gershonowitz , Meir Stern , Amir Sherman
IPC分类号： A61N1/30
CPC分类号： A61N1/30
摘要： The present invention relates to methods of transdermal delivery of pharmaceutical agents. In particular, the present invention relates to a method for transdermal delivery by generating micro-channels on the skin of a subject and delivering iontophoretically a pharmaceutical agent through the micro-channels. The method provides synergistic transdermal delivery of such pharmaceutical agents.
摘要翻译：本发明涉及药剂的透皮递送方法。特别地，本发明涉及一种通过在受试者的皮肤上产生微通道并通过微通道离子电渗药物给药的透皮递送方法。该方法提供这种药剂的协同透皮递送。

103. 发明授权

US07383084B2 Transdermal delivery system for dried particulate or lyophilized medications 有权
公开(公告)号：US07383084B2
公开(公告)日：2008-06-03
申请号：US11390844
申请日：2006-03-27
申请人： Meir Stern , Galit Levin
发明人： Meir Stern , Galit Levin
IPC分类号： A61L15/16 , A61N1/30 , A61K38/28
CPC分类号： A61N1/327 , A61K9/0021 , A61K9/703 , A61K9/7084 , A61L15/44 , A61L2300/252 , A61L2300/414 , A61L2300/43 , A61L2300/602 , A61M37/00 , A61N1/042 , A61N1/0436
摘要： The present invention provides a system for transdermal delivery of dried or lyophilized pharmaceutical compositions and methods using thereof. The system comprises an apparatus for facilitating transdermal delivery of an agent that generates hydrophilic micro-channels, and a patch comprising a therapeutically active agent. The present invention is useful for transdermal delivery of hydrophilic agents, particularly of high molecular weight proteins.

104. 发明申请

US20070292445A1 DELIVERY SYSTEM FOR TRANSDERMAL IMMUNIZATION 审中-公开
标题翻译：递送免疫系统
公开(公告)号：US20070292445A1
公开(公告)日：2007-12-20
申请号：US11571460
申请日：2005-07-05
申请人： Galit Levin
发明人： Galit Levin
IPC分类号： A61N1/30 , A61K39/00 , A61K39/12 , A61K39/02 , A61K39/35 , A61K39/38
CPC分类号： A61N1/327 , A61K9/0009 , A61K9/0021 , A61N1/042 , A61N1/0436 , Y02A50/475
摘要： The present invention relates to a delivery system for transdermal immunization. More particularly, the invention relates to a delivery system for effective topical administration of antigens using an apparatus that generates micro-channels in the skin of a subject. The delivery system is useful for immunization against bacterial, viral, and fungal antigens as well as for treating tumors and allergies.
摘要翻译：本发明涉及用于经皮免疫的递送系统。更具体地说，本发明涉及使用在受试者的皮肤中产生微通道的装置有效局部施用抗原的递送系统。递送系统可用于免疫细菌，病毒和真菌抗原以及治疗肿瘤和过敏。

105. 发明授权

US07164942B2 Handheld apparatus and method for transdermal drug delivery and analyte extraction 有权
标题翻译：用于透皮药物递送和分析物提取的手持设备和方法
公开(公告)号：US07164942B2
公开(公告)日：2007-01-16
申请号：US10775725
申请日：2004-02-09
申请人： Zohar Avrahami , Ze'ev Sohn
发明人： Zohar Avrahami , Ze'ev Sohn
IPC分类号： A61N1/30 , A61M31/00 , A61B5/04
CPC分类号： A61N1/30 , A61N1/325
摘要： A device is provided for treating skin on the body of a subject. The device includes a plurality of electrodes, which are adapted to be placed in contact with the skin and then moved across the skin while maintaining electrical contact with the skin. The device additionally includes a power source, which is adapted to apply a current between two or more of the plurality of electrodes at the same time as the electrodes are being moved across the skin.
摘要翻译：提供一种用于治疗受试者身体皮肤的装置。该装置包括多个电极，其适于被放置成与皮肤接触，然后移动穿过皮肤，同时保持与皮肤的电接触。该装置还包括电源，其适于在电极移动穿过皮肤的同时在多个电极中的两个或更多个之间施加电流。

106. 发明授权

US08041421B2 Transdermal delivery system for polynucleotides 有权
标题翻译：多核苷酸的透皮递送系统
公开(公告)号：US08041421B2
公开(公告)日：2011-10-18
申请号：US10597431
申请日：2005-01-25
申请人： James Birchall , Galit Levin , Amikam Gershonowitz
发明人： James Birchall , Galit Levin , Amikam Gershonowitz
IPC分类号： A61N1/30 , A61M31/00
CPC分类号： A61N1/327
摘要： A system for intradermal or transdermal delivery of oligonucleotides or polynucleotides and methods of use thereof employ an apparatus that generates micro-channels in the skin of a subject in conjunction with a pharmaceutical composition comprising an oligonucleotide or polynucleotide, wherein the oligonucleotide or polynucleotide can be delivered into the organism through the micro-channels. The system and methods achieve expression of target proteins encoded by the polynucleotides, and hence are useful in immunization and gene therapy.
摘要翻译：寡核苷酸或多核苷酸的皮内或透皮递送系统及其使用方法采用与包含寡核苷酸或多核苷酸的药物组合物结合的受试者皮肤中产生微通道的装置，其中所述寡核苷酸或多核苷酸可被递送通过微通道进入生物体。该系统和方法实现由多核苷酸编码的靶蛋白的表达，因此可用于免疫和基因治疗。

107. 发明授权

US08016810B2 Transdermal delivery system for cosmetic agents 有权
标题翻译：化妆品的透皮递送系统
公开(公告)号：US08016810B2
公开(公告)日：2011-09-13
申请号：US10561933
申请日：2004-06-23
申请人： Galit Levin , Hagit Sacks , Sergey Rudaev
发明人： Galit Levin , Hagit Sacks , Sergey Rudaev
IPC分类号： A61M31/00
CPC分类号： A61N1/327 , A61B18/14 , A61B2017/00765 , A61K8/347 , A61K8/368 , A61K8/4953 , A61N1/0424 , A61Q19/02 , A61Q19/06 , A61Q19/08
摘要： An intradermal or transdermal delivery system for topical administration of cosmetic agents, particularly water-soluble, poorly water-soluble, or water-insoluble cosmetic agents, in conjunction with an apparatus that generates micro-channels in the skin of a subject, is useful in treating skin conditions such as cellulite, hyper-pigmentation, skin aging, and acne.
摘要翻译：用于局部施用化妆品，特别是水溶性，水溶性差或水不溶性的化妆品的皮内或透皮递送系统与在受试者的皮肤中产生微通道的装置结合使用可用于治疗皮肤病，如脂肪团，色素沉着过度，皮肤老化和痤疮。

108. 发明申请

US20110178518A1 HANDHELD TRANSDERMAL DRUG DELIVERY AND ANALYTE EXTRACTION 有权
标题翻译：手持式药物传递和分析提取
公开(公告)号：US20110178518A1
公开(公告)日：2011-07-21
申请号：US13013413
申请日：2011-01-25
申请人： Ze'ev Sohn
发明人： Ze'ev Sohn
IPC分类号： A61B18/00
CPC分类号： A61N1/327 , A61B18/14 , A61B2018/00208 , A61B2018/00452 , A61B2018/1467 , A61B2018/1861 , A61M37/00 , A61N1/0424 , A61N1/044 , A61N1/0476 , A61N1/306
摘要： Apparatus (20) for application to skin of a subject is provided. The apparatus includes a board (30) having a first surface and a second surface, the first surface including a plurality of ablation electrodes (41), which are adapted to be applied to the skin, and the second surface including one or more contact pads (32), each one of the contact pads electrically coupled to at least one of the ablation electrodes. The apparatus further includes one or more driving electrodes (28). An energy applicator (e.g., motor 22), coupled to the driving electrodes, is adapted to pass the driving electrodes over the contact pads. A power source (e.g., power unit 102) is adapted to drive a current from the driving electrodes, to the contact pads, and to the ablation electrodes. The current is capable of ablating at least a portion of stratum corneum of the skin in a vicinity of the ablation electrodes, so as to facilitate transdermal transport of a substance.
摘要翻译：提供了用于受试者皮肤的装置（20）。所述装置包括具有第一表面和第二表面的板（30），所述第一表面包括适于施加到皮肤的多个消融电极（41），所述第二表面包括一个或多个接触垫（32），所述接触垫中的每一个电耦合到所述消融电极中的至少一个。该装置还包括一个或多个驱动电极（28）。耦合到驱动电极的能量施加器（例如，马达22）适于使驱动电极穿过接触垫。电源（例如，功率单元102）适于驱动来自驱动电极，接触焊盘和消融电极的电流。该电流能够在消融电极附近烧蚀皮肤的角质层的至少一部分，以促进物质的透皮转运。

109. 发明授权

US07662404B2 Transdermal delivery system for dried particulate or lyophilized peptides and polypeptides 有权
标题翻译：用于干燥颗粒或冻干肽和多肽的透皮递送系统
公开(公告)号：US07662404B2
公开(公告)日：2010-02-16
申请号：US11582920
申请日：2006-10-17
申请人： Meir Stern , Galit Levin
发明人： Meir Stern , Galit Levin
IPC分类号： A61L15/16 , A61N1/30 , A61K38/28
CPC分类号： A61K9/703 , A61K9/0021 , A61K9/7084 , A61N1/327
摘要： The present invention provides a system for transdermal delivery of dried or lyophilized pharmaceutical compositions and methods using thereof. The system comprises an apparatus for facilitating transdermal delivery of a peptide or polypeptide that generates hydrophilic micro-channels, and a patch comprising dried therapeutically peptide or polypeptide. Particularly, the system of the present invention facilitates transdermal delivery of parathyroid hormone useful for preventing or treating bone disorders.
摘要翻译：本发明提供了一种用于透皮递送干燥或冻干的药物组合物及其使用方法的系统。该系统包括用于促进产生亲水性微通道的肽或多肽的透皮递送的装置，以及包含干燥的治疗性肽或多肽的贴剂。特别地，本发明的系统有利于用于预防或治疗骨骼疾病的甲状旁腺激素的透皮递送。

110. 发明申请

US20080274166A1 Patch for Transdermal Drug Delivery 审中-公开
标题翻译：透皮给药补片
公开(公告)号：US20080274166A1
公开(公告)日：2008-11-06
申请号：US11915831
申请日：2006-06-11
申请人： Hagit Sacks , Meir Stern , Galit Levin , Bar El Yossi , Giora Arbel
发明人： Hagit Sacks , Meir Stern , Galit Levin , Bar El Yossi , Giora Arbel
IPC分类号： A61K9/70 , A61P43/00
CPC分类号： A61K9/703 , A61F2013/0296 , A61K9/7084
摘要： Apparatus is provided including a transdermal drug delivery patch product (10, 100), which includes a patch (20, 120), which includes a drug; and protective packaging, adapted to store the patch (20, 120), and to allow the drug to dry while the patch (20, 120) is stored in the protective packaging. Other embodiments are also described.
摘要翻译：提供了包括透皮药物递送贴片产品（10,100）的装置，其包括贴剂（20,120），其包括药物; 和保护性包装，其适于储存所述贴片（20,120），并且当所述贴片（20,120）存储在所述保护性包装中时允许所述药物干燥。还描述了其它实施例。

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